메뉴 건너뛰기




Volumn 75, Issue 4, 2012, Pages 389-398

Pleiotropic functions of bile acids mediated by the farnesoid X receptor

Author keywords

Atherosclerosis; Cholestasis; Diabetes; Liver; Metabolism

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; 6 ETHYL CHENODEOXYCHOLIC ACID; BILE ACID; BILE ACID CONJUGATE; FARNESOID X RECEPTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CELL RECEPTOR; CHOLESTEROL; FARNESOID X-ACTIVATED RECEPTOR; GLUCOSE;

EID: 84875034795     PISSN: 00015644     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (29)

References (90)
  • 2
    • 1542513682 scopus 로고    scopus 로고
    • Expression and activation of the farnesoid X receptor in the vasculature
    • BISHOP-BAILEY D., WALSH DT., WARNER TD. Expression and activation of the farnesoid X receptor in the vasculature. Proc. Natl. Acad. Sci. USA, 2004, 101: 3668-3673.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 3668-3673
    • Bishop-Bailey, D.1    Walsh, D.T.2    Warner, T.D.3
  • 3
    • 77952561299 scopus 로고    scopus 로고
    • Bile acids as regulators of hepatic lipid and glucose metabolism
    • TRAUNER M., CLAUDEL T., FICKERT P., MOUSTAFA T., WAGNER M. Bile acids as regulators of hepatic lipid and glucose metabolism. Dig. Dis., 2010, 28: 220-224.
    • (2010) Dig. Dis. , vol.28 , pp. 220-224
    • Trauner, M.1    Claudel, T.2    Fickert, P.3    Moustafa, T.4    Wagner, M.5
  • 4
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • WANG H., CHEN J., HOLLISTER K., SOWERS LC., FORMAN BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell., 1999, 3: 543-553.
    • (1999) Mol. Cell. , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 6
    • 0037094415 scopus 로고    scopus 로고
    • Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
    • HUBER R.M., MURPHY K., MIAO B., LINK J.R., CUNNINGHAM M.R., RUPAR M.J. et al. Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. Gene., 2002, 290: 35-43.
    • (2002) Gene. , vol.290 , pp. 35-43
    • Huber, R.M.1    Murphy, K.2    Miao, B.3    Link, J.R.4    Cunningham, M.R.5    Rupar, M.J.6
  • 7
    • 23944521260 scopus 로고    scopus 로고
    • Farnesoid X receptor: Form structure to potential clinical applications
    • PELLICCIARI R., COSTANTINO G., FIORUCCI S. Farnesoid X receptor: form structure to potential clinical applications. J. Med. Chem., 2005, 48: 5383-5403.
    • (2005) J. Med. Chem. , vol.48 , pp. 5383-5403
    • Pellicciari, R.1    Costantino, G.2    Fiorucci, S.3
  • 10
    • 79952749979 scopus 로고    scopus 로고
    • Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
    • SWANN J.R., WANT E.J., GEIER F.M., SPAGOU K., WILSON I.D., SIDAWAY J.E. et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc. Natl. Acad. Sci. USA, 2011; 108 Suppl. 1: 4523-30.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , Issue.SUPPL. 1 , pp. 4523-4530
    • Swann, J.R.1    Want, E.J.2    Geier, F.M.3    Spagou, K.4    Wilson, I.D.5    Sidaway, J.E.6
  • 11
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • LEFEBVRE P., CARIOU B., LIEN F., KUIPERS F., STAELS B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev., 2009, 89: 147-191.
    • (2009) Physiol. Rev. , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 13
    • 0037101810 scopus 로고    scopus 로고
    • 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anti-cholestatic activity
    • PELLICCIARI R., FIORUCCI S., CAMAIONI E., CLERICI C., COSTANTINO G., MALONEY P.R. et al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anti-cholestatic activity. J. Med. Chem., 2002, 45: 3569-3572.
    • (2002) J. Med. Chem. , vol.45 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3    Clerici, C.4    Costantino, G.5    Maloney, P.R.6
  • 14
    • 77955334203 scopus 로고    scopus 로고
    • Farnesoid-X receptor agonists: A new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid
    • MASON A., LUKETIC V., LINDOR K., HIRSCHFIELD G., GORDON S., MAYO M. et al. Farnesoid-X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid. J. Hepatol., 2010; 52 (Suppl 1): S1-S2.
    • (2010) J. Hepatol. , vol.52 , Issue.SUPPL. 1
    • Mason, A.1    Luketic, V.2    Lindor, K.3    Hirschfield, G.4    Gordon, S.5    Mayo, M.6
  • 15
    • 77949875041 scopus 로고    scopus 로고
    • A new therapy for nonalcoholic fatty liver disease and diabetes? INT-747-the first FXR hepatic therapeutic study
    • SANYAL A.J., MUDALIAR R.R., HENRY R.R., MARSCHALL H.U., MORROW L., SCIACCA C.I. et al. A new therapy for nonalcoholic fatty liver disease and diabetes? INT-747-the first FXR hepatic therapeutic study. Hepatology, 2009, 50: 389-390.
    • (2009) Hepatology , vol.50 , pp. 389-390
    • Sanyal, A.J.1    Mudaliar, R.R.2    Henry, R.R.3    Marschall, H.U.4    Morrow, L.5    Sciacca, C.I.6
  • 17
    • 0033636789 scopus 로고    scopus 로고
    • Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
    • LU T.T., MAKISHIMA M., REPA J.J., SCHOONJANS K., KERR T.A., AUWERX J. et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol. Cell., 2000, 6: 507-515.
    • (2000) Mol. Cell. , vol.6 , pp. 507-515
    • Lu, T.T.1    Makishima, M.2    Repa, J.J.3    Schoonjans, K.4    Kerr, T.A.5    Auwerx, J.6
  • 18
    • 43449097571 scopus 로고    scopus 로고
    • Molecular basis of endocrine regulation by orphan nuclear receptor small heterodimer partner
    • CHANDA D., PARK J.H., CHOI H.S. Molecular basis of endocrine regulation by orphan nuclear receptor small heterodimer partner. Endocr. J., 2008, 55: 253-268.
    • (2008) Endocr. J. , vol.55 , pp. 253-268
    • Chanda, D.1    Park, J.H.2    Choi, H.S.3
  • 19
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • MALONEY P.R., WILLSON T.M., KLIEWER S.A. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol. Cell., 2000, 6: 517-526.
    • (2000) Mol. Cell. , vol.6 , pp. 517-526
    • Maloney, P.R.1    Willson, T.M.2    Kliewer, S.A.3
  • 20
    • 0035834771 scopus 로고    scopus 로고
    • Transcriptional regulation of the human sterol 12 alpha-hydroxylase gene (CYP8B1): Roles of hepatocyte nuclear factor 4alpha in mediating bile acid repression
    • ZHANG M., CHIANG Y.J. Transcriptional regulation of the human sterol 12 alpha-hydroxylase gene (CYP8B1): roles of hepatocyte nuclear factor 4alpha in mediating bile acid repression. J. Biol. Chem., 2001, 276: 41690-41699.
    • (2001) J. Biol. Chem. , vol.276 , pp. 41690-41699
    • Zhang, M.1    Chiang, Y.J.2
  • 21
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • INAGAKI T., CHOI M., MOSCHETTA A., PENG L., CUMMINS C.L., MC DONALD J.G. et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab., 2005, 2: 217-225.
    • (2005) Cell Metab. , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6
  • 22
    • 65449177586 scopus 로고    scopus 로고
    • High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
    • SCHAAP F.G., VAN DER GAAG N.A., GOUMA D.J., JANSEN P.L. High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology, 2009, 49: 1228-1235.
    • (2009) Hepatology , vol.49 , pp. 1228-1235
    • Schaap, F.G.1    van der Gaag, N.A.2    Gouma, D.J.3    Jansen, P.L.4
  • 23
    • 2542470676 scopus 로고    scopus 로고
    • Modulation of metabolic syndrome by fibro-blast growth factor 19 (FGF19)?
    • STRACK A.M., MYERS R.W. Modulation of metabolic syndrome by fibro-blast growth factor 19 (FGF19)? Endocrinology, 2004, 145: 2591-2593.
    • (2004) Endocrinology , vol.145 , pp. 2591-2593
    • Strack, A.M.1    Myers, R.W.2
  • 25
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump (BSEP) promoter is transactivated by the farnesoid X receptor/bile acid receptor (FXR/BAR)
    • ANANTHANARAYANAN M., BALASUBRAMANIAN N.V., MAKISHIMA M., MANGELSDORF D.J., SUCHY F.J. Human bile salt export pump (BSEP) promoter is transactivated by the farnesoid X receptor/bile acid receptor (FXR/BAR). J. Biol. Chem., 2001, 276: 28857-28865.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.V.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 26
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid Xactivated receptor, and constitutive androstane receptor
    • KAST H.R., GOODWIN B., TARR P.T., JONES S.A., ANISFELD A.M., STOLTZ C.M. et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid Xactivated receptor, and constitutive androstane receptor. J. Biol. Chem., 2002, 277: 2908-2915.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6
  • 27
    • 17344366172 scopus 로고    scopus 로고
    • A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
    • STRAUTNIEKS S.S., BULL L.N., KNISELY A.S., KOCOSHIS S.A., DAHL N., ARNELL H. et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat. Genet., 1998, 20: 233-238.
    • (1998) Nat. Genet. , vol.20 , pp. 233-238
    • Strautnieks, S.S.1    Bull, L.N.2    Knisely, A.S.3    Kocoshis, S.A.4    Dahl, N.5    Arnell, H.6
  • 29
    • 33646871585 scopus 로고    scopus 로고
    • Upregulation of a basolateral FXR-dependent bile acid efflux transporter OST α /OST β in cholestasis in humans and rodents
    • BOYER J.L., TRAUNER M., MENNONE A., SOROKA C.J., CAI S.Y., MOUSTAFA T. et al. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OST α /OST β in cholestasis in humans and rodents. Am. J. Physiol. Gastrointest. Liver Physiol., 2006, 290: 1124-1130.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290 , pp. 1124-1130
    • Boyer, J.L.1    Trauner, M.2    Mennone, A.3    Soroka, C.J.4    Cai, S.Y.5    Moustafa, T.6
  • 30
    • 0037827787 scopus 로고    scopus 로고
    • Liver receptor homologue-1 mediates species-and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter
    • CHEN F., MA L., DAWSON P.A., SINAL C.J., SEHAYEK E., GONZALEZ F.J. et al. Liver receptor homologue-1 mediates species-and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J. Biol. Chem., 2003, 278: 19909-19916.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19909-19916
    • Chen, F.1    Ma, L.2    Dawson, P.A.3    Sinal, C.J.4    Sehayek, E.5    Gonzalez, F.J.6
  • 31
    • 30844460667 scopus 로고    scopus 로고
    • OSTalpha-OSTbeta: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    • BALLATORI N., CHRISTIAN W.V., LEE J.Y., DAWSON P.A., SOROKA C.J., BOYER J.L. et al. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology, 2005, 42: 1270-1279.
    • (2005) Hepatology , vol.42 , pp. 1270-1279
    • Ballatori, N.1    Christian, W.V.2    Lee, J.Y.3    Dawson, P.A.4    Soroka, C.J.5    Boyer, J.L.6
  • 32
    • 79958263832 scopus 로고    scopus 로고
    • Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease
    • CLAUDEL T., ZOLLNER G., WAGNER M., TRAUNER T. Role of nuclear receptors for bile acid metabolism, bile secretion, cholestasis, and gallstone disease. Biochim. Biophys. Acta, 2011, 1812: 867-878.
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 867-878
    • Claudel, T.1    Zollner, G.2    Wagner, M.3    Trauner, T.4
  • 33
    • 6944234902 scopus 로고    scopus 로고
    • Regulation of CYP3A4 by the bile acid receptor FXR: Evidence for functional binding sites in the CYP3A4 gene
    • GNERRE C., BLATTLER S., KAUFMANN M.R., LOOSER R., MEYER U.A. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmaco-genetics, 2004, 14: 635-645.
    • (2004) Pharmaco-genetics , vol.14 , pp. 635-645
    • Gnerre, C.1    Blattler, S.2    Kaufmann, M.R.3    Looser, R.4    Meyer, U.A.5
  • 34
    • 0035834769 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor
    • SONG C.S., ECHCHGADDA I., BAEK B.S., AHN S.C., OH T., ROY A.K. et al. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. J. Biol. Chem., 2001, 276: 42549-42556.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42549-42556
    • Song, C.S.1    Echchgadda, I.2    Baek, B.S.3    Ahn, S.C.4    Oh, T.5    Roy, A.K.6
  • 35
    • 0038281429 scopus 로고    scopus 로고
    • FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity
    • BARBIER O., TORRA I.P., SIRVENT A., CLAUDEL T., BLANQUART C., DURAN-SANDOVAL D. et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology, 2003, 124: 1926-1940.
    • (2003) Gastroenterology , vol.124 , pp. 1926-1940
    • Barbier, O.1    Torra, I.P.2    Sirvent, A.3    Claudel, T.4    Blanquart, C.5    Duran-Sandoval, D.6
  • 36
    • 0019507465 scopus 로고
    • Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: The national cooperative gallstone study. A controlled trial of efficacy and safety
    • SCHOENFIELD L.J., LACHIN J.M. Chenodiol (chenodeoxycholic acid) for dissolution of gallstones: the national cooperative gallstone study. A controlled trial of efficacy and safety. Ann. Intern. Med., 1981, 95: 257-282.
    • (1981) Ann. Intern. Med. , vol.95 , pp. 257-282
    • Schoenfield, L.J.1    Lachin, J.M.2
  • 37
    • 0037020162 scopus 로고    scopus 로고
    • Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA
    • NAKAHARA M., FUJII H., MALONEY P.R., SHIMIZU M., SATO R. Bile acids enhance low density lipoprotein receptor gene expression via a MAPK cascade-mediated stabilization of mRNA. J. Biol. Chem., 2002, 277: 37229-37234.
    • (2002) J. Biol. Chem. , vol.277 , pp. 37229-37234
    • Nakahara, M.1    Fujii, H.2    Maloney, P.R.3    Shimizu, M.4    Sato, R.5
  • 38
    • 0019995346 scopus 로고
    • Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones
    • LEISS O., VON BERGMANN K. Different effects of chenodeoxycholic acid and ursodeoxycholic acid on serum lipoprotein concentrations in patients with radiolucent gallstones. Scand. J. Gastroenterol., 1982, 17: 587-592.
    • (1982) Scand. J. Gastroenterol. , vol.17 , pp. 587-592
    • Leiss, O.1    von Bergmann, K.2
  • 39
    • 38749102779 scopus 로고    scopus 로고
    • High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: Significance for cardiovascular risk: The IDEAL and EPIC-Norfolk studies
    • VAN DER STEEG W.A., HOLME I., BOEKHOLDT S.M., LARSEN M.L., LINDAHL C., STROES E.S. et al. High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies. J. Am. Coll. Cardiol., 2008, 51: 634-642.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , pp. 634-642
    • van der Steeg, W.A.1    Holme, I.2    Boekholdt, S.M.3    Larsen, M.L.4    Lindahl, C.5    Stroes, E.S.6
  • 41
    • 33244464484 scopus 로고    scopus 로고
    • A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids
    • SHIH D.M., KAST-WOELBERN H.R., WONG J., XIA Y.R., EDWARDS P.A., LUSIS A.J. A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. J. Lipid Res., 2006, 47: 384-392.
    • (2006) J. Lipid Res. , vol.47 , pp. 384-392
    • Shih, D.M.1    Kast-Woelbern, H.R.2    Wong, J.3    Xia, Y.R.4    Edwards, P.A.5    Lusis, A.J.6
  • 42
    • 0034671526 scopus 로고    scopus 로고
    • The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression
    • URIZAR N.L., DOWHAN D.H., MOORE D.D. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression. J. Biol. Chem., 2000, 275: 39313-39317.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39313-39317
    • Urizar, N.L.1    Dowhan, D.H.2    Moore, D.D.3
  • 43
    • 77951942185 scopus 로고    scopus 로고
    • FXR an emerging target for the treatment of atherosclerosis
    • MENCARELLI A., FIORUCCI S. FXR an emerging target for the treatment of atherosclerosis. J. Cell. Mol. Med., 2010, 14: 79-92.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 79-92
    • Mencarelli, A.1    Fiorucci, S.2
  • 44
    • 33644861794 scopus 로고    scopus 로고
    • Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells
    • HE F., LI J., MU Y., KURUBA R., MA Z., WILSON A. et al. Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circ. Res., 2006, 98: 192-199.
    • (2006) Circ. Res. , vol.98 , pp. 192-199
    • He, F.1    Li, J.2    Mu, Y.3    Kuruba, R.4    Ma, Z.5    Wilson, A.6
  • 45
    • 38849164313 scopus 로고    scopus 로고
    • FXRmediated regulation of enos expression in vascular endothelial cells
    • LI J., WILSON A., KURUBA R., ZHANG Q., GAO X., HE F. et al. FXRmediated regulation of enos expression in vascular endothelial cells. Cardio-vasc. Res., 2008, 77: 169-177.
    • (2008) Cardio-vasc. Res. , vol.77 , pp. 169-177
    • Li, J.1    Wilson, A.2    Kuruba, R.3    Zhang, Q.4    Gao, X.5    He, F.6
  • 46
    • 67651174552 scopus 로고    scopus 로고
    • Bile-acid-activated farnesoid x receptor regulates hydrogen sulfide production and hepatic microcirculation
    • RENGA B., MENCARELLI A., MIGLIORATI M., DISTRUTTI E., FIORUCCI S. Bile-acid-activated farnesoid x receptor regulates hydrogen sulfide production and hepatic microcirculation. World. J. Gastroenterol., 2009, 15: 2097-2108.
    • (2009) World. J. Gastroenterol. , vol.15 , pp. 2097-2108
    • Renga, B.1    Mencarelli, A.2    Migliorati, M.3    Distrutti, E.4    Fiorucci, S.5
  • 48
    • 33746834460 scopus 로고    scopus 로고
    • Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38
    • QIN P., TANG X., ELLOSO M.M., HARNISH D.C. Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38. Am. J. Physiol. Heart Circ. Physiol., 2006, 291: 741-747.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.291 , pp. 741-747
    • Qin, P.1    Tang, X.2    Elloso, M.M.3    Harnish, D.C.4
  • 49
    • 0015839395 scopus 로고
    • Serum lipids in cholelithiasis: Effect of chenodeoxycholic acid therapy
    • BELL G.D. Serum lipids in cholelithiasis: effect of chenodeoxycholic acid therapy. BMJ, 1973, 3: 520-523.
    • (1973) BMJ , vol.3 , pp. 520-523
    • Bell, G.D.1
  • 50
    • 0016201510 scopus 로고
    • Triglyceride-lowering effect of chemodeoxycholic acid in patients with endogenous hypertriglyceridemia
    • MILLER N.E., NESTEL P.J. Triglyceride-lowering effect of chemodeoxycholic acid in patients with endogenous hypertriglyceridemia. Lancet, 1974, 2: 929-31.
    • (1974) Lancet , vol.2 , pp. 929-931
    • Miller, N.E.1    Nestel, P.J.2
  • 52
    • 0034791544 scopus 로고    scopus 로고
    • Farnesoid X-activated receptor induces apolipoprotein C-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids
    • KAST H.R., NGUYEN C.M., SINAL C.J., JONES S.A., LAFFITTE B.A., REUE K. et al. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Mol. Endocrinol., 2001, 15: 1720-1728.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1720-1728
    • Kast, H.R.1    Nguyen, C.M.2    Sinal, C.J.3    Jones, S.A.4    Laffitte, B.A.5    Reue, K.6
  • 54
    • 2442463396 scopus 로고    scopus 로고
    • The farnesoid X receptor induces very low density lipoprotein receptor gene expression
    • SIRVENT A., CLAUDEL T., MARTIN G., BROZEK J., KOSYKH V., DARTEIL R. et al. The farnesoid X receptor induces very low density lipoprotein receptor gene expression. FEBS Lett., 2004, 566: 173-177.
    • (2004) FEBS Lett. , vol.566 , pp. 173-177
    • Sirvent, A.1    Claudel, T.2    Martin, G.3    Brozek, J.4    Kosykh, V.5    Darteil, R.6
  • 55
    • 0942279602 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
    • ZHANG Y., CASTELLANI L.W., SINAL C.J., GONZALEZ F.J., EDWARDS P.A. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev., 2004, 18: 157-169.
    • (2004) Genes Dev. , vol.18 , pp. 157-169
    • Zhang, Y.1    Castellani, L.W.2    Sinal, C.J.3    Gonzalez, F.J.4    Edwards, P.A.5
  • 56
    • 79955890870 scopus 로고    scopus 로고
    • Bile acid metabolism and the pathogenesis of type 2 diabetes
    • PRAWITT J., CARON S., STAELS B. Bile acid metabolism and the pathogenesis of type 2 diabetes. Curr. Diab. Rep., 2011, 11: 160-166.
    • (2011) Curr. Diab. Rep. , vol.11 , pp. 160-166
    • Prawitt, J.1    Caron, S.2    Staels, B.3
  • 57
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • ZHANG Y., LEE F.Y., BARRERA G., LEE H., VALES C., GONZALES F.J. et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc. Natl. Acad. Sci. USA, 2006, 103: 1006-1011.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzales, F.J.6
  • 58
    • 77950613528 scopus 로고    scopus 로고
    • FXR activation reverses insulin resistance and lipid anormalities and protect against liver steatosis in Zucker (fa/fa) obese rats
    • CIPRIANI S., MENCARELLI A., PALLADINO G., FIORUCCI S. FXR activation reverses insulin resistance and lipid anormalities and protect against liver steatosis in Zucker (fa/fa) obese rats. J. Lipid Res., 2010, 51: 771-784.
    • (2010) J. Lipid Res. , vol.51 , pp. 771-784
    • Cipriani, S.1    Mencarelli, A.2    Palladino, G.3    Fiorucci, S.4
  • 59
    • 84858796689 scopus 로고    scopus 로고
    • Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
    • CALKIN A.C., TONTONOZ P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat. Rev. Mol. Cell. Biol., 2012, 13: 213-224.
    • (2012) Nat. Rev. Mol. Cell. Biol. , vol.13 , pp. 213-224
    • Calkin, A.C.1    Tontonoz, P.2
  • 60
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    • YAMAGATA K., DAITOKU H., SHIMAMOTO Y., MATSUZAKI H., HIROTA K., ISHIDA J. et al. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J. Biol. Chem., 2004, 279: 23158-23165.
    • (2004) J. Biol. Chem. , vol.279 , pp. 23158-23165
    • Yamagata, K.1    Daitoku, H.2    Shimamoto, Y.3    Matsuzaki, H.4    Hirota, K.5    Ishida, J.6
  • 61
    • 79958066536 scopus 로고    scopus 로고
    • Fgf15/19 regulates hepatic glucose metabolism by inhibiting the creb-pgc-1α pathway
    • POTTHOFF M., BONEY-MONTOYA J., CHOI M., HE T., SUNNY N.E., SATAPATI S. et al. Fgf15/19 regulates hepatic glucose metabolism by inhibiting the creb-pgc-1α pathway. Cell Metab., 2011, 13: 729-738.
    • (2011) Cell Metab. , vol.13 , pp. 729-738
    • Potthoff, M.1    Boney-Montoya, J.2    Choi, M.3    He, T.4    Sunny, N.E.5    Satapati, S.6
  • 62
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • ZHANG Y., LEE F.Y., BARRERA G., LEE H., VALES C., GONZALES F. et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc. Natl. Acad. Sci. USA, 2006, 103: 1006-1011.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzales, F.6
  • 65
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • MA K., SAHA P.K., CHAN L., MOORE D.D. et al. Farnesoid X receptor is essential for normal glucose homeostasis. J. Clin. Invest., 2006, 116: 1102-1109.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 66
    • 33845881411 scopus 로고    scopus 로고
    • Mechanism linking obesity to insulin resistance to insulin resistance and type 2 diabetes
    • KAHN S.E., HULL R.L., UTZSCHENEIDER K.M. Mechanism linking obesity to insulin resistance to insulin resistance and type 2 diabetes. Nature, 2006, 444: 840-846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzscheneider, K.M.3
  • 67
    • 77953708142 scopus 로고    scopus 로고
    • The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity
    • POPESCU I.R., HELLEBOID-CHAPMAN A., LUCAS A., VANDEWALLE B., DUMONT J., BOUCHAERT E. et al. The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity. FEBS Lett., 2010, 584: 2845-2851.
    • (2010) FEBS Lett. , vol.584 , pp. 2845-2851
    • Popescu, I.R.1    Helleboid-Chapman, A.2    Lucas, A.3    Vandewalle, B.4    Dumont, J.5    Bouchaert, E.6
  • 68
    • 84865499656 scopus 로고    scopus 로고
    • Farnesoid X receptor targeting to treat nonalcocholic steatohepatitis
    • ADORINI L., PRUZANSKI M., SHAPIRO D. Farnesoid X receptor targeting to treat nonalcocholic steatohepatitis. Drug Discov. Today, 2012, http://dx.doi.org/10.1016/j.drudis.2012.05.012.
    • (2012) Drug Discov. Today
    • Adorini, L.1    Pruzanski, M.2    Shapiro, D.3
  • 70
    • 84856701167 scopus 로고    scopus 로고
    • Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: A randomised controlled study
    • BEYSEN C., MURPHY E.J., DEINES K., CHAN M., TSANG E., GLASS A. et al. Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study. Diabetologia, 2012, 55: 432-442.
    • (2012) Diabetologia , vol.55 , pp. 432-442
    • Beysen, C.1    Murphy, E.J.2    Deines, K.3    Chan, M.4    Tsang, E.5    Glass, A.6
  • 71
    • 13844299425 scopus 로고    scopus 로고
    • Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
    • KATSUMA S., HIRASAWA A., TSUJIMOTO G. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem. Biophys. Res. Commun., 2005, 329: 386-390.
    • (2005) Biochem. Biophys. Res. Commun. , vol.329 , pp. 386-390
    • Katsuma, S.1    Hirasawa, A.2    Tsujimoto, G.3
  • 72
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • OZCAN U., YILMAZ E., OZCAN L., FURUHASHI M., VAILLANCOURT E., SMITH R.O. et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science, 2006, 313: 1137-1140.
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6
  • 73
    • 77955248678 scopus 로고    scopus 로고
    • Genetic predisposition for type 1 diabetes mellitus-the role of endoplasmic reticulum stress in human disease etiopathogenesis
    • STANKOV K. Genetic predisposition for type 1 diabetes mellitus-the role of endoplasmic reticulum stress in human disease etiopathogenesis. J. Med. Biochem., 2010, 29: 139-149.
    • (2010) J. Med. Biochem. , vol.29 , pp. 139-149
    • Stankov, K.1
  • 74
    • 33751518532 scopus 로고    scopus 로고
    • Pharmacology of bile acids and their derivates: Absorption promoters and therapeutic agents
    • MIKOV M., FAWCETT J.P., KUHAJDA K., KEVRESAN S. Pharmacology of bile acids and their derivates: absorption promoters and therapeutic agents. Eur. J. Drug. Metab. Pharmacokinet., 2006, 31: 237-251.
    • (2006) Eur. J. Drug. Metab. Pharmacokinet. , vol.31 , pp. 237-251
    • Mikov, M.1    Fawcett, J.P.2    Kuhajda, K.3    Kevresan, S.4
  • 75
    • 56249104781 scopus 로고    scopus 로고
    • The influence of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes
    • MIKOV M., AL-SALAMI H., GOLOCORBIN-KON S., SKRBIC R., RASKOVIC A., FAWCETT J.P. The influence of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes. Eur. J. Drug. Metab. Pharmacokinet., 2008, 33: 137-142.
    • (2008) Eur. J. Drug. Metab. Pharmacokinet. , vol.33 , pp. 137-142
    • Mikov, M.1    Al-Salami, H.2    Golocorbin-Kon, S.3    Skrbic, R.4    Raskovic, A.5    Fawcett, J.P.6
  • 76
    • 51049086629 scopus 로고    scopus 로고
    • Influence of sodium monoketocholate on the hypolipidemic activity of lovastatin in healthy and diabetic rats
    • KOJIC-DAMJANOV S., DJERIC M., MIKOV M., KUHAJDA K., KEVRESAN S. Influence of sodium monoketocholate on the hypolipidemic activity of lovastatin in healthy and diabetic rats. Eur. J. Drug. Metab. Pharmacokinet., 2008, 33: 77-84.
    • (2008) Eur. J. Drug. Metab. Pharmacokinet. , vol.33 , pp. 77-84
    • Kojic-Damjanov, S.1    Djeric, M.2    Mikov, M.3    Kuhajda, K.4    Kevresan, S.5
  • 80
    • 33745774784 scopus 로고    scopus 로고
    • Role of nuclear receptors in the adaptive response to bile acids and cholestasis: Pathogenetic and therapeutic considerations
    • ZOLLNER G., MARSCHALL H.U., WAGNER M., TRAUNER M. Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol. Pharm., 2006, 3: 231-251.
    • (2006) Mol. Pharm. , vol.3 , pp. 231-251
    • Zollner, G.1    Marschall, H.U.2    Wagner, M.3    Trauner, M.4
  • 81
    • 0346690402 scopus 로고    scopus 로고
    • Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis
    • LIU Y., BINZ J., NUMERICK M.J., DENNIS S., LUO G., DESAI B. et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra-and extrahepatic cholestasis. J. Clin. Invest., 2003, 112: 1678-1687.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1678-1687
    • Liu, Y.1    Binz, J.2    Numerick, M.J.3    Dennis, S.4    Luo, G.5    Desai, B.6
  • 82
    • 20944450029 scopus 로고    scopus 로고
    • Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen induced cholestasis
    • FIORUCCI S., CLERICI C., ANTONELLI E., ORLANDI S., GOODWIN B., SADEGHPOUR B.M. et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen induced cholestasis. J. Pharmacol. Exp. Ther., 2005, 313: 604-612.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 604-612
    • Fiorucci, S.1    Clerici, C.2    Antonelli, E.3    Orlandi, S.4    Goodwin, B.5    Sadeghpour, B.M.6
  • 83
    • 65549145901 scopus 로고    scopus 로고
    • Nuclear receptors as therapeutic targets in cholestatic liver diseases
    • ZOLLNER G., TRAUNER M. Nuclear receptors as therapeutic targets in cholestatic liver diseases. Br. J. Pharmacol., 2009, 156: 7-27.
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 7-27
    • Zollner, G.1    Trauner, M.2
  • 84
    • 0036788262 scopus 로고    scopus 로고
    • Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
    • FICKERT P., ZOLLNER G., FUCHSBICHLER A., STUMPTNER C., WEIGLEIN A.H., LAMMERT F. et al. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology, 2002, 123: 1238-1251.
    • (2002) Gastroenterology , vol.123 , pp. 1238-1251
    • Fickert, P.1    Zollner, G.2    Fuchsbichler, A.3    Stumptner, C.4    Weiglein, A.H.5    Lammert, F.6
  • 86
    • 84856159269 scopus 로고    scopus 로고
    • Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
    • MODICA S., PETRUZZELLI M., BELLAFANTE E., MURZILLI S., SALVATORE L., CELLI N. et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastro-enterology, 2012, 142: 355-365.
    • (2012) Gastro-enterology , vol.142 , pp. 355-365
    • Modica, S.1    Petruzzelli, M.2    Bellafante, E.3    Murzilli, S.4    Salvatore, L.5    Celli, N.6
  • 87
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor B in hepatic inflammatory response
    • WANG Y.D., CHEN W.D., WANG M., YU D., FORMAN B.M., HUANG W. Farnesoid X receptor antagonizes nuclear factor B in hepatic inflammatory response. Hepatology, 2008, 48: 1632-1643.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 88
    • 25644443217 scopus 로고    scopus 로고
    • Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferatoractivated receptor gamma contributes to the anti-fibrotic activity of FXR ligands in rodent models of liver cirrhosis
    • FIORUCCI S., RIZZO G., ANTONELLI E., RENGA B., MENCARELLI A., RICCARDI L. et al. Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferatoractivated receptor gamma contributes to the anti-fibrotic activity of FXR ligands in rodent models of liver cirrhosis. J. Pharmacol. Exp. Ther., 2005, 315: 58-68.
    • (2005) J. Pharmacol. Exp. Ther. , vol.315 , pp. 58-68
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6
  • 89
    • 73549089485 scopus 로고    scopus 로고
    • Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts
    • FICKERT P., FUCHSBICHLER A., MOUSTAFA T., WAGNER M., ZOLLNER G., HALILBASIC E. et al. Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts. Am. J. Pathol., 2009, 175: 2392-2405.
    • (2009) Am. J. Pathol. , vol.175 , pp. 2392-2405
    • Fickert, P.1    Fuchsbichler, A.2    Moustafa, T.3    Wagner, M.4    Zollner, G.5    Halilbasic, E.6
  • 90
    • 79955055532 scopus 로고    scopus 로고
    • Farnesoid X receptor agonists for primary biliary cirrhosis
    • LINDOR K.D. Farnesoid X receptor agonists for primary biliary cirrhosis. Curr. Opin. Gastroenterol., 2011, 27: 285-288.
    • (2011) Curr. Opin. Gastroenterol. , vol.27 , pp. 285-288
    • Lindor, K.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.