The role of TRP proteins in mast cells

Frontiers in Immunology

Volumn 3, Issue JUN, 2012, Pages

  Freichel, Marc ^a   Almering, Julia ^a   Tsvilovskyy, Volodymyr ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Ca2+ Signaling; Cation channels; Mast Cell Activation; TRP proteins

Indexed keywords

EID: 84873710327     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2012.00150     Document Type: Review

References (181)

1. Aarts, M., Iihara, K., Wei, W. L., Xiong, Z. G., Arundine, M., Cerwinski, W., Macdonald, J. F., and Tymianski, M. (2003). A key role for TRPM7 channels in anoxic neuronal death. Cell 115, 863-877.
2. 2+ stores. Biochem. J. 304(Pt 2), 431-440.
3. Bai, C. X., Giamarchi, A., Rodat Despoix, L., Padilla, F., Downs, T., Tsiokas, L., and Delmas, P. (2008). Formation of a new receptor operated channel by heteromeric assembly of TRPP2 and TRPC1 sub units. EMBO Rep. 9, 472-479.
4. Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., and Patapoutian, A. (2004). Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849-857.
5. Bargal, R., Avidan, N., Ben-Asher, E., Olender, Z., Zeigler, M., Frumkin, A., Raas-Rothschild, A., Glusman, G., Lancet, D., and Bach, G. (2000). Identification of the gene causing mucolipidosis type IV. Nat. Genet. 26, 118-123.
6. Bautista, D. M., Jordt, S. E., Nikai, T., Tsuruda, P. R., Read, A. J., Poblete, J., Yamoah, E. N., Basbaum, A. I., and Julius, D. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124, 1269-1282.
7. Bautista, D. M., Siemens, J., Glazer, J. M., Tsuruda, P. R., Basbaum, A. I., Stucky, C. L., Jordt, S. E., and Julius, D. (2007). The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204-208.
8. Beaven, M. A., Rogers, J., Moore, J. P., Hesketh,T. R.,Smith,G.A.,and Metcalfe, J. C. (1984). The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J. Biol. Chem. 259, 7129-7136.
9. Biro, T., Maurer, M., Modarres, S., Lewin, N. E., Brodie, C., Acs, G., Acs, P., Paus, R., and Blumberg, P. M. (1998). Characterization of functional vanilloid receptors expressed by mast cells. Blood 91, 1332-1340.
10. Blank, U., and Rivera, J. (2004). The ins and outs of IgE-dependent mast cell exocytosis. Trends Immunol. 25, 266-273.
11. Bradding, P., Okayama, Y., Kambe, N., and Saito, H. (2003). Ion channel gene expression in human lung,skin, and cord blood-derived mast cells. J. Leukoc. Biol. 73, 614-620.
12. Buess, M., Engler, O., Hirsch, H. H., and Moroni, C. (1999). Search for oncogenic regulators in an autocrine tumor model using differential display PCR: identification of novel candidate genes including the calcium channel mtrp6. Oncogene 18, 1487-1494.
13. Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., and Julius, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824.
14. Cavalie, A. (2007). Ionic channels formed by TRPC4. Handb. Exp. Pharmacol. 179, 93-108.
15. 2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of cfos through ERK-dependent and independent pathways in mast cells. FASEB J. 20, 2381-2383.
16. Chen, X. Z., Vassilev, P. M., Basora, N., Peng, J. B., Nomura, H., Segal, Y., Brown, E. M., Reeders, S. T., Hediger, M. A., and Zhou, J. (1999). Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature 401, 383-386.
17. Cheng,W.,Yang, F., Takanishi, C. L., and Zheng, J. (2007). Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J. Gen. Physiol. 129, 191-207.
18. Cheng, X., Shen, D., Samie, M., and Xu, H. (2010). Mucolipins: intracellular TRPML1-3 channels. FEBS Lett. 584, 2013-2021.
19. Cho, Y., Jang, Y., Yang, Y. D., Lee, C. H., Lee, Y., and Oh, U. (2010). TRPM8 mediates cold and menthol allergies associated with mast cell activation. Cell Calcium 48, 202-208.
20. Chubanov, V., Mederos, Y., Schnitzler, M., Waring, J., Plank, A., and Gudermann, T. (2005). Emerging roles of TRPM6/TRPM7 channel kinase signal transduction complexes. Naunyn Schmiedebergs Arch. Pharmacol. 371, 334-341.
21. Chubanov, V., Waldegger, S., Mederos, Y., Schnitzler, M., Vitzthum, H., Sassen, M. C., Seyberth, H. W., Konrad, M., and Gudermann, T. (2004). Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc. Natl. Acad. Sci. U.S.A. 101, 2894-2899.
22. Clapham, D., Nilius, B., and Owsianik, G. (2012). Transient Receptor Potential Channels [Online]. [accessed March 5, 2012]. Available at: http://www.iuphardb.org/DATABASE/FamilyMenuForward?familyId=78
23. Clapham, D. E., Julius, D., Montell, C., and Schultz, G. (2005). International union of pharmacology. XLIX. Nomenclature and structure function relationships of transient receptor potential channels. Pharmacol. Rev. 57, 427-450.
24. 2+ responses in mast cells. J. Immunol. 183, 6478-6488.
25. 2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/-mice. Proc. Natl. Acad. Sci. U.S.A. 107, 5208-5213.
26. Corey, D. P., Garcia-Anoveros, J., Holt, J. R., Kwan, K. Y., Lin, S. Y., Vollrath, M. A., Amalfitano, A., Cheung, E. L., Derfler, B. H., Duggan,A., Geleoc, G. S., Gray, P. A., Hoffman, M. P., Rehm, H. L., Tamasauskas, D., and Zhang, D. S. (2004). TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432, 723-730.
27. Curcio-Morelli, C., Zhang, P., Venugopal, B., Charles, F. A., Browning, M. F., Cantiello, H. F., and Slaugenhaupt, S. A. (2010). Functional multimerization of mucolipin channel proteins. J. Cell. Physiol. 222, 328-335.
28. Di, A., Gao, X. P., Qian, F., Kawamura, T., Han, J., Hecquet, C., Ye, R. D., Vogel, S. M., and Malik, A. B. (2011). The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat. Immunol. 13, 29-34.
29. 2+ signaling in mast cells. Immunol. Rev. 231, 45-58.
30. Dietrich, A., Mederos,Y. S. M., Gollasch, M., Gross, V., Storch, U., Dubrovska, G., Obst, M., Yildirim, E., Salanova, B., Kalwa, H., Essin, K., Pinkenburg, O., Luft, F. C., Gudermann, T., and Birnbaumer, L. (2005). Increased vascular smooth muscle contractility in TRPC6-/-mice. Mol. Cell. Biol. 25, 6980-6989.
31. Dong, X. P., Cheng, X., Mills, E., Delling, M., Wang, F., Kurz, T., and Xu, H. (2008). The type IV mucolipidosis associated protein TRPML1 is an endolysosomal iron release channel. Nature 455, 992-996.
32. Dong, X. P., Wang, X., and Xu, H. (2010). TRP channels of intracellular membranes. J. Neurochem. 113, 313-328.
33. Duncan, L. M., Deeds, J., Hunter, J., Shao, J., Holmgren, L. M., Woolf, E. A., Tepper, R. I., and Shyjan, A. W. (1998). Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res. 58, 1515-1520.
34. 2+ influx pathway that is permeable to sodium and manganese. J. Cell. Physiol. 164, 205-213.
35. 2+ and Mn2+ influx through receptor mediated activation of nonspecific cation channels in mast cells. Proc. Natl. Acad. Sci. U.S.A. 90, 3068-3072.
36. Feske, S., Gwack, Y., Prakriya, M., Srikanth,S.,Puppel,S. H.,Tanasa,B., Hogan, P. G., Lewis, R. S., Daly, M., and Rao, A. (2006). A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179-185.
37. Foreman, J. C., Hallett, M. B., and Mongar, J. L. (1977). Movement of strontium ions into mast cells and its relationship to the secretory response. J. Physiol. (Lond.) 271, 233-251.
38. Foreman, J. C., and Mongar, J. L. (1972). The role of the alkaline earth ions in anaphylactic histamine secretion. J. Physiol. (Lond.) 224, 753-769.
39. Freichel, M., and Flockerzi, V. (2007). Biological functions of TRPs unravelled by spontaneous mutations and transgenic animals. Biochem. Soc. Trans. 35, 120-123.
40. Freichel, M., Kriebs, U., Vogt, D., Mannebach, S., and Weißgerber, P. (2011). "Strategies and protocols to generate mouse models with targeted mutations to analyze TRP channel functions," in TRP Channels, ed. M. Zhu (Boca Raton: CRC Press), 167-193.
41. 2+ current impairs agonist-dependent vasorelaxation in TRP4-/-mice. Nat. Cell Biol. 3, 121-127.
42. Galli, S. J., Nakae, S., and Tsai, M. (2005). Mast cells in the development of adaptive immune responses. Nat. Immunol. 6, 135-142.
43. 2+ signaling. Cold Spring Harb. Perspect. Biol. 2, a003962.
44. Gilfillan, A. M., and Tkaczyk, C. (2006). Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol. 6, 218-230.
45. Goel, M., Sinkins, W. G., and Schilling, W. P. (2002). Selective association of TRPC channel subunits in rat brain synaptosomes. J. Biol. Chem. 277, 48303-48310.
46. Grabbe, J. (2001). Pathomechanisms in physical urticaria. J. Investig. Dermatol. Symp. Proc. 6, 135-136.
47. Gri, G., Piconese, S., Frossi, B., Manfroi, V., Merluzzi, S., Tripodo, C., Viola, A., Odom, S., Rivera, J., Colombo, M. P., and Pucillo, C. E. (2008). CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40OX40L interaction. Immunity 29, 771-781.
48. 2+ (CRAC) channels. J. Biol. Chem. 282, 19375-19384.
49. Guo, L., Schreiber, T. H., Weremowicz, S., Morton, C. C., Lee, C., and Zhou, J. (2000). Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. Genomics 64, 241-251.
50. Gwack, Y., Srikanth, S., Oh-Hora, M., Hogan, P. G., Lamperti, E. D., Yamashita, M., Gelinas, C., Neems, D. S., Sasaki, Y., Feske, S., Prakriya, M., Rajewsky, K., and Rao,A. (2008). Hair loss and defective T and B cell function in mice lacking ORAI1. Mol. Cell. Biol. 28, 5209-5222.
51. 2+ permeable channel activated by changes in redox status confers susceptibility to cell death. Mol. Cell 9, 163-173.
52. 2+ mobilization. Trends Neurosci. 16, 371-376.
53. Hartmann, K., Henz, B. M., Kruger Krasagakes, S., Kohl, J., Burger, R., Guhl, S., Haase, I., Lippert, U., and Zuberbier, T. (1997). C3a and C5a stimulate chemotaxis of human mast cells. Blood 89, 2863-2870.
54. Hellwig, N., Albrecht, N., Harteneck, C., Schultz, G., and Schaefer, M. (2005). Homo and heteromeric assembly of TRPV channel subunits. J. Cell Sci. 118, 917-928.
55. Hernandez-Hansen, V., Smith, A. J., Surviladze, Z., Chigaev, A., Mazel, T., Kalesnikoff, J., Lowell, C. A., Krystal, G., Sklar, L. A., Wilson, B. S., and Oliver, J. M. (2004). Dys regulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J. Immunol. 173, 100-112.
56. 2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J. Clin. Invest. 112, 1906-1914.
57. 2+ channels TRPV5 and TRPV6. EMBO J. 22, 776-785.
58. Hofmann, T., Chubanov, V., Gudermann, T., and Montell, C. (2003). TRPM5 is a voltage-modulated and Ca(2+)activated monovalent selective cation channel. Curr. Biol. 13, 1153-1158.
59. Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., and Schultz, G. (1999). Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397, 259-263.
60. Hofmann, T., Schaefer, M., Schultz, G., and Gudermann, T. (2002). Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl. Acad. Sci. U.S.A. 99, 7461-7466.
61. Hoth, M., and Penner, R. (1992). Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355, 353-356.
62. Hoth, M., and Penner, R. (1993). Calcium release-activated calcium current in rat mast cells. J. Physiol. (Lond.) 465, 359-386.
63. Huang, A. L., Chen, X., Hoon, M. A., Chandrashekar, J., Guo, W., Trankner, D., Ryba, N. J., and Zuker, C. S. (2006). The cells and logic for mammalian sour taste detection. Nature 442, 934-938.
64. Iida, T., Moriyama, T., Kobata, K., Morita, A., Murayama, N., Hashizume, S., Fushiki, T., Yazawa, S., Watanabe, T., and Tominaga, M. (2003). TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology 44, 958-967.
65. Jiang, L. H. (2007). Subunit interaction in channel assembly and functional regulation of transient receptor potential melastatin (TRPM) channels. Biochem. Soc. Trans. 35, 86-88.
66. Jin, J., Desai, B. N., Navarro, B., Donovan, A., Andrews, N. C., and Clapham, D. E. (2008). Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322, 756-760.
67. Jordt, S. E., Tominaga, M., and Julius, D. (2000). Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl. Acad. Sci. U.S.A. 97, 8134-8139.
68. Kahr, H., Schindl, R., Fritsch, R., Heinze, B., Hofbauer, M., Hack, M. E., Mortelmaier, M. A., Groschner, K., Peng, J. B., Takanaga, H., Hediger, M. A., and Romanin, C. (2004). CaT1 knock-down strategies fail to affect CRAC channels in mucosal type mast cells. J. Physiol. (Lond.) 557, 121-132.
69. 2+ (CRAC) channels. J. Biol. Chem. 286, 14795-14803.
70. 2+) dependent gene regulation. Curr. Biol. 22, 242-247.
71. Kim, K. S., Shin, D. H., Nam, J. H., Park, K. S., Zhang, Y. H., Kim, W. K., and Kim, S. J. (2010). Functional expression of TRPV4 cation channels in human mast cell line (HMC1). Korean J. Physiol. Pharmacol. 14, 419-425.
72. Kiselyov, K., Xu, X., Mozhayeva, G., Kuo, T., Pessah, I., Mignery, G., Zhu, X., Birnbaumer, L., and Muallem, S. (1998). Functional interaction between InsP3 receptors and store operated Htrp3 channels. Nature 396, 478-482.
73. Kobori, T., Smith, G. D., Sandford, R., and Edwardson, J. M. (2009). The transient receptor potential channels TRPP2 and TRPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. J. Biol. Chem. 284, 35507-35513.
74. Kottgen, M., Buchholz, B., GarciaGonzalez, M. A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., Nitschke, R., Suzuki, M., Kramer-Zucker, A., Germino, G. G., Watnick, T., Prenen, J., Nilius, B., Kuehn, E. W., and Walz, G. (2008). TRPP2 and TRPV4 form a polymodal sensory channel complex. J. Cell Biol. 182, 437-447.
75. Kuno, M., and Kimura, M. (1992). Noise of secretagogue-induced inward currents dependent on extracellular calcium in rat mast cells. J. Membr. Biol. 128, 53-61.
76. Kwan, K. Y., Allchorne, A. J., Vollrath, M. A., Christensen, A. P., Zhang, D. S., Woolf, C. J., and Corey, D. P. (2006). TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50, 277-289.
77. Lam, R. S., Shumilina, E., Matzner, N., Zemtsova, I. M., Sobiesiak, M., Lang, C., Felder, E., Dietl, P., Huber, S. M., and Lang, F. (2008). Phosphatidylinositol-3-kinase regulates mast cell ion channel activity. Cell. Physiol. Biochem. 22, 169-176.
78. Launay, P., Cheng, H., Srivatsan, S., Penner, R., Fleig, A., and Kinet, J. P. (2004). TRPM4 regulates calcium oscillations after T cell activation. Science 306, 1374-1377.
79. 2+ activated nonselective cation channel mediating cell membrane depolarization. Cell 109, 397-407.
80. Lazzeri, M., Vannucchi, M. G., Zardo, C., Spinelli, M., Beneforti, P., Turini, D., and Faussone-Pellegrini, M. S. (2004). Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder. Eur. Urol. 46, 792-798.
81. Lewis, R. S. (2007). The molecular choreography of a storeoperated calcium channel. Nature 446, 284-287.
82. Li, M., Jiang, J. ,and Yue, L. (2006). Functional characterization of homoand heteromeric channel kinases TRPM6 and TRPM7. J. Gen. Physiol. 127, 525-537.
83. Li, Z., Sergouniotis, P. I., Michaelides, M., Mackay, D. S., Wright, G. A., Devery, S., Moore, A. T., Holder, G. E., Robson, A. G., and Webster, A. R. (2009). Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. Am. J. Hum. Genet. 85, 711-719.
84. Liao, Y., Erxleben, C., Abramowitz, J., Flockerzi,V., Zhu, M. X.,Armstrong, D. L., and Birnbaumer, L. (2008). Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proc. Natl. Acad. Sci. U.S.A. 105, 2895-2900.
85. Liao, Y., Erxleben, C., Yildirim, E., Abramowitz, J., Armstrong, D. L., and Birnbaumer, L. (2007). Orai proteins interact with TRPC channels and confer responsiveness to store depletion. Proc. Natl. Acad. Sci. U.S.A. 104, 4682-4687.
86. Link, T. M., Park, U., Vonakis, B. M., Raben, D. M., Soloski, M. J., and Caterina, M. J. (2010). TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat. Immunol. 11, 232-239.
87. 2+ sensitive cation channels. J. Biol. Chem. 275, 27799-27805.
88. 2+ selectivity filter in the Drosophila transient receptor potential channel. J. Neurosci. 27,604-615.
89. 2+ channels. Role of acidic amino acid residues in the S5-S6 region. J. Biol. Chem. 278, 11337-11343.
90. Lucas, P., Ukhanov, K., LeindersZufall, T., and Zufall, F. (2003). A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40, 551-561.
91. 2+ signaling with particular focus on mast cells. Crit. Rev. Immunol. 29, 155-186.
92. Ma, H. T., and Beaven, M. A. (2011). Regulators of Ca(2+) signaling in mast cells: potential targets for treatment of mast cell-related diseases? Adv. Exp. Med. Biol. 716, 62-90.
93. 2+ and degranulation in a rat mast cell line. J. Immunol. 180, 2233-2239.
94. Ma, R., Li, W. P., Rundle, D., Kong, J., Akbarali, H. I., and Tsiokas, L. (2005). PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol. Cell. Biol. 25, 8285-8298.
95. 2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane. Arterioscler. Thromb. Vasc. Biol. 30, 2249-2255.
96. Manzoni, M., Monti, E., Bresciani, R., Bozzato, A., Barlati, S., Bassi, M. T., and Borsani, G. (2004). Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization. FEBS Lett. 567, 219-224.
97. Marshall, J. S. (2004). Mast-cell responses to pathogens. Nat. Rev. Immunol. 4, 787-799.
98. Mathar, I., Vennekens, R., Meissner, M., Kees, F., Van Der Mieren, G., Camacho Londono, J. E., Uhl, S., Voets, T., Hummel, B., Van Den Bergh, A., Herijgers, P., Nilius, B., Flockerzi, V., Schweda, F., and Freichel, M. (2010). Increased catecholamine secretion contributes to hypertension in TRPM4deficient mice. J. Clin. Invest. 120, 3267-3279.
99. McKemy, D. D., Neuhausser, W. M., and Julius, D. (2002). Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58.
100. Medic, N., Desai, A., Komarow, H., Burch,L. H.,Bandara,G.,Beaven,M. A., Metcalfe, D. D., and Gilfillan, A. M. (2011). Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria. Cell Calcium 50, 473-480.
101. Meissner, M., Obmann,V., Hoschke, M., Link, S., Jung, M., Held, G., Philipp, S., Zimmermann, R., and Flockerzi, V. (2011). "Lessons of studying TRP channels with antibodies," in TRP Channels, ed. M. Zhu (Boca Raton: CRC Press), 135-148.
102. Metcalfe, D. D., Baram, D., and Mekori, Y. A. (1997). Mast cells. Physiol. Rev. 77, 1033-1079.
103. Metz, M., and Maurer, M. (2007). Mast cells-key effector cells in immune responses. Trends Immunol. 28, 234-241.
104. Montell, C., Birnbaumer, L., and Flockerzi, V. (2002). The TRP channels, a remarkably functional family. Cell 108, 595-598.
105. Montell, C., and Rubin, G. M. (1989). Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2, 1313-1323.
106. Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S., Andahazy, M., Story, G. M., and Patapoutian, A. (2005). Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472.
107. Morgans, C. W., Zhang, J., Jeffrey, B. G., Nelson, S. M., Burke, N. S., Duvoisin, R. M., and Brown, R. L. (2009). TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc. Natl. Acad. Sci. U.S.A. 106, 19174-19178.
108. Nadler, M. J., Hermosura, M. C., Inabe, K., Perraud, A. L., Zhu, Q., Stokes, A. J., Kurosaki, T., Kinet, J. P., Penner, R., Scharenberg, A. M., and Fleig, A. (2001). LTRPC7 is a Mg. ATP regulated divalent cation channel required for cell viability. Nature 411, 590-595.
109. Nilius, B., and Owsianik, G. (2010). Transient receptor potential channelopathies. Pflugers Arch. 460, 437-450.
110. Oancea, E., Vriens, J., Brauchi, S., Jun, J., Splawski, I., and Clapham, D. E. (2009). TRPM1 forms ion channels associated with melanin content in melanocytes. Sci. Signal. 2, ra21.
111. Owsianik, G., D'Hoedt, D., Voets, T., and Nilius, B. (2006a). Structurefunction relationship of the TRP channel superfamily. Rev. Physiol. Biochem. Pharmacol. 156, 61-90.
112. Owsianik, G., Talavera, K.,Voets, T., and Nilius, B. (2006b). Permeation and selectivity of TRP channels. Annu. Rev. Physiol. 68, 685-717.
113. 2+ and purified isozymes in washed permeabilized cells. J. Biol. Chem. 268, 1749-1756.
114. Parekh, A. B. (2010). Store-operated CRAC channels: function in health and disease. Nat. Rev. Drug Discov. 9, 399-410.
115. Parekh, A. B., and Putney, J. W. Jr. (2005). Store-operated calcium channels. Physiol. Rev. 85, 757-810.
116. Penner, R., Matthews, G., and Neher, E. (1988). Regulation of calcium influx by second messengers in rat mast cells. Nature 334, 499-504.
117. Perraud, A. L., Takanishi, C. L., Shen, B., Kang, S., Smith, M. K., Schmitz, C., Knowles, H. M., Ferraris, D., Li, W., Zhang, J., Stoddard, B. L., and Scharenberg, A. M. (2005). Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J. Biol. Chem. 280, 6138-6148.
118. Philipp,S.,Cavalie,A.,Freichel,M.,Wissenbach, U., Zimmer, S., Trost, C., Marquart, A., Murakami, M., and Flockerzi, V. (1996). A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL. EMBO J. 15, 6166-6171.
119. Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., and Paul, W. E. (1989). Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature 339, 64-67.
120. Prasad, P., Yanagihara, A. A., SmallHoward, A. L., Turner, H., and Stokes, A. J. (2008). Secretogranin III directs secretory vesicle biogenesis in mast cells in a manner dependent upon interaction with chromogranin A. J. Immunol. 181, 5024-5034.
121. Puertollano, R., and Kiselyov, K. (2009). TRPMLs: in sickness and in health. Am. J. Physiol. Renal Physiol. 296, F1245-F1254.
122. Putney, J. W. Jr. (1986). A model for receptor-regulated calcium entry. Cell Calcium 7, 1-12.
123. 2+) homeostasis in mammals. Nat. Commun. 1, 109.
124. Sanchez-Miranda, E., Ibarra-Sanchez, A., and Gonzalez-Espinosa, C. (2010). Fyn kinase controls FcepsilonRI receptor-operated calcium entry necessary for full degranulation in mast cells. Biochem. Biophys. Res. Commun. 391, 1714-1720.
125. Schaefer, M. (2005). Homoand heteromeric assembly of TRP channel subunits. Pflugers Arch. 451, 35-42.
126. Schlingmann,K. P.,Weber,S.,Peters,M., Niemann Nejsum, L., Vitzthum, H., Klingel, K., Kratz, M., Haddad, E., Ristoff, E., Dinour, D., Syrrou, M., Nielsen, S., Sassen, M., Waldegger, S., Seyberth, H. W., and Konrad, M. (2002). Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat. Genet. 31, 166-170.
127. Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J., and Patapoutian, A. (2009). Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron 64, 498-509.
128. Sel, S., Rost, B. R., Yildirim, A. O., Sel, B., Kalwa, H., Fehrenbach, H., Renz, H., Gudermann, T., and Dietrich, A. (2008). Loss of classical transient receptor potential 6 channel reduces allergic airway response. Clin. Exp. Allergy 38, 1548-1558.
129. Shimizu, T., Owsianik, G., Freichel, M., Flockerzi, V., Nilius, B., and Vennekens, R. (2009). TRPM4 regulates migration of mast cells in mice. Cell Calcium 45, 226-232.
130. 2+ activated K+ channel KCa3.1.J. Immunol. 180, 8040-8047.
131. Stander, S., Moormann, C., Schumacher, M., Buddenkotte, J., Artuc, M., Shpacovitch, V., Brzoska, T., Lippert, U., Henz, B. M., Luger, T. A., Metze, D., and Steinhoff, M. (2004). Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp. Dermatol. 13, 129-139.
132. Stewart, A. P., Smith, G. D., Sandford, R. N., and Edwardson, J. M. (2010). Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys. J. 99, 790-797.
133. Stokes, A. J., Shimoda, L. M., KoblanHuberson, M., Adra, C. N., and Turner, H. (2004). A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J. Exp. Med. 200, 137-147.
134. Stokes, A. J., Wakano, C., Del Carmen, K. A., Koblan-Huberson, M., and Turner, H. (2005). Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J. Cell. Biochem. 94, 669-683.
135. Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., Mcintyre, P., Jegla, T., Bevan, S., and Patapoutian, A. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819-829.
136. Strubing, C., Krapivinsky, G., Krapivinsky, L., and Clapham, D. E. (2001). TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29, 645-655.
137. Strubing, C., Krapivinsky, G., Krapivinsky, L., and Clapham, D. E. (2003). Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. 278, 39014-39019.
138. 2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J. Leukoc. Biol. 88, 863-875.
139. Tani, D., Monteilh-Zoller, M. K., Fleig, A., and Penner, R. (2007). Cell cycle-dependent regulation of store-operated I(CRAC) and Mg2+nucleotide-regulated MagNuM (TRPM7) currents. Cell Calcium 41, 249-260.
140. Taub, D., Dastych, J., Inamura, N., Upton, J., Kelvin, D., Metcalfe, D., and Oppenheim, J. (1995). Bone marrow-derived murine mast cells migrate, but do not degranulate, in response to chemokines. J. Immunol. 154, 2393-2402.
141. Tsavaler, L., Shapero, M. H., Morkowski, S., and Laus, R. (2001). Trpp8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 61, 3760-3769.
142. Tsiokas, L., Arnould, T., Zhu, C., Kim, E., Walz, G., and Sukhatme, V. P. (1999). Specific association of the gene product of PKD2 with the TRPC1 channel. Proc. Natl. Acad. Sci. U.S.A. 96, 3934-3939.
143. Tsvilovskyy, V. V., Zholos, A. V., Aberle, T., Philipp, S. E., Dietrich, A., Zhu, M. X., Birnbaumer, L., Freichel, M., and Flockerzi, V. (2009). Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motilityinvivo. Gastroenterology 137, 1415-1424.
144. Turner, H., Del Carmen, K. A., and Stokes, A. (2007). Link between TRPV channels and mast cell function. Handb. Exp. Pharmacol. 179, 457-471.
145. van Haaster, C. M., Engels, W., Lemmens, P. J., Hornstra, G., Van Der Vusse, G. J., and Heemskerk, J. W. (1995). Differential release of histamine and prostaglandin D2 in rat peritoneal mast cells: roles of cytosolic calcium and protein tyrosine kinases. Biochim. Biophys. Acta 1265, 79-88.
146. Vazquez, G., Wedel, B. J., Trebak, M., St. John Bird, G., and Putney, J. W. Jr. (2003). Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. J. Biol. Chem. 278, 21649-21654.
147. Venkatachalam, K., Hofmann, T., and Montell, C. (2006). Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosisassociated protein TRPML1. J. Biol. Chem. 281, 17517-17527.
148. Venkatachalam, K., and Montell, C. (2007). TRP channels. Annu. Rev. Biochem. 76, 387-417.
149. Venkatachalam, K., Van Rossum, D. B., Patterson, R. L., Ma, H. T., and Gill, D. L. (2002). The cellular and molecular basis of store-operated calcium entry. Nat. Cell Biol. 4, E263-E272.
150. Vennekens, R.,Hoenderop,J. G.,Prenen, J., Stuiver, M.,Willems, P. H., Droogmans, G., Nilius, B., and Bindels, R. J. (2000). Permeation and gating properties of the novel epithelial Ca(2+) channel. J. Biol. Chem. 275, 3963-3969.
151. Vennekens, R., and Nilius, B. (2007). Insights into TRPM4 function, regulation and physiological role. Handb. Exp. Pharmacol. 179, 269-285.
152. Vennekens, R., Olausson, J., Meissner, M., Bloch, W., Mathar, I., Philipp, S. E., Schmitz, F., Weissgerber, P., Nilius, B., Flockerzi, V., and Freichel, M. (2007). Increased IgEdependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat. Immunol. 8, 312-320.
153. Vig, M., Dehaven, W. I., Bird, G. S., Billingsley, J. M., Wang, H., Rao, P. E., Hutchings, A. B., Jouvin, M. H., Putney, J. W., and Kinet, J. P. (2008). Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of storeoperated calcium release-activated calcium channels. Nat. Immunol. 9, 89-96.
154. 2+ entry. Science 312, 1220-1223.
155. Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V., and Nilius, B. (2004a). The principle of temperature-dependent gating in coldand heat-sensitive TRP channels. Nature 430, 748-754.
156. Voets, T., Nilius, B., Hoefs, S., Van Der Kemp, A. W., Droogmans, G., Bindels, R. J., and Hoenderop, J. G. (2004b). TRPM6 forms the Mg2+influx channel involved in intestinal and renal Mg2+absorption. J. Biol. Chem. 279, 19-25.
157. Voets, T., Prenen, J., Fleig, A.,Vennekens, R., Watanabe, H., Hoenderop, J. G., Bindels, R. J., Droogmans, G., Penner, R., and Nilius, B. (2001). CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J. Biol. Chem. 276, 47767-47770.
158. Vriens, J., Appendino, G., and Nilius, B. (2009). Pharmacology of vanilloid transient receptor potential cation channels. Mol. Pharmacol. 75, 1262-1279.
159. 2+ permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ. Res. 97, 908-915.
160. Wagner, T. F., Loch, S., Lambert, S., Straub, I., Mannebach, S., Mathar, I., Dufer, M., Lis, A., Flockerzi, V., Philipp, S. E., and Oberwinkler, J. (2008). Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat. Cell Biol. 10, 1421-1430.
161. Watanabe, H., Davis, J. B., Smart, D., Jerman, J. C., Smith, G. D., Hayes, P., Vriens,J., Cairns, W., Wissenbach,U., Prenen, J., Flockerzi, V., Droogmans, G., Benham, C. D., and Nilius, B. (2002). Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J. Biol. Chem. 277, 13569-13577.
162. 2+ concentration in the endoplasmic reticulum. EMBO J. 28, 490-499.
163. Weissgerber, P., Cavalie, A., Buchholz, S., Flockerzi, V., and Freichel, M. (2008). Early embryonic lethality following inactivation of the TRPM7 gene in mice. Naunyn Schmiedebergs Arch. Pharmacol. 377, 35.
164. 2+)+ absorption by TRPV6 in epididymal epithelia. Sci. Signal. 4, ra27.
165. Wes, P. D., Chevesich, J., Jeromin, A., Rosenberg, C., Stetten, G., and Montell, C. (1995). TRPC1, a human homolog of a Drosophila storeoperated channel. Proc. Natl. Acad. Sci. U.S.A. 92, 9652-9656.
166. Wu, L. J., Sweet, T. B., and Clapham, D. E. (2010). International union of basic and clinical pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol. Rev. 62, 381-404.
167. Wykes, R. C., Lee, M., Duffy, S. M.,Yang, W., Seward, E. P., and Bradding, P. (2007). Functional transient receptor potential melastatin 7 channels are critical for human mast cell survival. J. Immunol. 179, 4045-4052.
168. Xu, H., Delling, M., Li, L., Dong, X., and Clapham, D. E. (2007). Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc. Natl. Acad. Sci. U.S.A. 104, 18321-18326.
169. 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat. Med. 14, 738-747.
170. Yang, W., Chen, J., and Zhou, L. (2009). Effects of shear stress on intracellular calcium change and histamine release in rat basophilic leukemia (RBL-2H3) cells. J. Environ. Pathol. Toxicol. Oncol. 28, 223-230.
171. Yang, W. Z., Chen, J. Y., Yu, J. T., and Zhou, L. W. (2007). Effects of low power laser irradiation on intracellular calcium and histamine release in RBL-2H3 mast cells. Photochem. Photobiol. 83, 979-984.
172. Yildirim, E., Kawasaki, B. T., and Birnbaumer, L. (2005). Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. Proc. Natl. Acad. Sci. U.S.A. 102, 3307-3311.
173. 2+ channels. Mol. Immunol. 46, 1267-1277.
174. Yuan, J. P., Kim, M. S., Zeng, W., Shin, D. M., Huang, G., Worley, P. F., and Muallem, S. (2009). TRPC channels as STIM1-regulated SOCs. Channels (Austin) 3, 221-225.
175. Yuan, J. P., Zeng, W., Huang, G. N., Worley, P. F., and Muallem, S. (2007). STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat. Cell Biol. 9, 636-645.
176. Yue, L., Peng, J. B., Hediger, M. A., and Clapham, D. E. (2001). CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410, 705-709.
177. Zhang, D., Spielmann, A., Wang, L., Ding, G., Huang, F., Gu, Q., and Schwarz, W. (2011). Mastcell degranulation induced by physical stimuli involves the activation of transient-receptor-potential channel TRPV2. Physiol. Res. 61, 113-124.
178. Zhang, P., Luo, Y., Chasan, B., Gonzalez-Perrett, S., Montalbetti, N., Timpanaro, G. A., Cantero Mdel, R., Ramos, A. J., Goldmann, W. H., Zhou, J., and Cantiello, H. F. (2009). The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homoand hetero-multimers with TRPC1. Hum. Mol. Genet. 18, 1238-1251.
179. Zhang, Y., Hoon, M. A., Chandrashekar, J., Mueller, K. L., Cook, B., Wu, D., Zuker, C. S., and Ryba, N. J. (2003). Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112, 293-301.
180. Zhu, X., Chu, P. B., Peyton, M., and Birnbaumer, L. (1995). Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. FEBS Lett. 373, 193-198.
181. Zweifach, A., and Lewis, R. S. (1996). Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes. J. Gen. Physiol. 107, 597-610.