The role of P2Y14 and other P2Y receptors in degranulation of human LAD2 mast cells

Purinergic Signalling

Volumn 9, Issue 1, 2013, Pages 31-40

  Gao, Zhan Guo ^a   Wei, Qiang ^a   Jayasekara, M P Suresh ^a   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Degranulation; G protein coupled receptors; GPCR; Mast cells; P2Y; Uracil nucleotide

Indexed keywords

ADENOSINE DIPHOSPHATE; BETA N ACETYLHEXOSAMINIDASE; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y RECEPTOR AGONIST; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y13 RECEPTOR; PURINERGIC P2Y14 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MAST CELL DEGRANULATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 84873745806     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-012-9325-4     Document Type: Article

References (33)

1. Beaven MA (2009) Our perception of the mast cell from Paul Ehrlich to now. Eur J Immunol 39: 11-25.
2. Galli SJ, Tsai M, Piliponsky AM (2008) The development of allergic inflammation. Nature 454: 445-454.
3. Okayama Y, Saito H, Ra C (2008) Targeting human mast cells expressing g-protein-coupled receptors in allergic diseases. Allergol Int 57: 197-203.
4. Gilfillan AM, Tkaczyk C (2006) Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 6: 218-230.
5. Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM (2011) Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release. Immunol Lett 141: 45-54.
6. Di Virgilio F, Chiozzi P, Ferrari D, Falzoni S, Sanz JM, Morelli A, Torboli M, Bolognesi G, Baricordi OR (2001) Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 97: 587-600.
7. Bulanova E, Bulfone-Paus S (2010) P2 receptor-mediated signaling in mast cell biology. Purinergic Signal 6: 3-17.
8. Wareham K, Vial C, Wykes RC, Bradding P, Seward EP (2009) Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. Br J Pharmacol 157: 1215-1224.
9. Sudo N, Tanaka K, Koga Y, Okumura Y, Kubo C, Nomoto K (1996) Extracellular ATP activates mast cells via a mechanism that is different from the activation induced by the cross-linking of Fc receptors. J Immunol 156: 3970-3979.
10. Schulman ES, Glaum MC, Post T, Wang Y, Raible DG, Mohanty J, Butterfield JH, Pelleg A (1999) ATP modulates anti-IgE-induced release of histamine from human lung mast cells. Am J Respir Cell Mol Biol 20: 530-537.
11. 13 receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells. Pharmacol Res 62: 500-505.
12. 14 receptors is a mediator of mast cell degranulation. Biochem Pharmacol 79: 873-879.
13. Feng C, Mery AG, Beller EM, Favot C, Boyce JA (2004) Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor. J Immunol 173: 7539-7547.
14. 4 receptor. Mol Pharmacol 57: 926-931.
15. Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7: 93-104.
16. Kirshenbaum AS, Akin C, Wu Y, Rottem M, Goff JP, Beaven MA, Rao VK, Metcalfe DD (2003) Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk Res 27: 677-682.
17. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408.
18. 13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther 311: 1038-1043.
19. Leff P, Wood BE, O'Connor SE (1990) Suramin is a slowly-equilibrating but competitive antagonist at P2x-receptors in the rabbit isolated ear artery. Br J Pharmacol 101: 645-649.
20. Von Kügelgen I (2006) Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110: 415-432.
21. Jacobson KA, Jarvis MF, Williams M (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45: 4057-4093.
22. Kuehn HS, Gilfillan AM (2007) G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett 113: 59-69.
23. Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H (2011) G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2. Eur J Pharmacol 668: 299-304.
24. Olivera A, Rivera J (2011) An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv Exp Med Biol 716: 123-142.
25. Gomez G, Zhao W, Schwartz LB (2011) Disparity in FcεRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. J Clin Immunol 31: 479-487.
26. Guhl S, Babina M, Neou A, Zuberbier T, Artuc M (2010) Mast cell lines HMC-1 and LAD2 in comparison with mature human skin mast cells-drastically reduced levels of tryptase and chymase in mast cell lines. Exp Dermatol 19: 845-847.
27. Xia YC, Sun S, Kuek LE, Lopata AL, Hulett MD, Mackay GA (2011) Human mast cell line-1 (HMC-1) cells transfected with FcεRIα are sensitive to IgE/antigen-mediated stimulation demonstrating selectivity towards cytokine production. Int Immunopharmacol 11: 1002-1011.
28. Jaffar ZH, Pearce FL (1990) Histamine secretion from mast cells stimulated with ATP. Agents Actions 30: 64-66.
29. Diamant B, Krüger PG (1967) Histamine release from isolated rat peritoneal mast cells induced by adenosine-5′-triphosphate. Acta Physiol Scand 71: 291-302.
30. Leung CT, Li A, Gao ZG, Peterson-Yantorno K, Jacobson KA, Civan MM (2011) Purinergic regulation of degranulation by human LAD2 mast cells. Invest Ophthalmol Vis Sci. ARVO E-Abstract #2911.
31. Knowles AF (2011) The GDA1_CD39 superfamily: NTPDases with diverse functions. Purinergic Signal 7: 21-45.
32. 14. Bioorg Med Chem Lett 21: 2836-2839.
33. Belly M, Deschenes D, Fortin R, Fournier JF, Gagne S, Gareau Y, et al. (2009) Substituted 2-naphthoic acids as antagonists of GPR105 activity. WO 2009/070873A1.