메뉴 건너뛰기




Volumn 27, Issue 3, 2011, Pages 285-288

Farnesoid X receptor agonists for primary biliary cirrhosis

Author keywords

farnesoid X receptor; nuclear receptors; primary biliary cirrhosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANDROGEN RECEPTOR; BILE ACID; CHENODEOXYCHOLIC ACID; CONSTITUTIVE ANDROSTANE RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FARNESOID X RECEPTOR; GAMMA GLUTAMYLTRANSFERASE; GLUCOCORTICOID RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIVER X RECEPTOR; OBETICHOLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR; PROGESTERONE RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA; RETINOID X RECEPTOR BETA; RETINOID X RECEPTOR GAMMA; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; UNINDEXED DRUG; URSODEOXYCHOLIC ACID; VITAMIN D RECEPTOR;

EID: 79955055532     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32834452c8     Document Type: Article
Times cited : (42)

References (32)
  • 1
    • 70349421143 scopus 로고    scopus 로고
    • Review article: Nuclear receptors and liver disease - Current understanding and new therapeutic implications
    • Elfaki DA, Bjornsson E, Lindor KD. Review article: nuclear receptors and liver disease - current understanding and new therapeutic implications. Aliment Pharmacol Ther 2009; 30:816-825.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 816-825
    • Elfaki, D.A.1    Bjornsson, E.2    Lindor, K.D.3
  • 2
    • 33747818266 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in metabolic diseases: New approaches to therapy
    • DOI 10.1016/j.tem.2006.07.004, PII S1043276006001299
    • Tobin JF, Freedman LP. Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy. Trends Endocrinol Metab 2006; 17:284-290. (Pubitemid 44287472)
    • (2006) Trends in Endocrinology and Metabolism , vol.17 , Issue.7 , pp. 284-290
    • Tobin, J.F.1    Freedman, L.P.2
  • 3
    • 60549116406 scopus 로고    scopus 로고
    • Nuclear receptors: One big family
    • McEwan IJ. Nuclear receptors: one big family. Methods Mol Biol 2009; 505:3-18.
    • (2009) Methods Mol Biol , vol.505 , pp. 3-18
    • McEwan, I.J.1
  • 4
    • 0036623233 scopus 로고    scopus 로고
    • Nuclear receptor regulation of hepatic function
    • DOI 10.1016/S0168-8278(02)00129-0, PII S0168827802001290
    • Karpen SJ. Nuclear receptor regulation of hepatic function. J Hepatol 2002; 36:832-850. (Pubitemid 35177416)
    • (2002) Journal of Hepatology , vol.36 , Issue.6 , pp. 832-850
    • Karpen, S.J.1
  • 5
    • 21344439074 scopus 로고    scopus 로고
    • Nuclear receptors and drug disposition gene regulation
    • DOI 10.1002/jps.20324
    • Tirona RG, Kim RB. Nuclear receptors and drug disposition gene regulation. J Pharm Sci 2005; 94:1169-1186. (Pubitemid 40904182)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.6 , pp. 1169-1186
    • Tirona, R.G.1    Kim, R.B.2
  • 6
    • 40049109970 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis
    • Hansen MK, Connolly TM. Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis. Curr Opin Investig Drugs 2008; 9:247-255. (Pubitemid 351323377)
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.3 , pp. 247-255
    • Hansen, M.K.1    Connolly, T.M.2
  • 7
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, et al. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89:147-191.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3
  • 8
    • 50249180215 scopus 로고    scopus 로고
    • Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
    • Hofmann AF, Hagey LR. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 2008; 65:2461-2483.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2461-2483
    • Hofmann, A.F.1    Hagey, L.R.2
  • 9
    • 15444373825 scopus 로고    scopus 로고
    • Molecular regulation of hepatobiliary transport systems: Clinical implications for understanding and treating cholestasis
    • Trauner M, Wagner M, Fickert P, et al. Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J Clin Gastroenterol 2005; 39 (4 Suppl 2):S111-S124. (Pubitemid 40397024)
    • (2005) Journal of Clinical Gastroenterology , vol.39 , Issue.4 SUPPL.
    • Trauner, M.1    Wagner, M.2    Fickert, P.3    Zollner, G.4
  • 10
    • 1542781600 scopus 로고    scopus 로고
    • A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
    • DOI 10.1172/JCI200418385
    • Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest 2004; 113:137-143. (Pubitemid 38541640)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.1 , pp. 137-143
    • Huang, W.1    Zhang, J.2    Moore, D.D.3
  • 11
    • 65549145901 scopus 로고    scopus 로고
    • Nuclear receptors as therapeutic targets in cholestatic liver diseases
    • Zollner G, Trauner M. Nuclear receptors as therapeutic targets in cholestatic liver diseases. Br J Pharmacol 2009; 156:7-27.
    • (2009) Br J Pharmacol , vol.156 , pp. 7-27
    • Zollner, G.1    Trauner, M.2
  • 14
    • 38549109650 scopus 로고    scopus 로고
    • Mechanisms of cholestasis
    • DOI 10.1016/j.cld.2007.11.010, PII S1089326107001195
    • Zollner G, Trauner M. Mechanisms of cholestasis. Clin Liver Dis 2008; 12:1- 26; vii. (Pubitemid 351163143)
    • (2008) Clinics in Liver Disease , vol.12 , Issue.1 , pp. 1-26
    • Zollner, G.1    Trauner, M.2
  • 15
    • 33745830106 scopus 로고    scopus 로고
    • Pregnane X receptor is a target of farnesoid X receptor
    • DOI 10.1074/jbc.M600116200
    • Jung D, Mangelsdorf DJ, Meyer UA. Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem 2006; 281:19081-19091. (Pubitemid 44035412)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.28 , pp. 19081-19091
    • Jung, D.1    Mangelsdorf, D.J.2    Meyer, U.A.3
  • 16
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal CJ, Tohkin M, Miyata M, et al. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000; 102:731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3
  • 17
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • AnanthanarayananM, Balasubramanian N, MakishimaM, et al. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001; 276:28857-28865.
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramania, N.2
  • 20
    • 0037385387 scopus 로고    scopus 로고
    • Interim results of a pilot study demonstrating the early effects of the PPAR-γ ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
    • DOI 10.1016/S0168-8278(03)00027-8
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, et al. Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with nonalcoholic steatohepatitis. J Hepatol 2003; 38:434-440. (Pubitemid 36399245)
    • (2003) Journal of Hepatology , vol.38 , Issue.4 , pp. 434-440
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Sponseller, C.A.4    Hampton, K.5    Bacon, B.R.6
  • 21
    • 58949097425 scopus 로고    scopus 로고
    • Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
    • Song KH, Li T, Owsley E, et al. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 2009; 49:297-305.
    • (2009) Hepatology , vol.49 , pp. 297-305
    • Song, K.H.1    Li, T.2    Owsley, E.3
  • 22
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2:217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3
  • 23
    • 33645821043 scopus 로고    scopus 로고
    • Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
    • Huang W, Ma K, Zhang J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006; 312:233-236.
    • (2006) Science , vol.312 , pp. 233-236
    • Huang, W.1    Ma, K.2    Zhang, J.3
  • 24
    • 34447098081 scopus 로고    scopus 로고
    • Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
    • DOI 10.1093/carcin/bgl249
    • Kim I, Morimura K, Shah Y, et al. Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. Carcinogenesis 2007; 28:940-946. (Pubitemid 47072176)
    • (2007) Carcinogenesis , vol.28 , Issue.5 , pp. 940-946
    • Kim, I.1    Morimura, K.2    Shah, Y.3    Yang, Q.4    Ward, J.M.5    Gonzalez, F.J.6
  • 25
    • 33847044019 scopus 로고    scopus 로고
    • Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
    • Yang F, Huang X, Yi T, et al. Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res 2007; 67:863-867.
    • (2007) Cancer Res , vol.67 , pp. 863-867
    • Yang, F.1    Huang, X.2    Yi, T.3
  • 26
    • 0037315190 scopus 로고    scopus 로고
    • Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
    • DOI 10.1210/me.2002-0120
    • Pineda Torra I, Claudel T, Duval C, et al. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol 2003; 17:259-272. (Pubitemid 36183149)
    • (2003) Molecular Endocrinology , vol.17 , Issue.2 , pp. 259-272
    • Torra, I.P.1    Claudel, T.2    Duval, C.3    Kosykh, V.4    Fruchart, J.-C.5    Staels, B.6
  • 27
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, et al. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006; 116:1102-1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3
  • 31
    • 77955334203 scopus 로고    scopus 로고
    • Farnesoid-X receptor agonists: A new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid
    • MasonA LV, Lindor K, Hirschfield G, et al. Farnesoid-X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of INT-747 to ursodeoxycholic acid. J Hepatol 2010; 52(Suppl 1): S1-S2.
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Masona, L.V.1    Lindor, K.2    Hirschfield, G.3
  • 32
    • 0036788262 scopus 로고    scopus 로고
    • Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
    • Fickert P, Zollner G, Fuchsbichler A, et al. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology 2002; 123:1238-1251.
    • (2002) Gastroenterology , vol.123 , pp. 1238-1251
    • Fickert, P.1    Zollner, G.2    Fuchsbichler, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.