Homomeric and heteromeric P2X3 receptors in peripheral sensory neurons

Current Opinion in Investigational Drugs

Volumn 9, Issue 7, 2008, Pages 716-725

  Brederson, J D ^a   Jarvis, M F ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Bladder; Mechanoreceptor; Pain; Peripheral; Purinergic; Sensory

Indexed keywords

2',3' O (2,4,6 TRINITROPHENYL)ADENOSINE TRIPHOSPHATE; 3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; 5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X2 RECEPTOR ANTAGONIST; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X3 RECEPTOR AGONIST; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; RO 3; SURAMIN; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; CELLULAR DISTRIBUTION; CHRONIC INFLAMMATION; GENE DELETION; HYPOALGESIA; LIGAND BINDING; NEUROPATHIC PAIN; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RECEPTOR DENSITY; RECEPTOR UPREGULATION; REVIEW; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; ANIMAL; BLADDER; DRUG EFFECT; HUMAN; INNERVATION; MECHANORECEPTOR; MICTURITION; PERIPHERAL NERVE; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; HUMANS; MECHANORECEPTORS; NEURONS, AFFERENT; PERIPHERAL NERVES; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; URINARY BLADDER; URINATION;

EID: 46749136470     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Burnstock G: Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev (2007) 87(2):659-797.
2. Buell G, Collo G, Rassendren F: P2X receptors: An emerging channel family. Eur J Neurosci (1996) 8(10):2221-2228.
3. 3 receptors form stable trimers: A novel structural motif of ligand-gated ion channels. EMBO J (1998) 17(11):3016-3028.
4. Torres GE, Egan TM, Voigt MM: Identification of a domain involved in ATP-gated ionotropic receptor subunit assembly. J Biol Chem (1999) 274(32):22359-22365.
5. 2 purinoceptors. J Gen Physiol (1999) 113(5):695-720.
6. North RA: Molecular physiology of P2X receptors. Physiol Rev (2002) 82(4):1013-1067.
7. Khakh BS, North RA: P2X receptors as cell-surface ATP sensors in health and disease. Nature (2006) 442(7102):527-532.
8. Burnstock G, Williams M: P2 purinergic receptors: Modulation of cell function and therapeutic potential. J Pharmacol Exp Ther (2000) 295(3):862-869.
9. Jahr CE, Jessell TM: ATP excites a subpopulation of rat dorsal horn neurones. Nature (1983) 304(5928):730-733.
10. 3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology (1997) 36(9):1229-1242.
11. 3 is expressed by DRG neurons that terminate in inner lamina II. Eur J Neurosci (1998) 10(11):3470-3478.
12. 3 receptors in rat sensory neurons. Neuroreport (1998) 9(11):2245-2250.
13. Cook SP, McCleskey EW: Cell damage excites nociceptors through release of cytosolic ATP. Pain (2000) 95(1-2):41-47.
14. Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Touma E, Metzger RE, Kowaluk EA, Jarvis MF: P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J Neurophysiol (1999) 82(3):1590-1598.
15. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci (1996) 16(8):2495-2507.
16. Ding Y, Cesare P, Drew L, Nikitaki D, Wood JN: ATP, P2X receptors and pain pathways. J Auton Nerv Syst (2000) 81(1-3):289-294.
17. Harper AA, Lawson SN: Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J Physiol (1985) 359(1):31-46.
18. 3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res (2002) 147(4):511-519.
19. King BF, Townsend-Nicholson A, Burnstock G: Metabotropic receptors for ATP and UTP: Exploring the correspondence between native and recombinant nucleotide receptors. Trends Pharmacol Sci (1998) 19(12):506-514.
20. Jacobson KA, Jarvis MF, Williams M: Purine and pyrimidine (P2) receptors as drug targets. J Med Chem (2002) 45(19):4057-4093.
21. Jacobson KA, Costanzi S, Joshi BV, Besada P, Shin DH, Ko H, Ivanov AA, Mamedova L: Agonists and antagonists for P2 receptors. Novartis Found Symp (2006) 276:58-68.
22. 3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Ther Targets (2003) 7(4):513-522.
23. 2 receptor. Br J Pharmacol (1997) 121(7):1445-1453.
24. Mockett BG, Housley GD, Thorne PR: Fluorescence imaging of extracellular purinergic receptor sites and putative ecto-ATPase sites on isolated cochlear hair cells. J Neurosci (1994) 14(11 Pt 2):6992-7007.
25. Lewis CJ, Suprenant A, Evans RJ: 2′,3′-O- (2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br J Pharmacol (1998) 124(7):1463-1466.
26. 2/3 receptors. Mol Pharmacol (1998) 53(6):969-973.
27. Thomas S, Virginio C, North RA, Suprenant A: The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones. J Physiol (1998) 509(2):411-417.
28. 3 receptor selective antagonist.
29. Gever JR, Cockayne DA, Dillon MP, Burnstock G, Ford AP: Pharmacology of P2X channels. Pflugers Arch (2006) 452(5):513-537.
30. Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF: Painful purinergic receptors. J Pharmacol Exp Ther (2008) 324(2):409-415.
31. 3 in mechanotransduction.
32. Coutts AA, Jorizzo JL, Eady RA, Greaves MW, Burnstock G: Adenosine triphosphate-evoked vascular changes in human skin: Mechanism of action. Eur J Pharmacol (1981) 76(4):391-401.
33. Bleehen T, Keele CA: Observation on the algogenic actions of adenosine compounds on the human blister base preparation. Pain (1977) 3(4):367-377.
34. Hamilton SG, Warburton J, Bhattachar A, Ward J, McMahon SB: ATP in human skin elicits a dose-related pain response under conditions of hyperalgesia. Brain (2000) 123(6):1238-1246.
35. Hilliges M, Weidner C, Schmelz M, Schmidt R, Ørstavik K, Torebjörk E, Handwerker H: ATP responses in human C nociceptors. Pain (2002) 98(1-2):59-68.
36. Ho BT, Huo YY, Lu JG, Newman RA, Levin VA: Analgesic activity of anticancer agent suramin. Anticancer Drugs (1992) 3(2):91-94.
37. 3 receptor gene.
38. 3 receptor gene.
39. 3. Pain (2005) 116(1-2):96-108.
40. 3 receptor antisense reduces receptor expression and pain in rodents.
41. 3 receptor antisense reduces receptor expression and pain in rodents.
42. Inoue K, Koizumi S, Tsuda M: The role of nucleotides in the neuron - glia communication responsible for the brain functions. J Neurochem (2007) 102(5):1447-1458.
43. Sawynok J: Adenosine and ATP receptors. Handbook Exp Pharmacol (2007) 177:309-328.
44. 3 allosteric modulator, cibacron blue. Br J Pharmacol (2001) 132(1):259-269.
45. 2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration. Br J Pharmacol (2003) 140(8):1381-1388.
46. 2/3 receptor antagonist. Drug News Perspect (2005) 18(8):501-507.
47. Cook SP, McCleskey EW: ATP, pain and a full bladder. Nature (2000) 407(6807):951-952.
48. Rapp DE, Lyon MB, Bales GT, Cook SP: A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction. Eur Urol (2005) 48(2):303-308.
49. Ferguson DR, Kennedy I, Burton TJ: ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J Physiol (1997) 505(2):503-511.
50. 3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci (2001) 21(15):5670- 5677.
51. Zhong Y, Banning AS, Cockayne DA, Ford AP, Burnstock G, Mcmahon SB: Bladder and cutaneous sensory neurons of the rat express different functional P2X receptors. Neuroscience (2003) 120(3):667-675.
52. Lee HY, Bardini M, Burnstock G: P2X receptor immunoreactivity in the male genital organs of the rat. Cell Tissue Res (2000) 300(2):321-330.
53. Gur S, Kadowitz PJ, Hellstrom WJ: Purinergic (P2) receptor control of lower genitourinary tract function and new avenues for drug action: An overview. Curr Pharm Des (2007) 13(31):3236-3244.
54. Ford AP, Gever JR, Nunn PA, Zhong Y, Cefalu JS, Dillon MP, Cockayne DA: Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol (2006) 147(Suppl 2):S132-S143.
55. Ruggieri MR Sr: Mechanisms of disease: Role of purinergic signaling in the pathophysiology of bladder dysfunction. Nature (2006) 3(4):206-215.
56. Burnstock G: Purine-mediated signaling in pain and visceral perception. Trends Pharmacol Sci (2001) 22(4):182-188.
57. Sengupta JN, Gebhart GF: Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. J Neurophysiol (1994) 72(5):2420-2430.
58. Rong W, Spyer KM, Burnstock G: Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol (2002) 541(2):591-600.
59. Kontani H, Hayashi K: Urinary bladder response to hypogastric nerve stimulation after bilateral resection of the pelvic nerve or spinal cord injury in rats. Int J Urol (1997) 4(4):394-400.
60. Meen M, Coudore-Civiale MA, Eschalier A, Boucher M: Involvement of hypogastric and pelvic nerves for conveying cystitis induced nociception in conscious rat. J Urol (2001) 166(1):318-322.
61. Häbler HJ, Jänig W, Koltzenburg M: Activation of unmyelinated afferent fibres by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol (1990) 425(1):545-562.
62. Häbler HJ, Jänig W, Koltzenburg M: Receptive properties of myelinated primary afferents innervating the inflamed urinary bladder of the cat. J Neurophysiol (1993) 69(2):395-405.
63. Häbler HJ, Jänig W, Koltzenburg M: Myelinated primary afferents of the sacral spinal cord responding to slow filling and distension of the cat urinary bladder. J Physiol (1993) 463(1):449-460.
64. Häbler HJ, Jänig W, Koltzenburg M: Novel type of unmyelinated chemosensitive nociceptor in the acutely inflamed urinary bladder. Agents Actions (1988) 25(3-4):219-221.
65. Zagorodnyuk VP, Gibbins IL, Costa M, Brookes SJ, Gregory SJ: Properties of the major classes of mechanoreceptors in the guinea pig bladder. J Physiol (2007) 585(1):147-163.
66. Xu L, Gebhart GF: Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents. J Neurophysiol (2008) 99(1):244-253.
67. 2/3 antagonist A-317491 on cyclophosphamide-induced cystitis in rats. Naunyn Schmiedebergs Arch Pharmacol (2007): doi:10.1007/s00210-007-0197-z.
68. Lu SH, Groat WC, Lin AT, Chen KK, Chang LS: Evaluation of purinergic mechanism for the treatment of voiding dysfunction: A study in conscious spinal cord-injured rats. J Chin Med Assoc (2007) 70(10):439-444.
69. Dang K, Lamb K, Cohen M, Bielefeldt K, Gebhart GF: Cyclophosphamide- induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons. J Neurophysiol (2008) 99(1):49-59.
70. 7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther (2006) 319(3):1376-1385.
71. 4. J Pharmacol Sci (2004) 94(2):112- 114.
72. 2. Eur J Neurosci (2002) 16(10):1850-1860.
73. 12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J Neurosci (2008) 28(11):2892-2902.
74. 3-deficient mice. Eur J Neurosci (2001) 14(11):1784-1792.