Strategy for increasing drug solubility and efficacy through covalent attachment to polyvalent DNA-nanoparticle conjugates

ACS Nano

Volumn 5, Issue 9, 2011, Pages 6962-6970

  Zhang, Xue Qing ^a   Xu, Xiaoyang ^b   Lam, Robert ^a   Giljohann, David ^b   Ho, Dean ^a,d   Mirkin, Chad A ^a,b,c  

^a Northwestern University   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

cancer; chemoresistance; DNA; gold; nanomedicine; nanoparticle; Paclitaxel

Indexed keywords

AQUEOUS BUFFER; AQUEOUS MEDIA; CANCER; CELL LINES; CELL TYPES; CHEMORESISTANCE; COVALENT ATTACHMENT; DNA LINKERS; DRUG SOLUBILITY; GOLD NANOPARTICLES; NANOMEDICINES; PACLITAXEL; THERAPEUTIC AGENTS;

CELL CULTURE; CELLS; DISEASES; GOLD; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; SOLUBILITY;

DNA;

ANTINEOPLASTIC AGENT; DNA; FLUORESCENT DYE; GOLD; METAL NANOPARTICLE; PACLITAXEL;

ARTICLE; CHEMISTRY; HUMAN; MASS SPECTROMETRY; NICK END LABELING; SOLUBILITY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DNA; FLUORESCENT DYES; GOLD; HUMANS; IN SITU NICK-END LABELING; METAL NANOPARTICLES; PACLITAXEL; SOLUBILITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 80053307636     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn201446c     Document Type: Article

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