메뉴 건너뛰기




Volumn 252, Issue 1-3, 2008, Pages 92-98

Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane

Author keywords

Chemoprevention; Cytochrome P450; Erucin; Isothiocyanates; Precision cut slices; Sulforaphane

Indexed keywords

APOPROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 3A4; ERUCIN; ISOTHIOCYANIC ACID; PENTOXYRESORUFIN; SULFORAPHANE;

EID: 53249140296     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.08.002     Document Type: Article
Times cited : (27)

References (53)
  • 1
    • 2442587889 scopus 로고    scopus 로고
    • Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, but is not modified by GST genotype
    • Ambrosone C.B., McCann S.E., Freudenheim J.L., Marshall J.R., Zhang Y., and Shields P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, but is not modified by GST genotype. J. Nutr. 134 (2004) 1134-1138
    • (2004) J. Nutr. , vol.134 , pp. 1134-1138
    • Ambrosone, C.B.1    McCann, S.E.2    Freudenheim, J.L.3    Marshall, J.R.4    Zhang, Y.5    Shields, P.G.6
  • 2
    • 0028787561 scopus 로고
    • Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus
    • Ayalogu E.O., Snelling J., Lewis D.F.V., Talwar S., Clifford M.N., and Ioannides C. Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus. Biochim. Biophys. Acta 1272 (1995) 89-94
    • (1995) Biochim. Biophys. Acta , vol.1272 , pp. 89-94
    • Ayalogu, E.O.1    Snelling, J.2    Lewis, D.F.V.3    Talwar, S.4    Clifford, M.N.5    Ioannides, C.6
  • 3
    • 0029879994 scopus 로고    scopus 로고
    • CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane
    • Barcelo S., Gardiner J.M., Gescher A., and Chipman J.K. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis 17 (1996) 277-282
    • (1996) Carcinogenesis , vol.17 , pp. 277-282
    • Barcelo, S.1    Gardiner, J.M.2    Gescher, A.3    Chipman, J.K.4
  • 4
    • 16444380015 scopus 로고    scopus 로고
    • Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts
    • Barillari J., Canistro D., Paolini M., Ferroni F., Pedulli G.F., Iori R., and Valgimigli L. Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts. J. Agric. Food Chem. 53 (2005) 2475-2482
    • (2005) J. Agric. Food Chem. , vol.53 , pp. 2475-2482
    • Barillari, J.1    Canistro, D.2    Paolini, M.3    Ferroni, F.4    Pedulli, G.F.5    Iori, R.6    Valgimigli, L.7
  • 5
    • 34247626240 scopus 로고    scopus 로고
    • The metabolic fate of purified glucoraphanin in F344 rats
    • Bheemreddy R.M., and Jeffery E.H. The metabolic fate of purified glucoraphanin in F344 rats. J. Agric. Food Chem. 55 (2007) 2861-2866
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 2861-2866
    • Bheemreddy, R.M.1    Jeffery, E.H.2
  • 6
    • 0028897335 scopus 로고
    • Induction, binding to the hepatic aromatic hydrocarbon receptor and mutagenicity of a series of 11-alkoxy cyclopenta[a]phenanthren-17-ones: a structure activity relationship
    • Boyd G.W., Coombs M.M., and Ioannides C. Induction, binding to the hepatic aromatic hydrocarbon receptor and mutagenicity of a series of 11-alkoxy cyclopenta[a]phenanthren-17-ones: a structure activity relationship. Toxicology 95 (1995) 27-35
    • (1995) Toxicology , vol.95 , pp. 27-35
    • Boyd, G.W.1    Coombs, M.M.2    Ioannides, C.3
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0016333916 scopus 로고
    • Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
    • Burke M.D., and Mayer R.T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2 (1974) 583-588
    • (1974) Drug Metab. Dispos. , vol.2 , pp. 583-588
    • Burke, M.D.1    Mayer, R.T.2
  • 9
    • 0020601426 scopus 로고
    • Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal and cytochrome P450 binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins)
    • Burke M.D., and Mayer R.T. Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal and cytochrome P450 binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins). Chem. Biol. Interact. 45 (1983) 243-258
    • (1983) Chem. Biol. Interact. , vol.45 , pp. 243-258
    • Burke, M.D.1    Mayer, R.T.2
  • 10
    • 0027254216 scopus 로고
    • Mutagenicity of chrysene, its methyl and benzo derivatives, and their interactions with cytochromes P-450 and the Ah-receptor; relevance to their carcinogenic potency
    • Cheung Y.L., Gray T.J., and Ioannides C. Mutagenicity of chrysene, its methyl and benzo derivatives, and their interactions with cytochromes P-450 and the Ah-receptor; relevance to their carcinogenic potency. Toxicology 81 (1993) 69-86
    • (1993) Toxicology , vol.81 , pp. 69-86
    • Cheung, Y.L.1    Gray, T.J.2    Ioannides, C.3
  • 11
    • 0030201065 scopus 로고    scopus 로고
    • Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity
    • Cheung Y.-L., Snelling J., Mohammed N.N.D., Gray T.J.B., and Ioannides C. Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity. Toxicol. Appl. Pharmacol. 139 (1996) 203-211
    • (1996) Toxicol. Appl. Pharmacol. , vol.139 , pp. 203-211
    • Cheung, Y.-L.1    Snelling, J.2    Mohammed, N.N.D.3    Gray, T.J.B.4    Ioannides, C.5
  • 12
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung F.-L., Conaway C.C., Rao C.V., and Reddy B.S. Chemoprevention of aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21 (2000) 2287-2291
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.-L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 13
    • 0029801147 scopus 로고    scopus 로고
    • Inhibition of rat liver cytochrome P450 enzymes by isothiocyanates and their conjugates: a structure-activity relationship study
    • Conaway C.C., Jiao D., and Chung F.L. Inhibition of rat liver cytochrome P450 enzymes by isothiocyanates and their conjugates: a structure-activity relationship study. Carcinogenesis 17 (1996) 2423-2427
    • (1996) Carcinogenesis , vol.17 , pp. 2423-2427
    • Conaway, C.C.1    Jiao, D.2    Chung, F.L.3
  • 14
    • 0035987188 scopus 로고    scopus 로고
    • Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans
    • Conaway C.C., Yang Y.-m., and Chung F.-L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr. Drug Metab. 3 (2002) 233-255
    • (2002) Curr. Drug Metab. , vol.3 , pp. 233-255
    • Conaway, C.C.1    Yang, Y.-m.2    Chung, F.-L.3
  • 15
    • 0038768712 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
    • Denison M.S., and Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 309-334
    • (2003) Annu. Rev. Pharmacol. Toxicol. , vol.43 , pp. 309-334
    • Denison, M.S.1    Nagy, S.R.2
  • 17
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • Fahey J.W., Haristoy X., Dolan P.M., Kensler T.W., Scholtus I., Stephenson K.K., Talalay P., and Lozniewski A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. 99 (2002) 7610-7615
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3    Kensler, T.W.4    Scholtus, I.5    Stephenson, K.K.6    Talalay, P.7    Lozniewski, A.8
  • 18
    • 0035204635 scopus 로고    scopus 로고
    • Effects of benzyl iosothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1
    • Goosen T.C., Mills D.E., and Hollenberg P.F. Effects of benzyl iosothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1. J. Pharmacol. Exp. Ther. 296 (2001) 198-206
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 198-206
    • Goosen, T.C.1    Mills, D.E.2    Hollenberg, P.F.3
  • 19
    • 38949204895 scopus 로고    scopus 로고
    • Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat
    • Hanlon N., Coldham N., Gielbert A., Kuhnert N., Sauer M.J., King L.J., and Ioannides C. Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. Br. J. Nutr. 99 (2008) 559-564
    • (2008) Br. J. Nutr. , vol.99 , pp. 559-564
    • Hanlon, N.1    Coldham, N.2    Gielbert, A.3    Kuhnert, N.4    Sauer, M.J.5    King, L.J.6    Ioannides, C.7
  • 20
    • 53249092385 scopus 로고    scopus 로고
    • Hanlon, N., Okpara, A., Coldham, N., Sauer, M.J., Ioannides, C. Modulation of rat hepatic and pulmonary cytochromes P450 and other xenobiotic-metabolising enzyme systems by the isothiocyanate erucin, a metabolite of sulforaphane. J. Agric. Food Chem., in press.
    • Hanlon, N., Okpara, A., Coldham, N., Sauer, M.J., Ioannides, C. Modulation of rat hepatic and pulmonary cytochromes P450 and other xenobiotic-metabolising enzyme systems by the isothiocyanate erucin, a metabolite of sulforaphane. J. Agric. Food Chem., in press.
  • 21
    • 53249155137 scopus 로고    scopus 로고
    • Hanlon, N., Poynton, C.L., Coldham, N., Sauer, M.J., Ioannides, C. The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate quinone reductase in human liver compared with rat. Mol. Nutr. Food Res., in press.
    • Hanlon, N., Poynton, C.L., Coldham, N., Sauer, M.J., Ioannides, C. The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate quinone reductase in human liver compared with rat. Mol. Nutr. Food Res., in press.
  • 23
    • 0032973226 scopus 로고    scopus 로고
    • Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures
    • Hashemi E., Dobrota M., Till C., and Ioannides C. Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures. Xenobiotica 29 (1999) 11-25
    • (1999) Xenobiotica , vol.29 , pp. 11-25
    • Hashemi, E.1    Dobrota, M.2    Till, C.3    Ioannides, C.4
  • 24
    • 0034538640 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by isothiocyanates
    • Hecht S.S. Inhibition of carcinogenesis by isothiocyanates. Drug Metab. Rev. 32 (2000) 395-411
    • (2000) Drug Metab. Rev. , vol.32 , pp. 395-411
    • Hecht, S.S.1
  • 26
    • 10844224317 scopus 로고    scopus 로고
    • Cytochromes P450 in the bioactivation of chemicals
    • Ioannides C., and Lewis D.F.V. Cytochromes P450 in the bioactivation of chemicals. Curr. Topics Med. Chem. 4 (2004) 1767-1788
    • (2004) Curr. Topics Med. Chem. , vol.4 , pp. 1767-1788
    • Ioannides, C.1    Lewis, D.F.V.2
  • 27
    • 0025313982 scopus 로고
    • The cytochrome P450 I gene family of microsomal haemoproteins and their role in the metabolic activation of chemicals
    • Ioannides C., and Parke D.V. The cytochrome P450 I gene family of microsomal haemoproteins and their role in the metabolic activation of chemicals. Drug Metab. Rev. 22 (1990) 1-85
    • (1990) Drug Metab. Rev. , vol.22 , pp. 1-85
    • Ioannides, C.1    Parke, D.V.2
  • 29
    • 0030781225 scopus 로고    scopus 로고
    • Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates
    • Kassahun K., Davis M., Hu P., Martin B., and Baillie T. Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat: identification of phase I metabolites and glutathione conjugates. Chem. Res. Toxicol. 10 (1997) 1228-1233
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 1228-1233
    • Kassahun, K.1    Davis, M.2    Hu, P.3    Martin, B.4    Baillie, T.5
  • 30
    • 53249090573 scopus 로고    scopus 로고
    • Konsue, N., Ioannides, C. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate, Food Chem. Toxicol., in Press.
    • Konsue, N., Ioannides, C. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate, Food Chem. Toxicol., in Press.
  • 33
    • 0029909016 scopus 로고    scopus 로고
    • Enzyme induction and comparative oxidative desulfuration of isothiocyanates to isocyanates
    • Lee M.-S. Enzyme induction and comparative oxidative desulfuration of isothiocyanates to isocyanates. Chem. Res. Toxicol. 9 (1996) 1072-1078
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 1072-1078
    • Lee, M.-S.1
  • 34
    • 0034676501 scopus 로고    scopus 로고
    • Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology
    • Lerche-Langrand C., and Toutain H.J. Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153 (2000) 221-253
    • (2000) Toxicology , vol.153 , pp. 221-253
    • Lerche-Langrand, C.1    Toutain, H.J.2
  • 36
    • 0022521078 scopus 로고
    • Molecular dimensions of the substrate binding site of cytochrome P-448
    • Lewis D.F.V., Ioannides C., and Parke D.V. Molecular dimensions of the substrate binding site of cytochrome P-448. Biochem. Pharmacol. 35 (1986) 2179-2185
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 2179-2185
    • Lewis, D.F.V.1    Ioannides, C.2    Parke, D.V.3
  • 37
    • 0023553590 scopus 로고
    • Structural requirements for substrates of cytochromes P-450 and P-448
    • Lewis D.F.V., Ioannides C., and Parke D.V. Structural requirements for substrates of cytochromes P-450 and P-448. Chem. Biol. Interact. 64 (1987) 39-60
    • (1987) Chem. Biol. Interact. , vol.64 , pp. 39-60
    • Lewis, D.F.V.1    Ioannides, C.2    Parke, D.V.3
  • 39
    • 0034718294 scopus 로고    scopus 로고
    • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung cancer risk: a prospective study in Shanghai, China
    • London S.J., Yuan J.M., Chung F.L., Gao Y.T., Coetzee G.A., Ross R.K., and Yu M.C. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung cancer risk: a prospective study in Shanghai, China. Lancet 356 (2000) 724-729
    • (2000) Lancet , vol.356 , pp. 724-729
    • London, S.J.1    Yuan, J.M.2    Chung, F.L.3    Gao, Y.T.4    Coetzee, G.A.5    Ross, R.K.6    Yu, M.C.7
  • 40
    • 0022350885 scopus 로고
    • Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in the rat
    • Lubet R.A., Mayer R.T., Cameron J.W., Nims R.N., Burke M.D., Wolf T., and Guengerich F. Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238 (1985) 43-48
    • (1985) Arch. Biochem. Biophys. , vol.238 , pp. 43-48
    • Lubet, R.A.1    Mayer, R.T.2    Cameron, J.W.3    Nims, R.N.4    Burke, M.D.5    Wolf, T.6    Guengerich, F.7
  • 41
    • 0035909494 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated activity of mutagemic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay
    • Machala M., Vondracek J., Blaha L., Ciganek M., and Neca J. Aryl hydrocarbon receptor-mediated activity of mutagemic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay. Mutat. Res. 497 (2001) 49-62
    • (2001) Mutat. Res. , vol.497 , pp. 49-62
    • Machala, M.1    Vondracek, J.2    Blaha, L.3    Ciganek, M.4    Neca, J.5
  • 42
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochrome P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes
    • Maheo K., Morel F., Langouët S., Kramer H., Le Ferrec E., Ketterer B., and Guillouzo A. Inhibition of cytochrome P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 57 (1997) 3649-3652
    • (1997) Cancer Res. , vol.57 , pp. 3649-3652
    • Maheo, K.1    Morel, F.2    Langouët, S.3    Kramer, H.4    Le Ferrec, E.5    Ketterer, B.6    Guillouzo, A.7
  • 44
    • 33846844804 scopus 로고    scopus 로고
    • Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities
    • Pushparajah D.S., Umachandran M., Plant K.E., Plant N., and Ioannides C. Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology 231 (2007) 68-80
    • (2007) Toxicology , vol.231 , pp. 68-80
    • Pushparajah, D.S.1    Umachandran, M.2    Plant, K.E.3    Plant, N.4    Ioannides, C.5
  • 45
    • 37249077516 scopus 로고    scopus 로고
    • Up-regulation of CYP1A/B in rat lung and liver, and human precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size
    • Pushparajah D.S., Umachandran M., Nazir T., Plant K.E., Plant N., Lewis D.F.V., and Ioannides C. Up-regulation of CYP1A/B in rat lung and liver, and human precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Toxicol. In Vitro 22 (2008) 128-145
    • (2008) Toxicol. In Vitro , vol.22 , pp. 128-145
    • Pushparajah, D.S.1    Umachandran, M.2    Nazir, T.3    Plant, K.E.4    Plant, N.5    Lewis, D.F.V.6    Ioannides, C.7
  • 46
    • 35448932349 scopus 로고    scopus 로고
    • Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse
    • Shen G., Khor T.O., Hu R., Yu S., Nair S., Ho C.T., Reddy B.S., Huang M.T., Newmark H.L., and Kong A.N. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res. 67 (2007) 9937-9944
    • (2007) Cancer Res. , vol.67 , pp. 9937-9944
    • Shen, G.1    Khor, T.O.2    Hu, R.3    Yu, S.4    Nair, S.5    Ho, C.T.6    Reddy, B.S.7    Huang, M.T.8    Newmark, H.L.9    Kong, A.N.10
  • 47
    • 0031426310 scopus 로고    scopus 로고
    • Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1
    • Shu L., and Hollenberg P.F. Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1. Carcinogenesis 18 (1997) 801-810
    • (1997) Carcinogenesis , vol.18 , pp. 801-810
    • Shu, L.1    Hollenberg, P.F.2
  • 49
    • 0035987896 scopus 로고    scopus 로고
    • Cytochrome P450 fluorimetric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4
    • Stresser D.M., Turner S.D., Blanchard A.P., Miller V.P., and Crespi C.L. Cytochrome P450 fluorimetric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4. Drug Metab. Dispos. 30 (2002) 845-852
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 845-852
    • Stresser, D.M.1    Turner, S.D.2    Blanchard, A.P.3    Miller, V.P.4    Crespi, C.L.5
  • 50
    • 26444561456 scopus 로고    scopus 로고
    • Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: implications for its chemopreventive activity
    • Yoxall V., Kentish P., Coldham N., Kuhnert N., Sauer M.J., and Ioannides C. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: implications for its chemopreventive activity. Int. J. Cancer 117 (2005) 356-362
    • (2005) Int. J. Cancer , vol.117 , pp. 356-362
    • Yoxall, V.1    Kentish, P.2    Coldham, N.3    Kuhnert, N.4    Sauer, M.J.5    Ioannides, C.6
  • 51
    • 5144230473 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action
    • Zhang Y. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat. Res. 555 (2004) 173-190
    • (2004) Mutat. Res. , vol.555 , pp. 173-190
    • Zhang, Y.1
  • 52
    • 0028203252 scopus 로고    scopus 로고
    • Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
    • Zhang Y., Kensler T.W., Cho C.G., Posner G.H., and Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. 91 (2004) 3147-3150
    • (2004) Proc. Natl. Acad. Sci. , vol.91 , pp. 3147-3150
    • Zhang, Y.1    Kensler, T.W.2    Cho, C.G.3    Posner, G.H.4    Talalay, P.5
  • 53
    • 34147101044 scopus 로고    scopus 로고
    • Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk
    • Zhao H., Grossman H.B., Hernandez L.M., Dinney C.P., and Wu X. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int. J. Cancer 120 (2007) 2208-2213
    • (2007) Int. J. Cancer , vol.120 , pp. 2208-2213
    • Zhao, H.1    Grossman, H.B.2    Hernandez, L.M.3    Dinney, C.P.4    Wu, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.