Coupled cellular trafficking and diffusional limitations in delivery of immunotoxins to multicell tumor spheroids

Biotechnology and Bioengineering

Volumn 62, Issue 5, 1999, Pages 562-575

  Wenning, Larissa A ^a,b   Murphy, Regina M ^a  

^a University of Wisconsin Madison   (United States)

^b Northwestern University   (United States)

Author keywords

CRM 107; Gelonin; Immunotoxins; Transferrin receptor; Tumor spheroids

Indexed keywords

ANTIBODIES; BIOSYNTHESIS; CELL CULTURE; DIFFUSION; GROWTH KINETICS; MATHEMATICAL MODELS; ONCOLOGY; PROTEINS; TOXICITY;

IMMUNOTOXINS; TRANSFERRIN RECEPTORS;

IMMUNOLOGY;

GELONIN; IMMUNOTOXIN;

ARTICLE; AUTORADIOGRAPHY; CELL GROWTH; CELL KILLING; DIFFUSION; GENE TARGETING; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PROTEIN SYNTHESIS INHIBITION; RECEPTOR BINDING; SPHEROID CELL; TUMOR SPHEROID;

ANIMALS; BACTERIAL TOXINS; BINDING SITES; DIPHTHERIA TOXIN; HELA CELLS; HUMANS; IMMUNOTOXINS; MICROSCOPY, CONFOCAL; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NEOPLASMS; PLANT PROTEINS; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, TRANSFERRIN; SPHEROIDS, CELLULAR;

EID: 0033525358     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19990305)62:5<562::AID-BIT8>3.0.CO;2-4     Document Type: Article

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