Para-nitrophenol glucuronidation and sulfation in rat and human liver slices

Experimental and Toxicologic Pathology

Volumn 53, Issue 1, 2001, Pages 81-88

  Kuhn, U D ^a   Rost, M ^a   Muller D ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Beta naphthoflavone; Conjugation; Drug metabolism; Enzyme induction; Glucuronidation; In vitro testing; Liver slices; Para nitrophenol; Phenobarbital; Sulfation

Indexed keywords

4 NITROPHENOL; BETA NAPHTHOFLAVONE; CYTOCHROME P450; GLUCURONOSYLTRANSFERASE; PHENOBARBITAL; SULFOTRANSFERASE;

ANIMAL CELL; ARTICLE; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER METABOLISM; LIVER SLICE; LIVER TOXICITY; NONHUMAN; RAT; SULFATION;

ANIMALIA;

EID: 0035029783     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1078/0940-2993-00153     Document Type: Article

References (53)

1. A kinetic assay for p-nitrophenol hydroxylase in rat liver microsomes
2. Preservation and inducibility of xenobiotic metabolism in long-term cultures of adult rat liver cell aggregates
3. Conjugation of various drugs in isolated hepatocytes
4. A fluorometric assay for quantitating phenol sulfotransferase activities in homogenates of cells and tissues
5. Drug metabolizing enzymes related to laboratory medicine: Cytochromes P-450 and UDP-glucuronosyltransferases
6. Continuous fluorometric assay of phenol sulfotransferase
7. Phenol sulfotransferase. I. Purification of a rat liver enzyme by affinity chromatography
8. 4-Nitrophenol UDPglucuronyltransferase (rat liver)
9. Human liver phenol sulfotransferase: Assay conditions, biochemical properties and partial purification of isozymes of the thermostable form
10. The uridine diphosphate glucuronosyltransferase multigene family: Function and regulation
11. Biotransformationsuntersuchungen im hühnerei. Teil 2: Metabolische umwandlung von p-nitrophenol
12. Activities of several phase I and phase II xenobiotic biotransformation enzymes in cultured hepatocytes from male and female rats
13. Determination of p-nitrophenol hydroxylase activity of rat liver microsomes by high-pressure liquid chromatography
14. Assays for UDPglucuronyltransferase activities
15. Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes
16. Ethoxycoumarin O-deethylation (ECOD) activity in rat liver slices exposed to beta-naphthoflavone (BNF) in vitro
17. Effect of 3-methylcholanthrene pretreatment on glucuronidation and sulfation in perfused rat liver
18. Drug metabolism in hepatocyte sandwich cultures of rats and humans
19. In vivo modification of 3′-phosphoadenosine 5′-phosphosulfate and sulfate by infusion of sodium sulfate, cysteine, and methionine
20. Sulfation and sulfotransferases 5: The importance of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) in the regulation of sulfation
21. The influence of age on the protein concentration in serum, liver and kidney of rats determined by various methods
22. The utility of p-nitrophenol hydroxylation in P450IIE1 analysis
23. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin
24. Differential induction of rat liver microsomal UDP-glucuronosyltransferase activities by various inducing agents
25. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
26. Sex differences in sulfation and glucuronidation of phenol, 4-nitrophenol and N-hydroxy-2-acetylaminofluorene in the rat in vivo
27. Interrelationship between demethylation of p-nitroanisole and conjugation of p-nitrophenol in rat liver
28. p-Nitrophenol sulfation in rat liver cytosol: Multiple forms and substrate inhibition of aryl sulfotransferase
29. Oxidative and conjugative metabolism of p-nitroanisole and p-nitrophenol in isolated rat liver cells
30. High-performance liquid chromatographic analysis of p-nitrophenol and its conjugates in biological samples
31. Monooxygenation, cytochrome P4501A1 and P4501A1-mRNA in rat liver slices exposed to beta-naphthoflavone and dexamethasone in vitro
32. Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices
33. Induction of cytochrome P450 2B1-mRNA and pentoxyresorufin O-depentylation after exposure of precision-cut liver slices to phenobarbital
34. Assessment of rat liver slices as a suitable model system for studying the simultaneous sulphation and glucuronidation of phenolic xenobiotics
35. Fremdstoffmetabolismus
36. Isolated hepatocytes as an experimental tool in the study of drug conjugation reactions
37. Phase II reactions and in vitro induction of UDP-glucuronidyltransferase 2B12 in precision-cut rat liver slices
38. The influence of age and some inducers on UDP-glucuronyltransferase activity
39. Human phenol sulfotransferases SULT1A2 and SULT1A1: Genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations
40. Sulfation and sulfotransferases 2: Regulation of expression of the rodent cytosolic sulfotransferases
41. Induction of UDP-glycosyltransferase family 1 genes in rat liver: Different patterns of mRNA expression with two inducers, 3-methylcholanthrene and beta-naphthoflavone
42. Aryl sulfotransferases
43. Purification and properties of a rat liver phenobarbital-inducible 4-hydroxybiphenyl UDP-glucuronosyltransferase
44. Human intestinal phenol sulfotransferase: Assay conditions, activity levels and partial purification of the thermolabile form
45. High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, a putative cytochrome P-4502E1 activity, in human liver microsomes
46. High-performance liquid chromatographic determination of phenol, 4-nitrophenol, beta-naphthol and a number of their glucuronide and sulphate conjugates in organ perfusate
47. Rapid and sensitive assays using high-performance liquid chromatography to measure the activities of phase II drug metabolising enzymes: Glucuronyl transferase and sulfotransferase
48. Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16 alpha-carbonitrile
49. Phenol sulfotransferase in humans: Properties, regulation, and function
50. Sulfotransferase enzymes
51. Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes
52. Purification and properties of a form of UDP-glucuronyltransferase from liver microsomes of 3-methylcholanthrene-treated rats
53. Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1