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Volumn 71, Issue 3, 2011, Pages 298-305

Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin

Author keywords

Erucin; Glucoerucin; Glucoraphanin; Glucosinolates; Isothiocyanates; Sulforaphane

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ETHOXYRESORUFIN; ETHOXYRESORUFIN DEETHYLASE; GLUCOERUCIN; GLUCORAPHANIN; GLUCOSINOLATE; GLUTATHIONE TRANSFERASE; ISOTHIOCYANIC ACID DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); THIOGLUCOSIDASE; UNCLASSIFIED DRUG;

EID: 79851510819     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2010.06.015     Document Type: Article
Times cited : (46)

References (49)
  • 1
    • 34347326310 scopus 로고    scopus 로고
    • Lung cancer screening: current situation and perspective
    • Guessous I., Cornuz J., Paccaud F. Lung cancer screening: current situation and perspective. Swiss Med Wkly 2007, 137:304-311.
    • (2007) Swiss Med Wkly , vol.137 , pp. 304-311
    • Guessous, I.1    Cornuz, J.2    Paccaud, F.3
  • 4
    • 17844392872 scopus 로고    scopus 로고
    • Dietary intake of cruciferous vegetables, glutathiones S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population
    • Wang L.I., Giovannucci E.L., Hunter D., Neuberg D., Su L., Christiani D.C. Dietary intake of cruciferous vegetables, glutathiones S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population. Cancer Causes Control 2004, 15:977-985.
    • (2004) Cancer Causes Control , vol.15 , pp. 977-985
    • Wang, L.I.1    Giovannucci, E.L.2    Hunter, D.3    Neuberg, D.4    Su, L.5    Christiani, D.C.6
  • 5
    • 0034798401 scopus 로고    scopus 로고
    • Dietary isothiocyanates, glutathione S-transferase-M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore
    • Zhao B., Seow A., Lee E.J., Poh W.T., The M., Eng P., et al. Dietary isothiocyanates, glutathione S-transferase-M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiol Biomarkers Prev 2001, 10:1063-1067.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 1063-1067
    • Zhao, B.1    Seow, A.2    Lee, E.J.3    Poh, W.T.4    The, M.5    Eng, P.6
  • 6
    • 0033789926 scopus 로고    scopus 로고
    • Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk
    • Spitz M.R., Duphorne C.M., Detry M.A., Pillow P.C., Amos C.I., Lei L., et al. Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiol Biomarkers Prev 2000, 9:1017-1020.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 1017-1020
    • Spitz, M.R.1    Duphorne, C.M.2    Detry, M.A.3    Pillow, P.C.4    Amos, C.I.5    Lei, L.6
  • 7
    • 0034718294 scopus 로고    scopus 로고
    • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China
    • London S.J., Yuan J.M., Chung F.L., Gao Y.T., Coetzee G.A., Ross R.K., et al. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 2000, 356:724-729.
    • (2000) Lancet , vol.356 , pp. 724-729
    • London, S.J.1    Yuan, J.M.2    Chung, F.L.3    Gao, Y.T.4    Coetzee, G.A.5    Ross, R.K.6
  • 8
    • 0037058628 scopus 로고    scopus 로고
    • Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung
    • Hecht S.S., Kenney P.M., Wang M., Upadhyaya P. Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. Cancer Lett 2002, 187:87-94.
    • (2002) Cancer Lett , vol.187 , pp. 87-94
    • Hecht, S.S.1    Kenney, P.M.2    Wang, M.3    Upadhyaya, P.4
  • 9
    • 0029812570 scopus 로고    scopus 로고
    • Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate
    • Hecht S.S., Trushin N., Rigotty J., Carmella S.G., Borukhova A., Akerkar S., et al. Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate. Cancer Epidemiol Biomarkers Prev 1996, 5:645-652.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 645-652
    • Hecht, S.S.1    Trushin, N.2    Rigotty, J.3    Carmella, S.G.4    Borukhova, A.5    Akerkar, S.6
  • 10
    • 0030038193 scopus 로고    scopus 로고
    • Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats
    • Chung F.L., Kelloff G., Steele V., Pittman B., Zang E., Jiao D., et al. Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats. Cancer Res 1996, 56:772-778.
    • (1996) Cancer Res , vol.56 , pp. 772-778
    • Chung, F.L.1    Kelloff, G.2    Steele, V.3    Pittman, B.4    Zang, E.5    Jiao, D.6
  • 11
    • 0023616165 scopus 로고
    • Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice
    • Wattenberg L.W. Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. Carcinogenesis 1987, 8:1971-1973.
    • (1987) Carcinogenesis , vol.8 , pp. 1971-1973
    • Wattenberg, L.W.1
  • 12
    • 0027517761 scopus 로고
    • Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumour models
    • Lin J.M., Amin S., Trushin N., Hecht S.S. Effects of isothiocyanates on tumorigenesis by benzo[a]pyrene in murine tumour models. Cancer Lett 1993, 74:151-159.
    • (1993) Cancer Lett , vol.74 , pp. 151-159
    • Lin, J.M.1    Amin, S.2    Trushin, N.3    Hecht, S.S.4
  • 13
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • Conaway C.C., Wang C.X., Pittman B., Yang Y.M., Schwartz J.E., Tian D., et al. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res 2005, 65:8548-8557.
    • (2005) Cancer Res , vol.65 , pp. 8548-8557
    • Conaway, C.C.1    Wang, C.X.2    Pittman, B.3    Yang, Y.M.4    Schwartz, J.E.5    Tian, D.6
  • 14
    • 26444561456 scopus 로고    scopus 로고
    • Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity
    • Yoxall V., Kentish P., Coldham N., Kuhnert N., Sauer M.J., Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. Int J Cancer 2005, 117:356-362.
    • (2005) Int J Cancer , vol.117 , pp. 356-362
    • Yoxall, V.1    Kentish, P.2    Coldham, N.3    Kuhnert, N.4    Sauer, M.J.5    Ioannides, C.6
  • 15
    • 52649162392 scopus 로고    scopus 로고
    • Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane
    • Hanlon N., Okpara M., Coldham N., Sauer M.J., Ioannides C. Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane. J Agric Food Chem 2008, 56:7866-7871.
    • (2008) J Agric Food Chem , vol.56 , pp. 7866-7871
    • Hanlon, N.1    Okpara, M.2    Coldham, N.3    Sauer, M.J.4    Ioannides, C.5
  • 16
    • 55949121573 scopus 로고    scopus 로고
    • Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate
    • Konsue N., Ioannides C. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate. Food Chem Toxicol 2008, 46:3677-3683.
    • (2008) Food Chem Toxicol , vol.46 , pp. 3677-3683
    • Konsue, N.1    Ioannides, C.2
  • 17
    • 53249140296 scopus 로고    scopus 로고
    • Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane
    • Hanlon N., Coldham N., Sauer M.J., Ioannides C. Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane. Toxicology 2008, 252:92-98.
    • (2008) Toxicology , vol.252 , pp. 92-98
    • Hanlon, N.1    Coldham, N.2    Sauer, M.J.3    Ioannides, C.4
  • 18
    • 57649184041 scopus 로고    scopus 로고
    • Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane
    • Hanlon N., Coldham N., Sauer M.J., Ioannides C. Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane. Chem-Biol Inter 2009, 177:115-120.
    • (2009) Chem-Biol Inter , vol.177 , pp. 115-120
    • Hanlon, N.1    Coldham, N.2    Sauer, M.J.3    Ioannides, C.4
  • 19
    • 68149167105 scopus 로고    scopus 로고
    • The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H: quinone oxidoreductase (NQO1) in human liver compared with rat
    • Hanlon N., Poynton C.L., Coldham N., Sauer M.J., Ioannides C. The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H: quinone oxidoreductase (NQO1) in human liver compared with rat. Mol Nutr Food Res 2009, 53:836-844.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 836-844
    • Hanlon, N.1    Poynton, C.L.2    Coldham, N.3    Sauer, M.J.4    Ioannides, C.5
  • 20
    • 76749135648 scopus 로고    scopus 로고
    • Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables
    • Konsue N., Ioannides C. Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables. Toxicology 2010, 268:184-190.
    • (2010) Toxicology , vol.268 , pp. 184-190
    • Konsue, N.1    Ioannides, C.2
  • 21
    • 79952196644 scopus 로고    scopus 로고
    • Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate
    • in press.
    • Konsue N, Ioannides C. Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate. Mol Nutr Food Res; in press.
    • Mol Nutr Food Res.
    • Konsue, N.1    Ioannides, C.2
  • 22
    • 34247626240 scopus 로고    scopus 로고
    • The metabolic fate of purified glucoraphanin in F344 rats
    • Bheemreddy R.M., Jeffery E.H. The metabolic fate of purified glucoraphanin in F344 rats. J Agric Food Chem 2007, 55:2861-2866.
    • (2007) J Agric Food Chem , vol.55 , pp. 2861-2866
    • Bheemreddy, R.M.1    Jeffery, E.H.2
  • 23
    • 8444237430 scopus 로고    scopus 로고
    • Metabolic and structural viability of precision-cut rat lung slices in culture
    • Umachandran M., Howarth J., Ioannides C. Metabolic and structural viability of precision-cut rat lung slices in culture. Xenobiotica 2004, 34:771-780.
    • (2004) Xenobiotica , vol.34 , pp. 771-780
    • Umachandran, M.1    Howarth, J.2    Ioannides, C.3
  • 24
    • 33745203083 scopus 로고    scopus 로고
    • Stability of cytochromes P450 and phase II conjugation systems in precision-cut lung slices cultured up to 72h
    • Umachandran M., Ioannides C. Stability of cytochromes P450 and phase II conjugation systems in precision-cut lung slices cultured up to 72h. Toxicology 2006, 224:14-21.
    • (2006) Toxicology , vol.224 , pp. 14-21
    • Umachandran, M.1    Ioannides, C.2
  • 25
    • 0034676501 scopus 로고    scopus 로고
    • Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology
    • Lerche-Langrand C., Toutain H.J. Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 2000, 153:221-253.
    • (2000) Toxicology , vol.153 , pp. 221-253
    • Lerche-Langrand, C.1    Toutain, H.J.2
  • 26
    • 0036401287 scopus 로고    scopus 로고
    • Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung
    • Hukkanen J., Pelkonen O., Hakkola J., Raunio H. Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung. Crit Rev Toxicol 2002, 32:391-411.
    • (2002) Crit Rev Toxicol , vol.32 , pp. 391-411
    • Hukkanen, J.1    Pelkonen, O.2    Hakkola, J.3    Raunio, H.4
  • 27
    • 33846844804 scopus 로고    scopus 로고
    • Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities
    • Pushparajah D.S., Umachandran M., Plant K.E., Plant N., Ioannides C. Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology 2007, 231:68-80.
    • (2007) Toxicology , vol.231 , pp. 68-80
    • Pushparajah, D.S.1    Umachandran, M.2    Plant, K.E.3    Plant, N.4    Ioannides, C.5
  • 28
    • 0001923588 scopus 로고
    • Isolation and Identification of trans-4-(methylthio)-3-butenyl-glucosinolate from radish roots (Raphanus sativus L.)
    • Visentin M, Tava A., Iori R., Palmieri S. Isolation and Identification of trans-4-(methylthio)-3-butenyl-glucosinolate from radish roots (Raphanus sativus L.). J Agric Food Chem 1992, 40:1687-1691.
    • (1992) J Agric Food Chem , vol.40 , pp. 1687-1691
    • Visentin, M.1    Tava, A.2    Iori, R.3    Palmieri, S.4
  • 29
    • 74949124720 scopus 로고    scopus 로고
    • Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture
    • Wagner A.E., Ernst I., Iori R., Desel C., Rimbach G. Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture. Exp Dermatol 2010, 19:137-144.
    • (2010) Exp Dermatol , vol.19 , pp. 137-144
    • Wagner, A.E.1    Ernst, I.2    Iori, R.3    Desel, C.4    Rimbach, G.5
  • 30
    • 79851508536 scopus 로고
    • EEC Regulation 1864/90, Enclosure VIII.
    • EEC Regulation 1864/90, Enclosure VIII. Off J Eur Communities 1990;L170:27-34.
    • (1990) Off J Eur Communities. , vol.220 , pp. 27-34
  • 31
    • 0025359610 scopus 로고
    • An improved method for the purification of myrosinase and its physicochemical characterization
    • Pessina A., Thomas R.M., Palmieri S., Luisi P.L. An improved method for the purification of myrosinase and its physicochemical characterization. Arch Biochem Biophys 1990, 280:383-389.
    • (1990) Arch Biochem Biophys , vol.280 , pp. 383-389
    • Pessina, A.1    Thomas, R.M.2    Palmieri, S.3    Luisi, P.L.4
  • 32
    • 0016333916 scopus 로고
    • Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
    • Burke M.D., Mayer R.T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Met Disp 1974, 2:583-588.
    • (1974) Drug Met Disp , vol.2 , pp. 583-588
    • Burke, M.D.1    Mayer, R.T.2
  • 33
    • 0023930873 scopus 로고
    • Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers
    • Prohaska H.J., Santamaria A.B. Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal Biochem 1988, 169:328-336.
    • (1988) Anal Biochem , vol.169 , pp. 328-336
    • Prohaska, H.J.1    Santamaria, A.B.2
  • 34
    • 0016275313 scopus 로고
    • Glutathione S-transferase, the first enzymic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferase, the first enzymic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
    • (1974) J Biol Chem , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 35
    • 0019740345 scopus 로고
    • Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples
    • Akerboom T.P.H., Sies H. Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples. Meth Enzymol 1981, 7:373-382.
    • (1981) Meth Enzymol , vol.7 , pp. 373-382
    • Akerboom, T.P.H.1    Sies, H.2
  • 36
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 37
    • 33244477386 scopus 로고    scopus 로고
    • Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver
    • Perocco P., Bronzetti G., Canistro D., Valgimigli L., Sapone A., Affatato A., et al. Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. Mut Res 2006, 595:125-136.
    • (2006) Mut Res , vol.595 , pp. 125-136
    • Perocco, P.1    Bronzetti, G.2    Canistro, D.3    Valgimigli, L.4    Sapone, A.5    Affatato, A.6
  • 38
    • 9144244213 scopus 로고    scopus 로고
    • Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli
    • Paolini M., Perocco P., Canistro D., Vaglimigli K., Pedulli F., Iori R., et al. Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli. Carcinogenesis 2004, 25:61-67.
    • (2004) Carcinogenesis , vol.25 , pp. 61-67
    • Paolini, M.1    Perocco, P.2    Canistro, D.3    Vaglimigli, K.4    Pedulli, F.5    Iori, R.6
  • 40
    • 0032948428 scopus 로고    scopus 로고
    • Conversion of isothiocyanates in humans after ingestion of cooked watercress
    • Getahun S.M., Chung F.-L. Conversion of isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol Biomarkers Prev 1999, 8:447-451.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 447-451
    • Getahun, S.M.1    Chung, F.-L.2
  • 41
    • 3042783575 scopus 로고    scopus 로고
    • A critical review of the bioavailability of glucosinolates and related compounds
    • Holst B., Williamson G. A critical review of the bioavailability of glucosinolates and related compounds. Nat Prod Rep 2004, 21:425-447.
    • (2004) Nat Prod Rep , vol.21 , pp. 425-447
    • Holst, B.1    Williamson, G.2
  • 42
    • 79851516519 scopus 로고    scopus 로고
    • Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450
    • Arch Toxicol; in press.
    • Konsue C, Ioannides C. Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450. Arch Toxicol; in press.
    • Konsue, C.1    Ioannides, C.2
  • 43
    • 0032923785 scopus 로고    scopus 로고
    • Induction of cytochrome P4501A1
    • Whitlock J.P. Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 1999, 39:103-125.
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 103-125
    • Whitlock, J.P.1
  • 44
    • 0027055359 scopus 로고
    • Effect of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats
    • Guo Z., Smith T.J., Wang E., Sadrieh N., Ma Q., Thomas P.E., et al. Effect of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. Carcinogenesis 1992, 13:2205-2210.
    • (1992) Carcinogenesis , vol.13 , pp. 2205-2210
    • Guo, Z.1    Smith, T.J.2    Wang, E.3    Sadrieh, N.4    Ma, Q.5    Thomas, P.E.6
  • 46
    • 0022332393 scopus 로고
    • Differential activities of rat and human lung glutathione S-transferase isoenzymes towards benzo(a)pyrene epoxides
    • Awasthi Y.C., Singh S.V., Das M., Mukhtar H. Differential activities of rat and human lung glutathione S-transferase isoenzymes towards benzo(a)pyrene epoxides. Biochem Biophys Res Commun 1985, 133:863-867.
    • (1985) Biochem Biophys Res Commun , vol.133 , pp. 863-867
    • Awasthi, Y.C.1    Singh, S.V.2    Das, M.3    Mukhtar, H.4
  • 47
    • 10844224317 scopus 로고    scopus 로고
    • Cytochromes P450 in the bioactivation of chemicals
    • Ioannides C., Lewis D.F.V. Cytochromes P450 in the bioactivation of chemicals. Curr Topics Medicin Chem 2004, 4:1767-1788.
    • (2004) Curr Topics Medicin Chem , vol.4 , pp. 1767-1788
    • Ioannides, C.1    Lewis, D.F.V.2
  • 48
    • 0035930896 scopus 로고    scopus 로고
    • Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased BaP-DNA adducts
    • Uno S., Dalton D.P., Shertzer H.G., Gentet M.B., Warshawsky D., Talaska G., et al. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased BaP-DNA adducts. Biochem Biophys Res Commun 2001, 289:1049-1056.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 1049-1056
    • Uno, S.1    Dalton, D.P.2    Shertzer, H.G.3    Gentet, M.B.4    Warshawsky, D.5    Talaska, G.6
  • 49
    • 2142695286 scopus 로고    scopus 로고
    • Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important in metabolic activation
    • Uno S., Dalton D.P., Derkenne S., Curran C.P., Miller M.L., Shertzer H.G., et al. Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important in metabolic activation. Mol Pharmacol 2004, 65:1225-1237.
    • (2004) Mol Pharmacol , vol.65 , pp. 1225-1237
    • Uno, S.1    Dalton, D.P.2    Derkenne, S.3    Curran, C.P.4    Miller, M.L.5    Shertzer, H.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.