UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 18, 2012, Pages 5483-5495

  Ginsburg Shmuel, Tamar ^a   Haas, Michael ^b   Grbic, Djordje ^c   Arguin, Guillaume ^c   Nadel, Yael ^a   Gendron, Fernand Pierre ^c   Reiser, Georg ^b   Fischer, Bilha ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Nucleotides; P2Y6 receptor; UDP

Indexed keywords

BORANE DERIVATIVE; BORANOPHOSPHATE; DINUCLEOTIDE; NUCLEOTIDE PYROPHOSPHATASE; NUCLEOTIDE PYROPHOSPHATASE 1; NUCLEOTIDE PYROPHOSPHATASE 3; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIMIDINE NUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ARTICLE; BLOOD SAMPLING; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; ISOMER; STOMACH PH;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, PURINERGIC P2; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE TRIPHOSPHATE;

EID: 84866258052     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.042     Document Type: Article

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