Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

Arthritis and Rheumatism

Volumn 62, Issue 11, 2010, Pages 3237-3248

  Joosten, Leo A B ^a   Netea, Mihai G ^a   Mylona, Eleni ^a   Koenders, Marije I ^a   Malireddi, R K Subbarao ^b   Oosting, Marije ^a   Stienstra, Rinke ^a   Van De Veerdonk, Frank L ^a   Stalenhoef, Anton F ^a   Giamarellos Bourboulis, Evangelos J ^c   Kanneganti, Thirumala Devi ^b   Van Der Meer, Jos W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CRYOPYRIN; FATTY ACID; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; TOLL LIKE RECEPTOR 2; URATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GOUT; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; JOINT SWELLING; MACROPHAGE; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL;

ANIMALS; ARTHRITIS, GOUTY; CASPASE 1; CELLS, CULTURED; CYTOSKELETAL PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FATTY ACIDS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; KNEE JOINT; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TOLL-LIKE RECEPTOR 2; URIC ACID;

EID: 78249286865     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.27667     Document Type: Article

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