Multimodal gadolinium-enriched DNA-gold nanoparticle conjugates for cellular imaging

Angewandte Chemie - International Edition

Volumn 48, Issue 48, 2009, Pages 9143-9147

  Song, Ying ^a   Xu, Xiaoyang ^a   MacRenaris, Keith W ^a   Zhang, Xue Qing ^b   Mirkin, Chad A ^a   Meade, Thomas J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Northwestern University   (United States)

Author keywords

DNA; Fluorescence imaging; Gadolinium; Gold nanoparticles; Magnetic resonance imaging

Indexed keywords

CELL POPULATIONS; CELL UPTAKE; CELLULAR IMAGING; FLUORESCENCE IMAGING; GOLD NANOPARTICLES; MULTI-MODAL; RELAXIVITY;

CELL CULTURE; CELL PROLIFERATION; DNA; FLUORESCENCE; GENES; GOLD; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; NUCLEIC ACIDS;

GADOLINIUM;

DNA; GADOLINIUM; GOLD; METAL NANOPARTICLE;

ANIMAL; ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; MOUSE;

ANIMALS; CELL LINE; CELL MEMBRANE PERMEABILITY; DNA; GADOLINIUM; GOLD; HUMANS; METAL NANOPARTICLES; MICE; MICROSCOPY, FLUORESCENCE;

EID: 70449562074     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904666     Document Type: Article

References (53)

1. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, (Eds.: A. E. Merbach, E. Toth), Wiley, New York, 2001.
2. S. Aime, C. Cabella, S. Colombatto, S. Geninatti Crich, E. Gianolio, F. Maggioni, J. Magn. Reson. Imaging 2002, 16, 394.
3. X. Hu, D. G. Norris, Annu. Rev. Biomed. Eng. 2004, 6, 157.
4. P. M. Winter, S. D. Caruthers, S. A. Wickline, G. M. Lanza, Curr. Cardiol. Rep. 2006, 5, 65.
5. P. Caravan, Chem. Soc. Rev. 2006, 35, 512.
6. J. L. Major, T. J. Meade, Acc. Chem. Res. 2009, 42, 893.
7. S. Aime, D. Delli Castelli, S. Geninatti Crich, E. Gianolio, E. Terreno, Acc. Chem. Res. 2009, 42, 822.
8. J. A. Duimstra, F. J. Femia, T. J. Meade, J. Am. Chem. Soc. 2005, 127, 12847.
9. J. L. Major, G. Parigi, C. Luchinat, T. J. Meade, Proc. Natl. Acad. Sci. USA 2007, 104, 13881.
10. W-h. Li, S. E. Fraser, T. J. Meade, J. Am. Chem. Soc. 1999, 121, 1413.
11. P. Caravan, N. J. Cloutier, M. T. Greenfield, S. A. McDermid, S. U. Dunham, J. W. M. Bulte, J. C. Amedio, Jr., R. J. Looby, R. M. Supkowski, W. DeW Horrocks, Jr., T. J. McMurry, R. B. Lauffer, J. Am. Chem. Soc. 2002, 124, 3152.
12. F. K. Kaiman, M. Woods, P. Caravan, P. Jurek, M. Spiller, G. Tircso, R. Kiraly, E. Bruecher, A. D. Sherry, Inorg. Chem. 2007, 46, 5260.
13. M. Modo, K. Mellodew, D. Cash, S. E. Fraser, T. J. Meade, J. Price, S. C. R. Williams, Neuroimage 2004, 21, 311.
14. Molecular and Cellular MR Imaging (Eds. : M. Modo, J. W. Bulte), CRC, Boca Raton, 2007.
15. L. Biancone, G. C. Simonetta, V. Cantaluppi, M. R. Giuseppe, S. Russo, E. Scalabrino, G. Esposito, F. Figliolini, S. Beltramo, C. P. Paolo, P. S. Giuseppe, S. Aime, G. Camussi, NMR Biomed. 2007, 20, 40.
16. N. L. Rosi, D. A. Giljohann, C. S. Thaxton, A. K. R. Lytton-Jean, M. S. Han, C. A. Mirkin, Science 2006, 312, 1027.
17. D. S. Seferos, A. E. Prigodich, D. A. Giljohann, P. C. Patel, C. A. Mirkin, Nano Lett. 2009, 9, 308.
18. N. L. Rosi, C. A. Mirkin, Chem. Rev. 2005, 105, 1547.
19. D. A. Giljohann, D. S. Seferos, P. C. Patel, J. E. Millstone, N. L. Rosi, C. A. Mirkin, Nano Lett. 2007, 7, 3818.
20. C. A. Mirkin, R. L. Letsinger, R. C. Mucic, J. J. Storhoff, Nature 1996, 552, 607.
21. R. Elghanian, J. J. Storhoff, R. C. Mucic, R. L. Letsinger, C. A. Mirkin, Science 1997, 277, 1078.
22. T. A. Taton, C. A. Mirkin, R. L. Letsinger, Science 2000, 289, 1757.
23. Y. C. Cao, R. Jin, J.-M. Nam, C. S. Thaxton, C. A. Mirkin, J. Am. Chem. Soc. 2003, 125, 14676.
24. M. S. Han, A. K. R. Lytton-Jean, C. A. Mirkin, J. Am. Chem. Soc. 2006, 128, 4954.
25. J.-S. Lee, M. S. Han, C. A. Mirkin, Angew. Chem. 2007, 119, 4171;
26. Angew. Chem. Int. Ed. 2007, 46, 4093.
27. X. Xu, M. S. Han, C. A. Mirkin, Angew. Chem. 2007, 119, 3538;
28. Angew. Chem. Int. Ed. 2007, 46, 3468.
29. X. Xu, D. G. Georganopoulous, H. D. Hill, C. A. Mirkin, Anal. Chem. 2007, 79, 6650.
30. D. A. Giljohann, D. S. Seferos, A. E. Prigodich, P. C. Patel, C. A. Mirkin, J. Am. Chem. Soc. 2009, 131, 2072.
31. J. M. C. Bowman, E. T. Ballard, C. J. Ackerson, J. D'Antonio, D. L. Feldheim, D. Margolis, C. Melander, J. Am. Chem. Soc. 2008, 130, 6896.
32. J. Liu, Y. Lu, Angew. Chem. 2007, 119, 7731;
33. Angew. Chem. Int. Ed. 2007, 46, 7587.
34. S. S. Agasti, A. Chompoosor, C.-C. You, P. Ghosh, C. K. Kim, V. M. Rotello, J. Am. Chem. Soc. 2009, 131, 5728.
35. L. Frullano, T. J. Meade, J. Biol. Inorg. Chem. 2007, 12, 939.
36. Y. Song, E. K. Kohlmeir, T. J. Meade, J. Am. Chem. Soc. 2008, 130, 6662.
37. J. J. Storhoff, R. Elghanian, R. C. Mucic, C. A. Mirkin, R. L. Letsinger, J. Am. Chem. Soc. 1998, 120, 1959.
38. a) J.-A. Park, P. A. N. Reddy, H.-K. Kim, I.-S. Kim, G.-C. Kim, Y. Chang, T.-J. Kim, Bioorg. Med. Chem. Lett. 2008, 18, 6135;
39. b) P.-J. Debouttiere, S. Roux, F. Vocanson, C. Billotey, O. Beuf, A. Favre-Reguillon, Y. Lin, S. Pellet-Rostaing, R. Lamartine, P. Perriat, O. Tillement, Adv. Funct. Mater. 2006, 16, 2330;
40. c) C. Alric, J. Taleb, G. Le Due, C. Mandon, C. Billotey, A. Le MeurHerland, T. Brochard, F. Vocanson, M. Janier, P. Perriat, S. Roux, O. Tillement, J. Am. Chem. Soc. 2008, 130, 5908.
41. L. Moriggi, C. Cannizzo, E. Dumas, C. R. Mayer, A. Ulianov, L. Helm, J. Am. Chem. Soc. 2009, 131, 10828.
42. III conjugates/cell, which is two orders of magnitude higher than citrate-stabilized AuNPs of the same size.
43. The nanoparticle concentration is over two orders of magnitude lower since each particle contains approximately 50 strands of DNA-Gd conjugates.
44. a) M. J. Allen, K. W. MacRenaris, P. N. Venkatasubramanian, T. J. Meade, Chem. Biol. 2004, 11, 301;
45. b) P. J. Endres, K. W. MacRenaris, S. Vogt, M.J. Allen, T. J. Meade, Mol. Imaging 2006, 5, 485.
46. L. Biancone, S. G. Crich, V. Cantaluppi, G. M. Romanazzi, S. Russo, E. Scalabrino, G. Esposito, F. Figliolini, S. Beltramo, P. C. Perin, G. P. Segoloni, S. Aime, G. Camussi, NMR Biomed. 2007, 20, 40.
47. S. G. Crich, L. Biancone, V. Cantaluppi, D. Duo, G. Esposito, S. Russo, G. Camusi, S. Aime, Magn. Reson. Med. 2004, 51, 938.
48. D. S. Seferos, A. E. Prigodich, D. A. Giljohann, P. C. Patel, C. A. Mirkin, Nano Lett. 2009, 9, 308.
49. B. D. Chithrani, W. C. W. Chan, Nano Lett. 2007, 7, 1542.
50. A. M. Smith, H. Duan, A. M. Mohs, S. Nie, Adv. Drug Delivery Rev. 2008, 60, 1226.
51. P. Alivisatos, Nat. Biotechnol. 2004, 22, 47.
52. Y. N. Xia, Nat. Mater. 2008, 7, 758.
53. B. Y. S. Kim, W. Jiang, J. Oreopoulos, C. M. Yip, J. T. Rutka, W. C. W. Chan, Nano Lett. 2008, 5, 3887.