Use of fresh and cryopreserved human liver slices in toxicology with special reference to in vitro induction of cytochrome P450

Toxicology in Vitro

Volumn 13, Issue 4-5, 1999, Pages 531-535

  Glockner R ^a   Steinmetzer, P ^a   Drobner, C ^a   Muller D ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Naphthoflavone; Albumin secretion; CYP1A1 mRNA; Human cryopreservation; In vitro induction; Potassium; Precision cut liver slices; RT PCR

Indexed keywords

ALBUMIN; BETA NAPHTHOFLAVONE; CYTOCHROME P450; MESSENGER RNA; POTASSIUM; XENOBIOTIC AGENT;

ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CRYOPRESERVATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER; LIVER SLICE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0008792569     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00021-1     Document Type: Conference Paper

References (14)

1. de Kanter R., Olinga P., Hof I., de Jager M., Verwillegen W.A., Slooff M.J.H., Koster H.J., Meijer D.K.F., Groothius G.M.M. A rapid and simple method for cryopreservation of human liver slices. Xenobiotica. 28:1998;225-234.
2. Ekins S. Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism. Drug Metabolism Reviews. 28:1996;591-623.
3. Fisher R., Putnam C.W., Koep L.J. Cryopreservation of pig and human liver slices. Cryobiology. 28:1991;131-142.
4. Fisher R.L., Hasal S.J., Sanuik J.T., Scott K.S., Gandolfi A.J., Brendel K. Cold- and cryopreservation of human liver and kidney slices. Cryobiology. 30:1993;250-261.
5. Glöckner R., Steinmetzer P., Drobner C., Müller D. Application of cryopreserved precision-cut liver slices in pharmacotoxicology - -principles, literature data and own investigations with special reference to CYP1A1-mRNA induction. Experimental and Toxicologic Pathology. 50:1998;440-449.
6. Lake B.G., Ball S.E., Renwick A.B., Tredger J.M., Kao J., Beamand J.A., Price R.J. Induction of CYP 3A isoforms in cultured precision-cut human liver slices. Xenobiotica. 27:1997;1165-1173.
7. Lake B.G., Charzat C., Tredger J.M., Renwick A.B., Beamand J.A., Price R.J. Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices. Xenobiotica. 26:1996;297-306.
8. Müller D., Glöckner R., Rost M., Steinmetzer P. Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices. Experimental and Toxicologic Pathology. 50:1998;507-513.
9. Neupert G., Glöckner R., Müller D. Immunohistochemical localization of cytochrome P450 1A1 in precision-cut rat liver slices after in vitro exposure to β-naphthoflavone. Experimental and Toxicologic Pathology. 50:1998;514-518.
10. Olinga P., Meijer D.K.F., Slooff M.J.H., Groothuis G.M.M. Liver slices in in vitro pharmacology with special reference to the use of human liver tissue. Toxicology in Vitro. 12:1997;77-100.
11. Olinga P., Merema M.T., Hof I.H., de Jager M.H., de Jong K.P., Slooff M.J.H., Meijer D.K.F., Groothuis G.M.M. Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver. Xenobiotica. 28:1998;349-360.
12. Olinga P., Merema M., Hof I.H., de Joung K.P., Slooff M.J.H., Meijer D.K.F., Groothuis G.M.M. Effect of human liver source on the functionality of isolated hepatocytes and liver slices. Drug Metabolism and Disposition. 26:1998;5-11.
13. Omiecinski C.J., Redlich C.A., Costa P. Induction and developmental expression of cytochrome P4501A1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction. Cancer Research. 50:1990;4315-4321.
14. Parrish A.R., Gandolfi A.J., Brendel K. Precision cut liver slices: application in pharmacology and toxicology. Life Sciences. 57:1995;1887-1901.