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Volumn 1, Issue 6, 2012, Pages 815-827

Molecular structure of P2Y receptors: Mutagenesis, modeling, and chemical probes

Author keywords

[No Author keywords available]

Indexed keywords

PURINERGIC P2 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y14 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; UNCLASSIFIED DRUG;

EID: 84874616139     PISSN: 2190460X     EISSN: 21904618     Source Type: Journal    
DOI: 10.1002/wmts.68     Document Type: Review
Times cited : (21)

References (70)
  • 3
    • 6044234752 scopus 로고    scopus 로고
    • Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.
    • Costanzi S, Mamedova L, Gao ZG, Jacobson KA. Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. J Med Chem 2004, 47:5393-5404.
    • (2004) J Med Chem , vol.47 , pp. 5393-5404
    • Costanzi, S.1    Mamedova, L.2    Gao, Z.G.3    Jacobson, K.A.4
  • 5
    • 77954308978 scopus 로고    scopus 로고
    • P2Y nucleotide receptors: promise of therapeutic applications.
    • Jacobson KA, Boeynaems J-M. P2Y nucleotide receptors: promise of therapeutic applications. Drug Disc Today 2010, 15:570-578.
    • (2010) Drug Disc Today , vol.15 , pp. 570-578
    • Jacobson, K.A.1    Boeynaems, J.-M.2
  • 7
    • 0028987857 scopus 로고
    • Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity.
    • Erb L, Garrad R, Wang Y, Quinn T, Turner JT, Weisman GA. Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity. J Biol Chem 1995, 270:4185-4188.
    • (1995) J Biol Chem , vol.270 , pp. 4185-4188
    • Erb, L.1    Garrad, R.2    Wang, Y.3    Quinn, T.4    Turner, J.T.5    Weisman, G.A.6
  • 9
    • 0032559887 scopus 로고    scopus 로고
    • 1receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites.
    • 1receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem 1998, 41:1456-1466.
    • (1998) J Med Chem , vol.41 , pp. 1456-1466
    • Moro, S.1    Guo, D.2    Camaioni, E.3    Boyer, J.L.4    Harden, T.K.5    Jacobson, K.A.6
  • 10
  • 17
    • 34447136067 scopus 로고    scopus 로고
    • 11 nucleotide receptor deduced from computational modelling and mutational analysis.
    • 11 nucleotide receptor deduced from computational modelling and mutational analysis. Biochem J 2007, 405:277-286.
    • (2007) Biochem J , vol.405 , pp. 277-286
    • Zylberg, J.1    Ecke, D.2    Fischer, B.3    Reiser, G.4
  • 25
    • 84866326616 scopus 로고    scopus 로고
    • Identification of a Promising Drug Candidate for the Treatment of Type 2 Diabetes Based on a P2Y1 Receptor Agonist.
    • DOI: 10.1021/jm 3006355
    • Yelovitch S, Barr HM, Camden J, Weisman GA, Shai E, Varon D, Fischer B. Identification of a Promising Drug Candidate for the Treatment of Type 2 Diabetes Based on a P2Y1 Receptor Agonist. J Med Chem 2012. DOI: 10.1021/jm 3006355.
    • (2012) J Med Chem
    • Yelovitch, S.1    Barr, H.M.2    Camden, J.3    Weisman, G.A.4    Shai, E.5    Varon, D.6    Fischer, B.7
  • 26
    • 33645862308 scopus 로고    scopus 로고
    • P2 receptors activated by uracil nucleotides-an update.
    • Brunschweiger A, Müller CE. P2 receptors activated by uracil nucleotides-an update. Curr Med Chem 2006, 13:289-312.
    • (2006) Curr Med Chem , vol.13 , pp. 289-312
    • Brunschweiger, A.1    Müller, C.E.2
  • 28
    • 77949842456 scopus 로고    scopus 로고
    • A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold.
    • Eliahu S, Barr HM, Camden J, Weisman GA, Fischer B. A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold. J Med Chem 2010, 53:2472-2481.
    • (2010) J Med Chem , vol.53 , pp. 2472-2481
    • Eliahu, S.1    Barr, H.M.2    Camden, J.3    Weisman, G.A.4    Fischer, B.5
  • 32
    • 0036430178 scopus 로고    scopus 로고
    • Molecular modeling as a tool to investigate molecular recognition in P2Y receptors.
    • Moro S, Jacobson KA. Molecular modeling as a tool to investigate molecular recognition in P2Y receptors. Curr Pharm Des 2002, 8:99-110.
    • (2002) Curr Pharm Des , vol.8 , pp. 99-110
    • Moro, S.1    Jacobson, K.A.2
  • 35
    • 77957055780 scopus 로고
    • Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G protein-coupled receptors.
    • San Diego, CA: Academic Press
    • Ballesteros JA, Weinstein H. Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G protein-coupled receptors. In: Conn PM, Sealfon SC, eds. Methods in Neurosciences. Vol. 25. San Diego, CA: Academic Press; 1995, 366-428.
    • (1995) Methods in Neurosciences. , vol.25 , pp. 366-428
    • Ballesteros, J.A.1    Weinstein, H.2    Conn, P.M.3    Sealfon, S.C.4
  • 36
    • 34250792472 scopus 로고    scopus 로고
    • Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling.
    • Ivanov AA, Costanzi S, Jacobson KA. Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling. J Comput Aided Mol Des 2006, 20:417-426.
    • (2006) J Comput Aided Mol Des , vol.20 , pp. 417-426
    • Ivanov, A.A.1    Costanzi, S.2    Jacobson, K.A.3
  • 40
    • 60449095619 scopus 로고    scopus 로고
    • Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases).
    • Baqi Y, Weyler S, Iqbal J, Zimmermann H, Müller CE. Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases). Purinergic Signal 2009, 5:91-106.
    • (2009) Purinergic Signal , vol.5 , pp. 91-106
    • Baqi, Y.1    Weyler, S.2    Iqbal, J.3    Zimmermann, H.4    Müller, C.E.5
  • 41
    • 80052377991 scopus 로고    scopus 로고
    • P2 receptors and platelet function.
    • Hechler B, Gachet C. P2 receptors and platelet function. Purinergic Signal 2011, 4:293-303.
    • (2011) Purinergic Signal , vol.4 , pp. 293-303
    • Hechler, B.1    Gachet, C.2
  • 50
    • 0036720462 scopus 로고    scopus 로고
    • Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)-(2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y2 receptor agonist for the treatment of cystic fibrosis.
    • Yerxa BR, Sabater JR, Davis CW, Stutts MJ, Lang-Furr M, Picher M, Jones AC, Cowlen M, Dougherty R, Boyer J, et al. Pharmacology of INS37217 [P(1)-(uridine 5')-P(4)-(2'-deoxycytidine 5')tetraphosphate, tetrasodium salt], a next-generation P2Y2 receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther 2002, 302:871-880.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 871-880
    • Yerxa, B.R.1    Sabater, J.R.2    Davis, C.W.3    Stutts, M.J.4    Lang-Furr, M.5    Picher, M.6    Jones, A.C.7    Cowlen, M.8    Dougherty, R.9    Boyer, J.10
  • 53
    • 37549006404 scopus 로고    scopus 로고
    • Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.
    • Weyler S, Baqi Y, Hillmann P, Kaulich M, Hunder AM, Müller IA, Müller CE. Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists. Bioorg Med Chem Lett 2008, 18:223-227.
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 223-227
    • Weyler, S.1    Baqi, Y.2    Hillmann, P.3    Kaulich, M.4    Hunder, A.M.5    Müller, I.A.6    Müller, C.E.7
  • 57
    • 84866258052 scopus 로고    scopus 로고
    • UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety
    • doi:10.1016/j.bmc.2012.07.042. In press
    • Ginsburg-Shmuel T, Haas M, Grbic D, Arguin G, Nadel Y, Gendron FP, Reiser G, Fischer B. UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety. Bioorg Med Chem 2012. doi:10.1016/j.bmc.2012.07.042. In press.
    • (2012) Bioorg Med Chem
    • Ginsburg-Shmuel, T.1    Haas, M.2    Grbic, D.3    Arguin, G.4    Nadel, Y.5    Gendron, F.P.6    Reiser, G.7    Fischer, B.8
  • 58
    • 77649190704 scopus 로고    scopus 로고
    • Activation of distinct P2Y receptor subtypes stimulates insulin secretion and cytoprotection in MIN6 mouse pancreatic β cells.
    • Balasubramanian R, Ruiz de Azua I, Wess J, Jacobson KA. Activation of distinct P2Y receptor subtypes stimulates insulin secretion and cytoprotection in MIN6 mouse pancreatic β cells. Biochem Pharmacol 2010, 79:1317-1326.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1317-1326
    • Balasubramanian, R.1    Ruiz de Azua, I.2    Wess, J.3    Jacobson, K.A.4
  • 59
    • 79955961675 scopus 로고    scopus 로고
    • Molecular pharmacology, physiology, and structure of the P2Y receptors.
    • von Kügelgen I, Harden TK. Molecular pharmacology, physiology, and structure of the P2Y receptors. Adv Pharmacol 2011, 61:373-415.
    • (2011) Adv Pharmacol , vol.61 , pp. 373-415
    • von Kügelgen, I.1    Harden, T.K.2
  • 63
    • 84861183177 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents.
    • Zhang H, Liu J, Zhang L, Kong L, Yao H, Sun H. Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents. Bioorg Med Chem Lett 2012, 22:3598-3602.
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 3598-3602
    • Zhang, H.1    Liu, J.2    Zhang, L.3    Kong, L.4    Yao, H.5    Sun, H.6
  • 69
    • 84873745806 scopus 로고    scopus 로고
    • 14 and other P2Y receptors in degranulation of human LAD2 mast cells.
    • In press. DOI: 10.1007/s11302-012-9325-4
    • 14 and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal 2012. In press. DOI: 10.1007/s11302-012-9325-4.
    • (2012) Purinergic Signal
    • Gao, Z.G.1    Wei, Q.2    Jayasekara, M.P.S.3    Jacobson, K.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.