Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus-mediated autoimmune diabetes

Journal of Clinical Investigation

Volumn 109, Issue 1, 2002, Pages 79-87

  Horwitz, Marc S ^a   Ilic, Alex ^a   Fine, Cody ^a   Rodriguez, Enrique ^a   Sarvetnick, Nora ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CELL SPECIFICITY; DIABETES MELLITUS; DIABETOGENESIS; IMMUNE RESPONSE; INFLAMMATORY CELL; MEMORY CELL; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION;

EID: 0036141519     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0211198     Document Type: Article

References (47)

1. Detection of coxsackie B virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus
2. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM
3. Susceptibility of mice to group B coxsackie virus is influenced by the diabetic gene
4. Virus-induced diabetes mellitus. XV. Beta cell damage and insulin-dependent hyperglycemia in mice infected with coxsackie virus B4
5. Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
6. Coxsackie virus-induced diabetes: Initiation by bystander damage and not molecular mimicry
7. Following a diabetogenic T cell from genesis through pathogenesis
8. Inhibition of diabetes in BB rats by virus infection
9. Prevention of type I diabetes in nonobese diabetic mice by virus infection
10. Massive expansion of antigen-specific CD8 T cells during acute virus infection
11. Bystander virus infection prolongs activated T cell survival
12. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
13. Induction of bystander T cell proliferation by viruses and type I interferon in vivo
14. Streptozotocin interactions with pancreatic β cells and the induction of insulin-dependent diabetes
15. New model of progressive non-insulin-dependent diabetes mellitus in mice induced by streptozotocin
16. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes
17. Predisposing effect of anti-beta cell autoimmune process in NOD mice on the induction of diabetes by environmental insults
18. Protection from lethal coxsackievirus-induced pancreatitis by expression of gamma interferon
19. Interleukin-4 acts at the locus of the antigen presenting dendritic cell to counter regulate cytotoxic CD8+ T cell responses
20. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice
21. Viruses and T cell turnover: Evidence for bystander proliferation
22. Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages
23. The role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice
24. Defective TCR expression in transgenic mice constructed using cDNA α and β chain genes under the control of heterologous regulatory elements
25. Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice
26. Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
27. Microglia stimulate naive T cell differentiation without stimulating T cell proliferation
28. Transport of peptide-MHC class II complexes in developing dendritic cells
29. Expression of two T cell receptor alpha chains: Dual receptor T cells
30. Expression of two T cell receptor alpha chains on the surface of normal murine T cells
31. T cells with dual antigen specificity in T cell receptor transgenic mice rejecting allografts
32. Triggering a second T cell receptor on diabetogenic T cells can prevent induction of diabetes
33. Requirements for viral-mediated autoimmune diabetes: β cell damage and immune infiltration
34. Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T cells in pancreatic islets
35. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repettoire
36. Major expansion of CD8-T cells with a predominant V beta usage during the primary immune response to HIV
37. In vivo longitudinal analysis of a dominant TCR repertoire selected in human response to influenza virus
38. Attrition of T cell memory: Selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
39. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations
40. Minimal bystander activation of CD8 T cells during the virus-induced polyclonal T cell response
41. Molecular mimicry by herpes simplex virus-type 1: Autoimmune disease after viral infection
42. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
43. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease
44. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
45. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition
46. Secondary immune amplification following live poliovirus immunization in humans
47. Molecular mimicry and autoimmune disease