Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies

Drug Metabolism and Disposition

Volumn 33, Issue 11, 2005, Pages 1613-1620

  Van De Kerkhof, Esther G ^a,b   De Graaf, Inge A M ^a   De Jager, Marina H ^a   Meijer, Dirk K F ^a   Groothuis, Geny M M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b Department of Pharmacokinetics and Drug Delivery ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN; ALKALINE PHOSPHATASE; BETA NAPHTHOFLAVONE; KETOCONAZOLE; TESTOSTERONE; UMBELLIFERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CELL VIABILITY; CHEMICAL MODIFICATION; COLON; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SUBSTRATE; IN VITRO STUDY; INCUBATION TIME; INTESTINE EPITHELIUM; INTESTINE MUCOSA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; STOMACH; TESTOSTERONE METABOLISM; TISSUE SECTION; TISSUE STRUCTURE;

ANIMALS; BETA-NAPHTHOFLAVONE; COLON; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME INHIBITORS; GLUCURONIDES; INTESTINE, SMALL; KETOCONAZOLE; MALE; MODELS, ANIMAL; RATS; RATS, WISTAR; TESTOSTERONE; TIME FACTORS; TISSUE CULTURE TECHNIQUES; UMBELLIFERONES;

ANIMALIA;

EID: 27544446645     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.005686     Document Type: Article

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