Deorphanization of dresden G protein-coupled receptor for an odorant receptor

Journal of Receptors and Signal Transduction

Volumn 27, Issue 4, 2007, Pages 323-334

  Fujita, Yoshifumi ^a   Takahashi, Tomoko ^a   Suzuki, Akiko ^a   Kawashima, Kayo ^a   Nara, Futoshi ^a   Koishi, Ryuta ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

3 Methyl valeric acid; Deorphanization; Dresden GPCR; Orphan GPCR; Prostate cancer

Indexed keywords

3 METHYLVALERIC ACID; CYCLIC AMP; DRESDEN G PROTEIN COUPLED RECEPTOR; DRESDEN G PROTEIN COUPLED RECEPTOR AGONIST; G PROTEIN COUPLED RECEPTOR; ISOCAPROIC ACID; MESSENGER RNA; PROTEIN INHIBITOR; RECEPTOR SUBUNIT; RHODOPSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOASSAY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; OLFACTORY BULB; OLFACTORY RECEPTOR; PROTEIN EXPRESSION; PROTEOMICS; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; HUMANS; MALE; NEOPLASM PROTEINS; OLFACTORY RECEPTOR NEURONS; PENTANOIC ACIDS; PROSTATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, ODORANT; RHODOPSIN;

EID: 34548827378     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.1080/10799890701534180     Document Type: Article

References (15)

1. 12 to the serum response element and to cellular transformation. Proc Natl Acad Sci USA 1997, 94, 10098-10103.
2. Luther SA, Cyster JG. Chemokines as regulators of T cell differentiation. Nat Immunol 2001, 2, 102-107.
3. Ye X, Fukushima N, Kingsbury MA, Chun J. Lysophosphatidic acid in neural signaling. Neuroreport 2002, 13, 2169-2175.
4. Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 2004, 73, 321-354.
5. Anliker B, Chun J. Lysophospholipid G protein-coupled receptors. J Biol Chem 2004, 279, 20555-20558.
6. Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 2001, 22, 368-376.
7. Chalmers DT, Behan DP. The use of constitutively active GPCRs in drug discovery and functional genomics. Nat Rev Drug Discov 2002, 1, 599-608.
8. Weigle B, Fuessel S, Ebner R, Temme A, Schmitz M, Schwind S, Kiessling A, Rieger MA, Meye A, Bachmann M, Wirth MP, Rieber EP. D-GPCR: A novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate. Biochem Biophys Res Commun 2004, 322, 239-249.
9. Fuessel S, Weigle B, Schmidt U, Baretton G, Koch R, Bachmann M, Rieber EP, Wirth MP, Meye AT. Transcript quantification of Dresden G protein-coupled receptor (D-GPCR) in primary prostate cancer tissue pairs. Cancer Lett 2006, 236, 95-104.
10. Schmidt U, Fuessel S, Koch R, Baretton GB, Lohse A, Tomasetti S, Unversucht S, Froehner M, Wirth MP, Meye A. Quantitative multi-gene expression profiling of primary prostate cancer. Prostate 2006, 66, 1521-1534.
11. Krautwurst D, Yau KW, Reed RR. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 1998, 95, 917-926.
12. Xu LL, Stackhouse BG., Florence K, Zhang W, Shanmugam N, Sesterhenn IA, Zou Z, Srikantan V, Augustus M, Roschke V, Carter K, McLeod DG., Moul JW, Soppett D, Srivastava, S. PSGR, a novel prostate-specific gene with homology to a Gprotein-coupled receptor, is overexpressed in prostate cancer. Cancer Res 2000, 60, 6568-6572.
13. Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, An S, Yang JG. protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers. Oncogene 2004, 23, 6299-6303.
14. Saito H, Kubota M, Roberts RW, Chi Q, Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell 2004, 119, 679-691.
15. Katada S, Nakagawa T, Kataoka H, Touhara K. Odorant response assays for a heterologously expressed olfactory receptor. Biochem Biophys Res Commun 2003, 305, 964-969.