Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes

Toxicological Sciences

Volumn 104, Issue 2, 2008, Pages 261-273

  Aleksunes, Lauren M ^a,c   Campion, Sarah N ^a   Goedken, Michael J ^b   Manautou, José E ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; APAP; Autoprotection; Mrp3; Mrp4; Proliferation; Transporter

Indexed keywords

COLCHICINE; GLUTATHIONE; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; PARACETAMOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EXPOSURE; GENE OVEREXPRESSION; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MALE; MITOSIS INHIBITION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSITIVITY ANALYSIS; UPREGULATION;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; BIOLOGICAL MARKERS; CELL PROLIFERATION; COLCHICINE; DRUG ANTAGONISM; DRUG RESISTANCE, MULTIPLE; HEME OXYGENASE-1; HEPATITIS, TOXIC; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; TUBULIN MODULATORS; UP-REGULATION;

MUS;

EID: 47849118785     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn093     Document Type: Article

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