Induction of a low level of microsatellite instability by overexpression of DNA polymerase β

Cancer Research

Volumn 62, Issue 21, 2002, Pages 6061-6064

  Yamada, Nazumi A ^a   Farber, Rosann A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE;

ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL IMMORTALIZATION; CONTROLLED STUDY; DNA REPLICATION; EPISOME; FRAMESHIFT MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MITOSIS INDEX; MUTATION RATE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERTANT; TANDEM REPEAT;

BLOTTING, WESTERN; CELL DIVISION; CELLS, CULTURED; DIPLOIDY; DNA POLYMERASE BETA; FIBROBLASTS; FRAMESHIFT MUTATION; HUMANS; LUNG; MICROSATELLITE REPEATS; TRANSFECTION;

EID: 0036827991     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell. 61: 759-767, 1990.
2. Jackson, A. L., and Loeb, L. A. The mutation rate and cancer. Genetics, 148: 1483-1490, 1998.
3. Lynch, H. T., and Smyrk, T. An update on Lynch syndrome. Curr. Opin. Oncol., 10: 349-356, 1998.
4. Boland, C. R., Thibodeau, S. N., Hamilton, S. R., Sidransky, D., Eshleman, J. R., Burt, R. W., Meltzer, S. J., Rodriguez-Bigas, M. A., Fodde, R., Ranzani, G. N., and Srivastava, S. A National Cancer Institute Workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res., 58: 5248-5257, 1998.
5. Kambara, T., Matsubara, N., Nakagawa, H., Notohara, K., Nagasaka, T., Yoshino, T., Isozaki, H., Sharp, G. B., Shimizu, K., Jass, J., and Tanaka, N. High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Res., 61: 7743-7746, 2001.
6. Halford, S., Sasieni, P., Rowan, A., Wasan, H., Bodmer, W., Talbot, I., Hawkins, N., Ward, R., and Tomlinson, I. Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait. Cancer Res., 62: 53-57, 2002.
7. Canitrot, Y., Cazaux, C., Frechet, M., Bouayadi, K., Lesca, C., Salles, B., and Hoffmann, J. S. Overexpression of DNA polymerase β in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Proc. Natl. Acad. Sci. USA, 95: 12586-12590, 1998.
8. Bergoglio, V., Canitrot, Y., Hogarth, L., Minto, L., Howell, S. B., Cazaux, C., and Hoffmann, J. S. Enhanced expression and activity of DNA polymerase β in human ovarian tumor cells: Impact on sensitivity towards antitumor agents. Oncogene. 20: 6181-6187, 2001.
9. Gomi, A., Shinoda, S., Sakai, R., Hirai, H., Ozawa, K., and Masuzawa, T. Elevated expression of DNA polymerase β gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3- (2-chloroethyl)-3- nitrosourea. Biochem. Biophys. Res. Commun., 227: 558-563, 1996.
10. Singh, S. V., Scalamogna, D., Xia, H., O’Toole, S., Roy, D., Emerson, E. O., Gupta, V., and Zaren, H. A. Biochemical characterization of a mitomycin C-resistant human bladder cancer cell line. Int. J. Cancer, 65: 852-857, 1996.
11. Sobol, R. W., Horton, J. K., Kuhn, R., Gu, H., Singhal, R. K., Prasad, R., Rajewsky, K., and Wilson, S. H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature (Lond.), 379: 183-186, 1996.
12. Sobol, R. W., Prasad, R., Evenski, A., Baker, A., Yang, X. P., Horton, J. K., and Wilson, S. H. The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity. Nature (Lond.), 405: 807-810, 2000.
13. Zmudzka, B. Z., Fornace, A., Collins, J., and Wilson, S. H. Characterization of DNA polymerase β mRNA: Cell-cycle and growth response in cultured human cells. Nucleic Acids Res., 16: 9587-9596, 1988.
14. Osheroff, W. P., Jung, H. K., Beard, W. A., Wilson, S. H., and Kunkel, T. A. The fidelity of DNA polymerase β during distributive and processive DNA synthesis. J. Biol. Chem., 274: 3642-3650, 1999.
15. Srivastava, D. K., Husain, I., Arteaga, C. L., and Wilson, S. H. DNA polymerase β expression differences in selected human tumors and cell lines. Carcinogenesis (Lond.), 20: 1049-1054, 1999.
16. Zhou, J., Ahn, J., Wilson, S. H., and Prives, C. A role for p53 in base excision repair. EMBO J., 20: 914-923, 2001.
17. Gopalkrishnan, R. V., Christiansen, K. A., Goldstein, N. I., DePinho, R. A., and Fisher, P. B. Use of the human EF-1α promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: A study using the tetracycline-inducible system in human cancer cells. Nucleic Acids Res., 27: 4775-4782, 1999.
18. Abbotts, J., SenGupta, D. N., Zmudzka, B., Widen, S. G., Notario, V., and Wilson, S. H. Expression of human DNA polymerase β in Escherichia coli and characterization of recombinant enzyme. Biochemistry, 27: 901-909, 1988.
19. Boyer, J. C., Yamada, N. A., Roques, C. N., Hatch, S. B., Reiss, K., and Farber, R. A. Sequence dependent instability of mononucleotide microsatellites in cultured mismatch-repair-proficient and -deficient mammalian cells. Hum. Mol. Genet., 11: 707-713, 2002.
20. Luria, S., and Delbrück, M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics, 28: 491-511, 1943.
21. Wierdl, M., Dominska, M., and Petes, T. D. Microsatellite instability in yeast: Dependence on the length of the microsatellite. Genetics, 146: 769-779, 1997.
22. Lei, D., Kunzelmann, K., Koslowsky, T., Yezzi, M., Escobar, L., Xu, Z., Ellison, A., Rommens, J., Tsui L-C., Tylocinski, M., and Gruenert, D. Episomal expression of wild-type CFTR corrects cAMP-dependent chloride transport in respiratory epithelial cells. Gene Ther., 3: 427-436, 1996.
23. Viguera, E., Canceill, D., and Ehrlich, S. D. Replication slippage involves DNA polymerase pausing and dissociation. EMBO J., 20: 2587-2595, 2001.
24. Prasad, R., Dianov, G. L., Bohr, V. A., and Wilson, S. H. FENI stimulation of DNA polymerase β mediates an excision step in mammalian long patch base excision repair. J. Biol. Chem., 275: 4460-4466, 2000.
25. Dianova, I. I., Bohr, V. A., and Dianov, G. L. Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochem., 40: 12639-12644, 2001.
26. Pavlov, Y. I., Nguyen, D., and Kunkel, T. A. Mutator effects of overproducing DNA polymerase H (Rad30) and its catalytically inactive variant in yeast. Mutat. Res., 478: 129-139, 2001.
27. Hartwell, L. H., and Weinert, T. A. Checkpoints: Controls that ensure the order of cell cycle events. Science (Wash. DC), 246: 629-634, 1989.
28. Canitrot, Y., Hoffmann, J. S., Calsou, P., Hayakawa, H., Salles, B., and Cazaux, C. Nucleotide excision repair DNA synthesis by excess DNA polymerase β: A potential source of genetic instability in cancer cells. FASEB J., 14: 1765-1774, 2000.
29. Appella, E., and Anderson, C. W. Post-translational modifications and activation of p53 by genotoxic stress. Eur. J. Biochem., 10: 2764-2772, 2001.