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Volumn 12, Issue 7, 2011, Pages 487-498

Towards systematic functional characterization of cancer genomes

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MICRORNA;

EID: 79959480919     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg3013     Document Type: Review
Times cited : (71)

References (113)
  • 1
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson, M., Gabriel, S. & Getz, G. Advances in understanding cancer genomes through second-generation sequencing. Nature Rev. Genet. 11, 685-696 (2010).
    • (2010) Nature Rev. Genet. , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 2
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo, M. et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N. Engl. J. Med. 362, 2380-2388 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2380-2388
    • Maemondo, M.1
  • 4
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumours to anaplastic lymphoma kinase inhibitors
    • McDermott, U. et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumours to anaplastic lymphoma kinase inhibitors. Cancer Res. 68, 3389-3395 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3389-3395
    • McDermott, U.1
  • 6
    • 77957132245 scopus 로고    scopus 로고
    • Harnessing transposons for cancer gene discovery
    • Copeland, N. G. & Jenkins, N. A. Harnessing transposons for cancer gene discovery. Nature Rev. Cancer 10, 696-706 (2010).
    • (2010) Nature Rev. Cancer , vol.10 , pp. 696-706
    • Copeland, N.G.1    Jenkins, N.A.2
  • 7
    • 63049105067 scopus 로고    scopus 로고
    • A transposon-based genetic screen in mice identifies genes altered in colorectal cancer
    • Starr, T. K. et al. A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science 323, 1747-1750 (2009).
    • (2009) Science , vol.323 , pp. 1747-1750
    • Starr, T.K.1
  • 8
    • 23744479962 scopus 로고    scopus 로고
    • Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice
    • DOI 10.1016/j.cell.2005.07.013, PII S0092867405007075
    • Ding, S. et al. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122, 473-483 (2005). (Pubitemid 41127147)
    • (2005) Cell , vol.122 , Issue.3 , pp. 473-483
    • Ding, S.1    Wu, X.2    Li, G.3    Han, M.4    Zhuang, Y.5    Xu, T.6
  • 9
    • 78449294626 scopus 로고    scopus 로고
    • PiggyBac transposon mutagenesis: A tool for cancer gene discovery in mice
    • Rad, R. et al. PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science 330, 1104-1107 (2010).
    • (2010) Science , vol.330 , pp. 1104-1107
    • Rad, R.1
  • 11
    • 67649450275 scopus 로고    scopus 로고
    • High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
    • Kool, J. & Berns, A. High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nature Rev. Cancer 9, 389-399 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 389-399
    • Kool, J.1    Berns, A.2
  • 13
    • 70849098603 scopus 로고    scopus 로고
    • Haploid genetic screens in human cells identify host factors used by pathogens
    • Carette, J. E. et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231-1235 (2009).
    • (2009) Science , vol.326 , pp. 1231-1235
    • Carette, J.E.1
  • 14
    • 20444419344 scopus 로고    scopus 로고
    • Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance
    • DOI 10.1038/ncb1258
    • MacKeigan, J. P., Murphy, L. O. & Blenis, J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nature Cell Biol. 7, 591-600 (2005). (Pubitemid 40796982)
    • (2005) Nature Cell Biology , vol.7 , Issue.6 , pp. 591-600
    • MacKeigan, J.P.1    Murphy, L.O.2    Blenis, J.3
  • 16
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • DOI 10.1126/science.1068999
    • Brummelkamp, T. R., Bernards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002). (Pubitemid 34408678)
    • (2002) Science , vol.296 , Issue.5567 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 17
    • 33646033137 scopus 로고    scopus 로고
    • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
    • Moffat, J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
    • (2006) Cell , vol.124 , pp. 1283-1298
    • Moffat, J.1
  • 20
    • 79952696452 scopus 로고    scopus 로고
    • A rapid and scalable system for studying gene function in mice using conditional RNA interference
    • Premsrirut, P. K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145-158 (2011).
    • (2011) Cell , vol.145 , pp. 145-158
    • Premsrirut, P.K.1
  • 21
    • 79952697845 scopus 로고    scopus 로고
    • Functional identification of optimized RNAi triggers using a massively parallel ensor assay
    • Fellmann, C. et al. Functional identification of optimized RNAi triggers using a massively parallel ensor assay. Mol. Cell 41, 733-746 (2011).
    • (2011) Mol. Cell , vol.41 , pp. 733-746
    • Fellmann, C.1
  • 23
  • 24
    • 0020132123 scopus 로고
    • Isolation of a transforming sequence from a human bladder carcinoma cell line
    • Shih, C. & Weinberg, R. A. Isolation of a transforming sequence from a human bladder carcinoma cell line. Cell 29, 161-169 (1982).
    • (1982) Cell , vol.29 , pp. 161-169
    • Shih, C.1    Weinberg, R.A.2
  • 26
    • 73249119724 scopus 로고    scopus 로고
    • The completion of the Mammalian Gene Collection (MGC)
    • Temple, G. et al. The completion of the Mammalian Gene Collection (MGC). Genome Res. 19, 2324-2333 (2009).
    • (2009) Genome Res , vol.19 , pp. 2324-2333
    • Temple, G.1
  • 27
    • 38649139638 scopus 로고    scopus 로고
    • The full-ORF clone resource of the German cDNA Consortium
    • Bechtel, S. et al. The full-ORF clone resource of the German cDNA Consortium. BMC Genomics 8, 399 (2007).
    • (2007) BMC Genomics , vol.8 , pp. 399
    • Bechtel, S.1
  • 31
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen, C. M. et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468, 968-972 (2010).
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1
  • 32
    • 79960987021 scopus 로고    scopus 로고
    • A public genome-scale lentiviral expression library of human ORFs
    • in the press
    • Yang, X. et al. A public genome-scale lentiviral expression library of human ORFs. Nature Methods (in the press).
    • Nature Methods
    • Yang, X.1
  • 33
    • 33749059160 scopus 로고    scopus 로고
    • Mirbase: The microRNA sequence database
    • Griffiths-Jones, S. miRBase: the microRNA sequence database. Methods Mol. Biol. 342, 129-138 (2006).
    • (2006) Methods Mol. Biol. , vol.342 , pp. 129-138
    • Griffiths-Jones, S.1
  • 35
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumours
    • Voorhoeve, P. M. et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumours. Cell 124, 1169-1181 (2006).
    • (2006) Cell , vol.124 , pp. 1169-1181
    • Voorhoeve, P.M.1
  • 36
    • 65949104526 scopus 로고    scopus 로고
    • Ligand-dependent platelet-derived growth factor receptor (PDGFR)-α activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors
    • McDermott, U. et al. Ligand-dependent platelet-derived growth factor receptor (PDGFR)-α activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors. Cancer Res. 69, 3937-3946 (2009).
    • (2009) Cancer Res , vol.69 , pp. 3937-3946
    • McDermott, U.1
  • 37
    • 38049097938 scopus 로고    scopus 로고
    • Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumour cell line profiling
    • McDermott, U. et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumour cell line profiling. Proc. Natl Acad. Sci. USA 104, 19936-19941 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 19936-19941
    • McDermott, U.1
  • 38
    • 77956690873 scopus 로고    scopus 로고
    • Towards patient-based cancer therapeutics
    • Schreiber, S. L. et al. Towards patient-based cancer therapeutics. Nature Biotech. 28, 904-906 (2010).
    • (2010) Nature Biotech , vol.28 , pp. 904-906
    • Schreiber, S.L.1
  • 39
    • 37549020046 scopus 로고    scopus 로고
    • Towards the optimal screening collection: A synthesis strategy
    • Nielsen, T. E. & Schreiber, S. L. Towards the optimal screening collection: a synthesis strategy. Angew. Chem. Int. Ed. Engl. 47, 48-56 (2008).
    • (2008) Angew. Chem. Int. Ed. Engl , vol.47 , pp. 48-56
    • Nielsen, T.E.1    Schreiber, S.L.2
  • 40
    • 60249088794 scopus 로고    scopus 로고
    • A small molecule that binds Hedgehog and blocks its signalling in human cells
    • Stanton, B. Z. et al. A small molecule that binds Hedgehog and blocks its signalling in human cells. Nature Chem. Biol. 5, 154-156 (2009).
    • (2009) Nature Chem. Biol. , vol.5 , pp. 154-156
    • Stanton, B.Z.1
  • 41
    • 70449671729 scopus 로고    scopus 로고
    • Direct inhibition of the NOTCH transcription factor complex
    • Moellering, R. E. et al. Direct inhibition of the NOTCH transcription factor complex. Nature 462, 182-188 (2009).
    • (2009) Nature , vol.462 , pp. 182-188
    • Moellering, R.E.1
  • 42
    • 65349086683 scopus 로고    scopus 로고
    • A small molecule primes embryonic stem cells for differentiation
    • Zhu, S. et al. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell 4, 416-426 (2009).
    • (2009) Cell Stem Cell , vol.4 , pp. 416-426
    • Zhu, S.1
  • 43
    • 73049104551 scopus 로고    scopus 로고
    • An RNAi screen identifies TRRAP as a regulator of brain tumour-initiating cell differentiation
    • Wurdak, H. et al. An RNAi screen identifies TRRAP as a regulator of brain tumour-initiating cell differentiation. Cell Stem Cell 6, 37-47 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 37-47
    • Wurdak, H.1
  • 44
    • 77956399552 scopus 로고    scopus 로고
    • Live-cell imaging RNAi screen identifies PP2A-B55α and importin-β1 as key mitotic exit regulators in human cells
    • Schmitz, M. H. et al. Live-cell imaging RNAi screen identifies PP2A-B55α and importin-β1 as key mitotic exit regulators in human cells. Nature Cell Biol. 12, 886-893 (2010).
    • (2010) Nature Cell Biol. , vol.12 , pp. 886-893
    • Schmitz, M.H.1
  • 45
    • 20044366920 scopus 로고    scopus 로고
    • Cell microarrays and RNA interference chip away at gene function
    • DOI 10.1038/ng1560
    • Wheeler, D. B., Carpenter, A. E. & Sabatini, D. M. Cell microarrays and RNA interference chip away at gene function. Nature Genet. 37, S25-S30 (2005). (Pubitemid 40770400)
    • (2005) Nature Genetics , vol.37 , Issue.6 SUPPL.
    • Wheeler, D.B.1    Carpenter, A.E.2    Sabatini, D.M.3
  • 46
    • 45749110640 scopus 로고    scopus 로고
    • Small-molecule microarrays as tools in ligand discovery
    • Vegas, A. J., Fuller, J. H. & Koehler, A. N. Small-molecule microarrays as tools in ligand discovery. Chem. Soc. Rev. 37, 1385-1394 (2008).
    • (2008) Chem. Soc. Rev. , vol.37 , pp. 1385-1394
    • Vegas, A.J.1    Fuller, J.H.2    Koehler, A.N.3
  • 48
    • 77956283656 scopus 로고    scopus 로고
    • A genetic screen identifies the Triple T complex required for DNA damage signalling and ATM and ATR stability
    • Hurov, K. E., Cotta-Ramusino, C. & Elledge, S. J. A genetic screen identifies the Triple T complex required for DNA damage signalling and ATM and ATR stability. Genes Dev. 24, 1939-1950 (2010).
    • (2010) Genes Dev , vol.24 , pp. 1939-1950
    • Hurov, K.E.1    Cotta-Ramusino, C.2    Elledge, S.J.3
  • 49
    • 77954286076 scopus 로고    scopus 로고
    • A genetic screen identifies FAN1, a Fanconi anaemia-associated nuclease necessary for DNA interstrand crosslink repair
    • Smogorzewska, A. et al. A genetic screen identifies FAN1, a Fanconi anaemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol. Cell 39, 36-47 (2010).
    • (2010) Mol. Cell , vol.39 , pp. 36-47
    • Smogorzewska, A.1
  • 51
    • 0142259345 scopus 로고    scopus 로고
    • New tools for functional mammalian cancer genetics
    • Brummelkamp, T. R. & Bernards, R. New tools for functional mammalian cancer genetics. Nature Rev. Cancer 3, 781-789 (2003). (Pubitemid 37328816)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 781-789
    • Brummelkamp, T.R.1    Bernards, R.2
  • 52
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • Ngo, V. N. et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 441, 106-110 (2006).
    • (2006) Nature , vol.441 , pp. 106-110
    • Ngo, V.N.1
  • 53
    • 33747762617 scopus 로고    scopus 로고
    • Enzymatically prepared RNAi libraries
    • DOI 10.1038/nmeth912, PII NMETH912
    • Buchholz, F., Kittler, R., Slabicki, M. & Theis, M. Enzymatically prepared RNAi libraries. Nature Methods 3, 696-700 (2006). (Pubitemid 44275736)
    • (2006) Nature Methods , vol.3 , Issue.9 , pp. 696-700
    • Buchholz, F.1    Kittler, R.2    Slabicki, M.3    Theis, M.4
  • 55
    • 58149521944 scopus 로고    scopus 로고
    • Highly parallel identification of essential genes in cancer cells
    • Luo, B. et al. Highly parallel identification of essential genes in cancer cells. Proc. Natl Acad. Sci. USA 105, 20380-20385 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20380-20385
    • Luo, B.1
  • 56
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumour suppressors in liver cancer
    • Zender, L. et al. An oncogenomics-based in vivo RNAi screen identifies tumour suppressors in liver cancer. Cell 135, 852-864 (2008).
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1
  • 57
    • 70349454058 scopus 로고    scopus 로고
    • Functional identification of tumour-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
    • Bric, A. et al. Functional identification of tumour-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 16, 324-335 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 324-335
    • Bric, A.1
  • 58
    • 70349536006 scopus 로고    scopus 로고
    • Vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
    • Meacham, C. E., Ho, E. E., Dubrovsky, E., Gertler, F. B. & Haemann, M. T. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nature Genet. 41, 1133-1137 (2009).
    • (2009) Nature Genet , vol.41 , pp. 1133-1137
    • Meacham, C.E.1    Ho, E.E.2    Dubrovsky, E.3    Gertler, F.B.4    Haemann, M.T.5
  • 59
    • 78651312134 scopus 로고    scopus 로고
    • Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
    • Zuber, J. et al. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nature Biotech. 29, 79-83 (2011).
    • (2011) Nature Biotech , vol.29 , pp. 79-83
    • Zuber, J.1
  • 61
    • 70349565231 scopus 로고    scopus 로고
    • SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis
    • Cheng, H. et al. SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis. Sci. Signal. 2, ra35 (2009).
    • (2009) Sci. Signal , vol.2
    • Cheng, H.1
  • 62
    • 33845792555 scopus 로고    scopus 로고
    • CellProfiler: Image analysis software for identifying and quantifying cell phenotypes
    • Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
    • (2006) Genome Biol. , vol.7
    • Carpenter, A.E.1
  • 66
    • 52949111487 scopus 로고    scopus 로고
    • CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
    • Firestein, R. et al. CDK8 is a colorectal cancer oncogene that regulates β-catenin activity. Nature 455, 547-551 (2008).
    • (2008) Nature , vol.455 , pp. 547-551
    • Firestein, R.1
  • 68
    • 35548953686 scopus 로고    scopus 로고
    • An elaborate pathway required for Ras-mediated epigenetic silencing
    • DOI 10.1038/nature06251, PII NATURE06251
    • Gazin, C., Wajapeyee, N., Gobeil, S., Virbasius, C. M. & Green, M. R. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449, 1073-1077 (2007). (Pubitemid 350014604)
    • (2007) Nature , vol.449 , Issue.7165 , pp. 1073-1077
    • Gazin, C.1    Wajapeyee, N.2    Gobeil, S.3    Virbasius, C.-M.4    Green, M.R.5
  • 70
    • 78649872212 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration
    • Smolen, G. A. et al. A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev. 24, 2654-2665 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 2654-2665
    • Smolen, G.A.1
  • 72
    • 78649316608 scopus 로고    scopus 로고
    • A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability
    • O'Connell, B. C. et al. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol. Cell 40, 645-657 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 645-657
    • O'Connell, B.C.1
  • 73
    • 58049208190 scopus 로고    scopus 로고
    • Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis
    • Fotheringham, S. et al. Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis. Cancer Cell 15, 57-66 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 57-66
    • Fotheringham, S.1
  • 74
    • 77953163141 scopus 로고    scopus 로고
    • Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib
    • Chen, S. et al. Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib. Cancer Res. 70, 4318-4326 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 4318-4326
    • Chen, S.1
  • 75
    • 56449111358 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235
    • Eichhorn, P. J. et al. Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/ phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res. 68, 9221-9230 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9221-9230
    • Eichhorn, P.J.1
  • 76
    • 70349448673 scopus 로고    scopus 로고
    • Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen
    • Mullenders, J. et al. Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen. Clin. Cancer Res. 15, 5811-5819 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5811-5819
    • Mullenders, J.1
  • 77
    • 70349445412 scopus 로고    scopus 로고
    • Proteomic and genetic approaches identify Syk as an AML target
    • Hahn, C. K. et al. Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell 16, 281-294 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 281-294
    • Hahn, C.K.1
  • 79
    • 77955463320 scopus 로고    scopus 로고
    • Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease
    • Bradner, J. E. et al. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc. Natl Acad. Sci. USA 107, 12617-12622 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12617-12622
    • Bradner, J.E.1
  • 81
    • 60149089005 scopus 로고    scopus 로고
    • Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
    • Du, J. et al. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy. Nature Biotech. 27, 77-83 (2009).
    • (2009) Nature Biotech , vol.27 , pp. 77-83
    • Du, J.1
  • 83
    • 77954105792 scopus 로고    scopus 로고
    • Monitoring proteins and protein networks using reverse phase protein arrays
    • Wilson, B., Liotta, L. A. & Petricoin, E. Monitoring proteins and protein networks using reverse phase protein arrays. Disease Markers 28, 225-232 (2010).
    • (2010) Disease Markers , vol.28 , pp. 225-232
    • Wilson, B.1    Liotta, L.A.2    Petricoin, E.3
  • 84
    • 55649103338 scopus 로고    scopus 로고
    • Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction
    • Evangelista, M. et al. Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Sci. Signal. 1, ra7 (2008).
    • (2008) Sci. Signal , vol.1
    • Evangelista, M.1
  • 85
    • 58549104540 scopus 로고    scopus 로고
    • Compensatory IKKα activation of classical NF-κB signalling during IKKβ inhibition identified by an RNA interference sensitization screen
    • Lam, L. T. et al. Compensatory IKKα activation of classical NF-κB signalling during IKKβ inhibition identified by an RNA interference sensitization screen. Proc. Natl Acad. Sci. USA 105, 20798-20803 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20798-20803
    • Lam, L.T.1
  • 86
    • 77649314140 scopus 로고    scopus 로고
    • An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells
    • Sheng, Q. et al. An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell 17, 298-310 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 298-310
    • Sheng, Q.1
  • 87
    • 55949124308 scopus 로고    scopus 로고
    • Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells
    • Baldwin, A. et al. Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. Proc. Natl Acad. Sci. USA 105, 16478-16483 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16478-16483
    • Baldwin, A.1
  • 88
    • 0042467554 scopus 로고    scopus 로고
    • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
    • DOI 10.1038/nature01811
    • Brummelkamp, T. R., Nijman, S. M., Dirac, A. M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797-801 (2003). (Pubitemid 37021711)
    • (2003) Nature , vol.424 , Issue.6950 , pp. 797-801
    • Brummelkamp, T.R.1    Nijman, S.M.B.2    Dirac, A.M.G.3    Bernards, R.4
  • 92
    • 79952128110 scopus 로고    scopus 로고
    • High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy
    • Gonzalez-Malerva, L. et al. High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc. Natl Acad. Sci. USA 108, 2058-2063 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 2058-2063
    • Gonzalez-Malerva, L.1
  • 93
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie, D. A. et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462, 108-112 (2009).
    • (2009) Nature , vol.462 , pp. 108-112
    • Barbie, D.A.1
  • 94
    • 66149091940 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848 (2009).
    • (2009) Cell , vol.137 , pp. 835-848
    • Luo, J.1
  • 95
    • 65849111219 scopus 로고    scopus 로고
    • Synthetic lethal interaction between oncogenic KRAS dependency and suppression of STK33 in human cancer cells
    • Scholl, C. et al. Synthetic lethal interaction between oncogenic KRAS dependency and suppression of STK33 in human cancer cells. Cell 137, 821-834 (2009).
    • (2009) Cell , vol.137 , pp. 821-834
    • Scholl, C.1
  • 96
    • 78049418533 scopus 로고    scopus 로고
    • Wilms tumour 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
    • Vicent, S. et al. Wilms tumour 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J. Clin. Invest. 120, 3940-3952 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 3940-3952
    • Vicent, S.1
  • 97
    • 77955918876 scopus 로고    scopus 로고
    • Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells
    • Wang, Y. et al. Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells. Oncogene 29, 4658-4670 (2010).
    • (2010) Oncogene , vol.29 , pp. 4658-4670
    • Wang, Y.1
  • 98
    • 77955464738 scopus 로고    scopus 로고
    • Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3
    • Baldwin, A. et al. Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3. Proc. Natl Acad. Sci. USA 107, 12463-12468 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12463-12468
    • Baldwin, A.1
  • 99
    • 55949101858 scopus 로고    scopus 로고
    • Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen
    • Bommi-Reddy, A. et al. Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Proc. Natl Acad. Sci. USA 105, 16484-16489 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16484-16489
    • Bommi-Reddy, A.1
  • 102
    • 58249090328 scopus 로고    scopus 로고
    • Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization
    • Iorns, E., Lord, C. J. & Ashworth, A. Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. Biochem. J. 417, 361-370 (2009).
    • (2009) Biochem. J. , vol.417 , pp. 361-370
    • Iorns, E.1    Lord, C.J.2    Ashworth, A.3
  • 103
    • 77955090106 scopus 로고    scopus 로고
    • Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
    • Barretina, J. et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nature Genet. 42, 715-721 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 715-721
    • Barretina, J.1
  • 104
    • 79952497178 scopus 로고    scopus 로고
    • Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening
    • Sawey, E. T. et al. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening. Cancer Cell 19, 347-358 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 347-358
    • Sawey, E.T.1
  • 105
    • 38349088899 scopus 로고    scopus 로고
    • - syndrome gene by RNA interference screen
    • - syndrome gene by RNA interference screen. Nature 451, 335-339 (2008).
    • (2008) Nature , vol.451 , pp. 335-339
    • Ebert, B.L.1
  • 106
    • 66449094672 scopus 로고    scopus 로고
    • Cyfip1 is a putative invasion suppressor in epithelial cancers
    • Silva, J. M. et al. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell 137, 1047-1061 (2009).
    • (2009) Cell , vol.137 , pp. 1047-1061
    • Silva, J.M.1
  • 109
    • 79551686422 scopus 로고    scopus 로고
    • Oncogenically active MYD88 mutations in human lymphoma
    • Ngo, V. N. et al. Oncogenically active MYD88 mutations in human lymphoma. Nature 470, 115-119 (2011).
    • (2011) Nature , vol.470 , pp. 115-119
    • Ngo, V.N.1
  • 112
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumours from BRCA mutation carriers
    • Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumours from BRCA mutation carriers. N.Engl. J. Med. 361, 123-134 (2009).
    • (2009) N.Engl. J. Med. , vol.361 , pp. 123-134
    • Fong, P.C.1
  • 113
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta, P. B. et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138, 645-659 (2009).
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1


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