-
1
-
-
0037374498
-
The price of innovation: new estimates of drug development costs
-
DiMasi J., Hansen R., and Grabowski H. The price of innovation: new estimates of drug development costs. J Health Econ 22 (2003) 151-185
-
(2003)
J Health Econ
, vol.22
, pp. 151-185
-
-
DiMasi, J.1
Hansen, R.2
Grabowski, H.3
-
2
-
-
33751220296
-
-
UCSF, Center for Drug Development Science: Simulation in drug development: good practices. 1999; URL: http://cdds.ucsf.edu/research/sddgpreport.php
-
-
-
-
3
-
-
0035892596
-
The dynamics of molecular networks: applications to therapeutic discovery
-
Simogyi R., and Greller L.D. The dynamics of molecular networks: applications to therapeutic discovery. Drug Disc Today 6 (2001) 1267-1277
-
(2001)
Drug Disc Today
, vol.6
, pp. 1267-1277
-
-
Simogyi, R.1
Greller, L.D.2
-
4
-
-
4644249962
-
In silico predictions of target clinical efficacy
-
Friedrich C.M., and Paterson T.S. In silico predictions of target clinical efficacy. Drug Disc Today 3 (2004) 216-222
-
(2004)
Drug Disc Today
, vol.3
, pp. 216-222
-
-
Friedrich, C.M.1
Paterson, T.S.2
-
5
-
-
0010629999
-
Biosystems modelling for in silico target validation: challenges to implementation
-
Ho R.L. Biosystems modelling for in silico target validation: challenges to implementation. Emerging Therapeutic Targets 4 (2000) 699-714
-
(2000)
Emerging Therapeutic Targets
, vol.4
, pp. 699-714
-
-
Ho, R.L.1
-
6
-
-
0010596118
-
Biosimulation: dynamic modeling of biological systems
-
Hall K., Baillie R., and Michelson S. Biosimulation: dynamic modeling of biological systems. Annu Rep Med Chem 37 (2002) 279-288
-
(2002)
Annu Rep Med Chem
, vol.37
, pp. 279-288
-
-
Hall, K.1
Baillie, R.2
Michelson, S.3
-
7
-
-
4644319546
-
Assessing the impact of biosimulation on target selection and validation
-
Scherrer D., French J.M., and Michelson S. Assessing the impact of biosimulation on target selection and validation. Biosilico 1 (2003) 184-188
-
(2003)
Biosilico
, vol.1
, pp. 184-188
-
-
Scherrer, D.1
French, J.M.2
Michelson, S.3
-
8
-
-
11144315531
-
Vessel maturation effects on tumour growth: validation of a computer model in implanted human carcinoma spheroids
-
Arkelyan L., Merbl Y., and Agur Z. Vessel maturation effects on tumour growth: validation of a computer model in implanted human carcinoma spheroids. Eur J Cancer 41 (2005) 159-167
-
(2005)
Eur J Cancer
, vol.41
, pp. 159-167
-
-
Arkelyan, L.1
Merbl, Y.2
Agur, Z.3
-
9
-
-
0037840352
-
A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth
-
Arkelyan L., Vainstein V., and Agur Z. A computer algorithm describing the process of vessel formation and maturation, and its use for predicting the effects of anti-angiogenic and anti-maturation therapy on vascular tumor growth. Angiogenesis 5 (2002) 203-214
-
(2002)
Angiogenesis
, vol.5
, pp. 203-214
-
-
Arkelyan, L.1
Vainstein, V.2
Agur, Z.3
-
10
-
-
0031845830
-
The growth law of primary breast cancer as inferred from mammography screening trials data
-
Hart D., Shochat E., and Agur Z. The growth law of primary breast cancer as inferred from mammography screening trials data. Br J Cancer 78 (1998) 382-387
-
(1998)
Br J Cancer
, vol.78
, pp. 382-387
-
-
Hart, D.1
Shochat, E.2
Agur, Z.3
-
11
-
-
0032783433
-
Biological simulations in drug discovery
-
Noble D., Levin J., and Scott W. Biological simulations in drug discovery. Drug Discov Today 4 (1999) 10-16
-
(1999)
Drug Discov Today
, vol.4
, pp. 10-16
-
-
Noble, D.1
Levin, J.2
Scott, W.3
-
12
-
-
0036499997
-
Modeling the heart - from genes to cells to the whole organ
-
Noble D. Modeling the heart - from genes to cells to the whole organ. Science 295 (2002) 1678-1682
-
(2002)
Science
, vol.295
, pp. 1678-1682
-
-
Noble, D.1
-
13
-
-
0036891062
-
In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15
-
Boobis A., Gundert-Remy U., Kremers P., Macheras P., and Pelkonen O. In silico prediction of ADME and pharmacokinetics. Report of an expert meeting organised by COST B15. Eur J Pharm Sci 17 (2002) 183-193
-
(2002)
Eur J Pharm Sci
, vol.17
, pp. 183-193
-
-
Boobis, A.1
Gundert-Remy, U.2
Kremers, P.3
Macheras, P.4
Pelkonen, O.5
-
14
-
-
10944229063
-
Use of pharmacokinetic modeling to design studies for pathway specific exposure model evaluation
-
Hu Y., Akland G.G., Pellizzari E.D., Berry M.R., and Melnyk L.J. Use of pharmacokinetic modeling to design studies for pathway specific exposure model evaluation. Environ Health Perspect 112 (2004) 1697-1703
-
(2004)
Environ Health Perspect
, vol.112
, pp. 1697-1703
-
-
Hu, Y.1
Akland, G.G.2
Pellizzari, E.D.3
Berry, M.R.4
Melnyk, L.J.5
-
15
-
-
0033999569
-
Development of predictive pharmacokinetic simulation models for drug discovery
-
Norris D.A., Leesman G.D., Sinko P.J., and Grass G.M. Development of predictive pharmacokinetic simulation models for drug discovery. J Control Release 65 (2000) 55-62
-
(2000)
J Control Release
, vol.65
, pp. 55-62
-
-
Norris, D.A.1
Leesman, G.D.2
Sinko, P.J.3
Grass, G.M.4
-
16
-
-
0037222528
-
Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo
-
Sarkar C.A., and Lauffenburger D.A. Cell-level pharmacokinetic model of granulocyte colony-stimulating factor: implications for ligand lifetime and potency in vivo. Mol Pharmacol 63 (2003) 147-158
-
(2003)
Mol Pharmacol
, vol.63
, pp. 147-158
-
-
Sarkar, C.A.1
Lauffenburger, D.A.2
-
17
-
-
33644808298
-
Pharmacokinetics/pharmacodynamics and the stages of drug development: role of modeling and simulation
-
A review of the application of modeling and simulation technologies for the estimation and characterization of PK and PD effects in a clinical population. See especially Table 1 in this review for an excellent overview of the drug development pipeline and the role that modeling and simulation can play in each.
-
Chien J.Y., Friedrich S., Heathman M.A., de Alwis D.P., and Sinha V. Pharmacokinetics/pharmacodynamics and the stages of drug development: role of modeling and simulation. AAPS J 7 (2005) E544-E559. A review of the application of modeling and simulation technologies for the estimation and characterization of PK and PD effects in a clinical population. See especially Table 1 in this review for an excellent overview of the drug development pipeline and the role that modeling and simulation can play in each.
-
(2005)
AAPS J
, vol.7
-
-
Chien, J.Y.1
Friedrich, S.2
Heathman, M.A.3
de Alwis, D.P.4
Sinha, V.5
-
18
-
-
0030064823
-
Population pharmacodynamics: strategies for concentration- and effect-controlled clinical trials
-
Ebling W.F., and Levy G. Population pharmacodynamics: strategies for concentration- and effect-controlled clinical trials. Ann Pharmacother 30 (1996) 12-19
-
(1996)
Ann Pharmacother
, vol.30
, pp. 12-19
-
-
Ebling, W.F.1
Levy, G.2
-
19
-
-
30544448391
-
A pragmatic approach to the design of population pharmacokinetic studies
-
An excellent overview of the practical requirements to design, implement, and interpret population PK/PD studies. Included is a comparison between two simulation/analysis strategies (D-optimal designs and informative block designs) and their relative efficiencies in the derivation of the PK parameters of interest.
-
Roy A., and Ette E.I. A pragmatic approach to the design of population pharmacokinetic studies. AAPS J 7 (2005) E408-E420. An excellent overview of the practical requirements to design, implement, and interpret population PK/PD studies. Included is a comparison between two simulation/analysis strategies (D-optimal designs and informative block designs) and their relative efficiencies in the derivation of the PK parameters of interest.
-
(2005)
AAPS J
, vol.7
-
-
Roy, A.1
Ette, E.I.2
-
20
-
-
0037421584
-
Inheritance and drug response
-
Weinshilboum R. Inheritance and drug response. N Engl J Med 348 (2003) 529-537
-
(2003)
N Engl J Med
, vol.348
, pp. 529-537
-
-
Weinshilboum, R.1
-
21
-
-
0037421590
-
Pharmacogenomics - drug disposition, drug targets, and side effects
-
Evans W.E., and McLeod H.L. Pharmacogenomics - drug disposition, drug targets, and side effects. N Engl J Med 348 (2003) 538-549
-
(2003)
N Engl J Med
, vol.348
, pp. 538-549
-
-
Evans, W.E.1
McLeod, H.L.2
-
22
-
-
15944425080
-
Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity
-
Ekins S., Nikolsky Y., and Nikolskaya T. Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity. Trends Pharmacol Sci 26 (2005) 202-209
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 202-209
-
-
Ekins, S.1
Nikolsky, Y.2
Nikolskaya, T.3
-
23
-
-
0036204734
-
In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists
-
Fielden M.R., Matthews J.B., Fertuck K.C., Halgren R.G., and Zacharewski T.R. In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists. Crit Rev Toxicol 32 (2002) 67-112
-
(2002)
Crit Rev Toxicol
, vol.32
, pp. 67-112
-
-
Fielden, M.R.1
Matthews, J.B.2
Fertuck, K.C.3
Halgren, R.G.4
Zacharewski, T.R.5
-
24
-
-
4644285491
-
Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma
-
Makretsov N.A., Huntsman D.G., Nielsen T.O., Yorida E., Peacock M., Cheang M.C., Dunn S.E., Hayes M., van de R.M., Bajdik C., and Gilks C.B. Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma. Clin Cancer Res 10 (2004) 6143-6151
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6143-6151
-
-
Makretsov, N.A.1
Huntsman, D.G.2
Nielsen, T.O.3
Yorida, E.4
Peacock, M.5
Cheang, M.C.6
Dunn, S.E.7
Hayes, M.8
van de, R.M.9
Bajdik, C.10
Gilks, C.B.11
-
25
-
-
12444335268
-
Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma
-
Kari L., Loboda A., Nebozhyn M., Rook A.H., Vonderheid E.C., Nichols C., Virok D., Chang C., Horng W.H., Johnston J., et al. Classification and prediction of survival in patients with the leukemic phase of cutaneous T cell lymphoma. J Exp Med 197 (2003) 1477-1488
-
(2003)
J Exp Med
, vol.197
, pp. 1477-1488
-
-
Kari, L.1
Loboda, A.2
Nebozhyn, M.3
Rook, A.H.4
Vonderheid, E.C.5
Nichols, C.6
Virok, D.7
Chang, C.8
Horng, W.H.9
Johnston, J.10
-
26
-
-
23944524534
-
Data clustering in life sciences
-
Zhao Y., and Karypis G. Data clustering in life sciences. Mol Biotechnol 31 (2005) 55-80
-
(2005)
Mol Biotechnol
, vol.31
, pp. 55-80
-
-
Zhao, Y.1
Karypis, G.2
-
27
-
-
28544446695
-
Biomarkers in cancer staging, prognosis and treatment selection
-
Ludwig J.A., and Weinstein J.N. Biomarkers in cancer staging, prognosis and treatment selection. Nat Rev Cancer 5 (2005) 845-856
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 845-856
-
-
Ludwig, J.A.1
Weinstein, J.N.2
-
28
-
-
0033636139
-
Support vector machine classification and validation of cancer tissue samples using microarray expression data
-
Furey T.S., Cristianini N., Duffy N., Bednarski D.W., Schummer M., and Haussler D. Support vector machine classification and validation of cancer tissue samples using microarray expression data. Bioinformatics 16 (2000) 906-914
-
(2000)
Bioinformatics
, vol.16
, pp. 906-914
-
-
Furey, T.S.1
Cristianini, N.2
Duffy, N.3
Bednarski, D.W.4
Schummer, M.5
Haussler, D.6
-
29
-
-
0033027794
-
Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation
-
Tamayo P., Slonim D., Meisrov J., Zhu Q., Kitareewan S., Dmitrovsky E., Lander E., and Golub T. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci USA 96 (1999) 2907-2912
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2907-2912
-
-
Tamayo, P.1
Slonim, D.2
Meisrov, J.3
Zhu, Q.4
Kitareewan, S.5
Dmitrovsky, E.6
Lander, E.7
Golub, T.8
-
30
-
-
33751232721
-
-
Wang D, Ressom H, Musavi M, Domnisoru C: Double self-organizing maps to cluster gene expression data. ESANN′2002 proceedings - European Symposium on Artificial Neural Networks; Bruges, Belgium, 24-26 April 2002, pp. 45-50.
-
-
-
-
31
-
-
0037388166
-
Cell and tumor classification using gene expression data: Construction of forests
-
Zhang H., Yu C.-Y., and Singer B. Cell and tumor classification using gene expression data: Construction of forests. Proc Natl Acad Sci USA 100 (2003) 4168-4172
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4168-4172
-
-
Zhang, H.1
Yu, C.-Y.2
Singer, B.3
-
32
-
-
1342287336
-
Making sense of lung cancer gene-expression profiles
-
Wigle D.A., Tsao M., and Jurisica I. Making sense of lung cancer gene-expression profiles. Genome Biol 5 (2004) 309-311
-
(2004)
Genome Biol
, vol.5
, pp. 309-311
-
-
Wigle, D.A.1
Tsao, M.2
Jurisica, I.3
-
33
-
-
33745104130
-
The impact of systems biology and biosimulation on drug discovery and development
-
Michelson S. The impact of systems biology and biosimulation on drug discovery and development. Mol Biosyst 2 (2006) 288-291
-
(2006)
Mol Biosyst
, vol.2
, pp. 288-291
-
-
Michelson, S.1
-
34
-
-
0033996876
-
Clinical trial simulation in drug development
-
Bonate P.L. Clinical trial simulation in drug development. Pharm Res 17 (2000) 252-256
-
(2000)
Pharm Res
, vol.17
, pp. 252-256
-
-
Bonate, P.L.1
-
35
-
-
31144456067
-
Application of predictive biosimulation within pharmaceutical clinical development: examples of significance for translational medicine and clinical trial design
-
Kansal A., and Trimmer J. Application of predictive biosimulation within pharmaceutical clinical development: examples of significance for translational medicine and clinical trial design. IEE Proc-Syst Biol 152 (2006) 214-220
-
(2006)
IEE Proc-Syst Biol
, vol.152
, pp. 214-220
-
-
Kansal, A.1
Trimmer, J.2
-
36
-
-
0035889726
-
Combining drug-disease and economic modelling to inform drug development decisions
-
Poland B., and Wada R. Combining drug-disease and economic modelling to inform drug development decisions. Drug Discov Today 6 (2001) 1165-1170
-
(2001)
Drug Discov Today
, vol.6
, pp. 1165-1170
-
-
Poland, B.1
Wada, R.2
-
37
-
-
0030814837
-
Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling
-
Gieschke R., Reigner B.G., and Steimer J.L. Exploring clinical study design by computer simulation based on pharmacokinetic/pharmacodynamic modelling. Int J Clin Pharmacol Ther 35 (1997) 469-474
-
(1997)
Int J Clin Pharmacol Ther
, vol.35
, pp. 469-474
-
-
Gieschke, R.1
Reigner, B.G.2
Steimer, J.L.3
-
38
-
-
5644240874
-
Advances in risk-benefit evaluation using probabilistic simulation methods: an application to the prophylaxis of deep vein thrombosis
-
Lynd L.D., and O'Brien B.J. Advances in risk-benefit evaluation using probabilistic simulation methods: an application to the prophylaxis of deep vein thrombosis. J Clin Epidemiol 57 (2004) 795-803
-
(2004)
J Clin Epidemiol
, vol.57
, pp. 795-803
-
-
Lynd, L.D.1
O'Brien, B.J.2
-
39
-
-
0242300709
-
Archimedes: a trial-validated model of diabetes
-
Eddy D.M., and Schlessinger L. Archimedes: a trial-validated model of diabetes. Diabetes Care 26 (2003) 3093-3101
-
(2003)
Diabetes Care
, vol.26
, pp. 3093-3101
-
-
Eddy, D.M.1
Schlessinger, L.2
-
40
-
-
0242300707
-
Validation of the Archimedes diabetes model
-
Eddy D.M., and Schlessinger L. Validation of the Archimedes diabetes model. Diabetes Care 26 (2003) 3102-3110
-
(2003)
Diabetes Care
, vol.26
, pp. 3102-3110
-
-
Eddy, D.M.1
Schlessinger, L.2
-
41
-
-
33751242536
-
-
Trimmer J, McKenna C, Sudbeck B, Ho R: Use of systems biology in clinical development: design and prediction of a type 2 diabetes clinical Trial. PAREXEL Pharmaceutical R&D Sourcebook 2004 p.131.
-
-
-
-
42
-
-
0344530245
-
New TPO treatment schedules of increased safety and efficacy: pre-clincial validation of a thrombopoiesis simulation model
-
Skomorovski K., Harpak H., Ivanovski A., Vardi M., Visser T.P., Hartong S., van Vliet H., Wagemaker G., and Agur Z. New TPO treatment schedules of increased safety and efficacy: pre-clincial validation of a thrombopoiesis simulation model. Br J Haemtol 123 (2003) 683-691
-
(2003)
Br J Haemtol
, vol.123
, pp. 683-691
-
-
Skomorovski, K.1
Harpak, H.2
Ivanovski, A.3
Vardi, M.4
Visser, T.P.5
Hartong, S.6
van Vliet, H.7
Wagemaker, G.8
Agur, Z.9
|