-
1
-
-
80053497428
-
Prevalence of gout and hyperuricemia in the US general population: The national health and nutrition examination survey 2007-2008
-
Zhu, Y., Pandya, B. J. & Choi, H. K. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 63, 3136-3141 (2011).
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 3136-3141
-
-
Zhu, Y.1
Pandya, B.J.2
Choi, H.K.3
-
3
-
-
78449233958
-
Gout and its comorbidities
-
Pillinger, M. H., Goldfarb, D. S. & Keenan, R. T. Gout and its comorbidities. Bull. NYU Hosp. Jt Dis. 68, 199-203 (2010).
-
(2010)
Bull. NYU Hosp. Jt Dis.
, vol.68
, pp. 199-203
-
-
Pillinger, M.H.1
Goldfarb, D.S.2
Keenan, R.T.3
-
4
-
-
0141998606
-
Molecular identification of a danger signal that alerts the immune system to dying cells
-
DOI 10.1038/nature01991
-
Shi, Y., Evans, J. E. & Rock, K. L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425, 516-521 (2003). (Pubitemid 37237047)
-
(2003)
Nature
, vol.425
, Issue.6957
, pp. 516-521
-
-
Shi, Y.1
Evans, J.E.2
Rock, K.L.3
-
5
-
-
77953187009
-
Uric acid transport and disease
-
So, A. & Thorens, B. Uric acid transport and disease. J. Clin. Invest. 120, 1791-1799 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1791-1799
-
-
So, A.1
Thorens, B.2
-
6
-
-
0019787519
-
Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis
-
Ames, B. N., Cathcart, R., Schwiers, E. & Hochstein, P. Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused aging and cancer: a hypothesis. Proc. Natl Acad. Sci. USA 78, 6858-6862 (1981). (Pubitemid 12216861)
-
(1981)
Proceedings of the National Academy of Sciences of the United States of America
, vol.78
, Issue.11
, pp. 6858-6862
-
-
Ames, B.N.1
Cathcart, R.2
Schwiers, E.3
Hochstein, P.4
-
7
-
-
0017716084
-
Hereditary xanthinuria. Report on three patients and short review of the literature
-
Frayha, R. A., Salti, I. S., Arnaout, A., Khatchadurian, A. & Uthman, S. M. Hereditary xanthinuria: report on three patients and short review of the literature. Nephron 19, 328-332 (1977). (Pubitemid 8196094)
-
(1977)
Nephron
, vol.19
, Issue.6
, pp. 328-332
-
-
Frayha, R.A.1
Salti, I.S.2
Arnaout, A.3
-
8
-
-
84863252356
-
Serum uric acid levels in patients with multiple sclerosis: A meta-analysis
-
Liu, B. et al. Serum uric acid levels in patients with multiple sclerosis: a meta-analysis. Neurol. Res. 34, 163-171 (2012).
-
(2012)
Neurol. Res.
, vol.34
, pp. 163-171
-
-
Liu, B.1
-
9
-
-
45149122797
-
Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
-
DOI 10.1001/archneur.2008.65.6.nct70003
-
Schwarzschild, M. A. et al. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch. Neurol. 65, 716-723 (2008). (Pubitemid 351831449)
-
(2008)
Archives of Neurology
, vol.65
, Issue.6
, pp. 716-723
-
-
Schwarzschild, M.A.1
Schwid, S.R.2
Marek, K.3
Watts, A.4
Lang, A.E.5
Oakes, D.6
Shoulson, I.7
Ascherio, A.8
Hyson, C.9
Gorbold, E.10
Rudolph, A.11
Kieburtz, K.12
Fahn, S.13
Gauger, L.14
Goetz, C.15
Seibyl, J.16
Forrest, M.17
Ondrasik, J.18
-
12
-
-
78751560494
-
Pathogen recognition by the innate immune system
-
Kumar, H., Kawai, T. & Akira, S. Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30, 16-34 (2011).
-
(2011)
Int. Rev. Immunol.
, vol.30
, pp. 16-34
-
-
Kumar, H.1
Kawai, T.2
Akira, S.3
-
13
-
-
0037066427
-
The danger model: A renewed sense of self
-
DOI 10.1126/science.1071059
-
Matzinger, P. The danger model: a renewed sense of self. Science 296, 301-305 (2002). (Pubitemid 34303674)
-
(2002)
Science
, vol.296
, Issue.5566
, pp. 301-305
-
-
Matzinger, P.1
-
15
-
-
0032546352
-
Dendritic cells and the control of immunity
-
DOI 10.1038/32588
-
Banchereau, J. & Steinman, R. M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998). (Pubitemid 28155090)
-
(1998)
Nature
, vol.392
, Issue.6673
, pp. 245-252
-
-
Banchereau, J.1
Steinman, R.M.2
-
16
-
-
0031671268
-
CD28/B7 costimulation: A review
-
Greenfield, E. A., Nguyen, K. A. & Kuchroo, V. K. CD28/B7 costimulation: a review. Crit. Rev. Immunol. 18, 389-418 (1998). (Pubitemid 28447017)
-
(1998)
Critical Reviews in Immunology
, vol.18
, Issue.5
, pp. 389-418
-
-
Greenfield, E.A.1
Nguyen, K.A.2
Kuchroo, V.K.3
-
17
-
-
12444252115
-
-
Springer Semin. Immunopathol.
-
Rock, K. L., Hearn, A., Chen, C. J. & Shi, Y. Natural endogenous adjuvants. Springer Semin. Immunopathol. 26, 231-246 (2005).
-
(2005)
Natural Endogenous Adjuvants
, vol.26
, pp. 231-246
-
-
Rock, K.L.1
Hearn, A.2
Chen, C.J.3
Shi, Y.4
-
18
-
-
0032485487
-
Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLS
-
DOI 10.1038/32183
-
Albert, M. L., Sauter, B. & Bhardwaj, N. Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86-89 (1998). (Pubitemid 28150594)
-
(1998)
Nature
, vol.392
, Issue.6671
, pp. 86-89
-
-
Albert, M.L.1
Sauter, B.2
Bhardwaj, N.3
-
19
-
-
0032209520
-
Cutting edge: Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function
-
Rovere, P. et al. Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. J. Immunol. 161, 4467-4471 (1998). (Pubitemid 28492012)
-
(1998)
Journal of Immunology
, vol.161
, Issue.9
, pp. 4467-4471
-
-
Rovere, P.1
Vallinoto, C.2
Bondanza, A.3
Crosti, M.C.4
Rescigno, M.5
Ricciardi-Castagnoli, P.6
Rugarli, C.7
Manfredi, A.A.8
-
20
-
-
0032695108
-
Natural adjuvants: Endogenous activators of dendritic cells
-
DOI 10.1038/15200
-
Gallucci, S., Lolkema, M. & Matzinger, P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255 (1999). (Pubitemid 29535601)
-
(1999)
Nature Medicine
, vol.5
, Issue.11
, pp. 1249-1255
-
-
Gallucci, S.1
Lolkema, M.2
Matzinger, P.3
-
21
-
-
0034687696
-
Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses
-
DOI 10.1073/pnas.260497597
-
Shi, Y., Zheng, W. & Rock, K. L. Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc. Natl Acad. Sci. USA 97, 14590-14595 (2000). (Pubitemid 32016620)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.26
, pp. 14590-14595
-
-
Shi, Y.1
Zheng, W.2
Rock, K.L.3
-
22
-
-
77953187290
-
Uric acid promotes an acute inflammatory response to sterile cell death in mice
-
Kono, H., Chen, C. J., Ontiveros, F. & Rock, K. L. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J. Clin. Invest. 120, 1939-1949 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1939-1949
-
-
Kono, H.1
Chen, C.J.2
Ontiveros, F.3
Rock, K.L.4
-
23
-
-
41149118513
-
How dying cells alert the immune system to danger
-
DOI 10.1038/nri2215, PII NRI2215
-
Kono, H. & Rock, K. L. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8, 279-289 (2008). (Pubitemid 351432799)
-
(2008)
Nature Reviews Immunology
, vol.8
, Issue.4
, pp. 279-289
-
-
Kono, H.1
Rock, K.L.2
-
24
-
-
0026537198
-
A revised estimate of twin concordance in systemic lupus erythematosus
-
Deapen, D. et al. A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum. 35, 311-318 (1992).
-
(1992)
Arthritis Rheum.
, vol.35
, pp. 311-318
-
-
Deapen, D.1
-
25
-
-
33646022583
-
Cutting edge: Elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model
-
Shi, Y., Galusha, S. A. & Rock, K. L. Cutting edge: elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model. J. Immunol. 176, 3905-3908 (2006). (Pubitemid 44264366)
-
(2006)
Journal of Immunology
, vol.176
, Issue.7
, pp. 3905-3908
-
-
Shi, Y.1
Galusha, S.A.2
Rock, K.L.3
-
26
-
-
55249100762
-
The role of innate immunity in autoimmune tissue injury
-
Allam, R. & Anders, H. J. The role of innate immunity in autoimmune tissue injury. Curr. Opin. Rheumatol. 20, 538-544 (2008).
-
(2008)
Curr. Opin. Rheumatol.
, vol.20
, pp. 538-544
-
-
Allam, R.1
Anders, H.J.2
-
27
-
-
0017179001
-
Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
-
Like, A. A. & Rossini, A. A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193, 415-417 (1976).
-
(1976)
Science
, vol.193
, pp. 415-417
-
-
Like, A.A.1
Rossini, A.A.2
-
28
-
-
0036141519
-
Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes
-
DOI 10.1172/JCI200211198
-
Horwitz, M. S., Ilic, A., Fine, C, Rodriguez, E. & Sarvetnick, N. Presented antigen from damaged pancreatic ß cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J. Clin. Invest. 109, 79-87 (2002). (Pubitemid 34052544)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.1
, pp. 79-87
-
-
Horwitz, M.S.1
Ilic, A.2
Fine, C.3
Rodriguez, E.4
Sarvetnick, N.5
-
29
-
-
0031821976
-
Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction
-
DOI 10.1084/jem.188.2.409
-
Kurts, C, Miller, J. F., Subramaniam, R. M., Carbone, F. R. & Heath, W. R. Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J. Exp. Med. 188, 409-414 (1998). (Pubitemid 28357770)
-
(1998)
Journal of Experimental Medicine
, vol.188
, Issue.2
, pp. 409-414
-
-
Kurts, C.1
Miller, J.F.A.P.2
Subramaniam, R.M.3
Carbone, F.R.4
Heath, W.R.5
-
30
-
-
0031874342
-
Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
-
DOI 10.1038/nm0798-781
-
Horwitz, M. S. et al. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med. 4, 781-785 (1998). (Pubitemid 28331018)
-
(1998)
Nature Medicine
, vol.4
, Issue.7
, pp. 781-785
-
-
Horwitz, M.S.1
Bradley, L.M.2
Harbertson, J.3
Krahl, T.4
Lee, J.5
Sarvetnick, N.6
-
31
-
-
0004152023
-
-
Oxford University Press, New York
-
nd edn (Oxford University Press, New York, 2004).
-
(2004)
nd Edn
-
-
Majno, G.1
Joris, I.2
-
32
-
-
77952769075
-
Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
-
Kono, H., Karmarkar, D., Iwakura, Y. & Rock, K. L. Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. J. Immunol. 184, 4470-4478 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 4470-4478
-
-
Kono, H.1
Karmarkar, D.2
Iwakura, Y.3
Rock, K.L.4
-
33
-
-
77952294609
-
The sterile inflammatory response
-
Rock, K. L, Latz, E., Ontiveros, F. & Kono, H. The sterile inflammatory response. Annu. Rev. Immunol. 28, 321-342 (2010).
-
(2010)
Annu. Rev. Immunol.
, vol.28
, pp. 321-342
-
-
Rock, K.L.1
Latz, E.2
Ontiveros, F.3
Kono, H.4
-
34
-
-
67149130597
-
Anakinra for rheumatoid arthritis: A systematic review
-
Mertens, M. & Singh, J. A. Anakinra for rheumatoid arthritis: a systematic review. J. Rheumatol. 36, 1118-1125 (2009).
-
(2009)
J. Rheumatol.
, vol.36
, pp. 1118-1125
-
-
Mertens, M.1
Singh, J.A.2
-
35
-
-
80052138380
-
And adaptive immune responses to cell death
-
Rock, K. L, Lai, J. J. & Kono, H. Innate and adaptive immune responses to cell death. Immunol. Rev. 243, 191-205 (2011).
-
(2011)
Immunol. Rev.
, vol.243
, pp. 191-205
-
-
Rock, K.L.1
Lai, J.J.2
Innate, K.H.3
-
36
-
-
33746747096
-
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
-
Chen, C. J. et al. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J. Clin. Invest. 116, 2262-2271 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2262-2271
-
-
Chen, C.J.1
-
37
-
-
65649140025
-
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
-
Gasse, P. et al. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am. J. Respir. Crit. Care Med. 179, 903-913 (2009).
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.179
, pp. 903-913
-
-
Gasse, P.1
-
38
-
-
79953813107
-
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
-
Dinarello, C. A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117, 3720-3732 (2011).
-
(2011)
Blood
, vol.117
, pp. 3720-3732
-
-
Dinarello, C.A.1
-
39
-
-
58849151813
-
Cutting edge: Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1a released from dying cells
-
Eigenbrod, T., Park, J. H., Harder, J., Iwakura, Y & Nunez, G. Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1a released from dying cells. J. Immunol. 181, 8194-8198 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 8194-8198
-
-
Eigenbrod, T.1
Park, J.H.2
Harder, J.3
Iwakura, Y.4
Nunez, G.5
-
40
-
-
84858761335
-
Inflammasome activators induce interleukin-1a secretion via distinct pathways with differential requirement for the protease function of caspase-1
-
Gross, O. et al. Inflammasome activators induce interleukin-1a secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 36, 388-400 (2012).
-
(2012)
Immunity
, vol.36
, pp. 388-400
-
-
Gross, O.1
-
41
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
Dinarello, C. A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27, 519-550 (2009).
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
42
-
-
70249138036
-
Cutting edge: NF-KB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
Bauernfeind, F G. et al. Cutting edge: NF-KB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183, 787-791 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 787-791
-
-
Bauernfeind, F.G.1
-
43
-
-
0036671894
-
The Inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β
-
DOI 10.1016/S1097-2765(02)00599-3
-
Martinon, F, Burns, K. & Tschopp, J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-ß. Mol. Cell 10, 417-426 (2002). (Pubitemid 35007355)
-
(2002)
Molecular Cell
, vol.10
, Issue.2
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
44
-
-
77950362382
-
The inflammasomes
-
Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
45
-
-
0035179970
-
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
-
DOI 10.1038/ng756
-
Hoffman, H. M., Mueller, J. L, Broide, D. H., Wanderer, A. A. & Kolodner, R. D. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet. 29, 301-305 (2001). (Pubitemid 33096455)
-
(2001)
Nature Genetics
, vol.29
, Issue.3
, pp. 301-305
-
-
Hoffman, H.M.1
Mueller, J.L.2
Broide, D.H.3
Wanderer, A.A.4
Kolodner, R.D.5
-
46
-
-
0036899758
-
De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin-associated autoinflammatory diseases
-
DOI 10.1002/art.10688
-
Aksentijevich, I. et al. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 46, 3340-3348 (2002). (Pubitemid 35453546)
-
(2002)
Arthritis and Rheumatism
, vol.46
, Issue.12
, pp. 3340-3348
-
-
Aksentijevich, I.1
Nowak, M.2
Mallah, M.3
Chae, J.J.4
Watford, W.T.5
Hofmann, S.R.6
Stein, L.7
Russo, R.8
Goldsmith, D.9
Dent, P.10
Rosenberg, H.F.11
Austin, F.12
Remmers, E.F.13
Balow Jr., J.E.14
Rosenzweig, S.15
Komarow, H.16
Shoham, N.G.17
Wood, G.18
Jones, J.19
Mangra, N.20
Carrero, H.21
Adams, B.S.22
Moore, T.L.23
Schikler, K.24
Hoffman, H.25
Lovell, D.J.26
Lipnick, R.27
Barron, K.28
O'Shea, J.J.29
Kastner, D.L.30
Goldbach-Mansky, R.31
more..
-
47
-
-
77956631703
-
Cryopyrin-associated periodic syndromes: Background and therapeutics
-
Kubota, T. & Koike, R. Cryopyrin-associated periodic syndromes: background and therapeutics. Mod. Rheumatol. 20, 213-221 (2010).
-
(2010)
Mod. Rheumatol.
, vol.20
, pp. 213-221
-
-
Kubota, T.1
Koike, R.2
-
48
-
-
33744762863
-
-
Springer Semin. Immunopathol.
-
Church, L. D., Churchman, S. M., Hawkins, P. N. & McDermott, M. F. Hereditary auto-inflammatory disorders and biologics. Springer Semin. Immunopathol. 27, 494-508 (2006).
-
(2006)
Hereditary Auto-inflammatory Disorders and Biologics
, vol.27
, pp. 494-508
-
-
Church, L.D.1
Churchman, S.M.2
Hawkins, P.N.3
McDermott, M.F.4
-
49
-
-
0025182760
-
Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1α
-
Kobayashi, Y. et al. Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1α. Proc. Natl Acad. Sci. USA 87, 5548-5552 (1990).
-
(1990)
Proc. Natl Acad. Sci. USA
, vol.87
, pp. 5548-5552
-
-
Kobayashi, Y.1
-
50
-
-
82455175456
-
Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α
-
Afonina, I. S. et al. Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α. Mol. Cell 44, 265-278 (2011).
-
(2011)
Mol. Cell
, vol.44
, pp. 265-278
-
-
Afonina, I.S.1
-
51
-
-
81055145409
-
Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
-
Fettelschoss, A. et al. Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression. Proc. Natl Acad. Sci. USA 108, 18055-18060 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 18055-18060
-
-
Fettelschoss, A.1
-
52
-
-
0028920863
-
Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
-
Kuida, K. et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267, 2000-2003 (1995).
-
(1995)
Science
, vol.267
, pp. 2000-2003
-
-
Kuida, K.1
-
53
-
-
33644985564
-
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
-
Sutterwala, F. S. et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24, 317-327 (2006).
-
(2006)
Immunity
, vol.24
, pp. 317-327
-
-
Sutterwala, F.S.1
-
54
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
-
Hornung, V. et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 847-856
-
-
Hornung, V.1
-
55
-
-
77249118801
-
The inflammasomes: Mechanisms of activation and function
-
Latz, E. The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 22, 28-33 (2010).
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 28-33
-
-
Latz, E.1
-
56
-
-
51449124322
-
Its mechanism of action and efficacy in crystal-induced inflammation
-
Nuki, G. Colchicine: its mechanism of action and efficacy in crystal-induced inflammation. Curr. Rheumatol. Rep. 10, 218-227 (2008).
-
(2008)
Curr. Rheumatol. Rep.
, vol.10
, pp. 218-227
-
-
Nuki, G.1
Colchicine2
-
57
-
-
39549112322
-
Urate crystals, inflammation, and colchicine
-
DOI 10.1002/art.23069
-
McCarty, D. J. Urate crystals, inflammation, and colchicine. Arthritis Rheum. 58 (Suppl. S2), S20-S24 (2008). (Pubitemid 351281120)
-
(2008)
Arthritis and Rheumatism
, vol.58
, Issue.2 SUPPL.
-
-
McCarty, D.J.1
-
58
-
-
45749111446
-
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
-
DOI 10.1038/nature06939, PII NATURE06939
-
Eisenbarth, S. C., Colegio, O. R., O'Connor, W., Sutterwala, F. S. & Flavell, R. A. Crucial role for the NALP3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453, 1122-1126 (2008). (Pubitemid 351871731)
-
(2008)
Nature
, vol.453
, Issue.7198
, pp. 1122-1126
-
-
Eisenbarth, S.C.1
Colegio, O.R.2
O'Connor Jr., W.3
Sutterwala, F.S.4
Flavell, R.A.5
-
59
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
DOI 10.1038/nature04516, PII N04516
-
Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. & Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241 (2006). (Pubitemid 43372104)
-
(2006)
Nature
, vol.440
, Issue.7081
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
Tardivel, A.4
Tschopp, J.5
-
60
-
-
0029144844
-
Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils
-
Cronstein, B. N. et al. Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J. Clin. Invest. 96, 994-1002 (1995).
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 994-1002
-
-
Cronstein, B.N.1
-
61
-
-
43249125839
-
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
-
DOI 10.1126/science.1156995
-
Dostert, C. et al. Innate immune activation through NALP3 inflammasome sensing of asbestos and silica. Science 320, 674-677 (2008). (Pubitemid 351928351)
-
(2008)
Science
, vol.320
, Issue.5876
, pp. 674-677
-
-
Dostert, C.1
Petrilli, V.2
Van Bruggen, R.3
Steele, C.4
Mossman, B.T.5
Tschopp, J.6
-
62
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136-140 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
Choi, I.4
Tschopp, J.5
-
63
-
-
79951578449
-
Inflammasomes: Current understanding and open questions
-
Bauernfeind, F. et al. Inflammasomes: current understanding and open questions. Cell. Mol. Life Sci. 68, 765-783 (2011).
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, pp. 765-783
-
-
Bauernfeind, F.1
-
64
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
65
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
-
Masters, S. L. et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat. Immunol. 11, 897-904 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
-
66
-
-
47849085872
-
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
-
Halle, A. et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β. Nat. Immunol. 9, 857-865 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 857-865
-
-
Halle, A.1
-
67
-
-
0042914359
-
Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin
-
DOI 10.1038/sj.cdd.4401264
-
Hentze, H., Lin, X. Y., Choi, M. S. & Porter, A. G. Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ. 10, 956-968 (2003). (Pubitemid 37069473)
-
(2003)
Cell Death and Differentiation
, vol.10
, Issue.9
, pp. 956-968
-
-
Hentze, H.1
Lin, X.Y.2
Choi, M.S.K.3
Porter, A.G.4
-
68
-
-
58849160540
-
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
-
Sharp, F. A. et al. Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc. Natl Acad. Sci. USA 106, 870-875 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 870-875
-
-
Sharp, F.A.1
-
69
-
-
68349157477
-
Malarial hemozoin is a NALP3 inflammasome activating danger signal
-
Dostert, C. et al. Malarial hemozoin is a NALP3 inflammasome activating danger signal. PLoS ONE 4, e6510 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Dostert, C.1
-
70
-
-
67349271142
-
Syk kinase signalling couples to the NLRP3 inflammasome for anti-fungal host defence
-
Gross, O. et al. Syk kinase signalling couples to the NLRP3 inflammasome for anti-fungal host defence. Nature 459, 433-436 (2009).
-
(2009)
Nature
, vol.459
, pp. 433-436
-
-
Gross, O.1
-
71
-
-
0016478375
-
Mechanisms of lysosomal enzyme release from leukocytes. i V. Interaction of monosodium urate crystals with dogfish and human leukocytes
-
Hoffstein, S. & Weissmann, G. Mechanisms of lysosomal enzyme release from leukocytes. I V. Interaction of monosodium urate crystals with dogfish and human leukocytes. Arthritis Rheum. 18, 153-165 (1975).
-
(1975)
Arthritis Rheum.
, vol.18
, pp. 153-165
-
-
Hoffstein, S.1
Weissmann, G.2
-
72
-
-
34548027736
-
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
-
DOI 10.1038/sj.cdd.4402195, PII 4402195
-
Petrilli, V. et al. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14, 1583-1589 (2007). (Pubitemid 47278844)
-
(2007)
Cell Death and Differentiation
, vol.14
, Issue.9
, pp. 1583-1589
-
-
Petrilli, V.1
Papin, S.2
Dostert, C.3
Mayor, A.4
Martinon, F.5
Tschopp, J.6
-
73
-
-
78649526394
-
Sterile inflammation: Sensing and reacting to damage
-
Chen, G. Y. & Nunez, G. Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 10, 826-837 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 826-837
-
-
Chen, G.Y.1
Nunez, G.2
-
74
-
-
80052139666
-
Sensing damage by the NLRP3 inflammasome
-
Leemans, J. C., Cassel, S. L. & Sutterwala, F. S. Sensing damage by the NLRP3 inflammasome. Immunol. Rev. 243, 152-162 (2011).
-
(2011)
Immunol. Rev.
, vol.243
, pp. 152-162
-
-
Leemans, J.C.1
Cassel, S.L.2
Sutterwala, F.S.3
-
75
-
-
84862777872
-
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
-
Shimada, K. et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414 (2012).
-
(2012)
Immunity
, vol.36
, pp. 401-414
-
-
Shimada, K.1
-
76
-
-
73249144903
-
Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1β
-
Joosten, L. A. et al. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1β. Arthritis Rheum. 60, 3651-3662 (2009).
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 3651-3662
-
-
Joosten, L.A.1
-
77
-
-
73249139175
-
Caspase 1-independent activation of interleukin-1β in neutrophil-predominant inflammation
-
Guma, M. et al. Caspase 1-independent activation of interleukin-1β in neutrophil-predominant inflammation. Arthritis Rheum. 60, 3642-3650 (2009).
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 3642-3650
-
-
Guma, M.1
-
78
-
-
0025220123
-
Processing of precursor interleukin 1β and inflammatory disease
-
Hazuda, D. J., Strickler, J., Kueppers, F., Simon, P. L. & Young, P. R. Processing of precursor interleukin 1β and inflammatory disease. J. Biol. Chem. 265, 6318-6322 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 6318-6322
-
-
Hazuda, D.J.1
Strickler, J.2
Kueppers, F.3
Simon, P.L.4
Young, P.R.5
-
79
-
-
0026040529
-
Rapid and specific conversion of precursor interleukin 1β (IL-1β) to an active IL-1 species by human mast cell chymase
-
Mizutani, H., Schechter, N., Lazarus, G., Black, R. A. & Kupper, T. S. Rapid and specific conversion of precursor interleukin 1β (IL-1β) to an active IL-1 species by human mast cell chymase. J. Exp. Med. 174, 821-825 (1991).
-
(1991)
J. Exp. Med.
, vol.174
, pp. 821-825
-
-
Mizutani, H.1
Schechter, N.2
Lazarus, G.3
Black, R.A.4
Kupper, T.S.5
-
80
-
-
0032194115
-
Generation of biologically active IL-1β by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1β processing
-
Schonbeck, U., Mach, F. & Libby, P. Generation of biologically active IL-1β by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1β processing. J. Immunol. 161, 3340-3346 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 3340-3346
-
-
Schonbeck, U.1
MacH, F.2
Libby, P.3
-
81
-
-
0032989434
-
Converting enzyme-independent release of tumor necrosis factor and IL- 1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
-
DOI 10.1073/pnas.96.11.6261
-
Coeshott, C. et al. Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc. Natl Acad. Sci. USA 96, 6261-6266 (1999). (Pubitemid 29256653)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.11
, pp. 6261-6266
-
-
Coeshott, C.1
Ohnemus, C.2
Pilyavskaya, A.3
Ross, S.4
Wieczorek, M.5
Kroona, H.6
Leimer, A.H.7
Cheronis, J.8
-
83
-
-
0027518670
-
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I
-
McGuire, M. J., Lipsky, P. E. & Thiele, D. L. Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I. J. Biol. Chem. 268, 2458-2467 (1993). (Pubitemid 23057866)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.4
, pp. 2458-2467
-
-
McGuire, M.J.1
Lipsky, P.E.2
Thiele, D.L.3
-
84
-
-
0036168150
-
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis
-
DOI 10.1172/JCI200213462
-
Adkison, A. M., Raptis, S. Z., Kelley, D. G. & Pham, C. T. Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis. J. Clin. Invest. 109, 363-371 (2002). (Pubitemid 34141810)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.3
, pp. 363-371
-
-
Adkison, A.M.1
Raptis, S.Z.2
Kelley, D.G.3
Pham, C.T.N.4
-
85
-
-
17144371314
-
TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation
-
Liu-Bryan, R., Pritzker, K., Firestein, G. S. & Terkeltaub, R. TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation. J. Immunol. 174, 5016-5023 (2005). (Pubitemid 40514462)
-
(2005)
Journal of Immunology
, vol.174
, Issue.8
, pp. 5016-5023
-
-
Liu-Bryan, R.1
Pritzker, K.2
Firestein, G.S.3
Terkeltaub, R.4
-
86
-
-
78249286865
-
Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis
-
Joosten, L. A. et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 62, 3237-3248 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 3237-3248
-
-
Joosten, L.A.1
-
87
-
-
55349123588
-
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells
-
Ng, G. et al. Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity 29, 807-818 (2008).
-
(2008)
Immunity
, vol.29
, pp. 807-818
-
-
Ng, G.1
-
88
-
-
33750421914
-
Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals
-
Scott, P., Ma, H., Viriyakosol, S., Terkeltaub, R. & Liu-Bryan, R. Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J. Immunol. 177, 6370-6378 (2006). (Pubitemid 44642121)
-
(2006)
Journal of Immunology
, vol.177
, Issue.9
, pp. 6370-6378
-
-
Scott, P.1
Ma, H.2
Viriyakosol, S.3
Terkeltaub, R.4
Liu-Bryan, R.5
-
89
-
-
68149160812
-
Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C
-
Popa-Nita, O., Proulx, S., Pare, G., Rollet-Labelle, E. & Naccache, P. H. Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C. J. Immunol. 183, 2104-2114 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 2104-2114
-
-
Popa-Nita, O.1
Proulx, S.2
Pare, G.3
Rollet-Labelle, E.4
Naccache, P.H.5
-
90
-
-
4043148676
-
Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis
-
DOI 10.1002/art.20386
-
Tramontini, N., Huber, C., Liu-Bryan, R., Terkeltaub, R. A. & Kilgore, K. S. Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. Arthritis Rheum. 50, 2633-2639 (2004). (Pubitemid 39062725)
-
(2004)
Arthritis and Rheumatism
, vol.50
, Issue.8
, pp. 2633-2639
-
-
Tramontini, N.1
Huber, C.2
Liu-Bryan, R.3
Terkeltaub, R.A.4
Kilgore, K.S.5
-
91
-
-
0032031451
-
Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes
-
Pouliot, M., James, M. J., McColl, S. R., Naccache, P. H. & Cleland, L. G. Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes. Blood 91, 1769-1776 (1998). (Pubitemid 28110344)
-
(1998)
Blood
, vol.91
, Issue.5
, pp. 1769-1776
-
-
Pouliot, M.1
James, M.J.2
McColl, S.R.3
Naccache, P.H.4
Cleland, L.G.5
-
92
-
-
79954587515
-
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms
-
Kuroda, E. et al. Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity 34, 514-526 (2011).
-
(2011)
Immunity
, vol.34
, pp. 514-526
-
-
Kuroda, E.1
-
93
-
-
77954202860
-
Inflammation, oxidative stress and lipids: The risk triad for atherosclerosis in gout
-
Krishnan, E. Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout. Rheumatology (Oxford) 49, 1229-1238 (2010).
-
(2010)
Rheumatology (Oxford)
, vol.49
, pp. 1229-1238
-
-
Krishnan, E.1
-
94
-
-
84855872485
-
Comorbidities in patients with gout
-
Ichikawa, N., Taniguchi, A., Urano, W., Nakajima, A. & Yamanaka, H. Comorbidities in patients with gout. Nucleosides Nucleotides Nucleic Acids 30, 1045-1050 (2011).
-
(2011)
Nucleosides Nucleotides Nucleic Acids
, vol.30
, pp. 1045-1050
-
-
Ichikawa, N.1
Taniguchi, A.2
Urano, W.3
Nakajima, A.4
Yamanaka, H.5
-
95
-
-
20244365646
-
Hyperuricemia induces endothelial dysfunction
-
DOI 10.1111/j.1523-1755.2005.00273.x
-
Khosla, U. M. et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 67, 1739-1742 (2005). (Pubitemid 40577708)
-
(2005)
Kidney International
, vol.67
, Issue.5
, pp. 1739-1742
-
-
Khosla, U.M.1
Zharikov, S.2
Finch, J.L.3
Nakagawa, T.4
Roncal, C.5
Mu, W.6
Krotova, K.7
Block, E.R.8
Prabhakar, S.9
Johnson, R.J.10
-
96
-
-
0035723995
-
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism
-
Mazzali, M. et al. Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 38, 1101-1106 (2001). (Pubitemid 34252813)
-
(2001)
Hypertension
, vol.38
, Issue.5
, pp. 1101-1106
-
-
Mazzali, M.1
Hughes, J.2
Kim, Y.-G.3
Jefferson, J.A.4
Kang, D.-H.5
Gordon, K.L.6
Lan, H.Y.7
Kivlighn, S.8
Johnson, R.J.9
-
97
-
-
0036083844
-
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
-
Mazzali, M. et al. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am. J. Physiol. Renal Physiol. 282, F991-F997 (2002). (Pubitemid 34654464)
-
(2002)
American Journal of Physiology - Renal Physiology
, vol.282
, Issue.6
-
-
Mazzali, M.1
Kanellis, J.2
Han, L.3
Feng, L.4
Xia, Y.-Y.5
Chen, Q.6
Kang, D.-H.7
Gordon, K.L.8
Watanabe, S.9
Nakagawa, T.10
Lan, H.Y.11
Johnson, R.J.12
-
98
-
-
0037047070
-
Allopurinol improves endothelial dysfunction in chronic heart failure
-
DOI 10.1161/01.CIR.0000022140.61460.1D
-
Farquharson, C. A., Butler, R., Hill, A., Belch, J. J. & Struthers, A. D. Allopurinol improves endothelial dysfunction in chronic heart failure. Circulation 106, 221-226 (2002). (Pubitemid 34761303)
-
(2002)
Circulation
, vol.106
, Issue.2
, pp. 221-226
-
-
Farquharson, C.A.J.1
Butler, R.2
Hill, A.3
Belch, J.J.F.4
Struthers, A.D.5
-
99
-
-
84862776730
-
2+ exchanger-mediated mitochondrial calcium overload
-
2+ exchanger-mediated mitochondrial calcium overload. Cell Calcium 51, 402-410 (2012).
-
(2012)
Cell Calcium
, vol.51
, pp. 402-410
-
-
Hong, Q.1
-
100
-
-
84860470278
-
The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications
-
Puddu, P., Puddu, G. M., Cravero, E., Vizioli, L. & Muscari, A. The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: molecular mechanisms and clinical implications. J. Cardiol. 59, 235-242 (2012).
-
(2012)
J. Cardiol.
, vol.59
, pp. 235-242
-
-
Puddu, P.1
Puddu, G.M.2
Cravero, E.3
Vizioli, L.4
Muscari, A.5
-
101
-
-
57349084723
-
Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells
-
DOI 10.1152/ajpcell.00075.2008
-
Zharikov, S. et al. Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am. J. Physiol. Cell Physiol. 295, C1183-C1190 (2008). (Pubitemid 352790338)
-
(2008)
American Journal of Physiology - Cell Physiology
, vol.295
, Issue.5
-
-
Zharikov, S.1
Krotova, K.2
Hu, H.3
Baylis, C.4
Johnson, R.J.5
Block, E.R.6
Patel, J.7
-
102
-
-
33645560926
-
A causal role for uric acid in fructose-induced metabolic syndrome
-
DOI 10.1152/ajprenal.00140.2005
-
Nakagawa, T. et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am. J. Physiol. Renal Physiol. 290, F625-F631 (2006). (Pubitemid 43724964)
-
(2006)
American Journal of Physiology - Renal Physiology
, vol.290
, Issue.3
-
-
Nakagawa, T.1
Hu, H.2
Zharikov, S.3
Tuttle, K.R.4
Short, R.A.5
Glushakova, O.6
Ouyang, X.7
Feig, D.I.8
Block, E.R.9
Herrera-Acosta, J.10
Patel, J.M.11
Johnson, R.J.12
-
103
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
104
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361 (2010).
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
-
105
-
-
0031106185
-
Increased serum levels of interleukin-1β in the systemic circulation of patients with essential hypertension: Additional risk factor for atherogenesis in hypertensive patients?
-
Dalekos, G. N., Elisaf, M., Bairaktari, E., Tsolas, O. & Siamopoulos, K. C. Increased serum levels of interleukin-1β in the systemic circulation of patients with essential hypertension: additional risk factor for atherogenesis in hypertensive patients? J. Lab. Clin. Med. 129, 300-308 (1997). (Pubitemid 27169432)
-
(1997)
Journal of Laboratory and Clinical Medicine
, vol.129
, Issue.3
, pp. 300-308
-
-
Dalekos, G.N.1
Elisaf, M.2
Bairaktari, E.3
Tsolas, O.4
Siamopoulos, K.C.5
-
106
-
-
0029853147
-
Elevated interleukin-1β in the circulation of patients with essential hypertension before any drug therapy: A pilot study
-
Dalekos, G. N., Elisaf, M. S., Papagalanis, N., Tzallas, C. & Siamopoulos, K. C. Elevated interleukin-1β in the circulation of patients with essential hypertension before any drug therapy: a pilot study. Eur. J. Clin. Invest. 26, 936-939 (1996). (Pubitemid 26343786)
-
(1996)
European Journal of Clinical Investigation
, vol.26
, Issue.10
, pp. 936-939
-
-
Dalekos, G.N.1
Elisaf, M.S.2
Papagalanis, N.3
Tzallas, C.4
Siamopoulos, K.C.5
-
107
-
-
0035135886
-
Pro-inflammatory cytokines in patients with essential hypertension
-
DOI 10.1046/j.1365-2362.2001.00743.x
-
Peeters, A. C. et al. Pro-inflammatory cytokines in patients with essential hypertension. Eur. J. Clin. Invest. 31, 31-36 (2001). (Pubitemid 32151119)
-
(2001)
European Journal of Clinical Investigation
, vol.31
, Issue.1
, pp. 31-36
-
-
Peeters, A.C.T.M.1
Netea, M.G.2
Janssen, M.C.H.3
Kullberg, B.J.4
Van Der Meer, J.W.M.5
Thien, T.6
-
108
-
-
33646748459
-
Uric acid and inflammatory markers
-
Ruggiero, C. et al. Uric acid and inflammatory markers. Eur. Heart J. 27, 1174-1181 (2006).
-
(2006)
Eur. Heart J.
, vol.27
, pp. 1174-1181
-
-
Ruggiero, C.1
-
109
-
-
60749105826
-
High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles
-
Vekic, J. et al. High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles. Atherosclerosis 203, 236-242 (2009).
-
(2009)
Atherosclerosis
, vol.203
, pp. 236-242
-
-
Vekic, J.1
-
110
-
-
80051472381
-
Monosodium urate monohydrate crystals inhibit osteoblast viability and function: Implications for development of bone erosion in gout
-
Chhana, A. et al. Monosodium urate monohydrate crystals inhibit osteoblast viability and function: implications for development of bone erosion in gout. Ann. Rheum. Dis. 70, 1684-1691 (2011).
-
(2011)
Ann. Rheum. Dis.
, vol.70
, pp. 1684-1691
-
-
Chhana, A.1
-
111
-
-
78149484804
-
The pathogenesis of bone erosions in gouty arthritis
-
Schlesinger, N. & Thiele, R. G. The pathogenesis of bone erosions in gouty arthritis. Ann. Rheum. Dis. 69, 1907-1912 (2010).
-
(2010)
Ann. Rheum. Dis.
, vol.69
, pp. 1907-1912
-
-
Schlesinger, N.1
Thiele, R.G.2
-
112
-
-
34047174085
-
A pilot study of IL-1 inhibition by anakinra in acute gout
-
So, A., De Smedt, T., Revaz, S. & Tschopp, J. A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res. Ther. 9, R28 (2007).
-
(2007)
Arthritis Res. Ther.
, vol.9
-
-
So, A.1
De Smedt, T.2
Revaz, S.3
Tschopp, J.4
-
113
-
-
84857774498
-
Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: Results of a phase II randomized, double-blind, placebo-controlled trial
-
Schumacher, H. R. Jr. et al. Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 64, 876-884 (2012).
-
(2012)
Arthritis Rheum.
, vol.64
, pp. 876-884
-
-
Schumacher Jr., H.R.1
-
114
-
-
79957646006
-
Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: Results of a double-blind, randomised study
-
Schlesinger, N. et al. Canakinumab reduces the risk of acute gouty arthritis flares during initiation of allopurinol treatment: results of a double-blind, randomised study. Ann. Rheum. Dis. 70, 1264-1271 (2011).
-
(2011)
Ann. Rheum. Dis.
, vol.70
, pp. 1264-1271
-
-
Schlesinger, N.1
-
115
-
-
79953094557
-
Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat gouty arthritis by suppressing inflammation: Results of a randomized, dose-ranging study
-
Schlesinger, N. et al. Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat gouty arthritis by suppressing inflammation: results of a randomized, dose-ranging study. Arthritis Res. Ther. 13, R53 (2011).
-
(2011)
Arthritis Res. Ther.
, vol.13
-
-
Schlesinger, N.1
-
116
-
-
77957688721
-
Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study
-
So, A. et al. Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: results of a multicenter, phase II, dose-ranging study. Arthritis Rheum. 62, 3064-3076 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 3064-3076
-
-
So, A.1
-
117
-
-
0010324713
-
Immunological recognition of self
-
Burnet, F. M. Immunological recognition of self. Science 133, 307-311 (1961).
-
(1961)
Science
, vol.133
, pp. 307-311
-
-
Burnet, F.M.1
-
118
-
-
0033451923
-
Proteolysis and class I major histocompatibility complex antigen presentation
-
York, I. A., Goldberg, A. L., Mo, X. Y. & Rock, K. L. Proteolysis and class I major histocompatibility complex antigen presentation. Immunol. Rev. 172, 49-66 (1999). (Pubitemid 30000468)
-
(1999)
Immunological Reviews
, vol.172
, pp. 49-66
-
-
York, I.A.1
Goldberg, A.L.2
Mo, X.Y.3
Rock, K.L.4
-
119
-
-
0027468145
-
The biochemistry and cell biology and antigen processing and presentation
-
Germain, R. N. & Margulies, D. H. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11, 403-450 (1993). (Pubitemid 23115014)
-
(1993)
Annual Review of Immunology
, vol.11
, pp. 403-450
-
-
Germain, R.N.1
Margulies, D.H.2
-
120
-
-
77954240379
-
Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice
-
Hoffman, H. M. et al. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. Arthritis Rheum. 62, 2170-2179 (2010).
-
(2010)
Arthritis Rheum.
, vol.62
, pp. 2170-2179
-
-
Hoffman, H.M.1
-
121
-
-
70349379884
-
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
-
Torres, R. et al. Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis. Ann. Rheum. Dis 68, 1602-1608 (2009).
-
(2009)
Ann. Rheum. Dis
, vol.68
, pp. 1602-1608
-
-
Torres, R.1
-
122
-
-
47849132947
-
The NALP3 inflammasome is essential for the development of silicosis
-
Cassel, S. L. et al. The NALP3 inflammasome is essential for the development of silicosis. Proc. Natl Acad. Sci. USA 105, 9035-9040 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9035-9040
-
-
Cassel, S.L.1
-
123
-
-
80053320089
-
Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism
-
Palomaki, J. et al. Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism. ACS Nano 5, 6861-6870 (2011).
-
(2011)
ACS Nano
, vol.5
, pp. 6861-6870
-
-
Palomaki, J.1
-
124
-
-
77955356552
-
Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation
-
Rajamaki, K. et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS ONE 5, e11765 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Rajamaki, K.1
-
125
-
-
47849087075
-
Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
-
Li, H., Willingham, S. B., Ting, J. P. & Re, F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J. Immunol. 181, 17-21 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 17-21
-
-
Li, H.1
Willingham, S.B.2
Ting, J.P.3
Re, F.4
-
126
-
-
50849112477
-
The NLRP3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
-
Franchi, L. & Nunez, G. The NLRP3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity. Eur. J. Immunol. 38, 2085-2089 (2008).
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 2085-2089
-
-
Franchi, L.1
Nunez, G.2
-
127
-
-
56149119563
-
Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
-
Kool, M. et al. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol. 181, 3755-3759 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 3755-3759
-
-
Kool, M.1
-
128
-
-
79951846190
-
Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro
-
Pazar, B. et al. Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro. J. Immunol. 186, 2495-2502 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 2495-2502
-
-
Pazar, B.1
-
129
-
-
79551662979
-
Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice
-
Narayan, S. et al. Octacalcium phosphate crystals induce inflammation in vivo through interleukin-1 but independent of the NLRP3 inflammasome in mice. Arthritis Rheum. 63, 422-433 (2011).
-
(2011)
Arthritis Rheum.
, vol.63
, pp. 422-433
-
-
Narayan, S.1
-
130
-
-
80052581043
-
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
-
Jin, C. et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc. Natl Acad. Sci. USA 108, 14867-14872 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 14867-14872
-
-
Jin, C.1
-
131
-
-
78650610580
-
Nanoparticles activate the NLR pyrin domain containing 3 (NLRP3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
-
Yazdi, A. S. et al. Nanoparticles activate the NLR pyrin domain containing 3 (NLRP3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc. Natl Acad. Sci. USA 107, 19449-19454 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 19449-19454
-
-
Yazdi, A.S.1
|