The cellular and molecular basis of store-operated calcium entry

Nature Cell Biology

Volumn 4, Issue 11, 2002, Pages

  Venkatachalam, Katrik ^a   van Rossum, Damian B ^a   Patterson, Randen L ^a   Ma, Hong Tao ^a   Gill, Donald L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; DIACYLGLYCEROL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PHOSPHOLIPASE C; RHODOPSIN;

ACCURACY; ANIMAL CELL; APOPTOSIS; CALCIUM CURRENT; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL CYCLE; CELL DEATH; CELL DIVISION; CELL FUNCTION; CELL MEMBRANE; CELL PROLIFERATION; CELL SECRETION; CHANNEL GATING; CONTROLLED STUDY; CYTOLOGY; CYTOSOL; DROSOPHILA MELANOGASTER; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; GENETIC TRANSCRIPTION; MOLECULAR MECHANICS; NONHUMAN; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CELL MEMBRANE; DROSOPHILA MELANOGASTER; ENDOPLASMIC RETICULUM; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TIME FACTORS;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0036847977     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1102-e263     Document Type: Review

References (175)

1. Berridge, M. J., Bootman, M. D. & Lipp, P. Calcium - a life and death signal. Nature 395, 645-648 (1998).
2. Berridge, M. J., Lipp, P. & Bootman, M. D. The versatility and universality of calcium signalling. Nature Rev. Mol. Cell Biol. 1, 11-21 (2000).
3. Putney, J. W. & McKay, R. R. Capacitative calcium entry channels. Bioessays 21, 38-46 (1999).
4. Clapham, D. E. Calcium signaling. Cell 80, 259-268 (1995).
5. Berridge, M. J. Capacitative calcium entry. Biochem. J. 312, 1-11 (1995).
6. Putney, J. W. Capacitative calcium entry (Springer, New York, 1997).
7. Berridge, M. J. Elementary and global aspects of calcium signalling. J. Physiol. (Lond.) 499, 291-306 (1997).
8. Parekh, A. B. & Penner, R. Store depletion and calcium influx. Physiol. Rev. 77, 901-930 (1997).
9. 2+ signalling requirements. Biochem. J. 337, 153-169 (1999).
10. Putney, J. W. & Ribeiro, C. M. Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores. Cell Mol. Life Sci. 57, 1272-1286 (2000).
11. Lewis, R. S. Calcium signaling mechanisms in t lymphocytes. Annu. Rev. Immunol. 19, 497-521 (2001).
12. Putney, J. W. Jr., Broad, L. M., Braun, F. J., Lievremont, J. P., & Bird, G. S. Mechanisms of capacitative calcium entry. J. Cell Sci. 114, 2223-2229 (2001).
13. Putney, J. W. A model for receptor-regulated calcium entry. Cell Calcium 7, 1-12 (1986).
14. Putney, J. W. Capacitative calcium entry revisited. Cell Calcium 11, 611-624 (1990).
15. Gill, D. L. et al. Calcium pools, calcium entry, and cell growth. Biosci. Rep. 16, 139-157 (1996).
16. Hofmann, T. et al. Direct activation of human TRP6 and TRP3 channels by diacylglycerol. Nature 397, 259-263 (1999).
17. Hofmann, T., Schaefer, M., Schultz, G. & Gudermann, T. Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. J. Mol. Med. 78, 14-25 (2000).
18. Harteneck, C., Plant, T. D. & Schultz, G. From worm to man: three subfamilies of TRP channels. Trends Neurosci. 23, 159-166 (2000).
19. Montell, C. & Rubin, G. M. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2, 1313-1323 (1989).
20. Clapham, D. E., Runnels, L. W. & Strubing, C. The trp ion channel family. Nature Rev. Neurosci. 2, 387-396 (2001).
21. Zitt, C., Halaszovich, C. R. & Luckhoff, A. The TRP family of cation channels: probing and advancing the concepts on receptor-activated calcium entry. Prog. Neurobiol. 66, 243-264 (2002).
22. Montell, C. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci. STKE [online] (cited 10 July 2001) (2001).
23. Montell, C., Birnbaumer, L. & Flockerzi, V. The TRP channels, a remarkably functional family. Cell 108, 595-598 (2002).
24. 2+ influx. Nature 364, 809-813 (1993).
25. Thomas, D. & Hanley, M. R. Evaluation of calcium influx factors from stimulated jurkat T-lymphocytes by microinjection into Xenopus oocytes. J. Biol. Chem. 270, 6429-6432 (1995).
26. Csutora, P. et al. Calcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores. Proc. Natl Acad. Sci. USA 96, 121-126 (1999).
27. Trepakova, E. S. et al. Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cells. J. Biol. Chem. 275, 26158-26163 (2000).
28. Rzigalinski, B. A., Willoughby, K. A., Hoffman, S. W., Falck, J. R. & Ellis, E. F. Calcium influx factor, further evidence it is 5,6-epoxyeicosatrienoic acid. J. Biol. Chem. 274, 175-182 (1999).
29. 2+ influx factor and diacylglycerol. Am. J. Physiol. Cell Physiol. 280, C1284-C1292 (2001).
30. Xie, Q., Zhang, Y., Zhai, C. & Bonanno, J. A. Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells. J. Biol. Chem. 277, 16559-16566 (2002).
31. Glitsch, M. D., Bakowski, D. & Parekh, A. B. Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells. J. Physiol. 539, 93-106 (2002).
32. 2+ entry by inositol phosphates - a possible mechanism. FEBS Lett. 263, 5-9 (1990).
33. 2+ entry: evidence for a secretion-like coupling model. Cell 98, 487-499 (1999).
34. 2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger. Cell 98, 475-485 (1999).
35. Putney, J. W. "Kissin' cousins": intimate plasma membrane-ER interactions underlie capacitative calcium entry. Cell 99, 5-8 (1999).
36. 2+ store. Proc. Natl Acad. Sci. USA 90, 6295-6299 (1993).
37. Hoth, M. & Penner, R. Calcium release-activated calcium current in rat mast cells. J. Physiol. (Lond.) 465, 359-386 (1993).
38. Hoth, M. & Penner, R. Depletion of intracellular calcium stores activates a calcium current in mast cells. Nature 355, 353-356 (1992).
39. Zweifach, A. & Lewis, R. S. Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback. J. Gen. Physiol. 105, 209-226 (1995).
40. 2+ channel in Jurkat T lymphocytes. Science 283, 836-839 (1999).
41. Nadler, M. J. et al. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature 411, 590-595 (2001).
42. Hermosura, M. C., Monteilh-Zoller, M. K., Scharenberg, A. M., Penner, R., & Fleig, A. Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. J. Physiol 539, 445-458 (2002).
43. 2+-inhibited cation (MIC) channels. J. Gen. Physiol 119, 487-508 (2002).
44. Luckhoff, A. & Clapham, D. E. Calcium channels activated by depletion of internal calcium stores in A431 cells. Biophys. J. 67, 177-182 (1994).
45. 2+ channels in the plasma membrane of cultured vascular endothelial cells. Am. J. Physiol. 269, C733-C738 (1995).
46. Krause, E., Pfeiffer, F., Schmid, A. & Schulz, I. Depletion of intracellular calcium stores activates a calcium conducting nonselective cation current in mouse pancreatic acinar cells. J. Biol. Chem. 271, 32523-32528 (1996).
47. 3 receptors and store-operated Htrp3 channels. Nature 396, 478-482 (1998).
48. 3 receptor gates store-operated hTrp3 channels. Mol. Cell 4, 423-429 (1999).
49. 2+ entry. Proc. Natl Acad. Sci. USA 96, 14955-14960 (1999).
50. 2+ channels. Science 287, 1647-1651 (2000).
51. Berridge, M. J., Lipp, P. & Bootman, M. D. The calcium entry pas de deux. Science 287, 1604-1605 (2000).
52. Rosado, J. A. & Sage, S. O. Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets. Biochem. J. 356, 191-198 (2001).
53. 2+ stores are depleted. Biochem. J. 350, 631-635 (2000).
54. Zweifach, A. Target-cell contact activates a highly selective capacitative calcium entry pathway in cytotoxic T lymphocytes. J. Cell Biol. 148, 603-614 (2000).
55. Kurosaki, T. et al. Regulation of the phospholipase C-γ2 pathway in B cells. Immunol. Rev. 176, 19-29 (2000).
56. 2+ entry pathway. J. Immunol. 166, 6126-6133 (2001).
57. Zhang, L. & McCloskey, M. A. Immunoglobulin E receptor-activated calcium conductance in rat mast cells. J. Physiol. (Lond.) 483, 59-66 (1995).
58. 2+ entry and the regulation of smooth muscle tone. Trends Pharmacol. Sci. 19, 266-269 (1998).
59. Dolmetsch, R. E., Xu, K. L. & Lewis, R. S. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392, 933-936 (1998).
60. 2+ spike frequency can optimize gene expression. Nature 392, 936-941 (1998).
61. 2+ mobilization and activation of NF-κB and NFAT. Nature Immunol. 2, 403-409 (2001).
62. Hunton, D. L. et al. Capacitative calcium entry contributes to nuclear factor of activated T-cells nuclear translocation and hypertrophy in cardiomyocytes. J. Biol. Chem. 277, 14266-14273 (2002).
63. 2+ entry in human arterial myocytes. Am. J. Physiol 277, C343-C349 (1999).
64. Jayadev, S. et al. Reduced capacitative calcium entry correlates with vesicle accumulation and apoptosis. J. Biol. Chem. 274, 8261-8268 (1999).
65. 2+ influx in Bcl-2-overexpressing cells. J. Cell Biol. 148, 857-862 (2000).
66. 2+ entry sites. J. Biol. Chem. 271, 12438-12444 (1996).
67. 2+ entry. J. Biol. Chem. 273, 9297-9305 (1998).
68. Kim, Y. H. et al. Phospholipase C-δ1 is activated by capacitative calcium entry that follows phospholipase C-β activation upon bradykinin stimulation. J. Biol. Chem. 274, 26127-26134 (1999).
69. 2+ entry. J. Biol. Chem. 275, 17979-17985 (2000).
70. 2+ entry through basal membrane patch. Cell 88, 49-55 (1997).
71. 2+]i oscillations? - challenging the capacitative model. Cell Calcium 25, 237-246 (1999).
72. Corbett, E. F. & Michalak, M. Calcium, a signaling molecule in the endoplasmic reticulum? Trends Biochem. Sci. 25, 307-311 (2000).
73. Johnson, S., Michalak, M., Opas, M., & Eggleton, P. The ins and outs of calreticulin: from the ER lumen to the extracellular space. Trends Cell Biol. 11, 122-129 (2001).
74. 2+ pool content is linked to cell growth. Proc. Natl Acad. Sci. USA 90, 4986-4990 (1993).
75. 2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acid. J. Biol. Chem. 272, 29546-29553 (1997).
76. 2+ signaling in endothelial cells by 11,12-epoxyeicosatrienoic acid. J. Cardiovasc. Pharmacol. 33, 779-784 (1999).
77. 2+ release and influx in polarized epithelia. Nature 377, 643-646 (1995).
78. Petersen, C. C. & Berridge, M. J. Capacitative calcium entry is colocalised with calcium release in Xenopus oocytes: evidence against a highly diffusible calcium influx factor. Pflugers Arch. 432, 286-292 (1996).
79. 3 receptor in rat basophilic leukaemia cells. J. Physiol. (Lond.) 489, 377-382 (1995).
80. McDonald, T. V., Premack, B. A. & Gardner, P. Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells. J. Biol. Chem. 268, 3889-3896 (1993).
81. 2+]. J. Cell Biol. 140, 325-334 (1998).
82. Huang, Y. & Putney, J. W. Relationship between intracellular calcium store depletion and calcium release-activated calcium current in a mast cell line (RBL-1). J. Biol. Chem. 273, 19554-19559 (1998).
83. 2+ entry. J. Biol. Chem. 274, 35318-35324 (1999).
84. Fasolato, C., Hoth, M. & Penner, R. A GTP-dependent step in the activation mechanism of capacitative calcium influx. J. Biol. Chem. 268, 20737-20740 (1993).
85. Bird, G. S. & Putney, J. W. Inhibition of thapsigargin-induced calcium entry by microinjected guanide nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry. J. Biol. Chem. 268, 21486-21488 (1993).
86. 2+ inflow in hepatocytes. Biochem. J. 328, 463-471 (1997).
87. 2+ stores. Trends Neurosci. 24, 602-608 (2001).
88. Rosado, J. A., Jenner, S. & Sage, S. O. A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling. J. Biol. Chem. 275, 7527-7533 (2000).
89. 2+ inflow. J. Biol. Chem. 275, 22229-22237 (2000).
90. Wu, S. et al. Essential control of an endothelial cell ISOC by the spectrin membrane skeleton. J. Cell Biol. 154, 1225-1233 (2001).
91. 2+ current ICRAC in RBL-1 cells. J. Physiol 532, 55-71 (2001).
92. Montell, C. Visual transduction in Drosophila. Annu. Rev. Cell Dev. Biol. 15, 231-268 (1999).
93. Li, H. S. & Montell, C. TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells. J. Cell Biol. 150, 1411-1422 (2000).
94. Isshiki, M. & Anderson, R. G. Calcium signal transduction from caveolae. Cell Calcium 26, 201-208 (1999).
95. Lockwich, T. P. et al. Assembly of trp 1 in a signaling complex associated with caveolin - scaffolding lipid raft domains. J. Biol. Chem. 275, 11934-11942 (2000).
96. 2+ entry. J. Biol. Chem. 277, 6025-6031 (2002).
97. Valtorta, F., Meldolesi, J. & Fesce, R. Synaptic vesicles: is kissing a matter of competence? Trends Cell Biol. 11, 324-328 (2001).
98. 2+ channels are opened? Cell Calcium 23, 65-75 (1998).
99. Cooper, D. M. Calcium-sensitive adenylyl cyclase-aequorin chimeras as sensitive probes for discrete modes of elevation of cytosolic calcium. Methods Enzymol. 345, 105-112 (2002).
100. Montell, C. TRP trapped in fly signaling web. Curr. Opin. Neurobiol. 8, 397 (1998).
101. Zhu, X., Chu, P. B., Peyton, M. & Birnbaumer, L. Molecular-Cloning of A Widely Expressed Human Homolog for the Drosophila Trp Gene. FEBS Lett. 373, 193-198 (1995).
102. Wes, P. D. et al. TRPC1, a human homologue of a Drosophila store-operated channel. Proc. Natl Acad. Sci. USA 9652-9656 (1995).
103. 2+ entry. Cell 85, 661-671 (1996).
104. Montell, C. et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 9, 229-231 (2002).
105. 2+-permeable cation channel activated by calcium store depletion. Neuron 16, 1189-1196 (1996).
106. 2+ influx mechanism in salivary gland cells. J. Biol. Chem. 275, 3403-3411 (2000).
107. 2+ entry. J. Biol. Chem. 275, 36483-36486 (2000).
108. 2+ entry channel. Proc. Natl Acad. Sci. USA 96, 2060-2064 (1999).
109. Vazquez, G., Lievremont, J. P., St. Bird, G. & Putney, J. W. Jr. Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes. Proc. Natl Acad. Sci. USA 98, 11777-11782 (2001).
110. 2+ entry channels. J. Biol. Chem. 276, 48149-48158 (2001).
111. 2+. J. Physiol. (Lond.) 518, 631-638 (1999).
112. 2+ in Xenopus oocytes expressing rat TRP4. Cell Calcium 28, 151-159 (2000).
113. Philipp, S. et al. A novel capacitative calcium entry channel expressed in excitable cells. EMBO J. 17, 4274-4282 (1998).
114. Mizuno, N. et al. Molecular cloning and characterization of rat trp homologues from brain. Brain Res. Mol. Brain Res. 64, 41-51 (1999).
115. 2+ influx. J. Biol. Chem. 277, 12302-12309 (2002).
116. Singh, B. B. et al. Trp1-dependent enhancement of salivary gland fluid secretion: role of store-operated calcium entry. FASEB J. 15, 1652-1654 (2001).
117. 2+-like channels in adrenal cells. J. Biol. Chem. 275, 23965-23972 (2000).
118. 2+ entry in HEK-293 cells. Am. J. Physiol. 278, C526-C536 (2000).
119. Gailly, P. & Colson-Van Schoor, M. Involvement of trp-2 protein in store-operated influx of calcium in fibroblasts. Cell Calcium 30, 157-165 (2001).
120. 2+ entry pathway. FASEB J. 15, 1727-1738 (2001).
121. 2+ entry in human pulmonary artery myocytes during proliferation. Am. J. Physiol. Heart Circ. Physiol. 280, H746-H755 (2001).
122. -/- mice. Nature Cell Biol. 3, 121-127 (2001).
123. 2+ release from endoplasmic reticulum in B lymphocytes. J. Exp. Med. 195, 673-681 (2002).
124. Groschner, K. et al. Trp proteins form store-operated cation channels in human vascular endothelial cells [published erratum appears in FEBS Lett. 442, 122 (1999)]. FEBS Lett. 437, 101-106 (1998).
125. Sinkins, W. G., Estacion, M. & Schilling, W. P. Functional expression of TrpC1: a human homologue of the Drosophila Trp channel. Biochem. J. 331, 331-339 (1998).
126. Zitt, C. et al. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J. Cell Biol. 138, 1333-1341 (1997).
127. 2+ entry. J. Biol. Chem. 273, 133-142 (1998).
128. 2+ entry mediated by store-depletion, S-nitrosylation, and TRP3 channels: Comparison of coupling and function. J. Biol. Chem. 275, 28562-28568 (2000).
129. 3 receptor-knockout cells. J. Biol. Chem. 276, 33980-33985 (2001).
130. Schaefer, M. et al. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J. Biol. Chem. 275, 17517-17526 (2000).
131. McKay, R. R. et al. Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. Biochem. J. 351, 735-746 (2000).
132. 2+ to trigger exocytosis in neuroendocrine cells. J. Biol. Chem. 277, 16172-16178 (2002).
133. 2+ channel from mouse brain. J. Biol. Chem. 273, 10279-10287 (1998).
134. Kanki, H. et al. Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels. Mol. Pharmacol. 60, 989-998 (2001).
135. q class of G protein. J. Biol. Chem. 272, 29672-29680 (1997).
136. 2+-permeable cation channel. Circ. Res. 88, 325-332 (2001).
137. 2+-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J. Biol. Chem. 274, 27359-27370 (1999).
138. Wu, X., Babnigg, G., Zagranichnaya, T. & Villereal, M. L. The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. J. Biol. Chem. 277, 13597-13608 (2002).
139. Stowers, L., Holy, T. E., Meister, M., Dulac, C. & Koentges, G. Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295, 1493-1500 (2002).
140. Li, H.-S., Xu, X.-Z. S. & Montell, C. Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron 24, 261-273 (1999).
141. Liman, E. R., Corey, D. P. & Dulac, C. TRP2: a candidate transduction channel for mammalian pheromone sensory signaling. Proc. Natl Acad. Sci. USA 96, 5791-5796 (1999).
142. 2+ into mouse sperm triggered by egg ZP3. Nature Cell Biol. 3, 499-502 (2001).
143. Xu, X. Z., Li, H. S., Guggino, W. B. & Montell, C. Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89, 1155-1164 (1997).
144. Strubing, C., Krapivinsky, G., Krapivinsky, L. & Clapham, D. E. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29, 645-655 (2001).
145. 2+-sensitive cation channels. J. Biol. Chem. 275, 27799-27805 (2000).
146. Hofmann, T., Schaefer, M., Schultz, G. & Gudermann, T. Subunit composition of mammalian transient receptor potential channels in living cells. Proc. Natl Acad. Sci. USA 99, 7461-7466 (2002).
147. Ohki, G. et al. A calcium-activated cation current by an alternatively spliced form of Trp3 in the heart. J. Biol. Chem. 275, 39055-39060 (2000).
148. 2+ entry. Biochem. J. 341, 41-49 (1999).
149. Gunthorpe, M. J., Benham, C. D., Randall, A. & Davis, J. B. The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol. Sci. 23, 183-191 (2002).
150. Yue, L., Peng, J. B., Hediger, M. A. & Clapham, D. E. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410, 705-709 (2001).
151. Voets, T. et al. CaT1 and the calcium release-activated calcium channel manifest distinct pore properties. J. Biol. Chem. 276, 47767-47770 (2001).
152. 2+ Entry Channels. J. Biol. Chem. 276, 18888-18896 (2001).
153. Ma, H. T., Venkatachalam, K., Parys, J. B. & Gill, D. L. Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes. J. Biol. Chem. 277, 6915-6922 (2002).
154. 3 receptors. J. Physiol. 536, 3-19 (2001).
155. Schindl, R., Kahr, H., Graz, I., Groschner, K. & Romanin, C. Store-depletion activated CaT1 currents in RBL mast cells are inhibited by 2-APB: Evidence for a regulatory component that controls activation of both CaT1 and CRAC channels. J. Biol. Chem. (2002).
156. Runnels, L. W., Yue, L. & Clapham, D. E. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science 291, 1043-1047 (2001).
157. 2 hydrolysis. Nature Cell Biol. 4, 329-336 (2002).
158. 2+ channel isoforms. Molecular structures and functional characterization. J. Biol. Chem. 276, 13331-13339 (2001).
159. Estacion, M., Sinkins, W. G. & Schilling, W. P. Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanisms. J. Physiol 530, 1-19 (2001).
160. Chyb, S., Raghu, P. & Hardie, R. C. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature 397, 255-259 (1999).
161. Tang, Y. et al. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J. Biol. Chem. 275, 37559-37564 (2000).
162. Suh, P. G., Hwang, J. I., Ryu, S. H., Donowitz, M. & Kim, J. H. The roles of PDZ-containing proteins in PLC-beta-mediated signaling. Biochem. Biophys. Res. Commun. 288, 1-7 (2001).
163. Kuno, M. & Gardner, P. Ion Channels Activated by Inositol 1,4,5-Trisphosphate in Plasma-Membrane of Human Lymphocytes-T. Nature 326, 301-304 (1987).
164. 3. Pflugers Arch. 437, 305-314 (1999).
165. 3 receptors on the carboxyl-termini of Trp channels. J. Biol. Chem. 276, 21303-21310 (2001).
166. Zhang, Z. et al. Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proc. Natl Acad. Sci. USA 98, 3168-3173 (2001).
167. Mery, L., Magnino, F., Schmidt, K., Krause, K. H. & Dufour, J. F. Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors. FEBS Lett. 487, 377-383 (2001).
168. Sugawara, H., Kurosaki, M., Takata, M. & Kurosaki, T. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J. 16, 3078-3088 (1997).
169. Broad, L. M. et al. Role of the phospholipase c-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry. J. Biol. Chem. 276, 15945-15952 (2001).
170. 3 receptor is essential for growth and differentiation but not for vision in Drosophila. Neuron 18, 881-887 (1997).
171. Raghu, P. et al. Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Neuron 26, 169-179 (2000).
172. Kiselyov, K. I. et al. Gating of store-operated channels by conformational coupling to ryanodine receptors. Mol. Cell 6, 421-431 (2000).
173. 2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells. Biochem. J. 360, 17-22 (2001).
174. Kedei, N. et al. Analysis of the native quaternary structure of vanilloid receptor 1. J. Biol. Chem. 276, 28613-28619 (2001).
175. Xu, X. Z., Chien, F., Butler, A., Salkoff, L. & Montell, C. TRPγ, a Drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron 26, 647-657 (2000).