Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYP1A1 and CYP1A2 induction

Toxicology and Applied Pharmacology

Volumn 140, Issue 2, 1996, Pages 393-403

  Drahushuk, Adam T ^a   McGarrigle, Barbara P ^a   Tai, Hung Liang ^a   Kitareewan, Sutisak ^b   Goldstein, Joyce A ^b   Olson, James R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 ISOENZYME; MESSENGER RNA; PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG TOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; IN VITRO STUDY; LIVER SLICE; MALE; MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; ORGAN CULTURE; RAT;

ANIMALIA;

EID: 0030273433     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0236     Document Type: Article

References (47)

1. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
2. 2+-sedimented microsomes from rat liver. Biochem. Pharmacol. 21(24), 3249-3256.
3. Crespi, C. L., Langenbach, R., Rudo, K., Chem, Y. T., and Davies, R. L. (1989). Transfection of a human cytochrome P-450 into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. Carcinogenesis 10(20), 295-301.
4. Crespi, C. L., Penman, B. W., Steimel, D. T., Gelboin, H. V., and Gonzalez, F. J. (1991). The development of a human cell line stably expressing human CYP3A4: Role in the metabolic activation of aflatoxin B1 and comparison to CYP1A2 and CYP2A3. Carcinogenesis 12(2), 355-359.
5. Curtis, L. R., Kerkvliet, N. I., Baecher-Steppan, L., and Carpenter, H. M. (1990). 2,3,7,8-Tetrachlorodibenzo-p-dioxin pretreatment of female mice altered tissue distribution but not hepatic metabolism of a subsequent dose. Fundam. Appl. Toxicol. 14, 523-531.
6. Eaton, D. L., Gallagher, E. P., Bammler, T. K., and Kunze, K. L. (1995). Role of cytochrome P4501A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity. Pharmacogenetics 5, 259-274.
7. Fisher, R., Smith, P. F., Sipes, I. G., Gandolfi, A. J., Krumdieck, C. L., and Brendel, K. (1990). Toxicity of chlorobenzenes in cultured rat liver slices. In Vitro Toxicol. 3(2), 181-194.
8. Guengerich, F. P., Wang, P., and Davidson, N. K. (1982). Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry 21, 1698-1706.
9. Kedderis, L. B., Diliberto, J. J., Linko, P., Goldstein, J. A., and Birnbaum, L. S. (1991). Disposition of TBDD and TCDD in the rat: Biliary excretion and induction of cytochromes P4501A1 and P4501A2. Toxicol. Appl. Pharmacol. 111, 163-172.
10. Laemmli, V. K. (1970). Change of the structural protein during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
11. Leung, H. W., Poland, A., Paustenbach, D. J., Murray, F. J., and Andersen, M. E. (1990). Pharmacokinetics of [125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: Analysis with a physiological modeling approach. Toxicol. Appl. Pharmacol. 103, 411-419.
12. Luster, M. I., Lawson, L. D., Linko, P., and Goldstein, J. A. (1983). Immunochemical evidence for two 3-methylcholanthrene-inducible forms of cytochrome P-448 in rat liver microsomes using a double-antibody radioimmunoassay procedure. Mol. Pharmacol. 23(1), 252-257.
13. Narasimhan, T. R., Craig, A., Arellano, L., Harper, N., Howie, L., Menache, M., Birnbaum, L., and Safe, S. (1994). Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Fundam. Appl. Toxicol. 23, 598-607.
14. Nemoto, N., and Sakurai, J. (1993). Activation of Cyp1a1 and Cyp1a2 genes in adult mouse hepatocytes in primary culture. Jpn. J. Cancer Res. 84, 272-278.
15. Nerurkar, P. V., Park, S. S., Thomas, P. E., Nims, R. W., and Lubet, R. A. (1993). Methoxyresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochem. Pharmacol. 46(5), 933-943.
16. Olson, J. R. (1986). Metabolism and disposition of 2,3,7,8-tetrachlorodi-benzo-p-dioxin in guinea pigs. Toxicol. Appl. Pharmacol. 85, 263-273.
17. Olson, J. R., Kitareewan, S., McGarrigle, B. P., Tai, H. L., Drahushuk, A. T., Petrelli, N., Rodriguez, M. A., and Goldstein, J. A. (1994). Induction of cytochrome P450 1A1 and 1A2 (CYP1A1 and CYP1A2) in rat and human liver slices by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicologist 14(1), 1617.
18. Olson, J. R., Drahushuk, A. T., Kitareewan, S., McGarrigle, B. P., Tai, H. L., and Goldstein, J. A. (1995). Induction of cytochrome P4501A1 and 1A2 (CYP1A1 and CYP1A2) in rat and human liver slices by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicologist 15(1), 335.
19. Poiger, H., Pleuss, N., and Schlatter, C. (1989). Subchronic toxicity of some chlorinated dibenzofurans in rats. Chemosphere 18(1-6), 265-275.
20. Poland, A., Teitelbaum, P., Glover, E., and Kende, A. (1989a). Stimulation of in vivo hepatic binding of [125I]2-iodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonists for the Ah receptor. Mol. Pharmacol. 36, 121-127.
21. Poland, A., Teitelbaum, E., and Glover, E. (1989b). [125I]-iodo-3,7,8-trichlorodibenzo-p-dioxin binding species in mouse liver induced by agonists for the Ah receptor: Characterization and identification. Mol.Pharmacol. 36, 113-120.
22. Probst, M., Blum, A., Demierre, A., Grant, D., and Meyer, U. A. (1989). IV World Conference in clinical pharmacology and therapeutics. Functional expression of human cytochromes P-450 1A1 and P-450 1A2 in monkey COS cells. [Abstract 10-18]
23. Prough, R. A., Burke, M. D., and Mayer, R. T. (1978). Direct fluorometric methods for measuring mixed function oxidase activity. Methods Enzymol. 52, 372-377.
24. Rose, J. Q., Ramsey, J. C., Wentzler, T. H., Hummel, R. A., and Gehring, P. J. (1976). The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol. Appl. Pharmacol. 36, 209-226.
25. Safe, S. H. (1986). Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26, 371-399.
26. Schecter, A., Fürst, P., Fürst, C., Päpke, O., Ball, M., Ryan, J. J., Cau, H. D., Dai, L. C., Quynh, H. T., Cuong, H. Q., Phuong, N. T. N., Phiet, P. H., Beim, A., Constable, J., Startin, J., Samedy, M., and Seng, Y. K. (1994a). Chlorinated dioxins and dibenzofurans in human tissue from general populations: A selective review. Environ. Health Perspect. Suppl. 102(Suppl. 1), 159-171.
27. Schecter, A., Stanley, J., Boggess, K., Masuda, Y., Mes, J., Wolff, M., Fürst, P., Fürst, C., Wilson-Yang, K., and Chisholm, B. (1994b). Polychlorinated biphenyl levels in the tissues of exposed and nonexposed humans. Environ. Health Perspect. Suppl. 102(Suppl. 1), 149-158.
28. Shen, E. S., and Olson, J. R. (1987). Relationship between the murine Ah receptor phenotype and the hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Drug Metab. Dispos. 15(5), 653-660.
29. Sherratt, A. J., and Damani, L. A. (1989). Activities of cytosolic and microsomal drug oxidases of rat hepatocytes in primary culture. Drug Metab. Dispos. 17, 20-25.
30. Shimada, T., Iwasaki, M., Martin, M. V., and Guengerich, F. P. (1989). Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by Umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Res. 12, 3218-3228.
31. Shimada, T., Yun, C. H., Yamazaki, H., Gautier, J. C., Beaune, P. H., and Guengerich, F. P. (1992). Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. Mol. Pharmacol. 41, 856-864.
32. Sinclair, P. R., Bement, W. J., Lambrecht, R. W., Gorman, N., and Sinclair, J. F. (1990). Chlorinated biphenyls induce cytochrome P4501A2 and uroporphyrin accumulation in cultures of mouse hepatocytes. Arch. Biochem. Biophys. 281, 225-232.
33. Smith, P. F., McKee, R., Gandolfi, A. J., Krumdieck, C. L., and Fisher, R. (1989). Precision-cut liver slices: A new in vitro tool in toxicology. In In Vitro Toxicology: Model Systems and Methods (C. A. McQueen, Ed.), p. 93. Telford Press, Caldwell, NJ.
34. Steward, A. R., Dannan, G. A., Guzelian, P. S., and Guengerich, F. P. (1985a). Changes in the concentration of seven forms of cytochrome P-450 in primary cultures of adult rat hepatocytes. Mol. Pharmacol. 27(1), 125-132.
35. Steward, A. R., Wrighton, S. A., Pasco, D. S., Fagan, J. B., and Guzelian, P. S. (1985b). Synthesis and degradation of 3-methylcholanthrene-inducible cytochrome P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes. Arch. Biochem. Biophys. 241(2), 494-508.
36. Sutter, T. R., and Greenlee, W. F. (1992). Classification of members of the Ah gene battery. Chemosphere 25(1-2), 223-226.
37. Tai, H. L., McReynolds, J. H., Goldstein, J. A., Eugster, H. P., Sengstag, C., Alworth, W. L., and Olson, J. R. (1993). Cytochrome P4501A1 mediates the metabolism of 2,3,7,8-tetrachlorodibenzofuran in the rat and human. Toxicol. Appl. Pharmacol. 123, 34-42.
38. Tritscher, A. M., Goldstein, J. A., Portier, C. J., McCoy, Z., Clark, G. C., and Lucier, G. W. (1992). Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat liver tumor promotion model: Quantitation and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res. 52, 3436-3442.
39. Tsyrlov, I. B., and Duzchak, T. G. (1990). Interspecies features of hepatic cytochromes P4501A1 and P4501A2 in rodents. Xenobiotica 20, 1163-1170.
40. Van den Berg, M., De Jongh, J., Poiger, H., and Olson, J. R. (1994). The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit. Rev. Toxicol. 24(1), 1-74.
41. Vanden Heuval, J. P., Clark, G. C., Thompson, C. L., McCoy, Z., Miler, C. R., Lucier, G. W., and Bell, A. (1993a). CYP1A1 mRNA levels as a human exposure biomarker: Use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis 14(10), 2003-2006.
42. Vanden Heuval, J. P., Tyson, F. L., and Bell, D. A. (1993b). Construction of recombinant RNA templates for use as internal standards in quantitative RT-PCR. Biotechniques 14, 395-398.
43. Voorman, R., and Aust, S. D. (1987). Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity. Toxicol. Appl. Pharmacol. 90, 69-78.
44. Voorman, R., and Aust, S. D. (1989). TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a tight binding inhibitor of cytochrome P-450d. J. Biochem. Toxicol. 4, 105-109.
45. Whitlock, J. P., Jr. (1993). Mechanistic aspects of dioxin action. Chem. Res. Toxicol. 6, 754-763.
46. Wright, M. C., and Paine, A. J. (1992). Evidence that the loss of rat liver cytochrome P450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix. Biochem. Pharmacol. 43(2), 237-243.
47. Zeillinger, R., Schneeberger, C., and Speiser, P. (1993). Rapid quantitative analysis of differential PCR products by high-performance liquid chromatography. Biotechniques 15(1), 89-95.