메뉴 건너뛰기




Volumn 9, Issue 1, 2013, Pages 13-23

Uric acid as a danger signal in gout and its comorbidities

Author keywords

[No Author keywords available]

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; AMYLOID BETA PROTEIN; ASBESTOS; CALCIUM PHOSPHATE; CALCIUM PYROPHOSPHATE; CANAKINUMAB; COLCHICINE; CRYOPYRIN; CXCL1 CHEMOKINE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RILONACEPT; SILICON DIOXIDE; TITANIUM; TOLL LIKE RECEPTOR; URATE; URIC ACID; URICOSURIC AGENT; XANTHINE OXIDASE INHIBITOR;

EID: 84871733357     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2012.143     Document Type: Review
Times cited : (381)

References (131)
  • 1
    • 80053497428 scopus 로고    scopus 로고
    • Prevalence of gout and hyperuricemia in the US general population: The national health and nutrition examination survey 2007-2008
    • Zhu, Y., Pandya, B. J. & Choi, H. K. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 63, 3136-3141 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 3136-3141
    • Zhu, Y.1    Pandya, B.J.2    Choi, H.K.3
  • 4
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • DOI 10.1038/nature01991
    • Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003). (Pubitemid 37237047)
    • (2003) Nature , vol.425 , Issue.6957 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 5
    • 77953187009 scopus 로고    scopus 로고
    • Uric acid transport and disease
    • So, A. & Thorens, B. Uric acid transport and disease. J. Clin. Invest. 120, 1791-1799 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1791-1799
    • So, A.1    Thorens, B.2
  • 7
    • 0017716084 scopus 로고
    • Hereditary xanthinuria. Report on three patients and short review of the literature
    • Frayha, R. A., Salti, I. S., Arnaout, A., Khatchadurian, A. & Uthman, S. M. Hereditary xanthinuria: report on three patients and short review of the literature. Nephron 19, 328-332 (1977). (Pubitemid 8196094)
    • (1977) Nephron , vol.19 , Issue.6 , pp. 328-332
    • Frayha, R.A.1    Salti, I.S.2    Arnaout, A.3
  • 8
    • 84863252356 scopus 로고    scopus 로고
    • Serum uric acid levels in patients with multiple sclerosis: A meta-analysis
    • Liu, B. et al. Serum uric acid levels in patients with multiple sclerosis: a meta-analysis. Neurol. Res. 34, 163-171 (2012).
    • (2012) Neurol. Res. , vol.34 , pp. 163-171
    • Liu, B.1
  • 12
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar, H., Kawai, T. & Akira, S. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30, 16-34 (2011).
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 13
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • DOI 10.1126/science.1071059
    • Matzinger, P. The danger model: a renewed sense of self. Science 296, 301-305 (2002). (Pubitemid 34303674)
    • (2002) Science , vol.296 , Issue.5566 , pp. 301-305
    • Matzinger, P.1
  • 15
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • DOI 10.1038/32588
    • Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998). (Pubitemid 28155090)
    • (1998) Nature , vol.392 , Issue.6673 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 18
    • 0032485487 scopus 로고    scopus 로고
    • Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLS
    • DOI 10.1038/32183
    • Albert, M. L., Sauter, B. & Bhardwaj, N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86-89 (1998). (Pubitemid 28150594)
    • (1998) Nature , vol.392 , Issue.6671 , pp. 86-89
    • Albert, M.L.1    Sauter, B.2    Bhardwaj, N.3
  • 20
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • DOI 10.1038/15200
    • Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255 (1999). (Pubitemid 29535601)
    • (1999) Nature Medicine , vol.5 , Issue.11 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 22
    • 77953187290 scopus 로고    scopus 로고
    • Uric acid promotes an acute inflammatory response to sterile cell death in mice
    • Kono, H., Chen, C. J., Ontiveros, F. & Rock, K. L. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J. Clin. Invest. 120, 1939-1949 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1939-1949
    • Kono, H.1    Chen, C.J.2    Ontiveros, F.3    Rock, K.L.4
  • 23
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • DOI 10.1038/nri2215, PII NRI2215
    • Kono, H. & Rock, K. L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8, 279-289 (2008). (Pubitemid 351432799)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.4 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 24
    • 0026537198 scopus 로고
    • A revised estimate of twin concordance in systemic lupus erythematosus
    • Deapen, D. et al. A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum. 35, 311-318 (1992).
    • (1992) Arthritis Rheum. , vol.35 , pp. 311-318
    • Deapen, D.1
  • 25
    • 33646022583 scopus 로고    scopus 로고
    • Cutting edge: Elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model
    • Shi, Y., Galusha, S. A. & Rock, K. L. Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model. J. Immunol. 176, 3905-3908 (2006). (Pubitemid 44264366)
    • (2006) Journal of Immunology , vol.176 , Issue.7 , pp. 3905-3908
    • Shi, Y.1    Galusha, S.A.2    Rock, K.L.3
  • 26
    • 55249100762 scopus 로고    scopus 로고
    • The role of innate immunity in autoimmune tissue injury
    • Allam, R. & Anders, H. J. The role of innate immunity in autoimmune tissue injury. Curr. Opin. Rheumatol. 20, 538-544 (2008).
    • (2008) Curr. Opin. Rheumatol. , vol.20 , pp. 538-544
    • Allam, R.1    Anders, H.J.2
  • 27
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
    • Like, A. A. & Rossini, A. A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193, 415-417 (1976).
    • (1976) Science , vol.193 , pp. 415-417
    • Like, A.A.1    Rossini, A.A.2
  • 28
    • 0036141519 scopus 로고    scopus 로고
    • Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes
    • DOI 10.1172/JCI200211198
    • Horwitz, M. S., Ilic, A., Fine, C, Rodriguez, E. & Sarvetnick, N. Presented antigen from damaged pancreatic ß cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J. Clin. Invest. 109, 79-87 (2002). (Pubitemid 34052544)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.1 , pp. 79-87
    • Horwitz, M.S.1    Ilic, A.2    Fine, C.3    Rodriguez, E.4    Sarvetnick, N.5
  • 29
    • 0031821976 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
    • DOI 10.1084/jem.188.2.409
    • Kurts, C, Miller, J. F., Subramaniam, R. M., Carbone, F. R. & Heath, W. R. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J. Exp. Med. 188, 409-414 (1998). (Pubitemid 28357770)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.2 , pp. 409-414
    • Kurts, C.1    Miller, J.F.A.P.2    Subramaniam, R.M.3    Carbone, F.R.4    Heath, W.R.5
  • 30
  • 31
    • 0004152023 scopus 로고    scopus 로고
    • Oxford University Press, New York
    • nd edn (Oxford University Press, New York, 2004).
    • (2004) nd Edn
    • Majno, G.1    Joris, I.2
  • 32
    • 77952769075 scopus 로고    scopus 로고
    • Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    • Kono, H., Karmarkar, D., Iwakura, Y. & Rock, K. L. Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. J. Immunol. 184, 4470-4478 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 4470-4478
    • Kono, H.1    Karmarkar, D.2    Iwakura, Y.3    Rock, K.L.4
  • 34
    • 67149130597 scopus 로고    scopus 로고
    • Anakinra for rheumatoid arthritis: A systematic review
    • Mertens, M. & Singh, J. A. Anakinra for rheumatoid arthritis: a systematic review. J. Rheumatol. 36, 1118-1125 (2009).
    • (2009) J. Rheumatol. , vol.36 , pp. 1118-1125
    • Mertens, M.1    Singh, J.A.2
  • 35
    • 80052138380 scopus 로고    scopus 로고
    • And adaptive immune responses to cell death
    • Rock, K. L, Lai, J. J. & Kono, H. Innate and adaptive immune responses to cell death. Immunol. Rev. 243, 191-205 (2011).
    • (2011) Immunol. Rev. , vol.243 , pp. 191-205
    • Rock, K.L.1    Lai, J.J.2    Innate, K.H.3
  • 36
    • 33746747096 scopus 로고    scopus 로고
    • MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    • Chen, C. J. et al. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J. Clin. Invest. 116, 2262-2271 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 2262-2271
    • Chen, C.J.1
  • 37
    • 65649140025 scopus 로고    scopus 로고
    • Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    • Gasse, P. et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 179, 903-913 (2009).
    • (2009) Am. J. Respir. Crit. Care Med. , vol.179 , pp. 903-913
    • Gasse, P.1
  • 38
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello, C. A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117, 3720-3732 (2011).
    • (2011) Blood , vol.117 , pp. 3720-3732
    • Dinarello, C.A.1
  • 39
    • 58849151813 scopus 로고    scopus 로고
    • Cutting edge: Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1a released from dying cells
    • Eigenbrod, T., Park, J. H., Harder, J., Iwakura, Y & Nunez, G. Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1a released from dying cells. J. Immunol. 181, 8194-8198 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8194-8198
    • Eigenbrod, T.1    Park, J.H.2    Harder, J.3    Iwakura, Y.4    Nunez, G.5
  • 40
    • 84858761335 scopus 로고    scopus 로고
    • Inflammasome activators induce interleukin-1a secretion via distinct pathways with differential requirement for the protease function of caspase-1
    • Gross, O. et al. Inflammasome activators induce interleukin-1a secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36, 388-400 (2012).
    • (2012) Immunity , vol.36 , pp. 388-400
    • Gross, O.1
  • 41
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello, C. A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 42
    • 70249138036 scopus 로고    scopus 로고
    • Cutting edge: NF-KB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    • Bauernfeind, F G. et al. Cutting edge: NF-KB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787-791 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 787-791
    • Bauernfeind, F.G.1
  • 43
    • 0036671894 scopus 로고    scopus 로고
    • The Inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
    • DOI 10.1016/S1097-2765(02)00599-3
    • Martinon, F, Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-ß. Mol. Cell 10, 417-426 (2002). (Pubitemid 35007355)
    • (2002) Molecular Cell , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 44
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 45
    • 0035179970 scopus 로고    scopus 로고
    • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    • DOI 10.1038/ng756
    • Hoffman, H. M., Mueller, J. L, Broide, D. H., Wanderer, A. A. & Kolodner, R. D. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 29, 301-305 (2001). (Pubitemid 33096455)
    • (2001) Nature Genetics , vol.29 , Issue.3 , pp. 301-305
    • Hoffman, H.M.1    Mueller, J.L.2    Broide, D.H.3    Wanderer, A.A.4    Kolodner, R.D.5
  • 47
    • 77956631703 scopus 로고    scopus 로고
    • Cryopyrin-associated periodic syndromes: Background and therapeutics
    • Kubota, T. & Koike, R. Cryopyrin-associated periodic syndromes: background and therapeutics. Mod. Rheumatol. 20, 213-221 (2010).
    • (2010) Mod. Rheumatol. , vol.20 , pp. 213-221
    • Kubota, T.1    Koike, R.2
  • 49
    • 0025182760 scopus 로고
    • Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1α
    • Kobayashi, Y. et al. Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1α. Proc. Natl Acad. Sci. USA 87, 5548-5552 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 5548-5552
    • Kobayashi, Y.1
  • 50
    • 82455175456 scopus 로고    scopus 로고
    • Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α
    • Afonina, I. S. et al. Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. Mol. Cell 44, 265-278 (2011).
    • (2011) Mol. Cell , vol.44 , pp. 265-278
    • Afonina, I.S.1
  • 51
    • 81055145409 scopus 로고    scopus 로고
    • Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
    • Fettelschoss, A. et al. Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression. Proc. Natl Acad. Sci. USA 108, 18055-18060 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 18055-18060
    • Fettelschoss, A.1
  • 52
    • 0028920863 scopus 로고
    • Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
    • Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267, 2000-2003 (1995).
    • (1995) Science , vol.267 , pp. 2000-2003
    • Kuida, K.1
  • 53
    • 33644985564 scopus 로고    scopus 로고
    • Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    • Sutterwala, F. S. et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24, 317-327 (2006).
    • (2006) Immunity , vol.24 , pp. 317-327
    • Sutterwala, F.S.1
  • 54
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung, V. et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 847-856
    • Hornung, V.1
  • 55
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: Mechanisms of activation and function
    • Latz, E. The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 22, 28-33 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 28-33
    • Latz, E.1
  • 56
    • 51449124322 scopus 로고    scopus 로고
    • Its mechanism of action and efficacy in crystal-induced inflammation
    • Nuki, G. Colchicine: its mechanism of action and efficacy in crystal-induced inflammation. Curr. Rheumatol. Rep. 10, 218-227 (2008).
    • (2008) Curr. Rheumatol. Rep. , vol.10 , pp. 218-227
    • Nuki, G.1    Colchicine2
  • 57
    • 39549112322 scopus 로고    scopus 로고
    • Urate crystals, inflammation, and colchicine
    • DOI 10.1002/art.23069
    • McCarty, D. J. Urate crystals, inflammation, and colchicine. Arthritis Rheum. 58 (Suppl. S2), S20-S24 (2008). (Pubitemid 351281120)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.2 SUPPL.
    • McCarty, D.J.1
  • 58
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • DOI 10.1038/nature06939, PII NATURE06939
    • Eisenbarth, S. C., Colegio, O. R., O'Connor, W., Sutterwala, F. S. & Flavell, R. A. Crucial role for the NALP3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453, 1122-1126 (2008). (Pubitemid 351871731)
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1122-1126
    • Eisenbarth, S.C.1    Colegio, O.R.2    O'Connor Jr., W.3    Sutterwala, F.S.4    Flavell, R.A.5
  • 59
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • DOI 10.1038/nature04516, PII N04516
    • Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006). (Pubitemid 43372104)
    • (2006) Nature , vol.440 , Issue.7081 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 60
    • 0029144844 scopus 로고
    • Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils
    • Cronstein, B. N. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J. Clin. Invest. 96, 994-1002 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 994-1002
    • Cronstein, B.N.1
  • 61
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • DOI 10.1126/science.1156995
    • Dostert, C. et al. Innate immune activation through NALP3 inflammasome sensing of asbestos and silica. Science 320, 674-677 (2008). (Pubitemid 351928351)
    • (2008) Science , vol.320 , Issue.5876 , pp. 674-677
    • Dostert, C.1    Petrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 62
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 63
    • 79951578449 scopus 로고    scopus 로고
    • Inflammasomes: Current understanding and open questions
    • Bauernfeind, F. et al. Inflammasomes: current understanding and open questions. Cell. Mol. Life Sci. 68, 765-783 (2011).
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 765-783
    • Bauernfeind, F.1
  • 64
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 65
    • 77956958947 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
    • Masters, S. L. et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat. Immunol. 11, 897-904 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 897-904
    • Masters, S.L.1
  • 66
    • 47849085872 scopus 로고    scopus 로고
    • The NALP3 inflammasome is involved in the innate immune response to amyloid-β
    • Halle, A. et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat. Immunol. 9, 857-865 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 857-865
    • Halle, A.1
  • 67
    • 0042914359 scopus 로고    scopus 로고
    • Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin
    • DOI 10.1038/sj.cdd.4401264
    • Hentze, H., Lin, X. Y., Choi, M. S. & Porter, A. G. Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ. 10, 956-968 (2003). (Pubitemid 37069473)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.9 , pp. 956-968
    • Hentze, H.1    Lin, X.Y.2    Choi, M.S.K.3    Porter, A.G.4
  • 68
    • 58849160540 scopus 로고    scopus 로고
    • Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
    • Sharp, F. A. et al. Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc. Natl Acad. Sci. USA 106, 870-875 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 870-875
    • Sharp, F.A.1
  • 69
    • 68349157477 scopus 로고    scopus 로고
    • Malarial hemozoin is a NALP3 inflammasome activating danger signal
    • Dostert, C. et al. Malarial hemozoin is a NALP3 inflammasome activating danger signal. PLoS ONE 4, e6510 (2009).
    • (2009) PLoS ONE , vol.4
    • Dostert, C.1
  • 70
    • 67349271142 scopus 로고    scopus 로고
    • Syk kinase signalling couples to the NLRP3 inflammasome for anti-fungal host defence
    • Gross, O. et al. Syk kinase signalling couples to the NLRP3 inflammasome for anti-fungal host defence. Nature 459, 433-436 (2009).
    • (2009) Nature , vol.459 , pp. 433-436
    • Gross, O.1
  • 71
    • 0016478375 scopus 로고
    • Mechanisms of lysosomal enzyme release from leukocytes. i V. Interaction of monosodium urate crystals with dogfish and human leukocytes
    • Hoffstein, S. & Weissmann, G. Mechanisms of lysosomal enzyme release from leukocytes. I V. Interaction of monosodium urate crystals with dogfish and human leukocytes. Arthritis Rheum. 18, 153-165 (1975).
    • (1975) Arthritis Rheum. , vol.18 , pp. 153-165
    • Hoffstein, S.1    Weissmann, G.2
  • 73
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • Chen, G. Y. & Nunez, G. Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 10, 826-837 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 75
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada, K. et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414 (2012).
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1
  • 76
    • 73249144903 scopus 로고    scopus 로고
    • Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1β
    • Joosten, L. A. et al. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1β. Arthritis Rheum. 60, 3651-3662 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3651-3662
    • Joosten, L.A.1
  • 77
    • 73249139175 scopus 로고    scopus 로고
    • Caspase 1-independent activation of interleukin-1β in neutrophil-predominant inflammation
    • Guma, M. et al. Caspase 1-independent activation of interleukin-1β in neutrophil-predominant inflammation. Arthritis Rheum. 60, 3642-3650 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3642-3650
    • Guma, M.1
  • 79
    • 0026040529 scopus 로고
    • Rapid and specific conversion of precursor interleukin 1β (IL-1β) to an active IL-1 species by human mast cell chymase
    • Mizutani, H., Schechter, N., Lazarus, G., Black, R. A. & Kupper, T. S. Rapid and specific conversion of precursor interleukin 1β (IL-1β) to an active IL-1 species by human mast cell chymase. J. Exp. Med. 174, 821-825 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 821-825
    • Mizutani, H.1    Schechter, N.2    Lazarus, G.3    Black, R.A.4    Kupper, T.S.5
  • 80
    • 0032194115 scopus 로고    scopus 로고
    • Generation of biologically active IL-1β by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1β processing
    • Schonbeck, U., Mach, F. & Libby, P. Generation of biologically active IL-1β by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1β processing. J. Immunol. 161, 3340-3346 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 3340-3346
    • Schonbeck, U.1    MacH, F.2    Libby, P.3
  • 83
    • 0027518670 scopus 로고
    • Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I
    • McGuire, M. J., Lipsky, P. E. & Thiele, D. L. Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I. J. Biol. Chem. 268, 2458-2467 (1993). (Pubitemid 23057866)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.4 , pp. 2458-2467
    • McGuire, M.J.1    Lipsky, P.E.2    Thiele, D.L.3
  • 84
    • 0036168150 scopus 로고    scopus 로고
    • Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
    • DOI 10.1172/JCI200213462
    • Adkison, A. M., Raptis, S. Z., Kelley, D. G. & Pham, C. T. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J. Clin. Invest. 109, 363-371 (2002). (Pubitemid 34141810)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.3 , pp. 363-371
    • Adkison, A.M.1    Raptis, S.Z.2    Kelley, D.G.3    Pham, C.T.N.4
  • 85
    • 17144371314 scopus 로고    scopus 로고
    • TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation
    • Liu-Bryan, R., Pritzker, K., Firestein, G. S. & Terkeltaub, R. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J. Immunol. 174, 5016-5023 (2005). (Pubitemid 40514462)
    • (2005) Journal of Immunology , vol.174 , Issue.8 , pp. 5016-5023
    • Liu-Bryan, R.1    Pritzker, K.2    Firestein, G.S.3    Terkeltaub, R.4
  • 86
    • 78249286865 scopus 로고    scopus 로고
    • Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
    • Joosten, L. A. et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 62, 3237-3248 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 3237-3248
    • Joosten, L.A.1
  • 87
    • 55349123588 scopus 로고    scopus 로고
    • Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells
    • Ng, G. et al. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29, 807-818 (2008).
    • (2008) Immunity , vol.29 , pp. 807-818
    • Ng, G.1
  • 88
    • 33750421914 scopus 로고    scopus 로고
    • Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals
    • Scott, P., Ma, H., Viriyakosol, S., Terkeltaub, R. & Liu-Bryan, R. Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J. Immunol. 177, 6370-6378 (2006). (Pubitemid 44642121)
    • (2006) Journal of Immunology , vol.177 , Issue.9 , pp. 6370-6378
    • Scott, P.1    Ma, H.2    Viriyakosol, S.3    Terkeltaub, R.4    Liu-Bryan, R.5
  • 89
    • 68149160812 scopus 로고    scopus 로고
    • Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C
    • Popa-Nita, O., Proulx, S., Pare, G., Rollet-Labelle, E. & Naccache, P. H. Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C. J. Immunol. 183, 2104-2114 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 2104-2114
    • Popa-Nita, O.1    Proulx, S.2    Pare, G.3    Rollet-Labelle, E.4    Naccache, P.H.5
  • 90
    • 4043148676 scopus 로고    scopus 로고
    • Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis
    • DOI 10.1002/art.20386
    • Tramontini, N., Huber, C., Liu-Bryan, R., Terkeltaub, R. A. & Kilgore, K. S. Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. Arthritis Rheum. 50, 2633-2639 (2004). (Pubitemid 39062725)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.8 , pp. 2633-2639
    • Tramontini, N.1    Huber, C.2    Liu-Bryan, R.3    Terkeltaub, R.A.4    Kilgore, K.S.5
  • 91
    • 0032031451 scopus 로고    scopus 로고
    • Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes
    • Pouliot, M., James, M. J., McColl, S. R., Naccache, P. H. & Cleland, L. G. Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes. Blood 91, 1769-1776 (1998). (Pubitemid 28110344)
    • (1998) Blood , vol.91 , Issue.5 , pp. 1769-1776
    • Pouliot, M.1    James, M.J.2    McColl, S.R.3    Naccache, P.H.4    Cleland, L.G.5
  • 92
    • 79954587515 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
    • Kuroda, E. et al. Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity 34, 514-526 (2011).
    • (2011) Immunity , vol.34 , pp. 514-526
    • Kuroda, E.1
  • 93
    • 77954202860 scopus 로고    scopus 로고
    • Inflammation, oxidative stress and lipids: The risk triad for atherosclerosis in gout
    • Krishnan, E. Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout. Rheumatology (Oxford) 49, 1229-1238 (2010).
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1229-1238
    • Krishnan, E.1
  • 98
    • 0037047070 scopus 로고    scopus 로고
    • Allopurinol improves endothelial dysfunction in chronic heart failure
    • DOI 10.1161/01.CIR.0000022140.61460.1D
    • Farquharson, C. A., Butler, R., Hill, A., Belch, J. J. & Struthers, A. D. Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation 106, 221-226 (2002). (Pubitemid 34761303)
    • (2002) Circulation , vol.106 , Issue.2 , pp. 221-226
    • Farquharson, C.A.J.1    Butler, R.2    Hill, A.3    Belch, J.J.F.4    Struthers, A.D.5
  • 99
    • 84862776730 scopus 로고    scopus 로고
    • 2+ exchanger-mediated mitochondrial calcium overload
    • 2+ exchanger-mediated mitochondrial calcium overload. Cell Calcium 51, 402-410 (2012).
    • (2012) Cell Calcium , vol.51 , pp. 402-410
    • Hong, Q.1
  • 100
    • 84860470278 scopus 로고    scopus 로고
    • The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications
    • Puddu, P., Puddu, G. M., Cravero, E., Vizioli, L. & Muscari, A. The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: molecular mechanisms and clinical implications. J. Cardiol. 59, 235-242 (2012).
    • (2012) J. Cardiol. , vol.59 , pp. 235-242
    • Puddu, P.1    Puddu, G.M.2    Cravero, E.3    Vizioli, L.4    Muscari, A.5
  • 103
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 179-188
    • Vandanmagsar, B.1
  • 104
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361 (2010).
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1
  • 105
    • 0031106185 scopus 로고    scopus 로고
    • Increased serum levels of interleukin-1β in the systemic circulation of patients with essential hypertension: Additional risk factor for atherogenesis in hypertensive patients?
    • Dalekos, G. N., Elisaf, M., Bairaktari, E., Tsolas, O. & Siamopoulos, K. C. Increased serum levels of interleukin-1β in the systemic circulation of patients with essential hypertension: additional risk factor for atherogenesis in hypertensive patients? J. Lab. Clin. Med. 129, 300-308 (1997). (Pubitemid 27169432)
    • (1997) Journal of Laboratory and Clinical Medicine , vol.129 , Issue.3 , pp. 300-308
    • Dalekos, G.N.1    Elisaf, M.2    Bairaktari, E.3    Tsolas, O.4    Siamopoulos, K.C.5
  • 106
    • 0029853147 scopus 로고    scopus 로고
    • Elevated interleukin-1β in the circulation of patients with essential hypertension before any drug therapy: A pilot study
    • Dalekos, G. N., Elisaf, M. S., Papagalanis, N., Tzallas, C. & Siamopoulos, K. C. Elevated interleukin-1β in the circulation of patients with essential hypertension before any drug therapy: a pilot study. Eur. J. Clin. Invest. 26, 936-939 (1996). (Pubitemid 26343786)
    • (1996) European Journal of Clinical Investigation , vol.26 , Issue.10 , pp. 936-939
    • Dalekos, G.N.1    Elisaf, M.S.2    Papagalanis, N.3    Tzallas, C.4    Siamopoulos, K.C.5
  • 108
    • 33646748459 scopus 로고    scopus 로고
    • Uric acid and inflammatory markers
    • Ruggiero, C. et al. Uric acid and inflammatory markers. Eur. Heart J. 27, 1174-1181 (2006).
    • (2006) Eur. Heart J. , vol.27 , pp. 1174-1181
    • Ruggiero, C.1
  • 109
    • 60749105826 scopus 로고    scopus 로고
    • High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles
    • Vekic, J. et al. High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles. Atherosclerosis 203, 236-242 (2009).
    • (2009) Atherosclerosis , vol.203 , pp. 236-242
    • Vekic, J.1
  • 110
    • 80051472381 scopus 로고    scopus 로고
    • Monosodium urate monohydrate crystals inhibit osteoblast viability and function: Implications for development of bone erosion in gout
    • Chhana, A. et al. Monosodium urate monohydrate crystals inhibit osteoblast viability and function: implications for development of bone erosion in gout. Ann. Rheum. Dis. 70, 1684-1691 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1684-1691
    • Chhana, A.1
  • 111
    • 78149484804 scopus 로고    scopus 로고
    • The pathogenesis of bone erosions in gouty arthritis
    • Schlesinger, N. & Thiele, R. G. The pathogenesis of bone erosions in gouty arthritis. Ann. Rheum. Dis. 69, 1907-1912 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1907-1912
    • Schlesinger, N.1    Thiele, R.G.2
  • 112
  • 113
    • 84857774498 scopus 로고    scopus 로고
    • Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: Results of a phase II randomized, double-blind, placebo-controlled trial
    • Schumacher, H. R. Jr. et al. Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 64, 876-884 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. 876-884
    • Schumacher Jr., H.R.1
  • 114
    • 79957646006 scopus 로고    scopus 로고
    • Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: Results of a double-blind, randomised study
    • Schlesinger, N. et al. Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study. Ann. Rheum. Dis. 70, 1264-1271 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1264-1271
    • Schlesinger, N.1
  • 115
    • 79953094557 scopus 로고    scopus 로고
    • Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat gouty arthritis by suppressing inflammation: Results of a randomized, dose-ranging study
    • Schlesinger, N. et al. Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat gouty arthritis by suppressing inflammation: results of a randomized, dose-ranging study. Arthritis Res. Ther. 13, R53 (2011).
    • (2011) Arthritis Res. Ther. , vol.13
    • Schlesinger, N.1
  • 116
    • 77957688721 scopus 로고    scopus 로고
    • Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study
    • So, A. et al. Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: results of a multicenter, phase II, dose-ranging study. Arthritis Rheum. 62, 3064-3076 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 3064-3076
    • So, A.1
  • 117
    • 0010324713 scopus 로고
    • Immunological recognition of self
    • Burnet, F. M. Immunological recognition of self. Science 133, 307-311 (1961).
    • (1961) Science , vol.133 , pp. 307-311
    • Burnet, F.M.1
  • 118
    • 0033451923 scopus 로고    scopus 로고
    • Proteolysis and class I major histocompatibility complex antigen presentation
    • York, I. A., Goldberg, A. L., Mo, X. Y. & Rock, K. L. Proteolysis and class I major histocompatibility complex antigen presentation. Immunol. Rev. 172, 49-66 (1999). (Pubitemid 30000468)
    • (1999) Immunological Reviews , vol.172 , pp. 49-66
    • York, I.A.1    Goldberg, A.L.2    Mo, X.Y.3    Rock, K.L.4
  • 119
    • 0027468145 scopus 로고
    • The biochemistry and cell biology and antigen processing and presentation
    • Germain, R. N. & Margulies, D. H. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11, 403-450 (1993). (Pubitemid 23115014)
    • (1993) Annual Review of Immunology , vol.11 , pp. 403-450
    • Germain, R.N.1    Margulies, D.H.2
  • 120
    • 77954240379 scopus 로고    scopus 로고
    • Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice
    • Hoffman, H. M. et al. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum. 62, 2170-2179 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2170-2179
    • Hoffman, H.M.1
  • 121
    • 70349379884 scopus 로고    scopus 로고
    • Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
    • Torres, R. et al. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann. Rheum. Dis 68, 1602-1608 (2009).
    • (2009) Ann. Rheum. Dis , vol.68 , pp. 1602-1608
    • Torres, R.1
  • 122
    • 47849132947 scopus 로고    scopus 로고
    • The NALP3 inflammasome is essential for the development of silicosis
    • Cassel, S. L. et al. The NALP3 inflammasome is essential for the development of silicosis. Proc. Natl Acad. Sci. USA 105, 9035-9040 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9035-9040
    • Cassel, S.L.1
  • 123
    • 80053320089 scopus 로고    scopus 로고
    • Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism
    • Palomaki, J. et al. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5, 6861-6870 (2011).
    • (2011) ACS Nano , vol.5 , pp. 6861-6870
    • Palomaki, J.1
  • 124
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation
    • Rajamaki, K. et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE 5, e11765 (2010).
    • (2010) PLoS ONE , vol.5
    • Rajamaki, K.1
  • 125
    • 47849087075 scopus 로고    scopus 로고
    • Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    • Li, H., Willingham, S. B., Ting, J. P. & Re, F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J. Immunol. 181, 17-21 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 17-21
    • Li, H.1    Willingham, S.B.2    Ting, J.P.3    Re, F.4
  • 126
    • 50849112477 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
    • Franchi, L. & Nunez, G. The NLRP3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity. Eur. J. Immunol. 38, 2085-2089 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2085-2089
    • Franchi, L.1    Nunez, G.2
  • 127
    • 56149119563 scopus 로고    scopus 로고
    • Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    • Kool, M. et al. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol. 181, 3755-3759 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 3755-3759
    • Kool, M.1
  • 128
    • 79951846190 scopus 로고    scopus 로고
    • Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro
    • Pazar, B. et al. Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro. J. Immunol. 186, 2495-2502 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 2495-2502
    • Pazar, B.1
  • 129
    • 79551662979 scopus 로고    scopus 로고
    • Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice
    • Narayan, S. et al. Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice. Arthritis Rheum. 63, 422-433 (2011).
    • (2011) Arthritis Rheum. , vol.63 , pp. 422-433
    • Narayan, S.1
  • 130
    • 80052581043 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
    • Jin, C. et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc. Natl Acad. Sci. USA 108, 14867-14872 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 14867-14872
    • Jin, C.1
  • 131
    • 78650610580 scopus 로고    scopus 로고
    • Nanoparticles activate the NLR pyrin domain containing 3 (NLRP3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    • Yazdi, A. S. et al. Nanoparticles activate the NLR pyrin domain containing 3 (NLRP3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc. Natl Acad. Sci. USA 107, 19449-19454 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 19449-19454
    • Yazdi, A.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.