Somatic mutations are frequent and increase with age in human kidney epithelial cells

Human Molecular Genetics

Volumn 5, Issue 2, 1996, Pages 215-221

  Martin, George M ^a   Ogburn, Charles E ^a   Colgin, Lorel M ^a   Gown, Allen M ^a   Edland, Steven D ^a   Monnat Jr , Raymond J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TIOGUANINE;

ARTICLE; CELL AGING; CELL MUTANT; CLONING; CONTROLLED STUDY; DNA SEQUENCE; DRUG RESISTANCE; EPITHELIUM CELL; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CARCINOMA; KIDNEY EPITHELIUM; MALE; NEPHRECTOMY; PRIORITY JOURNAL; SOMATIC MUTATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BASE SEQUENCE; CARCINOMA; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; DNA PRIMERS; EPITHELIUM; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KIDNEY; KIDNEY CORTEX; KIDNEY NEOPLASMS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; NEPHRECTOMY; THIOGUANINE;

EID: 0030028185     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/5.2.215     Document Type: Article

References (43)

1. Failla, G. (1958) The aging process and carcinogenesis. Ann. N.Y Acad. Sci. 74, 1124-1135.
2. Szilard, L. (1959) On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45, 30-45.
3. Wright, N. and Alison, M. (1984) The Biology of Epithelial Cell Populations. Clarendon Press, Oxford.
4. Jacobs, L. and DeMars, R. (1984) In Kilbey, B. J., Legator, M., Nichols, W., and Ramel, C. (eds.), In Handbook of Mutagenicity Test Procedures, Elsevier Science Publishers, Amsterdam, pp. 321-356.
5. Fenwick, R. G. (1985) In Gottesman, M. (ed.), Molecular Cell Genetics, Wiley, New York, pp. 333-373.
6. Rossiter, B. J. F. and Caskey, C. T. (1995) In Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D. (eds.), The Metabolic and Molecular Bases of Inherited Disease, 7th Ed., McGraw-Hill,Inc. Ney York, pp. 1679-1706.
7. Cariello, N. F. (1994) Database and software for the analysis of mutations in the human hprt gene. Nucleic Acids Res. 22, 3547-3548.
8. Wright, N. and Alison, M. (1984) The Biology of Epithelial Cell Populations, Clarendon Press, Oxford, pp. 981-1003.
9. Hebert, S. C. (1992) In Windhager, E. E. (ed.), Handbook of Physiology Section 8. Renal Physiology, Oxford University Press, New York, pp 876-926
10. Schoolwerth, A. C. and Drewnowska, K. (1995) in Massry, S. G. and Glassock, R. J. (eds.), Massry and Glassock's Textbook of Nephrology, Williams & Wilkins, Baltimore, pp. 123-137.
11. Berry, C. A. and Rector, Jr. (1991) In Brenner, B. M. and Rector, Jr. (eds.), The Kidney, W.B. Saunders Company, Philadelphia, pp. 245-282.
12. Tannenbaum, M. (1971) Ultrastructural pathology of human renal cell tumors. Pathology Ann. 6, 249-277.
13. Bennington, J. L. and Beckwith, J. B. (1975) Tumors of the Kidney, Renal Pelvis, and Ureter, Armed Forces Institute of Pathology, Washington,D.C.
14. Pellett, O. L., Smith, M. L., Thoene, J. G., Schneider, J. A., and Jonas, A. J. (1984) Renal cell culture using autopsy material from children with cystinosis. In Vitro 20, 53-58
15. Monnat, R. J., Jr. (1989) Molecular analysis of spontaneous hypoxanthine phosphoribosyltransferase mutations in thioguanine-resistant HL-60 human leukemia cells Cancer Research 49, 81-87.
16. Fukuchi, K., Martin, G. M., and Monnat, R. J., Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci USA 86, 5893-5897.
17. Thilly, W. G., DeLuca, J. G., Furth, E. E., Hoppe IV, H., Kaden, D. A., Krolewski, J. J., Liber, H. L., Skopek, T. R., Slapikoff, S. A., Tizard, R. J , and Penman, B. W (1980) In de Serres, F. J. and Hollaender, A. (eds.), Chemical Mutagens 6, Plenum Press, New York, pp. 331-364.
18. Turker, M. S., Monnat, R. J., Jr., Fukuchi, K.-i., Johnston, P. A., Ogburn, C. E., Weller, R. E., Park, J. F., and Martin, G. M. (1988) A novel class of unstable 6-thioguanine-resistant cells from dog and human kidneys. Cell. Biol. Toxicol. 4, 211-223.
19. Martin, G.M., Sprague, C.A , Norwood, T.H , and Pendergrass, W.R. (1974) Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia. Am. J: Pathol. 74, 137-154.
20. Cole, J. and Skopek, T. R. (1994) Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo Mutat. Res. 304, 33-105.
21. Licht, M. R. and Novick, A. C. (1993) Nephron sparing surgery for renal cell carcinoma. Urol. 149, 1-7.
22. Morley, A. A., Cox, S., and Holliday, R. (1982) Human lymphocytes resistant to 6-thioguanine increase with age. Mech. Ageing Dev. 19, 21-26.
23. Trainor, K. J., Wigmore, D. J., Chrysostomou, A., Dempsey, J. L., Seshadri, R., and Morley, A. A (1984) Mutation frequency in human lymphocytes increases with age. Mech. Ageing Dev. 27, 83-86.
24. Morley, A. A., Trainor, K. J., Seshadri, R., and Ryall, R. G. (1983) Measurement of in vivo mutations in human lymphocytes. Nature 302, 155-156.
25. Dempsey, J. L., Pfeiffer, M., and Morley, A. A. (1993) Effect of dietary restriction on in vivo somatic mutation in mice. Mutat. Res. 291, 141-145.
26. Holliday, R. (1995) Understanding Ageing, Cambridge University Press, Cambridge.
27. Horn, P. L., Turker, M. S., Ogburn, C. E., Disteche, C. M., and Martin, G. M. (1984) A cloning assay for 6-thioguanine resistance provides evidence against certain somatic mutational theories of aging. J Cell. Physiol. 121, 309-315.
28. Dewey, M. J., Martin, Jr., Martin, G. R., and Mintz, B. (1977) Mosaic mice with teratocarcinoma-derived mutant cells deficient in hypoxanthine phosphoribosyltransferase. Proc. Natl. Acad. Sci. USA 74, 5564-5568.
29. Ansell, J. D., Samuel, K., Whittingham, D. G., Patek, C. E., Hardy, K., Handyside, A. H., Jones, K. W., Muggleton-Harris, A L., Taylor, A. H., and Hooper, M. L. (1991) Hypoxanthine phosphoribosyl transferase deficiency, haematopoiesis and fertility in the mouse. Development 112, 489-498.
30. Levi, M. and Rowe, J W. (1992) In Seldin. D. W. and Giebisch, G. (eds.), The Kidney: Physiology and Pathophysiology, Raven Press, New York, pp. 3433-3456.
31. Zawada, Jr., Boice, J. L , and Santella, R. N. (1995) In Massry, S. G. and Glassock, R. J (eds.), Massry and Glassock's Textbook of Nephrology, Williams&Wilkins, Baltimore,MD, pp. 1138-1147.
32. Stein, W. D. and Stein, A. D. (1995) Familial and sporadic human renal cell carcinoma: evidence against a double-loss mechanism of carcinogenesis. J. Clin. Epidemiol. 48, 767-777.
33. McCredie, M. (1994) Bladder and kidney cancers. Cancer Surv. 19, 343-368.
34. Lindeman, R. D. (1995) In Masoro, E. J. (ed.), Handbook of Physiology Section 11:Aging, Oxford University Press, New York, pp. 485-503.
35. Gown, A. M. and Vogel, A. M. (1982) Monoclonal antibodies to intermediate filament proteins of human cells: unique and cross-reacting antibodies. J. Cell Biol. 95, 414-421.
36. Tsukada, T., Tippens, D., Gordon, D., Ross, R., and Gown, A. M. (1987) HHF35: a muscle-actin-specific monoclonal antibody. I. Immunocytochemical and biochemical characterization. Am. J. Pathol. 126, 51-60.
37. Henikoff, S. (1983) Cloning exons for mapping of transcription: characterization of the Drosophila melanogaster alcohol dehydrogenase gene. Nucleic Acids Res. 11, 4735-4752.
38. Monnat, R. J. Jr., Chiaverotti, T. A., Hackmann, A. F. M., and Maresh, G. A. (1992) Molecular structure and genetic stability of human hypoxanthine phosphoribosyltransferase gene duplications. Genomics 13, 788-796.
39. Edwards, A , Voss, H., Rice, P., Civitello, A., Stegemann, J., Schwager, C., Zimmermann, J., Erfle, H., Caskey, C. T., and Ansorge, W. (1990) Automated DNA sequencing of the human HPRT locus. Genomics 6, 593-608.
40. Box, G. E. P. and Cox, D. R. (1964) The analysis of transformations. J. Royal Stat. Soc. B 26, 211-252.
41. Venables, W. N. and Ripley, B. D. (1994) Modern Applied Statistics with S-Plus, Springer-Verlag, New York.
42. Jolly, D. J., Okayama, H., Berg, P., Esty, A. C., Filpula, D., Bohlen, P., Johnson, G. G., Shively, J., Hunkapillar, T., and Friedmann, T. (1983) Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyltransferase. Proc. Natl. Acad. Sci. USA 80, 477-481.
43. Wilson, J.M., Tarr, G.E , Mahoney, W.C., and Kelly, W.N. (1982) Human hypoxanthine guanine phosphoribosyltransferase: complete amino acid sequence of the erythrocyte enzyme. J. Biol. Chem. 257, 10978-10985.