Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 514, Issue 1-2, 2002, Pages 153-163

  Giese, Heidi ^a   Snyder, Wendy K ^a   Van Oostrom, Conny ^b   Van Steeg, Harry ^b   Dollé, Martijn E T ^a   Vijg, Jan ^a  

^a University of Texas Health Science Center   (United States)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Aging; LacZ transgenic reporter mice; Mutation accumulation; Trp53 knockout mice; Tumors

Indexed keywords

ETHYLNITROSOUREA; PROTEIN P53;

AGING; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER; CANCER INHIBITION; CELL CYCLE; CELL DAMAGE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE INDUCTION; GENE LOCUS; GENE MUTATION; GENE TARGETING; GENOME; GENOTYPE; HYBRID; KNOCKOUT MOUSE; LIVER; MALE; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; REPORTER GENE; SPLEEN;

AGING; ANIMALS; ETHYLNITROSOUREA; FEMALE; GENES, P53; GENES, REPORTER; LAC OPERON; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS MUSCULUS;

EID: 0037082948     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00329-1     Document Type: Article

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