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Volumn 5, Issue 1, 2013, Pages 48-65

Toward personalized cancer nanomedicine-past, present, and future

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BEVACIZUMAB; CRIZOTINIB; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GEFITINIB; IMATINIB; LAPATINIB; METAL NANOPARTICLE; NANOCONJUGATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; RAS PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTOME; TRASTUZUMAB; VEMURAFENIB; VISMODEGIB;

EID: 84871820504     PISSN: 17579694     EISSN: 17579708     Source Type: Journal    
DOI: 10.1039/c2ib20104f     Document Type: Review
Times cited : (42)

References (149)
  • 1
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • E. L. Kwak et al., Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer N. Engl. J. Med. 2010 363 18 1693 1703
    • (2010) N. Engl. J. Med. , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1
  • 2
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • P. B. Chapman et al., Improved survival with vemurafenib in melanoma with BRAF V600E mutation N. Engl. J. Med. 2011 364 26 2507 2516
    • (2011) N. Engl. J. Med. , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1
  • 3
    • 0034473393 scopus 로고    scopus 로고
    • Trastuzumab and chemotherapeutics: Drug interactions and synergies
    • discussion 92-100
    • M. D. Pegram et al., Trastuzumab and chemotherapeutics: drug interactions and synergies Semin. Oncol. 2000 27 6 Suppl 11 21 25
    • (2000) Semin. Oncol. , vol.27 , Issue.6 SUPPL. 11 , pp. 21-25
    • Pegram, M.D.1
  • 4
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • B. J. Druker et al., Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia N. Engl. J. Med. 2001 344 14 1031 1037
    • (2001) N. Engl. J. Med. , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1
  • 5
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • T. J. Lynch et al., Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N. Engl. J. Med. 2004 350 21 2129 2139
    • (2004) N. Engl. J. Med. , vol.350 , Issue.21 , pp. 2129-2139
    • Lynch, T.J.1
  • 6
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • J. G. Paez et al., EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 2004 304 5676 1497 1500
    • (2004) Science , vol.304 , Issue.5676 , pp. 1497-1500
    • Paez, J.G.1
  • 7
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib
    • W. Pao et al., EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib Proc. Natl. Acad. Sci. U. S. A. 2004 101 36 13306 13311
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.36 , pp. 13306-13311
    • Pao, W.1
  • 8
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • H. Hurwitz et al., Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer N. Engl. J. Med. 2004 350 23 2335 2342
    • (2004) N. Engl. J. Med. , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1
  • 9
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • A. Sandler et al., Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer N. Engl. J. Med. 2006 355 24 2542 2550
    • (2006) N. Engl. J. Med. , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1
  • 10
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • J. C. Yang et al., A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer N. Engl. J. Med. 2003 349 5 427 434
    • (2003) N. Engl. J. Med. , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1
  • 11
    • 36049037819 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    • J. J. Vredenburgh et al., Bevacizumab plus irinotecan in recurrent glioblastoma multiforme J. Clin. Oncol. 2007 25 30 4722 4729
    • (2007) J. Clin. Oncol. , vol.25 , Issue.30 , pp. 4722-4729
    • Vredenburgh, J.J.1
  • 12
    • 33947191055 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
    • J. J. Vredenburgh et al., Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma Clin. Cancer Res. 2007 13 4 1253 1259
    • (2007) Clin. Cancer Res. , vol.13 , Issue.4 , pp. 1253-1259
    • Vredenburgh, J.J.1
  • 13
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • H. Davies et al., Mutations of the BRAF gene in human cancer Nature 2002 417 6892 949 954
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1
  • 14
    • 42949149240 scopus 로고    scopus 로고
    • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
    • J. Tsai et al., Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc. Natl. Acad. Sci. U. S. A. 2008 105 8 3041 3046
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , Issue.8 , pp. 3041-3046
    • Tsai, J.1
  • 15
    • 77957089182 scopus 로고    scopus 로고
    • The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    • E. W. Joseph et al., The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner Proc. Natl. Acad. Sci. U. S. A. 2010 107 33 14903 14908
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.33 , pp. 14903-14908
    • Joseph, E.W.1
  • 16
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • S. Verstovsek et al., Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis N. Engl. J. Med. 2010 363 12 1117 1127
    • (2010) N. Engl. J. Med. , vol.363 , Issue.12 , pp. 1117-1127
    • Verstovsek, S.1
  • 17
    • 79959936054 scopus 로고    scopus 로고
    • Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
    • R. Kurzrock et al., Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer J. Clin. Oncol. 2011 29 19 2660 2666
    • (2011) J. Clin. Oncol. , vol.29 , Issue.19 , pp. 2660-2666
    • Kurzrock, R.1
  • 18
    • 77949881462 scopus 로고    scopus 로고
    • The PI3K pathway as drug target in human cancer
    • K. D. Courtney et al., The PI3K pathway as drug target in human cancer J. Clin. Oncol. 2010 28 6 1075 1083
    • (2010) J. Clin. Oncol. , vol.28 , Issue.6 , pp. 1075-1083
    • Courtney, K.D.1
  • 19
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • D. D. Von Hoff et al., Inhibition of the hedgehog pathway in advanced basal-cell carcinoma N. Engl. J. Med. 2009 361 12 1164 1172
    • (2009) N. Engl. J. Med. , vol.361 , Issue.12 , pp. 1164-1172
    • Von Hoff, D.D.1
  • 20
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • P. C. Fong et al., Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers N. Engl. J. Med. 2009 361 2 123 134
    • (2009) N. Engl. J. Med. , vol.361 , Issue.2 , pp. 123-134
    • Fong, P.C.1
  • 21
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • L. L. Rubin F. J. de Sauvage Targeting the Hedgehog pathway in cancer Nat. Rev. Drug Discovery 2006 5 12 1026 1033
    • (2006) Nat. Rev. Drug Discovery , vol.5 , Issue.12 , pp. 1026-1033
    • Rubin, L.L.1    De Sauvage, F.J.2
  • 22
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • H. Farmer et al., Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 2005 434 7035 917 921
    • (2005) Nature , vol.434 , Issue.7035 , pp. 917-921
    • Farmer, H.1
  • 23
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • H. E. Bryant et al., Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 2005 434 7035 913 917
    • (2005) Nature , vol.434 , Issue.7035 , pp. 913-917
    • Bryant, H.E.1
  • 24
    • 59049107421 scopus 로고    scopus 로고
    • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    • C. D. Van Raamsdonk et al., Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi Nature 2009 457 7229 599 602
    • (2009) Nature , vol.457 , Issue.7229 , pp. 599-602
    • Van Raamsdonk, C.D.1
  • 25
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • X. S. Puente et al., Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Nature 2011 475 7354 101 105
    • (2011) Nature , vol.475 , Issue.7354 , pp. 101-105
    • Puente, X.S.1
  • 26
    • 79951494668 scopus 로고    scopus 로고
    • Initial genome sequencing and analysis of multiple myeloma
    • M. A. Chapman et al., Initial genome sequencing and analysis of multiple myeloma Nature 2011 471 7339 467 472
    • (2011) Nature , vol.471 , Issue.7339 , pp. 467-472
    • Chapman, M.A.1
  • 27
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • G. L. Dalgliesh et al., Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 2010 463 7279 360 363
    • (2010) Nature , vol.463 , Issue.7279 , pp. 360-363
    • Dalgliesh, G.L.1
  • 28
    • 77957731999 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
    • S. Jones et al., Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma Science 2010 330 6001 228 231
    • (2010) Science , vol.330 , Issue.6001 , pp. 228-231
    • Jones, S.1
  • 29
    • 77049099785 scopus 로고    scopus 로고
    • Histone methyltransferases in cancer
    • M. Albert K. Helin Histone methyltransferases in cancer Semin. Cell Dev. Biol. 2009 21 2 209 220
    • (2009) Semin. Cell Dev. Biol. , vol.21 , Issue.2 , pp. 209-220
    • Albert, M.1    Helin, K.2
  • 30
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • T. J. Ley et al., DNMT3A mutations in acute myeloid leukemia N. Engl. J. Med. 2010 363 25 2424 2433
    • (2010) N. Engl. J. Med. , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1
  • 31
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • H. Yan et al., IDH1 and IDH2 mutations in gliomas N. Engl. J. Med. 2009 360 8 765 773
    • (2009) N. Engl. J. Med. , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1
  • 32
    • 73649110641 scopus 로고    scopus 로고
    • DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
    • M. E. Figueroa et al., DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia Cancer Cell 2010 17 1 13 27
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 13-27
    • Figueroa, M.E.1
  • 33
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • F. Delhommeau et al., Mutation in TET2 in myeloid cancers N. Engl. J. Med. 2009 360 22 2289 2301
    • (2009) N. Engl. J. Med. , vol.360 , Issue.22 , pp. 2289-2301
    • Delhommeau, F.1
  • 34
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network, (7216)
    • The Cancer Genome Atlas Research Network, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, 2008, 455 (7216), 1061 1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 35
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • The Cancer Genome Atlas Research Network, (7353)
    • The Cancer Genome Atlas Research Network, Integrated genomic analyses of ovarian carcinoma, Nature, 2011, 474 (7353), 609 615
    • (2011) Nature , vol.474 , pp. 609-615
  • 36
    • 41649109807 scopus 로고    scopus 로고
    • Translating insights from the cancer genome into clinical practice
    • L. Chin J. W. Gray Translating insights from the cancer genome into clinical practice Nature 2008 452 7187 553 563
    • (2008) Nature , vol.452 , Issue.7187 , pp. 553-563
    • Chin, L.1    Gray, J.W.2
  • 37
    • 22144489899 scopus 로고    scopus 로고
    • INK4a/ARF: A multifunctional tumor suppressor locus
    • N. E. Sharpless INK4a/ARF: a multifunctional tumor suppressor locus Mutat. Res. 2005 576 1-2 22 38
    • (2005) Mutat. Res. , vol.576 , Issue.12 , pp. 22-38
    • Sharpless, N.E.1
  • 38
    • 0032590011 scopus 로고    scopus 로고
    • PIK3CA is implicated as an oncogene in ovarian cancer
    • L. Shayesteh et al., PIK3CA is implicated as an oncogene in ovarian cancer Nat. Genet. 1999 21 1 99 102
    • (1999) Nat. Genet. , vol.21 , Issue.1 , pp. 99-102
    • Shayesteh, L.1
  • 39
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Y. Samuels et al., High frequency of mutations of the PIK3CA gene in human cancers Science 2004 304 5670 554
    • (2004) Science , vol.304 , Issue.5670 , pp. 554
    • Samuels, Y.1
  • 40
    • 11244258643 scopus 로고    scopus 로고
    • An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis
    • A. Sweet-Cordero et al., An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis Nat. Genet. 2005 37 1 48 55
    • (2005) Nat. Genet. , vol.37 , Issue.1 , pp. 48-55
    • Sweet-Cordero, A.1
  • 41
    • 30444436343 scopus 로고    scopus 로고
    • Activating Notch1 mutations in mouse models of T-ALL
    • J. O'Neil et al., Activating Notch1 mutations in mouse models of T-ALL Blood 2006 107 2 781 785
    • (2006) Blood , vol.107 , Issue.2 , pp. 781-785
    • O'Neil, J.1
  • 42
    • 33745288277 scopus 로고    scopus 로고
    • Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene
    • M. Kim et al., Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene Cell 2006 125 7 1269 1281
    • (2006) Cell , vol.125 , Issue.7 , pp. 1269-1281
    • Kim, M.1
  • 43
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • L. Zender et al., Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach Cell 2006 125 7 1253 1267
    • (2006) Cell , vol.125 , Issue.7 , pp. 1253-1267
    • Zender, L.1
  • 44
    • 27544442628 scopus 로고    scopus 로고
    • Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling
    • J. G. Hodgson et al., Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling Cancer Res. 2005 65 21 9695 9704
    • (2005) Cancer Res. , vol.65 , Issue.21 , pp. 9695-9704
    • Hodgson, J.G.1
  • 45
    • 79952610870 scopus 로고    scopus 로고
    • Making sense of cancer genomic data
    • L. Chin et al., Making sense of cancer genomic data Genes Dev. 2011 25 6 534 555
    • (2011) Genes Dev. , vol.25 , Issue.6 , pp. 534-555
    • Chin, L.1
  • 46
    • 79959480919 scopus 로고    scopus 로고
    • Towards systematic functional characterization of cancer genomes
    • J. S. Boehm W. C. Hahn Towards systematic functional characterization of cancer genomes Nat. Rev. Genet. 2011 12 7 487 498
    • (2011) Nat. Rev. Genet. , vol.12 , Issue.7 , pp. 487-498
    • Boehm, J.S.1    Hahn, W.C.2
  • 47
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
    • H. W. Cheung et al., Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer Proc. Natl. Acad. Sci. U. S. A. 2011 108 30 12372 12377
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , Issue.30 , pp. 12372-12377
    • Cheung, H.W.1
  • 48
    • 80053465657 scopus 로고    scopus 로고
    • Functional Viability Profiles of Breast Cancer
    • R. Brough et al., Functional Viability Profiles of Breast Cancer Cancer Discovery 2011 1 3 260 273
    • (2011) Cancer Discovery , vol.1 , Issue.3 , pp. 260-273
    • Brough, R.1
  • 49
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • D. A. Barbie et al., Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 Nature 2009 462 7269 108 112
    • (2009) Nature , vol.462 , Issue.7269 , pp. 108-112
    • Barbie, D.A.1
  • 50
    • 66149091940 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • J. Luo et al., A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene Cell 2009 137 5 835 848
    • (2009) Cell , vol.137 , Issue.5 , pp. 835-848
    • Luo, J.1
  • 51
    • 77955464738 scopus 로고    scopus 로고
    • Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
    • A. Baldwin et al., Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3 Proc. Natl. Acad. Sci. U. S. A. 2010 107 28 12463 12468
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.28 , pp. 12463-12468
    • Baldwin, A.1
  • 52
    • 55949101858 scopus 로고    scopus 로고
    • Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen
    • A. Bommi-Reddy et al., Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen Proc. Natl. Acad. Sci. U. S. A. 2008 105 43 16484 16489
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , Issue.43 , pp. 16484-16489
    • Bommi-Reddy, A.1
  • 53
    • 78649703966 scopus 로고    scopus 로고
    • Rewiring of genetic networks in response to DNA damage
    • S. Bandyopadhyay et al., Rewiring of genetic networks in response to DNA damage Science 2010 330 6009 1385 1389
    • (2010) Science , vol.330 , Issue.6009 , pp. 1385-1389
    • Bandyopadhyay, S.1
  • 54
    • 79953289737 scopus 로고    scopus 로고
    • Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
    • T. Horn et al., Mapping of signaling networks through synthetic genetic interaction analysis by RNAi Nat. Methods 2011 8 4 341 346
    • (2011) Nat. Methods , vol.8 , Issue.4 , pp. 341-346
    • Horn, T.1
  • 55
    • 33748331308 scopus 로고    scopus 로고
    • The mighty mouse: Genetically engineered mouse models in cancer drug development
    • N. E. Sharpless R. A. Depinho The mighty mouse: genetically engineered mouse models in cancer drug development Nat. Rev. Drug Discovery 2006 5 9 741 754
    • (2006) Nat. Rev. Drug Discovery , vol.5 , Issue.9 , pp. 741-754
    • Sharpless, N.E.1    Depinho, R.A.2
  • 56
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • A. Akinc et al., A combinatorial library of lipid-like materials for delivery of RNAi therapeutics Nat. Biotechnol. 2008 26 5 561 569
    • (2008) Nat. Biotechnol. , vol.26 , Issue.5 , pp. 561-569
    • Akinc, A.1
  • 57
    • 34250863886 scopus 로고    scopus 로고
    • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
    • R. S. Maser et al., Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers Nature 2007 447 7147 966 971
    • (2007) Nature , vol.447 , Issue.7147 , pp. 966-971
    • Maser, R.S.1
  • 58
    • 77953998205 scopus 로고    scopus 로고
    • Non-germline genetically engineered mouse models for translational cancer research
    • J. Heyer et al., Non-germline genetically engineered mouse models for translational cancer research Nat. Rev. Cancer 2010 10 7 470 480
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.7 , pp. 470-480
    • Heyer, J.1
  • 59
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • R. M. Bachoo et al., Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis Cancer Cell 2002 1 3 269 277
    • (2002) Cancer Cell , vol.1 , Issue.3 , pp. 269-277
    • Bachoo, R.M.1
  • 60
    • 70349454058 scopus 로고    scopus 로고
    • Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
    • A. Bric et al., Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model Cancer Cell 2009 16 4 324 335
    • (2009) Cancer Cell , vol.16 , Issue.4 , pp. 324-335
    • Bric, A.1
  • 61
    • 2942623871 scopus 로고    scopus 로고
    • Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
    • N. J. Abbott Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology Neurochem. Int. 2004 45 4 545 552
    • (2004) Neurochem. Int. , vol.45 , Issue.4 , pp. 545-552
    • Abbott, N.J.1
  • 62
    • 34447260549 scopus 로고    scopus 로고
    • Stromal biology of pancreatic cancer
    • G. C. Chu et al., Stromal biology of pancreatic cancer J. Cell. Biochem. 2007 101 4 887 907
    • (2007) J. Cell. Biochem. , vol.101 , Issue.4 , pp. 887-907
    • Chu, G.C.1
  • 63
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adenocarcinoma
    • A. F. Hezel et al., Genetics and biology of pancreatic ductal adenocarcinoma Genes Dev. 2006 20 10 1218 1249
    • (2006) Genes Dev. , vol.20 , Issue.10 , pp. 1218-1249
    • Hezel, A.F.1
  • 64
    • 43749107912 scopus 로고    scopus 로고
    • Acquired resistance to tyrosine kinase inhibitors during cancer therapy
    • J. A. Engelman J. Settleman Acquired resistance to tyrosine kinase inhibitors during cancer therapy Curr. Opin. Genet. Dev. 2008 18 1 73 79
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , Issue.1 , pp. 73-79
    • Engelman, J.A.1    Settleman, J.2
  • 65
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Y. Matsumura H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 1986 46 12 Pt 1 6387 6392
    • (1986) Cancer Res. , vol.46 , Issue.12 PART 1 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 66
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
    • H. Maeda et al., Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Controlled Release 2000 65 1-2 271 284
    • (2000) J. Controlled Release , vol.65 , Issue.1-2 , pp. 271-284
    • Maeda, H.1
  • 67
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • R. A. Petros J. M. DeSimone Strategies in the design of nanoparticles for therapeutic applications Nat. Rev. Drug Discovery 2010 9 8 615 627
    • (2010) Nat. Rev. Drug Discovery , vol.9 , Issue.8 , pp. 615-627
    • Petros, R.A.1    Desimone, J.M.2
  • 68
    • 15544377122 scopus 로고    scopus 로고
    • Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes
    • C. P. Dillon et al., Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes Annu. Rev. Physiol. 2005 67 147 173
    • (2005) Annu. Rev. Physiol. , vol.67 , pp. 147-173
    • Dillon, C.P.1
  • 69
    • 59849103061 scopus 로고    scopus 로고
    • Drug delivery of siRNA therapeutics: Potentials and limits of nanosystems
    • D. Reischl A. Zimmer Drug delivery of siRNA therapeutics: potentials and limits of nanosystems Nanomedicine 2009 5 1 8 20
    • (2009) Nanomedicine , vol.5 , Issue.1 , pp. 8-20
    • Reischl, D.1    Zimmer, A.2
  • 70
    • 4644350944 scopus 로고    scopus 로고
    • Unlocking the potential of the human genome with RNA interference
    • G. J. Hannon J. J. Rossi Unlocking the potential of the human genome with RNA interference Nature 2004 431 7006 371 378
    • (2004) Nature , vol.431 , Issue.7006 , pp. 371-378
    • Hannon, G.J.1    Rossi, J.J.2
  • 71
    • 36849044732 scopus 로고    scopus 로고
    • Nonviral delivery of synthetic siRNAs in vivo
    • S. Akhtar I. F. Benter Nonviral delivery of synthetic siRNAs in vivo J. Clin. Invest. 2007 117 12 3623 3632
    • (2007) J. Clin. Invest. , vol.117 , Issue.12 , pp. 3623-3632
    • Akhtar, S.1    Benter, I.F.2
  • 72
    • 34548735210 scopus 로고    scopus 로고
    • Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
    • D. B. Rozema et al., Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes Proc. Natl. Acad. Sci. U. S. A. 2007 104 32 12982 12987
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.32 , pp. 12982-12987
    • Rozema, D.B.1
  • 73
    • 34347272315 scopus 로고    scopus 로고
    • Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
    • J. D. Heidel et al., Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA Proc. Natl. Acad. Sci. U. S. A. 2007 104 14 5715 5721
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.14 , pp. 5715-5721
    • Heidel, J.D.1
  • 74
    • 34848918210 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    • D. W. Bartlett et al., Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc. Natl. Acad. Sci. U. S. A. 2007 104 39 15549 15554
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.39 , pp. 15549-15554
    • Bartlett, D.W.1
  • 75
    • 34248544999 scopus 로고    scopus 로고
    • Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels
    • H. Lee et al., Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels J. Controlled Release 2007 119 2 245 252
    • (2007) J. Controlled Release , vol.119 , Issue.2 , pp. 245-252
    • Lee, H.1
  • 76
    • 60049097220 scopus 로고    scopus 로고
    • Efficient siRNA delivery with non-viral polymeric vehicles
    • W. J. Kim S. W. Kim Efficient siRNA delivery with non-viral polymeric vehicles Pharm. Res. 2009 26 3 657 666
    • (2009) Pharm. Res. , vol.26 , Issue.3 , pp. 657-666
    • Kim, W.J.1    Kim, S.W.2
  • 77
    • 48949098577 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Synthetic polymer-based systems
    • D. Schaffert E. Wagner Gene therapy progress and prospects: synthetic polymer-based systems Gene Ther. 2008 15 16 1131 1138
    • (2008) Gene Ther. , vol.15 , Issue.16 , pp. 1131-1138
    • Schaffert, D.1    Wagner, E.2
  • 78
    • 68549130637 scopus 로고    scopus 로고
    • Chemical vectors for gene delivery: A current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
    • P. Midoux et al., Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers Br. J. Pharmacol. 2009 157 2 166 178
    • (2009) Br. J. Pharmacol. , vol.157 , Issue.2 , pp. 166-178
    • Midoux, P.1
  • 79
    • 63749103281 scopus 로고    scopus 로고
    • Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery
    • M. S. Shim Y. J. Kwon Acid-responsive linear polyethylenimine for efficient, specific, and biocompatible siRNA delivery Bioconjugate Chem. 2009 20 3 488 499
    • (2009) Bioconjugate Chem. , vol.20 , Issue.3 , pp. 488-499
    • Shim, M.S.1    Kwon, Y.J.2
  • 80
    • 58649092401 scopus 로고    scopus 로고
    • Development of a novel endosomolytic diblock copolymer for siRNA delivery
    • A. J. Convertine et al., Development of a novel endosomolytic diblock copolymer for siRNA delivery J. Controlled Release 2009 133 3 221 229
    • (2009) J. Controlled Release , vol.133 , Issue.3 , pp. 221-229
    • Convertine, A.J.1
  • 81
    • 33846813849 scopus 로고    scopus 로고
    • Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    • S. Oliveira et al., Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes Int. J. Pharm. 2007 331 2 211 214
    • (2007) Int. J. Pharm. , vol.331 , Issue.2 , pp. 211-214
    • Oliveira, S.1
  • 82
    • 69949155656 scopus 로고    scopus 로고
    • A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
    • H. Hatakeyama et al., A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo J. Controlled Release 2009 139 2 127 132
    • (2009) J. Controlled Release , vol.139 , Issue.2 , pp. 127-132
    • Hatakeyama, H.1
  • 83
    • 33646190173 scopus 로고    scopus 로고
    • Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs
    • A. Aigner Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs J. Biotechnol. 2006 124 1 12 25
    • (2006) J. Biotechnol. , vol.124 , Issue.1 , pp. 12-25
    • Aigner, A.1
  • 84
    • 70350130799 scopus 로고    scopus 로고
    • Comparative assessment of siRNA and shRNA off target effects: What is slowing clinical development
    • D. D. Rao et al., Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development Cancer Gene Ther. 2009 16 11 807 809
    • (2009) Cancer Gene Ther. , vol.16 , Issue.11 , pp. 807-809
    • Rao, D.D.1
  • 85
    • 65749088084 scopus 로고    scopus 로고
    • SiRNA vs. shRNA: Similarities and differences
    • D. D. Rao et al., siRNA vs. shRNA: similarities and differences Adv. Drug Delivery Rev. 2009 61 9 746 759
    • (2009) Adv. Drug Delivery Rev. , vol.61 , Issue.9 , pp. 746-759
    • Rao, D.D.1
  • 86
    • 33751430435 scopus 로고    scopus 로고
    • Building oligonucleotide therapeutics using non-natural chemistries
    • C. Wilson A. D. Keefe Building oligonucleotide therapeutics using non-natural chemistries Curr. Opin. Chem. Biol. 2006 10 6 607 614
    • (2006) Curr. Opin. Chem. Biol. , vol.10 , Issue.6 , pp. 607-614
    • Wilson, C.1    Keefe, A.D.2
  • 87
    • 34047190259 scopus 로고    scopus 로고
    • Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
    • D. De Paula et al., Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting RNA 2007 13 4 431 456
    • (2007) RNA , vol.13 , Issue.4 , pp. 431-456
    • De Paula, D.1
  • 88
    • 68249122805 scopus 로고    scopus 로고
    • Nonviral siRNA delivery to the lung: Investigation of PEG-PEI polyplexes and their in vivo performance
    • O. M. Merkel et al., Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance Mol. Pharm. 2009 6 4 1246 1260
    • (2009) Mol. Pharm. , vol.6 , Issue.4 , pp. 1246-1260
    • Merkel, O.M.1
  • 89
    • 67651202350 scopus 로고    scopus 로고
    • Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
    • O. M. Merkel et al., Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging J. Controlled Release 2009 138 2 148 159
    • (2009) J. Controlled Release , vol.138 , Issue.2 , pp. 148-159
    • Merkel, O.M.1
  • 90
    • 58149217884 scopus 로고    scopus 로고
    • A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells
    • L. Crombez et al., A new potent secondary amphipathic cell-penetrating peptide for siRNA delivery into mammalian cells Mol. Ther. 2009 17 1 95 103
    • (2009) Mol. Ther. , vol.17 , Issue.1 , pp. 95-103
    • Crombez, L.1
  • 91
    • 68149125757 scopus 로고    scopus 로고
    • Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth
    • L. Crombez et al., Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth Nucleic Acids Res. 2009 37 14 4559 4569
    • (2009) Nucleic Acids Res. , vol.37 , Issue.14 , pp. 4559-4569
    • Crombez, L.1
  • 92
    • 67149093390 scopus 로고    scopus 로고
    • Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein
    • A. Eguchi et al., Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein Nat. Biotechnol. 2009 27 6 567 571
    • (2009) Nat. Biotechnol. , vol.27 , Issue.6 , pp. 567-571
    • Eguchi, A.1
  • 93
    • 39449113001 scopus 로고    scopus 로고
    • PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy
    • A. Malek et al., PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacy J. Drug Targeting 2008 16 2 124 139
    • (2008) J. Drug Targeting , vol.16 , Issue.2 , pp. 124-139
    • Malek, A.1
  • 94
    • 47749100430 scopus 로고    scopus 로고
    • Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity
    • A. Zintchenko et al., Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity Bioconjugate Chem. 2008 19 7 1448 1455
    • (2008) Bioconjugate Chem. , vol.19 , Issue.7 , pp. 1448-1455
    • Zintchenko, A.1
  • 95
    • 39749099838 scopus 로고    scopus 로고
    • Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine
    • M. S. Shim Y. J. Kwon Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine Biomacromolecules 2008 9 2 444 455
    • (2008) Biomacromolecules , vol.9 , Issue.2 , pp. 444-455
    • Shim, M.S.1    Kwon, Y.J.2
  • 96
    • 70349335809 scopus 로고    scopus 로고
    • RNAi using a chitosan/siRNA nanoparticle system: In vitro and in vivo applications
    • M. O. Andersen et al., RNAi using a chitosan/siRNA nanoparticle system: in vitro and in vivo applications Methods Mol. Biol. (Totowa, N. J.) 2009 555 77 86
    • (2009) Methods Mol. Biol. (Totowa, N. J.) , vol.555 , pp. 77-86
    • Andersen, M.O.1
  • 97
    • 50349087243 scopus 로고    scopus 로고
    • Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery
    • T. M. Sun et al., Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery Biomaterials 2008 29 32 4348 4355
    • (2008) Biomaterials , vol.29 , Issue.32 , pp. 4348-4355
    • Sun, T.M.1
  • 98
    • 47649089265 scopus 로고    scopus 로고
    • Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran
    • N. Tietze et al., Induction of apoptosis in murine neuroblastoma by systemic delivery of transferrin-shielded siRNA polyplexes for downregulation of Ran Oligonucleotides 2008 18 2 161 174
    • (2008) Oligonucleotides , vol.18 , Issue.2 , pp. 161-174
    • Tietze, N.1
  • 99
    • 33846302477 scopus 로고    scopus 로고
    • Reducible poly(amido ethylenimine) directed to enhance RNA interference
    • J. Hoon Jeong et al., Reducible poly(amido ethylenimine) directed to enhance RNA interference Biomaterials 2007 28 10 1912 1917
    • (2007) Biomaterials , vol.28 , Issue.10 , pp. 1912-1917
    • Hoon Jeong, J.1
  • 100
    • 40949100345 scopus 로고    scopus 로고
    • Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells
    • D. Jere et al., Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells Biomaterials 2008 29 16 2535 2547
    • (2008) Biomaterials , vol.29 , Issue.16 , pp. 2535-2547
    • Jere, D.1
  • 101
    • 34648825525 scopus 로고    scopus 로고
    • Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing
    • S. J. Tseng S. C. Tang Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing Bioconjugate Chem. 2007 18 5 1383 1390
    • (2007) Bioconjugate Chem. , vol.18 , Issue.5 , pp. 1383-1390
    • Tseng, S.J.1    Tang, S.C.2
  • 102
    • 76349111051 scopus 로고    scopus 로고
    • Rational design of cationic lipids for siRNA delivery
    • S. C. Semple et al., Rational design of cationic lipids for siRNA delivery Nat. Biotechnol. 2010 28 2 172 176
    • (2010) Nat. Biotechnol. , vol.28 , Issue.2 , pp. 172-176
    • Semple, S.C.1
  • 103
    • 76649098887 scopus 로고    scopus 로고
    • Lipid-like materials for low-dose, in vivo gene silencing
    • K. T. Love et al., Lipid-like materials for low-dose, in vivo gene silencing Proc. Natl. Acad. Sci. U. S. A. 2010 107 5 1864 1869
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.5 , pp. 1864-1869
    • Love, K.T.1
  • 105
    • 78649476052 scopus 로고    scopus 로고
    • Shared and separate functions of polo-like kinases and aurora kinases in cancer
    • S. M. Lens et al., Shared and separate functions of polo-like kinases and aurora kinases in cancer Nat. Rev. Cancer 2010 10 12 825 841
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.12 , pp. 825-841
    • Lens, S.M.1
  • 106
    • 84855168044 scopus 로고    scopus 로고
    • Phase i clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors
    • D. Strumberg et al., Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors Int. J. Clin. Pharmacol. Ther. 2011 50 1 76 78
    • (2011) Int. J. Clin. Pharmacol. Ther. , vol.50 , Issue.1 , pp. 76-78
    • Strumberg, D.1
  • 107
    • 79960530841 scopus 로고    scopus 로고
    • In vivo delivery of RNAi with lipid-based nanoparticles
    • L. Huang Y. Liu In vivo delivery of RNAi with lipid-based nanoparticles Annu. Rev. Biomed. Eng. 2011 13 507 530
    • (2011) Annu. Rev. Biomed. Eng. , vol.13 , pp. 507-530
    • Huang, L.1    Liu, Y.2
  • 108
    • 71949099757 scopus 로고    scopus 로고
    • Lipid-based nanotherapeutics for siRNA delivery
    • A. Schroeder et al., Lipid-based nanotherapeutics for siRNA delivery J. Intern. Med. 2010 267 1 9 21
    • (2010) J. Intern. Med. , vol.267 , Issue.1 , pp. 9-21
    • Schroeder, A.1
  • 109
    • 68049144915 scopus 로고    scopus 로고
    • Dual targeting of EphA2 and FAK in ovarian carcinoma
    • M. M. Shahzad et al., Dual targeting of EphA2 and FAK in ovarian carcinoma Cancer Biol. Ther. 2009 8 11 1027 1034
    • (2009) Cancer Biol. Ther. , vol.8 , Issue.11 , pp. 1027-1034
    • Shahzad, M.M.1
  • 110
    • 38449095310 scopus 로고    scopus 로고
    • Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver
    • M. J. Gray et al., Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver J. Natl. Cancer Inst. 2008 100 2 109 120
    • (2008) J. Natl. Cancer Inst. , vol.100 , Issue.2 , pp. 109-120
    • Gray, M.J.1
  • 111
    • 40949126550 scopus 로고    scopus 로고
    • Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
    • W. M. Merritt et al., Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth J. Natl. Cancer Inst. 2008 100 5 359 372
    • (2008) J. Natl. Cancer Inst. , vol.100 , Issue.5 , pp. 359-372
    • Merritt, W.M.1
  • 112
    • 46549085779 scopus 로고    scopus 로고
    • Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    • S. H. Kim et al., Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer J. Controlled Release 2008 129 2 107 116
    • (2008) J. Controlled Release , vol.129 , Issue.2 , pp. 107-116
    • Kim, S.H.1
  • 113
    • 69249150822 scopus 로고    scopus 로고
    • A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo
    • N. Yagi et al., A nanoparticle system specifically designed to deliver short interfering RNA inhibits tumor growth in vivo Cancer Res. 2009 69 16 6531 6538
    • (2009) Cancer Res. , vol.69 , Issue.16 , pp. 6531-6538
    • Yagi, N.1
  • 114
    • 33646878087 scopus 로고    scopus 로고
    • Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma
    • N. Toub et al., Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma Pharm. Res. 2006 23 5 892 900
    • (2006) Pharm. Res. , vol.23 , Issue.5 , pp. 892-900
    • Toub, N.1
  • 115
    • 48549107647 scopus 로고    scopus 로고
    • SiRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model
    • O. Imamura et al., siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model Cancer Lett. (Shannon, Irel.) 2008 268 2 278 285
    • (2008) Cancer Lett. (Shannon, Irel.) , vol.268 , Issue.2 , pp. 278-285
    • Imamura, O.1
  • 116
    • 84856284163 scopus 로고    scopus 로고
    • Spherical nucleic acids
    • J. I. Cutler et al., Spherical nucleic acids J. Am. Chem. Soc. 2012 134 3 1376 1391
    • (2012) J. Am. Chem. Soc. , vol.134 , Issue.3 , pp. 1376-1391
    • Cutler, J.I.1
  • 117
    • 33845248415 scopus 로고    scopus 로고
    • Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing
    • M. Oishi et al., Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing Chem. Lett. 2006 35 9 1046 1047
    • (2006) Chem. Lett. , vol.35 , Issue.9 , pp. 1046-1047
    • Oishi, M.1
  • 118
    • 67749124305 scopus 로고    scopus 로고
    • Gene regulation with polyvalent siRNA-nanoparticle conjugates
    • D. A. Giljohann et al., Gene regulation with polyvalent siRNA-nanoparticle conjugates J. Am. Chem. Soc. 2009 131 6 2072 2073
    • (2009) J. Am. Chem. Soc. , vol.131 , Issue.6 , pp. 2072-2073
    • Giljohann, D.A.1
  • 119
    • 79959260405 scopus 로고    scopus 로고
    • Polyvalent nucleic acid nanostructures
    • J. I. Cutler et al., Polyvalent nucleic acid nanostructures J. Am. Chem. Soc. 2011 133 24 9254 9257
    • (2011) J. Am. Chem. Soc. , vol.133 , Issue.24 , pp. 9254-9257
    • Cutler, J.I.1
  • 120
    • 78650317021 scopus 로고    scopus 로고
    • Scavenger receptors mediate cellular uptake of polyvalent oligonucleotide-functionalized gold nanoparticles
    • P. C. Patel et al., Scavenger receptors mediate cellular uptake of polyvalent oligonucleotide-functionalized gold nanoparticles Bioconjugate Chem. 2010 21 12 2250 2256
    • (2010) Bioconjugate Chem. , vol.21 , Issue.12 , pp. 2250-2256
    • Patel, P.C.1
  • 121
    • 61649093632 scopus 로고    scopus 로고
    • Polyvalent DNA nanoparticle conjugates stabilize nucleic acids
    • D. S. Seferos et al., Polyvalent DNA nanoparticle conjugates stabilize nucleic acids Nano Lett. 2009 9 1 308 311
    • (2009) Nano Lett. , vol.9 , Issue.1 , pp. 308-311
    • Seferos, D.S.1
  • 122
    • 80053307636 scopus 로고    scopus 로고
    • Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA-nanoparticle conjugates
    • X. Q. Zhang et al., Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA-nanoparticle conjugates ACS Nano 2009 5 9 6962 6970
    • (2009) ACS Nano , vol.5 , Issue.9 , pp. 6962-6970
    • Zhang, X.Q.1
  • 123
    • 70449562074 scopus 로고    scopus 로고
    • Multimodal gadolinium-enriched DNA-gold nanoparticle conjugates for cellular imaging
    • Y. Song et al., Multimodal gadolinium-enriched DNA-gold nanoparticle conjugates for cellular imaging Angew. Chem., Int. Ed. 2009 48 48 9143 9147
    • (2009) Angew. Chem., Int. Ed. , vol.48 , Issue.48 , pp. 9143-9147
    • Song, Y.1
  • 124
    • 66749180499 scopus 로고    scopus 로고
    • Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery
    • J. S. Lee et al., Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery Nano Lett. 2009 9 6 2402 2406
    • (2009) Nano Lett. , vol.9 , Issue.6 , pp. 2402-2406
    • Lee, J.S.1
  • 125
    • 68649125408 scopus 로고    scopus 로고
    • Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates
    • G. B. Braun et al., Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates ACS Nano 2009 3 7 2007 2015
    • (2009) ACS Nano , vol.3 , Issue.7 , pp. 2007-2015
    • Braun, G.B.1
  • 126
    • 77951053004 scopus 로고    scopus 로고
    • Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection
    • W. Lu et al., Tumor site-specific silencing of NF-kappaB p65 by targeted hollow gold nanosphere-mediated photothermal transfection Cancer Res. 2010 70 8 3177 3188
    • (2010) Cancer Res. , vol.70 , Issue.8 , pp. 3177-3188
    • Lu, W.1
  • 127
    • 66449127352 scopus 로고    scopus 로고
    • Layer-by-layer assembled gold nanoparticles for siRNA delivery
    • A. Elbakry et al., Layer-by-layer assembled gold nanoparticles for siRNA delivery Nano Lett. 2009 9 5 2059 2064
    • (2009) Nano Lett. , vol.9 , Issue.5 , pp. 2059-2064
    • Elbakry, A.1
  • 128
    • 77957302255 scopus 로고    scopus 로고
    • Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte
    • S. Guo et al., Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte ACS Nano 2010 4 9 5505 5511
    • (2010) ACS Nano , vol.4 , Issue.9 , pp. 5505-5511
    • Guo, S.1
  • 129
    • 76749089244 scopus 로고    scopus 로고
    • Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery
    • W. J. Song et al., Gold nanoparticles capped with polyethyleneimine for enhanced siRNA delivery Small 2009 6 2 239 246
    • (2009) Small , vol.6 , Issue.2 , pp. 239-246
    • Song, W.J.1
  • 130
    • 77950838438 scopus 로고    scopus 로고
    • Tailored design of Au nanoparticle-siRNA carriers utilizing reversible addition-fragmentation chain transfer polymers
    • S. Kirkland-York et al., Tailored design of Au nanoparticle-siRNA carriers utilizing reversible addition-fragmentation chain transfer polymers Biomacromolecules 2010 11 4 1052 1059
    • (2010) Biomacromolecules , vol.11 , Issue.4 , pp. 1052-1059
    • Kirkland-York, S.1
  • 131
    • 53949108095 scopus 로고    scopus 로고
    • Amine-functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers
    • S. H. Lee et al., Amine-functionalized gold nanoparticles as non-cytotoxic and efficient intracellular siRNA delivery carriers Int. J. Pharm. 2008 364 1 94 101
    • (2008) Int. J. Pharm. , vol.364 , Issue.1 , pp. 94-101
    • Lee, S.H.1
  • 132
    • 65249105506 scopus 로고    scopus 로고
    • Nanotechnology approach for drug addiction therapy: Gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons
    • A. C. Bonoiu et al., Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons Proc. Natl. Acad. Sci. U. S. A. 2009 106 14 5546 5550
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , Issue.14 , pp. 5546-5550
    • Bonoiu, A.C.1
  • 133
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • M. E. Davis et al., Nanoparticle therapeutics: an emerging treatment modality for cancer Nat. Rev. Drug Discovery 2008 7 9 771 782
    • (2008) Nat. Rev. Drug Discovery , vol.7 , Issue.9 , pp. 771-782
    • Davis, M.E.1
  • 134
    • 80051965473 scopus 로고    scopus 로고
    • Passive and active tumour targeting with nanocarriers
    • S. Hirsjarvi et al., Passive and active tumour targeting with nanocarriers Curr. Drug Discovery Technol. 2011 8 3 188 196
    • (2011) Curr. Drug Discovery Technol. , vol.8 , Issue.3 , pp. 188-196
    • Hirsjarvi, S.1
  • 135
    • 54949125913 scopus 로고    scopus 로고
    • Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts
    • T. Yoshizawa et al., Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts Eur. J. Pharm. Biopharm. 2008 70 3 718 725
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , Issue.3 , pp. 718-725
    • Yoshizawa, T.1
  • 136
    • 77951132901 scopus 로고    scopus 로고
    • Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
    • M. E. Davis et al., Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles Nature 2010 464 7291 1067 1070
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1067-1070
    • Davis, M.E.1
  • 137
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • E. Song et al., RNA interference targeting Fas protects mice from fulminant hepatitis Nat. Med. (N. Y.) 2003 9 3 347 351
    • (2003) Nat. Med. (N. Y.) , vol.9 , Issue.3 , pp. 347-351
    • Song, E.1
  • 138
    • 30644473108 scopus 로고    scopus 로고
    • Antibody-directed cell-type-specific delivery of siRNA
    • H. P. Vornlocher Antibody-directed cell-type-specific delivery of siRNA Trends Mol. Med. 2006 12 1 1 3
    • (2006) Trends Mol. Med. , vol.12 , Issue.1 , pp. 1-3
    • Vornlocher, H.P.1
  • 139
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • E. Song et al., Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors Nat. Biotechnol. 2005 23 6 709 717
    • (2005) Nat. Biotechnol. , vol.23 , Issue.6 , pp. 709-717
    • Song, E.1
  • 140
    • 34447114618 scopus 로고    scopus 로고
    • Transvascular delivery of small interfering RNA to the central nervous system
    • P. Kumar et al., Transvascular delivery of small interfering RNA to the central nervous system Nature 2007 448 7149 39 43
    • (2007) Nature , vol.448 , Issue.7149 , pp. 39-43
    • Kumar, P.1
  • 141
    • 14544298301 scopus 로고    scopus 로고
    • Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
    • R. M. Schiffelers et al., Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle Nucleic Acids Res. 2004 32 19 e149
    • (2004) Nucleic Acids Res. , vol.32 , Issue.19 , pp. 149
    • Schiffelers, R.M.1
  • 142
    • 33747031960 scopus 로고    scopus 로고
    • Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
    • J. O. McNamara, 2nd et al., Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras Nat. Biotechnol. 2006 24 8 1005 1015
    • (2006) Nat. Biotechnol. , vol.24 , Issue.8 , pp. 1005-1015
    • McNamara II, J.O.1
  • 143
    • 61849153021 scopus 로고    scopus 로고
    • Impact of nanotechnology on drug delivery
    • O. C. Farokhzad R. Langer Impact of nanotechnology on drug delivery ACS Nano 2009 3 1 16 20
    • (2009) ACS Nano , vol.3 , Issue.1 , pp. 16-20
    • Farokhzad, O.C.1    Langer, R.2
  • 144
    • 84856753045 scopus 로고    scopus 로고
    • The genetic basis for cancer treatment decisions
    • J. E. Dancey et al., The genetic basis for cancer treatment decisions Cell 2012 148 3 409 420
    • (2012) Cell , vol.148 , Issue.3 , pp. 409-420
    • Dancey, J.E.1
  • 145
    • 84856996617 scopus 로고    scopus 로고
    • The RAF inhibitor paradox revisited
    • A. D. Cox C. J. Der The RAF inhibitor paradox revisited Cancer Cell 2012 21 2 147 149
    • (2012) Cancer Cell , vol.21 , Issue.2 , pp. 147-149
    • Cox, A.D.1    Der, C.J.2
  • 146
    • 84856190949 scopus 로고    scopus 로고
    • RAF around the edges - The paradox of BRAF inhibitors
    • A. T. Weeraratna RAF around the edges - the paradox of BRAF inhibitors N. Engl. J. Med. 2011 366 3 271 273
    • (2011) N. Engl. J. Med. , vol.366 , Issue.3 , pp. 271-273
    • Weeraratna, A.T.1
  • 147
    • 79952419254 scopus 로고    scopus 로고
    • Methodological and practical challenges for personalized cancer therapies
    • I. I. Wistuba et al., Methodological and practical challenges for personalized cancer therapies Nat. Rev. Clin. Oncol. 2011 8 3 135 141
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , Issue.3 , pp. 135-141
    • Wistuba, I.I.1
  • 148
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
    • [Epub ahead of print]
    • R. Straussman et al., Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion Nature 2012
    • (2012) Nature
    • Straussman, R.1
  • 149
    • 84862777541 scopus 로고    scopus 로고
    • A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
    • Z. Chen et al., A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response Nature 2012 483 7391 613 617
    • (2012) Nature , vol.483 , Issue.7391 , pp. 613-617
    • Chen, Z.1


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