Synthesis and P2Y 2 receptor agonist activities of uridine 5′-phosphonate analogues

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2304-2315

  Van Poecke, Sara ^a   Barrett, Matthew O ^b   Santhosh Kumar, T ^c   Sinnaeve, Davy ^a   Martins, José C ^a   Jacobson, Kenneth A ^c   Kendall Harden, T ^b   Van Calenbergh, Serge ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

G protein coupled receptor; Nucleoside phosphonates; P2Y 2 receptor; Partial agonists; Uracil nucleotides

Indexed keywords

1 [2' AMINO 2' DEOXY 5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) BETA DEXTRO RIBO HEXOFURANOSYL]URACIL; 1 [2' AMINO 2' DEOXY 5',6' DIDEOXY 6' (ETHOXYHYDROXYPHOSPHINYL) BETA DEXTRO RIBO HEXOFURANOSYL]URACIL; 1 [2' AZIDO 2' DEOXY 5',6' DIDEOXY 6' (ETHOXYHYDROXYPHOSPHINYL) BETA DEXTRO RIBO HEXOFURANOSYL]URACIL; 1 [2' CHLORO 2' DEOXY 5',6' DIDEOXY 6' (DIETHOXYHYDROXYPHOSPHINYL) BETA DEXTRO RIBO HEXOFURANOSYL]URACIL; 1 [2' CHLORO 2' DEOXY 5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) BETA DEXTRO RIBO HEXOFURANOSYL]URACIL; 1 [2,2' O ANHYDRO 5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) BETA DEXTRO RIBO ARABINOFURANOSYL]URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (4 FLUOROPHENYL)URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (BENZOTHIOPEN 3 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (FURAN 2 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (NAPTHALEN 2 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (P TOLYL)URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (THIEN 2 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 BROMOURACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 PHENYLURACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 STYRYLURACIL; 1 [5',6' DIDEOXY 6' (DIETHOXYPHOSPHINYL) BETA DEXTRO RIBO HEXOFURANOSYL]URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (4 FLUOROPHENYL)URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (BENZOTHIOPEN 3 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (FURAN 2 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (NAPTHALEN 2 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (P TOLYL)URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 (THIEN 2 YL)URACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 PHENYLURACIL; 1 [5',6' DIDEOXY 6' (DIHYDROXYPHOSPHINYL) 2',3' O ISOPROPYLIDENE BETA DEXTRO RIBO HEXOFURANOSYL] 5 STYRYLURACIL; 1' (DIISOPROPYL PHOSPHONOETHENYL) 2',3' O (ISOPROPYLIDINE) 4' (URACIL 1 YL) BICYCLO[3.1.0]HEXANE; 5' METHYLENEPHOSPHONATE; PHOSPHONIC ACID DERIVATIVE; PURINERGIC P2Y RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; URIDINE 5' PHOSPHONATE DERIVATIVE;

ARTICLE; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG HYDROLYSIS; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

CELL LINE; CELL PROLIFERATION; HUMANS; PHOSPHONIC ACIDS; PURINERGIC P2Y RECEPTOR AGONISTS; RECEPTORS, PURINERGIC P2Y2; URACIL NUCLEOTIDES; URIDINE TRIPHOSPHATE;

EID: 84858284228     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.012     Document Type: Article

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