Methapyrilene toxicity: Anchorage of pathologic observations to gene expression alterations

Toxicologic Pathology

Volumn 30, Issue 4, 2002, Pages 470-482

  Hamadeh, Hisham K ^a   Knight, Brian L ^b   Haugen, Astrid C ^a   Sieber, Stella ^a   Amin, Rupesh P ^a   Bushel, Pierre R ^a   Stoll, Raymond ^b   Blanchard, Kerry ^b   Jayadev, Supriya ^b   Tennant, Raymond W ^a   Cunningham, Michael L ^a   Afshari, Cynthia A ^a   Paules, Richard S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Gene expression; Hepatotoxicity; Histopathology; Methapyrilene; Phenotypic anchorage; Rat liver; Toxicity classification; Toxicogenomics

Indexed keywords

CALCIUM; HISTAMINE H1 RECEPTOR ANTAGONIST; METHAPYRILENE; CARCINOGEN; COMPLEMENTARY DNA;

ANIMAL; ARTICLE; BODY WEIGHT; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIPID PEROXIDATION; LIVER; MALE; METABOLISM; ORGAN SIZE; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; ANIMAL EXPERIMENT; ANIMAL TISSUE; BILE DUCT; CALCULATION; CELL VACUOLE; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; DRUG EXPOSURE; DRUG INDUCED DISEASE; HEPATITIS; HISTOPATHOLOGY; HYPERPLASIA; LIVER NECROSIS; LIVER TOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAT STRAIN;

ANIMALS; BODY WEIGHT; CALCIUM; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTAMINE H1 ANTAGONISTS; LIPID PEROXIDATION; LIVER; MALE; METHAPYRILENE; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; ANIMAL; ORGAN WEIGHT;

ANIMALIA; RODENTIA;

EID: 0036628957     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230290105712     Document Type: Article

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