Rise of the micromachines: Microfluidics and the future of cytometry

Methods in Cell Biology

Volumn 102, Issue , 2011, Pages 105-125

  Wlodkowic, Donald ^a   Darzynkiewicz, Zbigniew ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Array; Cell microarray technology; Microfabricated; Microfluidic cell sorting; Real time physiometry; Single cytomics

Indexed keywords

BOOK; CULTURE TECHNIQUE; FLOW CYTOMETRY; HUMAN; INSTRUMENTATION; LAB ON A CHIP; METHODOLOGY; MICROFLUIDIC ANALYSIS; PERFUSION; SINGLE CELL ANALYSIS;

CELL CULTURE TECHNIQUES; FLOW CYTOMETRY; HUMANS; LAB-ON-A-CHIP DEVICES; MICROFLUIDIC ANALYTICAL TECHNIQUES; PERFUSION; SINGLE-CELL ANALYSIS;

EID: 79959626987     PISSN: 0091679X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-374912-3.00005-5     Document Type: Book

References (95)

1. Adams J.D., Kim U., Soh H.T. Multitarget magnetic activated cell sorter. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:18165-18170.
2. Adams J.D., Tom Soh H. Perspectives on utilizing unique features of microfluidics technology for particle and cell sorting. JALA Charlottesv Va 2009, 14:331-340.
3. Andersson H., van den Berg A. Microtechnologies and nanotechnologies for single-cell analysis. Curr. Opin. Biotechnol. 2004, 15:44-49.
4. Arndt-Jovin D.J., Jovin T.M. Computer-controlled multiparameter analysis and sorting of cells and particles. J. Histochem. Cytochem. 1974, 22:622-625.
5. Baret J.C., Miller O.J., Taly V., Ryckelynck M., El-Harrak A., Frenz L., Rick C., Samuels M.L., Hutchison J.B., Agresti J.J., Link D.R., Weitz D.A., Griffiths A.D. Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity. Lab Chip 2009, 9:1850-1858.
6. Beebe D.J., Mensing G.A., Walker G.M. Physics and applications of microfluidics in biology. Annu. Rev. Biomed. Eng. 2002, 4:261-286.
7. Berthier E., Warrick J., Yu H., Beebe D.J. Managing evaporation for more robust microscale assays. Part 1. Volume loss in high throughput assays. Lab Chip 2008, 8:852-859.
8. Berthier E., Warrick J., Yu H., Beebe D.J. Managing evaporation for more robust microscale assays. Part 2. Characterization of convection and diffusion for cell biology. Lab Chip 2008, 8:860-864.
9. Bhagat A.A., Bow H., Hou H.W., Tan S.J., Han J., Lim C.T. Microfluidics for cell separation. Med. Biol. Eng. Comput. 2010, 48:999-1014.
10. Bhagat A.A., Kuntaegowdanahalli S.S., Kaval N., Seliskar C.J., Papautsky I. Inertial microfluidics for sheath-less high-throughput flow cytometry. Biomed. Microdevices 2010, 12:187-195.
11. Chan S.D., Luedke G., Valer M., Buhlmann C., Preckel T. Cytometric analysis of protein expression and apoptosis in human primary cells with a novel microfluidic chip-based system. Cytometry A 2003, 55:119-125.
12. Cheung K.C., Di Berardino M., Schade-Kampmann G., Hebeisen M., Pierzchalski A., Bocsi J., Mittag A., Tarnok A. Microfluidic impedance-based flow cytometry. Cytometry A 2010, 77:648-666.
13. Cho S.H., Chen C.H., Tsai F.S., Godin J.M., Lo Y.H. Human mammalian cell sorting using a highly integrated micro-fabricated fluorescence-activated cell sorter (microFACS). Lab Chip 2010, 10:1567-1573.
14. Chung T.D., Kim H.C. Recent advances in miniaturized microfluidic flow cytometry for clinical use. Electrophoresis 2007, 28:4511-4520.
15. Darzynkiewicz Z., Bedner E., Li X., Gorczyca W., Melamed M.R. Laser-scanning cytometry: A new instrumentation with many applications. Exp. Cell Res. 1999, 249:1-12.
16. Di Carlo D., Wu L.Y., Lee L.P. Dynamic single cell culture array. Lab Chip 2006, 6:1445-1449.
17. Dittrich P.S., Manz A. Lab-on-a-chip: microfluidics in drug discovery. Nat. Rev. Drug Discov. 2006, 5:210-218.
18. Eisenstein M. Cell sorting: divide and conquer. Nature 2006, 441:1179-1185.
19. Faley S.L., Copland M., Wlodkowic D., Kolch W., Seale K.T., Wikswo J.P., Cooper J.M. Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. Lab Chip 2009, 9:2659-2664.
20. Franke T.A., Wixforth A. Microfluidics for miniaturized laboratories on a chip. Chemphyschem 2008, 9:2140-2156.
21. Gluckstad J. Microfluidics: sorting particles with light. Nat Mater. 2004, 3:9-10.
22. Hallow D.M., Seeger R.A., Kamaev P.P., Prado G.R., LaPlaca M.C., Prausnitz M.R. Shear-induced intracellular loading of cells with molecules by controlled microfluidics. Biotechnol. Bioeng. 2008, 99:846-854.
23. Hill D.C. Trends in development of high-throughput screening technologies for rapid discovery of novel drugs. Curr. Opin. Drug Discov. Devel. 1998, 1:92-97.
24. Holmes D., Gawad S. The application of microfluidics in biology. Methods Mol. Biol. 2010, 583:55-80.
25. Huh D., Gu W., Kamotani Y., Grotberg J.B., Takayama S. Microfluidics for flow cytometric analysis of cells and particles. Physiol. Meas. 2005, 26:R73-98.
26. Hur S.C., Tse H.T., Di Carlo D. Sheathless inertial cell ordering for extreme throughput flow cytometry. Lab Chip 2010, 10:274-280.
27. Irimia D., Toner M. Spontaneous migration of cancer cells under conditions of mechanical confinement. Integr. Biol. (Camb) 2009, 1:506-512.
28. Jang L.S., Huang P.H., Lan K.C. Single-cell trapping utilizing negative dielectrophoretic quadrupole and microwell electrodes. Biosens. Bioelectron. 2009, 24:3637-3644.
29. Kastrup C.J., Runyon M.K., Lucchetta E.M., Price J.M., Ismagilov R.F. Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks. Acc. Chem. Res. 2008, 41:549-558.
30. Kiechle F.L., Holland C.A. Point-of-care testing and molecular diagnostics: miniaturization required. Clin. Lab. Med. 2009, 29:555-560.
31. Kummrow A., Theisen J., Frankowski M., Tuchscheerer A., Yildirim H., Brattke K., Schmidt M., Neukammer J. Microfluidic structures for flow cytometric analysis of hydrodynamically focussed blood cells fabricated by ultraprecision micromachining. Lab Chip 2009, 9:972-981.
32. Kuntaegowdanahalli S.S., Bhagat A.A., Kumar G., Papautsky I. Inertial microfluidics for continuous particle separation in spiral microchannels. Lab Chip 2009, 9:2973-2980.
33. Lan K.C., Jang L.S. Integration of single-cell trapping and impedance measurement utilizing microwell electrodes. Biosens Bioelectron. 2010, 26:2025-2031.
34. Lee M.G., Choi S., Park J.K. Three-dimensional hydrodynamic focusing with a single sheath flow in a single-layer microfluidic device. Lab Chip 2009, 9:3155-3160.
35. Lee W.G., Kim Y.G., Chung B.G., Demirci U., Khademhosseini A. Nano/microfluidics for diagnosis of infectious diseases in developing countries. Adv. Drug Deliv. Rev. 2010, 62:449-457.
36. Linder V. Microfluidics at the crossroad with point-of-care diagnostics. Analyst 2007, 132:1186-1192.
37. Lindstrom S., Andersson-Svahn H. Miniaturization of biological assays - Overview on microwell devices for single-cell analyses. Biochim. Biophys. Acta. 2010, 1810:308-316.
38. Lindstrom S., Eriksson M., Vazin T., Sandberg J., Lundeberg J., Frisen J., Andersson-Svahn H. High-density microwell chip for culture and analysis of stem cells. PLoS One 2009, 4:e6997.
39. Lindstrom S., Hammond M., Brismar H., Andersson-Svahn H., Ahmadian A. PCR amplification and genetic analysis in a microwell cell culturing chip. Lab Chip 2009, 9:3465-3471.
40. Lindstrom S., Mori K., Ohashi T., Andersson-Svahn H. A microwell array device with integrated microfluidic components for enhanced single-cell analysis. Electrophoresis 2009, 30:4166-4171.
41. Liu T., Li C., Li H., Zeng S., Qin J., Lin B. A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix. Electrophoresis 2009, 30:4285-4291.
42. Mach W.J., Thimmesch A.R., Orr J.A., Slusser J.G., Pierce J.D. Flow cytometry and laser scanning cytometry, a comparison of techniques. J. Clin. Monit. Comput. 2010, 24:251-259.
43. Mansfield C.D., Man A., Shaw R.A. Integration of microfluidics with biomedical infrared spectroscopy for analytical and diagnostic metabolic profiling. IEE Proc. Nanobiotechnol. 2006, 153:74-80.
44. Mao X., Lin S.C., Dong C., Huang T.J. Single-layer planar on-chip flow cytometer using microfluidic drifting based three-dimensional (3D) hydrodynamic focusing. Lab Chip 2009, 9:1583-1589.
45. Mauk M.G., Ziober B.L., Chen Z., Thompson J.A., Bau H.H. Lab-on-a-chip technologies for oral-based cancer screening and diagnostics: capabilities, issues, and prospects. Ann. N.Y. Acad. Sci. 2007, 1098:467-475.
46. Mayr L.M., Bojanic D. Novel trends in high-throughput screening. Curr. Opin. Pharmacol. 2009, 9:580-588.
47. Melamed M.R. A brief history of flow cytometry and sorting. Methods Cell Biol. 2001, 63:3-17.
48. Michelsen U. Microfluidics in medical applications. Med. Device Technol. 2007, 18:12-14.
49. Myers F.B., Lee L.P. Innovations in optical microfluidic technologies for point-of-care diagnostics. Lab Chip 2008, 8:2015-2031.
50. Oakey J., Applegate R.W., Arellano E., Di Carlo D., Graves S.W., Toner M. Particle focusing in staged inertial microfluidic devices for flow cytometry. Anal. Chem. 2010, 82:3862-3867.
51. Ong P.K., Lim D., Kim S. Are microfluidics-based blood viscometers ready for point-of-care applications? A review. Crit. Rev. Biomed. Eng. 2010, 38:189-200.
52. Palkova Z., Vachova L., Valer M., Preckel T. Single-cell analysis of yeast, mammalian cells, and fungal spores with a microfluidic pressure-driven chip-based system. Cytometry A 2004, 59:246-253.
53. Pfohl T., Mugele F., Seemann R., Herminghaus S. Trends in microfluidics with complex fluids. Chemphyschem 2003, 4:1291-1298.
54. Polson N.A., Hayes M.A. Microfluidics: controlling fluids in small places. Anal. Chem. 2001, 73:312A-319A.
55. Pugmire D.L., Waddell E.A., Haasch R., Tarlov M.J., Locascio L.E. Surface characterization of laser-ablated polymers used for microfluidics. Anal. Chem. 2002, 74:871-878.
56. Qi S., Liu X., Ford S., Barrows J., Thomas G., Kelly K., McCandless A., Lian K., Goettert J., Soper S.A. Microfluidic devices fabricated in poly(methyl methacrylate) using hot-embossing with integrated sampling capillary and fiber optics for fluorescence detection. Lab Chip 2002, 2:88-95.
57. Rettig J.R., Folch A. Large-scale single-cell trapping and imaging using microwell arrays. Anal. Chem. 2005, 77:5628-5634.
58. Revzin A., Sekine K., Sin A., Tompkins R.G., Toner M. Development of a microfabricated cytometry platform for characterization and sorting of individual leukocytes. Lab Chip 2005, 5:30-37.
59. Schaff U.Y., Xing M.M., Lin K.K., Pan N., Jeon N.L., Simon S.I. Vascular mimetics based on microfluidics for imaging the leukocyte--endothelial inflammatory response. Lab Chip 2007, 7:448-456.
60. Scott R., Sethu P., Harnett C.K. Three-dimensional hydrodynamic focusing in a microfluidic Coulter counter. Rev. Sci. Instrum. 2008, 79:046104.
61. Shapiro H.M. The evolution of cytometers. Cytometry A 2004, 58:13-20.
62. Sia S.K., Kricka L.J. Microfluidics and point-of-care testing. Lab Chip 2008, 8:1982-1983.
63. Sia S.K., Whitesides G.M. Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 2003, 24:3563-3576.
64. Sims C.E., Allbritton N.L. Analysis of single mammalian cells on-chip. Lab Chip 2007, 7:423-440.
65. Situma C., Hashimoto M., Soper S.A. Merging microfluidics with microarray-based bioassays. Biomol. Eng. 2006, 23:213-231.
66. Skommer J., Darzynkiewicz Z., Wlodkowic D. Cell death goes LIVE: technological advances in real-time tracking of cell death. Cell Cycle 2010, 9.
67. Stroock A.D., Fischbach C. Microfluidic culture models of tumor angiogenesis. Tissue Eng. Part A 2010, 16:2143-2146.
68. Svahn H.A., van den Berg A. Single cells or large populations?. Lab Chip 2007, 7:544-546.
69. Takayama S., Ostuni E., LeDuc P., Naruse K., Ingber D.E., Whitesides G.M. Subcellular positioning of small molecules. Nature 2001, 411:1016.
70. Takayama S., Ostuni E., LeDuc P., Naruse K., Ingber D.E., Whitesides G.M. Selective chemical treatment of cellular microdomains using multiple laminar streams. Chem. Biol. 2003, 10:123-130.
71. Takeda K., Jimma F. Maintenance free biosafety flowcytometer using disposable microfluidic chip (FISHMAN-R). Cytometry B 2009, 76B:405-406.
72. Takao M., Jimma F., Takeda K. Expanded applications of new-designed microfluidic flow cytometer (FISHMAN-R). Cytometry B 2009, 76B:405.
73. Thomas R.S., Morgan H., Green N.G. Negative DEP traps for single cell immobilisation. Lab Chip 2009, 9:1534-1540.
74. Wang J., Ren L., Li L., Liu W., Zhou J., Yu W., Tong D., Chen S. Microfluidics: a new cosset for neurobiology. Lab Chip 2009, 9:644-652.
75. Wang M.M., Tu E., Raymond D.E., Yang J.M., Zhang H., Hagen N., Dees B., Mercer E.M., Forster A.H., Kariv I., Marchand P.J., Butler W.F. Microfluidic sorting of mammalian cells by optical force switching. Nat. Biotechnol. 2005, 23:83-87.
76. Wang Z., Kim M.C., Marquez M., Thorsen T. High-density microfluidic arrays for cell cytotoxicity analysis. Lab Chip 2007, 7:740-745.
77. Warrick J.W., Murphy W.L., Beebe D.J. Screening the cellular microenvironment: a role for microfluidics. IEEE Rev. Biomed. Eng. 2008, 1:75-93.
78. Weibel D.B., Whitesides G.M. Applications of microfluidics in chemical biology. Curr. Opin. Chem. Biol. 2006, 10:584-591.
79. Weigl B., Domingo G., Labarre P., Gerlach J. Towards non- and minimally instrumented, microfluidics-based diagnostic devices. Lab Chip 2008, 8:1999-2014.
80. Wheeler D.B., Carpenter A.E., Sabatini D.M. Cell microarrays and RNA interference chip away at gene function. Nat. Genet. 2005, 37(Suppl):S25-30.
81. Whitesides G.M. The origins and the future of microfluidics. Nature 2006, 442:368-373.
82. Wlodkowic D., Cooper J.M. Microfabricated analytical systems for integrated cancer cytomics. Anal. Bioanal. Chem. 2010, 398:193-209.
83. Wlodkowic D., Cooper J.M. Microfluidic cell arrays in tumor analysis: new prospects for integrated cytomics. Expert Rev. Mol. Diagn. 2010, 10:521-530.
84. Wlodkowic D., Cooper J.M. Tumors on chips: oncology meets microfluidics. Curr. Opin. Chem. Biol. 2010, 14:556-567.
85. Wlodkowic D., Faley S., Skommer J., McGuinness D., Cooper J.M. Biological implications of polymeric microdevices for live cell assays. Anal. Chem. 2009, 81:9828-9833.
86. Wlodkowic D., Faley S., Zagnoni M., Wikswo J.P., Cooper J.M. Microfluidic single-cell array cytometry for the analysis of tumor apoptosis. Anal. Chem. 2009, 81:5517-5523.
87. Wlodkowic D., Skommer J., Darzynkiewicz Z. Cytometry in cell necrobiology revisited. Recent advances and new vistas. Cytometry A 2010, 77:591-606.
88. Wlodkowic D., Skommer J., Faley S., Darzynkiewicz Z., Cooper J.M. Dynamic analysis of apoptosis using cyanine SYTO probes: from classical to microfluidic cytometry. Exp. Cell Res. 2009, 315:1706-1714.
89. Wlodkowic D., Skommer J., McGuinness D., Faley S., Kolch W., Darzynkiewicz Z., Cooper J.M. Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells. Anal. Chem. 2009, 81:6952-6959.
90. Wolff A., Perch-Nielsen I.R., Larsen U.D., Friis P., Goranovic G., Poulsen C.R., Kutter J.P., Telleman P. Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter. Lab Chip 2003, 3:22-27.
91. Wood D.K., Weingeist D.M., Bhatia S.N., Engelward B.P. Single cell trapping and DNA damage analysis using microwell arrays. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:10008-10013.
92. Yarmush M.L., King K.R. Living-cell microarrays. Annu. Rev. Biomed. Eng. 2009, 11:235-257.
93. Zaouk R., Park B.Y., Madou M.J. Fabrication of polydimethylsiloxane microfluidics using SU-8 molds. Methods Mol. Biol. 2006, 321:17-21.
94. Zhang W., Lin S., Wang C., Hu J., Li C., Zhuang Z., Zhou Y., Mathies R.A., Yang C.J. PMMA/PDMS valves and pumps for disposable microfluidics. Lab Chip 2009, 9:3088-3094.
95. Zhu T., Luo C., Huang J., Xiong C., Ouyang Q., Fang J. Electroporation based on hydrodynamic focusing of microfluidics with low dc voltage. Biomed. Microdevices 2010, 12:35-40.