The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2836-2839

  Gauthier, Jacques Yves ^a   Belley, Michel ^a   Deschênes, Denis ^a   Fournier, Jean François ^a   Gagné, Sébastien ^a   Gareau, Yves ^a   Hamel, Martine ^a   Hénault, Martin ^a   Hyjazie, Huda ^a   Kargman, Stacia ^a   Lavallée, Geneviève ^a   Levesque, Jean François ^a   Li, Lianhai ^a   Mamane, Yaël ^a   Mancini, Joseph ^a   Morin, Nicolas ^a   Mulrooney, Erin ^a   Robichaud, Joël ^a   Thérien, Michel ^a   Tranmer, Geoffrey ^a   Wang, Zhaoyin ^a   Wu, Jin ^a   Black, W Cameron ^a   more..

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Competitive antagonist; Glucuronidation; GPR105; P2Y14; Pyrimidinergic receptor; SAR

Indexed keywords

2 NAPHTHOIC ACID DERIVATIVE; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y14 RECEPTOR ANTAGONIST; PURINERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON TRANSPORT; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CARBOXYLIC ACIDS; MICE; MOLECULAR STRUCTURE; NAPHTHALENES; PAN TROGLODYTES; PROTEIN BINDING; PURINERGIC P2 RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE DIPHOSPHATE;

EID: 79955552171     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.081     Document Type: Article

References (7)

1. K.A. Jacobson, A.A. Ivanov, S. de Castro, T.K. Harden, and H. Ko Purinergic Signal 5 2009 75
2. J.K. Chambers, L.E. Macdonald, H.M. Sarau, R.S. Ames, K. Freeman, J.J. Foley, Y. Zhu, M.M. McLaughlin, P. Murdock, L. McMillan, J. Trill, A. Swift, N. Aiyar, P. Taylor, L. Vawter, S. Naheed, P. Szekeres, G. Hervieu, C. Scott, J.M. Watson, A.J. Murphy, E. Duzic, C. Klein, D.J. Bergsma, S. Wilson, and G.P. Livi J. Biol. Chem. 175 2000 10767
3. Guay, D.; Beaulieu, C.; Belley, M.; Crane, S. N.; DeLuca, J. C.; Gareau, Y.; Hamel, M.; Henault, M.; Hyjazie, H.; Kargman, S.; Chan, C. C.; Xu, L.; Gordon, R.; Li, L.; Mamane, Y.; Morin, N.; Mancini, J.; Therien, M.; Truong, V. L.; Wang, Z.; Black, W. C. Biorg. Med. Chem. Lett. 2011, this issue, doi:10.1016/j.bmcl.2011.03.084.
4. D.L. Boger, N. Han, C.M. Tarby, C.W. Boyce, H. Cai, Q. Jin, and P.A. Kitos J. Org. Chem. 61 1996 4894
5. T. Umemoto, S. Fukami, G. Tomizawa, K. Harasawa, K. Kawada, and K. Tomita J. Am. Chem. Soc. 112 1990 8563
6. Y.C. Wong, L. Zhang, G. Lin, and Z. Zuo Expert Opin. Drug Metab. Toxicol. 11 2009 1399
7. Mouse hepatocytes were isolated by a two-step collagenase (50 U/mL) perfusion and incubations performed as described previously: R. Houle, J. Raoul, J.-F. Levesque, S. Pang, D.A. Nicoll-Griffith, and J.M. Silva Drug Metab. Dispos. 31 2003 447