Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein

Drug Metabolism and Disposition

Volumn 40, Issue 10, 2012, Pages 2031-2040

  Sugatani, Junko ^a   Uchida, Takahiro ^a   Kurosawa, Masatoshi ^a   Yamaguchi, Masahiko ^a   Yamazaki, Yasuhiro ^a   Ikari, Akira ^a   Miwa, Masao ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ASPARTIC ACID; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CONSTITUTIVE ANDROSTANE RECEPTOR; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; GLUCURONOSYLTRANSFERASE 1A1; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE; MESSENGER RNA; MUTANT PROTEIN; NUCLEAR RECEPTOR COACTIVATOR 2; PREGNANE X RECEPTOR; RIFAMPICIN; ROSCOVITINE; SERINE; SMALL INTERFERING RNA; STEROID RECEPTOR COACTIVATOR 1; THREONINE;

ACETYLATION; ARTICLE; CONTROLLED STUDY; CYTOPLASM VESICLE; ENZYME INHIBITION; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INDUCTION; GENE LOCATION; GENE MUTATION; GENETIC ANALYSIS; GLUCURONOSYLTRANSFERASE 1A1 GENE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PREGNANE X RECEPTOR GENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; WILD TYPE;

ACETYLATION; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CYCLIN-DEPENDENT KINASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HEP G2 CELLS; HSP40 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; MUTATION; NUCLEAR RECEPTOR COACTIVATOR 2; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PURINES; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RETINOID X RECEPTORS; RIFAMPIN; RNA INTERFERENCE; SERINE; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 84866465020     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046748     Document Type: Article

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