Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis

Journal of Clinical Investigation

Volumn 109, Issue 3, 2002, Pages 363-371

  Adkison, April M ^a   Raptis, Sofia Z ^a   Kelley, Diane G ^a   Pham, Christine T N ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Campus Box 8045 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; COLLAGEN TYPE 2; DIPEPTIDYL PEPTIDASE I; INTERLEUKIN 1BETA; LEUKOCYTE ELASTASE; MONOCLONAL ANTIBODY; MYELOBLASTIN; SERINE PROTEINASE; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN ANTIBODY COMPLEX; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOKINE PRODUCTION; DISEASE COURSE; ENZYME ACTIVATION; ENZYME INACTIVATION; HOST RESISTANCE; INFLAMMATION; INFLAMMATORY CELL; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PASSIVE IMMUNIZATION; PERITONITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE INJURY;

EID: 0036168150     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0213462     Document Type: Article

References (44)

1. Antimicrobial polypeptides of human neutrophils
2. Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses
3. Tissue destruction by neutrophils
4. Mechanisms of tissue damage by leukocytes
5. Serine proteinases of mast cell and leukocyte granules. A league of their own
6. Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: Defensins and azurocidin
7. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis
8. Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G
9. Cell surface-bound elastase and cathepsin G on human neutrophils: A novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteases
10. Alpha-1-proteinase inhibitor, anti-chymotrypsin, and a recombinant hybrid mutant of anti-chymotrypsin (LEX-032) modulate neutrophil adhesion interactions
11. Novel recombinant serpin, LEX-032, attenuates myocardial reperfusion injury in cats
12. Reperfusion-induced leukocyte infiltration: Role of elastase
13. Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels
14. Migration of neutrophils across human pulmonary endothelial cells is not blocked by matrix metalloproteinase or senne protease inhibitors
15. Disruption of subendothelial basement during neutrophil diapedesis in an in vitro construct of a blood vessel wall
16. More than destructive: Neutrophil-derived serine proteases in cytokine bioactivity control
17. Interleukin-18 and interleukin-1 beta: Two cytokine substrates for ICE (caspase-1)
18. Characterization of the tumor necrosis factor alpha-converting enzyme, TACE/ADAM17
19. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation
20. Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide
21. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
22. Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice
23. Normal neutrophil function in cathepsin G-deficient mice
24. The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system
25. A critical role for neutrophil elastase in experimental bullous pemphigoid
26. Collagen-induced arthritis in mice: Synergistic effect of E. coli lipopolysaccharide bypasses epitope specificity in the induction of arthritis with monoclonal antibodies to type II collagen
27. Passive transfer studies with type II collagen antibody in B10.D2/old and new line and C57B1/6 normal and beige (Chediak-Higashi) strains: Evidence of important roles for C5 and multiple inflammatory cell types in the development of erosive arthritis
28. Cytokine pathways and joint inflammation in rheumatoid arthritis
29. Zymosan modulates CD44 isoform expression in a murine model of inflammation resembling rheumatoid arthritis synovitis
30. Zymogen activation specificity and genomic structures of human neutrophil elastase and cathepsin G reveal a new branch of the chymotrypsinogen super family of serine proteases
31. Processing and targeting of granule proteins in human neutrophils
32. On the role of the proform-conformation for processing and intracellular sorting of human cathepsin G
33. Effect of alpha-1-proteinase inhibitor on neutrophil chemotaxis
34. The control of neutrophil chemotaxis by inhibition of cathepsin G and chymotrypsin
35. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1 beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
36. Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3
37. Amino-terminal processing of chemokine ENA-78 regulates biological activity
38. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line
39. Proteinase-3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro
40. Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness
41. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
42. Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD12, Mac-1, αMβ2) and modulates polymorphonuclear leukocyte adhesion
43. Proteolytic cleavage of ICAM-1 by human neutrophil elastase
44. Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor