Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore

Journal of Pharmacology and Experimental Therapeutics

Volumn 326, Issue 2, 2008, Pages 657-671

  Graham, Emma E ^a   Walsh, Rachel J ^a   Hirst, Charlotte M ^a   Maggs, James L ^a   Martin, Scott ^b   Wild, Martin J ^b   Wilson, Ian D ^b   Harding, John R ^b   Kenna, J Gerald ^b   Peter, Raimund M ^b   Williams, Dominic P ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; ALDEHYDE DERIVATIVE; BENZENE DERIVATIVE; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; GLUTATHIONE DERIVATIVE; METHAPYRILENE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFIDE; THIOL DERIVATIVE; THIOPHENE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL DAMAGE; CHEMICAL REACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPLETION; DEUTERIUM HYDROGEN EXCHANGE; DRUG ACTIVATION; DRUG BINDING; DRUG CYTOTOXICITY; DRUG METABOLISM; DRUG STRUCTURE; GLUTATHIONE METABOLISM; HUMAN; LIVER CELL; LIVER MICROSOME; LIVER NECROSIS; LIVER TOXICITY; MALE; MASS SPECTROMETRY; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS; TOXIN STRUCTURE;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUTATHIONE; HEPATITIS, TOXIC; HEPATOCYTES; HISTAMINE H1 ANTAGONISTS; HUMANS; MALE; METHAPYRILENE; MICE; MICE, INBRED STRAINS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; THIOPHENES;

EID: 47949133634     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.135483     Document Type: Article

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