Phosphatidylinositol-3-kinase regulates mast cell ion channel activity

Cellular Physiology and Biochemistry

Volumn 22, Issue 1-4, 2008, Pages 169-176

  Lam, Rebecca S ^a,c   Shumilina, Ekaterina ^a   Matzner, Nicole ^a   Zemtsova, Irina M ^a   Sobiesiak, Malgorzata ^a   Lang, Camelia ^a   Felder, Edward ^b   Dietl, Paul ^b   Huber, Stephan M ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

Allergy; Calcium; Glucocorticoids; K + channels; PI3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA N ACETYLHEXOSAMINIDASE; CALCIUM ACTIVATED POTASSIUM CHANNEL; FURA 2; IMMUNOGLOBULIN E; ION CHANNEL; IONOMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; RUTHENIUM RED; THAPSIGARGIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM TRANSPORT; CELL ACTIVATION; CONTROLLED STUDY; CYTOSOL; DEGRANULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FLUORESCENCE; MALE; MAST CELL; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

EID: 51149123707     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000149794     Document Type: Article

References (51)

1. Kawakami T, Kitaura J: Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol 2005;175:4167-4173.
2. Pawankar R: Mast cells in allergic airway disease and chronic rhinosinusitis. Chem Immunol Allergy 2005;87:111-129.
3. Vliagoftis H, Befus AD: Mast cells at mucosal frontiers. Curr Mol Med 2005;5:573-589.
4. Askenase PW, Van Loveren H, Kraeuter-Kops S, Ron Y, Meade R, Theoharides TC, Nordlund JJ, Scovern H, Gerhson MD, Ptak W: Defective elicitation of delayed-type hypersensitivity in W/Wv and SI/SId mast cell-deficient mice. J Immunol 1983;131:2687-2694.
5. Galli SJ, Nakae S, Tsai M: Mast cells in the development of adaptive immune responses. Nat Immunol 2005;6:135-142.
6. Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M: Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005;23:749-786.
7. Biedermann T, Kneilling M, Mailhammer R, Maier K, Sander CA, Kollias G, Kunkel SL, Hultner L, Rocken M: Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. J Exp Med 2000;192:1441-1452.
8. Malaviya R, Ikeda T, Ross E, Abraham SN: Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 1996;381:77-80.
9. Andrade MV, Hiragun T, Beaven MA: Dexamethasone suppresses antigen-induced activation of phosphatidylinositol 3-kinase and downstream responses in mast cells. J Immunol 2004;172:7254-7262.
10. Gilfillan AM, Tkaczyk C: Integrated signalling pathways for mast-cell activation. Nat Rev Immunol 2006;6:218-230.
11. Wymann MP, Bjorklof K, Calvez R, Finan P, Thomast M, Trifilieff A, Barbier M, Altruda F, Hirsch E, Laffargue M: Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy. Biochem Soc Trans 2003;31:275-280.
12. Kalesnikoff J, Baur N, Leitges M, Hughes MR, Damen JE, Huber M, Krystal G: SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activity. J Immunol 2002;168:4737-4746.
13. Manetz TS, Gonzalez-Espinosa C, Arudchandran R, Xirasagar S, Tybulewicz V, Rivera J: Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. Mol Cell Biol 2001;21:3763-3774.
14. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM: The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem 2003;278:48474-48484.
15. Serve H, Yee NS, Stella G, Sepp-Lorenzino L, Tan JC, Besmer P: Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J 1995;14:473-483.
16. Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B: Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 2004;431:1007-1011.
17. Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y: Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 1993;268:25846-25856.
18. Bradding P: Mast cell ion channels. Chem Immunol Allergy 2005;87:163-178.
19. Kahr H, Schindl R, Fritsch R, Heinze B, Hofbauer M, Hack ME, Mortelmaier MA, Groschner K, Peng JB, Takanaga H, Hediger MA, Romanin C: CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells. J Physiol 2004;557:121-132.
20. Bradding P, Conley EC: Human mast cell ion channels. Clin Exp Allergy 2002;32:979-983.
21. Duffy SM, Cruse G, Lawley WJ, Bradding P: Beta2-adrenoceptor regulation of the K+ channel iKCa1 in human mast cells. FASEB J 2005;19:1006-1008.
22. 2+ influx and degranulation in human lung mast cells. J Allergy Clin Immunol 2004;114:66-72.
23. Duffy SM, Leyland ML, Conley EC, Bradding P: Voltage-dependent and calcium-activated ion channels in the human mast cell line HMC-1. J Leukoc Biol 2001;70:233-240.
24. Duffy SM, Lawley WJ, Conley EC, Bradding P: Resting and activation-dependent ion channels in human mast cells. J Immunol 2001;167:4261-4270.
25. Bradding P, Okayama Y, Kambe N, Saito H: Ion channel gene expression in human lung, skin, and cord blood-derived mast cells. J Leukoc Biol 2003;73:614-620.
26. 2+ entry mechanism. J Biol Chem 2001;276:14814-14820.
27. Hoth M, Penner R: Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 1992;355:353-356.
28. Labrecque GF, Holowka D, Baird B: Antigen-triggered membrane potential changes in IgE-sensitized rat basophilic leukemia cells: evidence for a repolarizing response that is important in the stimulation of cellular degranulation. J Immunol 1989;142:236-243.
29. Mohr FC, Fewtrell C: IgE receptor-mediated depolarization of rat basophilic leukemia cells measured with the fluorescent probe bis-oxonol. J Immunol 1987;138:1564-1570.
30. Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M: Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol 2007;8:312-320.
31. Narenjkar J, Marsh SJ, Assem e: Inhibition of the antigen-induced activation of RBL-2H3 cells by charybdotoxin and cetiedil. Eur J Pharmacol 2004;483:95-106.
32. Narenjkar J, Assem e, Ganellin CR: Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analogues. Eur J Pharmacol 2004;483:107-116.
33. + Channel KCa3.1. J Immunol 2008;180:8040-8047
34. El kholy W, MacDonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB: The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J 2003;17:720-722.
35. Penna A, Juvin V, Chemin J, Compan V, Monet M, Rassendren FA: PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane. Cell Calcium 2006;39:495-507.
36. + channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells. J Am Soc Nephrol 2007;18:1652-1661.
37. 2+ currents via increased PI3Kalpha/PKB signaling. Circ Res 2006;98:1390-1397.
38. + channel KCa3.1. Mol Cell Biol 2005;25:3630-3638.
39. Hamill OP, Marty A, Neher E, Sakmann B, Sigeorth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 1981;391:85-100.
40. Barry PH, Lynch JW: Liquid junction potentials and small cell effects in patch-clamp analysis. J Membr Biol 1991;121:101-117.
41. Stokes AJ, Shimoda LM, Koblan-Huberson M, Adra CN, Turner H: A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells. J Exp Med 2004;200:137-147.
42. Ramsey IS, Delling M, Clapham DE: An introduction to TRP channels. Annu Rev Physiol 2006;68:619-647.
43. Ali S, Watson MS, Osborne RH: The stimulant cathartic, emodin, contracts the rat isolated ileum by triggering release of endogenous acetylcholine. Auton Autacoid Pharmacol 2004;24:103-105.
44. Parekh AB, Penner R: Store depletion and calcium influx. Physiol Rev 1997;77:901-930.
45. Baba Y, Nishida K, Fujii Y, Hirano T, Hikida M, Kurosaki T: Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol 2008;9:81-88.
46. 2+ influx. Biochemistry 1998;37:9776-9783.
47. 2+ entry mechanism. J Biol Chem 2000;275:16242-16250.
48. Wischmeyer E, Lentes KU, Karschin A: Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line. Pflugers Arch 1995;429:809-819.
49. Tseng PH, Lin HP, Hu H, Wang C, Zhu MX, Chen CS: The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. Biochemistry 2004;43:11701-11708.
50. Srivastava S, Choudhury P, Li Z, Liu G, Nadkarni V, Ko K, Coetzee WA, Skolnik EY: Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Mol Biol Cell 2006;17:146-154.
51. Srivastava S, Li Z, Ko K, Choudhury P, Albaqumi M, Johnson AK, Yan Y, Backer JM, Unutmaz D, Coetzee WA, Skolnik EY: Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Mol Cell 2006;24:665-675.