Silencing glycogen synthase kinase-3β inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8244-8255

  Shinohara, Mie ^a   Ybanez, Maria D ^a   Win, Sanda ^a   Than, Tin Aung ^a   Jain, Shilpa ^a   Gaarde, William A ^b   Han, Derick ^a   Kaplowitz, Neil ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; C-JUN N-TERMINAL KINASE; GLUTAMATE-CYSTEINE LIGASE; GLYCOGEN SYNTHASE KINASE-3; HEPATOTOXICITY; JNK ACTIVATION; LIVER INJURIES; MITOCHONDRIAL MEMBRANES; MYELOID CELLS; PROTEIN KINASE B; RATE-LIMITING ENZYMES; SIGNALING PATHWAYS;

CELL MEMBRANES; DEGRADATION; ENZYME ACTIVITY; MITOCHONDRIA;

LIVER;

ANTISENSE OLIGONUCLEOTIDE; GLUTAMATE CYSTEINE LIGASE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE P38; PARACETAMOL; PROTEIN KINASE B BETA; PROTEIN MCL 1; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; AKT2 PROTEIN, MOUSE; ANALGESIC AGENT; BAX PROTEIN, MOUSE; BUTHIONINE SULFOXIMINE; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 ALPHA; GLYCOGEN SYNTHASE KINASE 3 BETA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTISENSE THERAPY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; LIVER MITOCHONDRION; LIVER PROTECTION; LIVER TOXICITY; MALE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; CYTOPLASM; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LIVER CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; TOXIC HEPATITIS;

MUS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BUTHIONINE SULFOXIMINE; CELLS, CULTURED; CYTOPLASM; DRUG-INDUCED LIVER INJURY; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; GLYCOGEN SYNTHASE KINASE 3; HEPATOCYTES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, LIVER; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 77950886196     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.054999     Document Type: Article

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