The reciprocal interaction: Chemotherapy and tumor microenvironment

Current Drug Discovery Technologies

Volumn 8, Issue 2, 2011, Pages 102-106

  Kim, Soo Hyun ^a   Kuh, Hyo Jeong ^a   Dass, Crispin R ^b  

^a The Catholic University of Korea   (South Korea)

^b VICTORIA UNIVERSITY   (Australia)

Author keywords

3 D multicellular culture system; Drug distribution; Drug penetration; Tumor environment

Indexed keywords

AMMONIUM CHLORIDE; BAFILOMYCIN A1; CHLOROQUINE; COLLAGENASE; DOCETAXEL; DOXORUBICIN; FOLIC ACID; HYALURONIDASE; LOSARTAN; MONOCLONAL ANTIBODY DC101; OMEPRAZOLE; PACLITAXEL;

ARTICLE; CANCER CHEMOTHERAPY; CELL CULTURE; CELL DENSITY; CELL JUNCTION; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG PENETRATION; EXTRACELLULAR MATRIX; PRIORITY JOURNAL; SOLID TUMOR; TUMOR BLOOD FLOW; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASMS; PERMEABILITY; TUMOR MICROENVIRONMENT;

EID: 79956154757     PISSN: 15701638     EISSN: 18756220     Source Type: Journal    
DOI: 10.2174/157016311795563875     Document Type: Article

References (61)

1. Primeau AJ, Rendon A, Hedley D, Lilge L, Tannock IF. The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors. Clin Cancer Res 2005; 11(24 Pt 1): 8782-8. (Pubitemid 43005929)
2. Huxham LA, Kyle AH, Baker JH, Nykilchuk LK, Minchinton AI. Microregional effects of gemcitabine in HCT-116 xenografts. Cancer Res 2004; 64(18): 6537-41. (Pubitemid 39297911)
3. Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer 2006; 6(8): 583-92. (Pubitemid 44140857)
4. Trédan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 2007; 99(19): 1441-54.
5. Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res 1991; 51(1): 265-73.
6. Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK. Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvasc Res 1996; 51(3): 327-46. (Pubitemid 26162001)
7. Brown JM. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 1979; 52(620): 650-6. (Pubitemid 9239867)
8. Brown JM. The hypoxic cell: a target for selective cancer therapy- eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res 1999; 59(23): 5863-70. (Pubitemid 30004940)
9. Moulder JE, Rockwell S. Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev 1987; 5(4): 313-41.
10. Tsunemoto H, Ando K, Koike S, Urano M. Repopulation of tumour cells following irradiation with X-rays or low energy neutrons. Int J Radiat Biol 1994; 65(2): 255-61. (Pubitemid 24097197)
11. Meijne EI, Ploemacher RE, Huiskamp R. Sensitivity of murine haemopoietic stem cell populations to X-rays and 1 MeV fission neutrons in vitro and in vivo under hypoxic conditions. Int J Radiat Biol 1996; 70(5): 571-7. (Pubitemid 26388948)
12. Sutherland RM. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988; 240(4849): 177-84.
13. Hicks KO, Fleming Y, Siim BG, Koch CJ, Wilson WR. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. Int J Radiat Oncol Biol Phys 1998; 42(3): 641-9. (Pubitemid 28501116)
14. Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev 1990; 9(3): 253-66. (Pubitemid 20380382)
15. Jain RK, Baxter LT. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res 1988; 48(24 Pt 1): 7022-32. (Pubitemid 19013976)
16. Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res 2000; 60(9): 2497-503. (Pubitemid 30262444)
17. Vincent T, Mechti N. Extracellular matrix in bone marrow can mediate drug resistance in myeloma. Leuk Lymphoma 2005; 46(6): 803-11. (Pubitemid 40959669)
18. Hodkinson PS, Mackinnon AC, Sethi T. Extracellular matrix regulation of drug resistance in small-cell lung cancer. Int J Radiat Biol 2007; 83(11-12): 733-41. (Pubitemid 350219111)
19. Rintoul RC, Sethi T. Extracellular matrix regulation of drug resistance in small-cell lung cancer. Clin Sci (Lond) 2002; 102(4): 417-24. (Pubitemid 34275794)
20. Sethi T, Rintoul RC, Moore SM, et al. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 1999; 5(6): 662-8. (Pubitemid 29289430)
21. Conn KG, Knudsen KA. Effect of tight junctional resistance on penetration of LLC-PK1 epithelial cell layers by metastatic B16- F10 melanoma cells. Cancer Res 1989; 49(24 Pt 1): 7098-105. (Pubitemid 20016599)
22. Olive PL, Durand RE. Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metastasis Rev 1994; 13(2): 121-38. (Pubitemid 24220001)
23. Kobayashi H, Man S, Graham CH, Kapitain SJ, Teicher BA, Kerbel RS. Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc Natl Acad Sci USA 1993; 90(8): 3294-8. (Pubitemid 23111352)
24. Phillips RM, Loadman PM, Cronin BP. Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. Br J Cancer 1998; 77(12): 2112-9. (Pubitemid 28263930)
25. Tunggal JK, Ballinger JR, Tannock IF. Influence of cell concentration in limiting the therapeutic benefit of P-glycoprotein reversal agents. Int J Cancer 1999; 81(5): 741-7. (Pubitemid 29214384)
26. Al-Abd AM, Lee JH, Kim SY, Kun N, Kuh HJ. Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel. Cancer Sci 2008; 99(2): 423-31. (Pubitemid 351228501)
27. Grantab R, Sivananthan S, Tannock IF. The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells. Cancer Res 2006; 66(2): 1033-9. (Pubitemid 43165971)
28. Kuh HJ, Jang SH, Wientjes MG, Weaver JR, Au JL. Determinants of paclitaxel penetration and accumulation in human solid tumor. J Pharmacol Exp Ther 1999; 290(2): 871-80. (Pubitemid 29344588)
29. Jang SH, Wientjes MG, Au JL. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J Pharmacol Exp Ther 2001; 296(3): 1035-42. (Pubitemid 32187379)
30. Au JL, Jang SH, Zheng J, Chen CT, Song S, Hu L, Wientjes MG. Determinants of drug delivery and transport to solid tumors. J Control Release 2001; 74(1-3): 31-46. (Pubitemid 32727607)
31. Jang SH, Wientjes MG, Lu D, Au JL. Drug delivery and transport to solid tumors. Pharm Res 2003; 20(9): 1337-50. (Pubitemid 37164040)
32. Madden TD, Harrigan PR, Tai LC, Bally MB, Mayer LD, Redelmeier TE, Loughrey HC, Tilcock CP, Reinish LW, Cullis PR. The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey. Chem Phys Lipids 1990; 53(1): 37-46. (Pubitemid 20104038)
33. Mayer LD, Bally MB, Cullis PR. Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochim Biophys Acta 1986; 857(1): 123-6. (Pubitemid 16085119)
34. Lee CM, Tannock IF. Inhibition of endosomal sequestration of basic anticancer drugs: influence on cytotoxicity and tissue penetration. Br J Cancer 2006; 94(6): 863-9.
35. Hicks KO, Ohms SJ, van Zijl PL, Denny WA, Hunter PJ, Wilson WR. An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours. Br J Cancer 1997; 76(7): 894-903. (Pubitemid 27401941)
36. Cichowicz DJ, Foo SK, Shane B. Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells. Mol Cell Biochem 1981; 39: 209-28. (Pubitemid 12178451)
37. Cowan DS, Tannock IF. Factors that influence the penetration of methotrexate through solid tissue. Int J Cancer 2001; 91(1): 120-5.
38. Cowan DS, Hicks KO, Wilson WR. Multicellular membranes as an in vitro model for extravascular diffusion in tumours. Br J Cancer Suppl 1996; 27: S28-31. (Pubitemid 26237922)
39. Sutherland RM, Inch WR, McCredie JA, Kruuv J. A multicomponent radiation survival curve using an in vitro tumour model. Int J Radiat Biol Relat Stud Phys Chem Med 1970; 18(5): 491-5.
40. Kunz-Schughart LA, Freyer JP, Hofstaedter F, Ebner R. The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen 2004; 9(4): 273-85.
41. Ong SM, Zhao Z, Arooz T, et al. Engineering a scaffold-free 3Dtumor model for in vitro drug penetration studies. Biomaterials 2010; 31(6): 1180-90.
42. Ong SM, Zhang C, Toh YC, et al. A gel-free 3D microfluidic cell culture system. Biomaterials 2008; 29(22): 3237-44.
43. Kim MS, Yeon JH, Park JK. A microfluidic platform for 3- dimensional cell culture and cell-based assays. Biomed Microdevices 2007; 9(1): 25-34. (Pubitemid 46050126)
44. Kim MS, Kim T, Kong SY, et al. Breast cancer diagnosis using amicrofluidic multiplexed immunohistochemistry platform. PLoS One 2010; 5(5): e10441.
45. Kim MS, Kwon S, Kim T, Lee ES, Park JK. Quantitative proteomic profiling of breast cancers using a multiplexed microfluidic platform for immunohistochemistry and immunocytochemistry. Biomaterials 2011; 32(5): 1396-403.
46. Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res 1999; 59(15): 3776-82. (Pubitemid 29381886)
47. Lu D, Wientjes MG, Lu Z, Au JL. Tumor priming enhances delivery and efficacy of nanomedicines. J Pharmacol Exp Ther 2007; 322(1): 80-8. (Pubitemid 46956353)
48. Wong HL, Shen Z, Lu Z, Wientjes MG, Au JL. Paclitaxel Tumor- Priming Enhances siRNA Delivery and Transfection in 3- Dimensional Tumor Cultures. Mol Pharm 2011; [Epub ahead of print].
49. Taghian AG, Abi-Raad R, Assaad SI, et al. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol 2005; 23(9): 1951-61. (Pubitemid 46211374)
50. Myoung H, Hong SD, Kim YY, Hong SP, Kim MJ. Evaluation of the anti-tumor and anti-angiogenic effect of paclitaxel and thalidomide on the xenotransplanted oral squamous cell carcinoma. Cancer Lett 2001; 163(2): 191-200. (Pubitemid 32126365)
51. Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004; 64(11): 3731-6. (Pubitemid 38697278)
52. Eikenes L, Bruland ØS, Brekken C, Davies Cde L. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res 2004; 64(14): 4768-73. (Pubitemid 38930817)
53. Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci USA 2011; 108(7): 2909-14.
54. Eikenes L, Tari M, Tufto I, Bruland OS, de Lange Davies C. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts. Br J Cancer 2005; 93(1): 81-8. (Pubitemid 41078799)
55. Erikson A, Tufto I, Bjønnum AB, Bruland ØS, Davies Cde L. The impact of enzymatic degradation on the uptake of differently sized therapeutic molecules. Anticancer Res 2008; 28(6A): 3557-66.
56. Tufto I, Hansen R, Byberg D, Nygaard KH, Tufto J, Davies Cde L. The effect of collagenase and hyaluronidase on transient perfusion in human osteosarcoma xenografts grown orthotopically and in dorsal skinfold chambers. Anticancer Res 2007; 27(3B): 1475-81.
57. Tirumalasetty PP, Eley JG. Evaluation of dodecylmaltoside as a permeability enhancer for insulin using human carcinoma cells. J Pharm Sci 2005; 94(2): 246-55. (Pubitemid 40293322)
58. Lu Z, Tsai M, Lu D, Wang J, Wientjes MG, Au JL. Tumorpenetrating microparticles for intraperitoneal therapy of ovarian cancer. J Pharmacol Exp Ther 2008; 327(3): 673-82.
59. Kim TH, Mount CW, Gombotz WR, Pun SH. The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. Biomaterials 2010; 31(28): 7386-97.
60. Sugahara KN, Teesalu T, Karmali PP, et al. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell 2009; 16(6): 510-20.
61. Sugahara KN, Teesalu T, Karmali PP, et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 2010; 328(5981): 1031-5.