Tissue engineered tumor models

Biotechnic and Histochemistry

Volumn 85, Issue 4, 2010, Pages 213-229

  Ingram, M ^a   Techy, G B ^a   Ward, B R ^a   Imam, S A ^a   Atkinson, R ^b   Ho, H ^c   Taylor, C R ^d  

^a HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^b Clarient Inc   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Bioreactor; Cell interactions; Drug testing; Flow cytometry; Histoids; Image analysis; Surrogate tumors; Three dimensional culture

Indexed keywords

ARTICLE; BIOLOGICAL MODEL; BIOREACTOR; COCULTURE; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; EPITHELIUM CELL; FLOW CYTOMETRY; HUMAN; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; METHODOLOGY; MULTICELLULAR SPHEROID; NEOPLASM; PARTICLE SIZE; PATHOLOGY; PHYSIOLOGY; STROMA CELL; TUMOR CELL LINE; DRUG EFFECTS; NEOPLASMS; PROCEDURES;

BIOREACTORS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; COCULTURE TECHNIQUES; EPITHELIAL CELLS; FLOW CYTOMETRY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MODELS, BIOLOGICAL; NEOPLASMS; PARTICLE SIZE; SPHEROIDS, CELLULAR; STROMAL CELLS;

EID: 77954693898     PISSN: 10520295     EISSN: 14737760     Source Type: Journal    
DOI: 10.3109/10520295.2010.483655     Document Type: Article

References (70)

1. Acker H, Carlsson J, Durand R, Sutherland RM , Eds. (1984) Spheroids in Cancer Research. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo.
2. Acker H, Carlsson J, Holtermann G, Nederman T, Nylen T (1987) Influence of glucose and buffer capacity in the culture medium on growth and pH in spheroids of human thyroid carcinoma and human glioma origin. Cancer Res. 471: 3504-3508.
3. Acker H, Carlsson J, Mueller-Klieser W, Sutherland RM (1987) Comparative pO2 measurements in cell spheroids cultured with different techniques. Br. J. Cancer 56: 325-327.
4. Apfelbach CW, de la Torre-Bueno (2003) Making image analysis technology accessible to community pathologists. IVD Technol. 9: 933-938.
5. Bauer KD, de la Torre J, Diel IJ, Hawes D, Decker WJ, Priddy C, Bossy B, Ludmann S, Yamamoto K, Masih AS (2002) Reliable and sensitive analysis of occult bone marrow metastases using automated cellular imaging. Clin. Cancer Res. 6: 3552-3559.
6. Bjerkvig R , Ed. (1992) Spheroid Cultures in Cancer Research. CRC Press, Boca Raton, FL.
7. Bloom KJ, Torre-Bueno J, Press M, Gown A, Bauer K, Harrington D (2000) Comparison of HER-2/neu analysis using FISH and IHC when Hercep Test is scored using conventional microscopy and image analysis. Breast Cancer Res. Treat. 64: 99-101.
8. Bredel GA, Karlsbach U, Walenta S, Vollrath L, Mueller-Klieser W (1992) Proliferation-associated oxygen consumption and morphology of tumor cells in monolayer and spheroid cultures. J. Cell. Physiol 153: 44-52.
9. Cailleau R, Olive M, Cruciger OV (1978) Long term human breast carcinoma cell lines of metastatic origin: preliminary characterization. In Vitro Cell Dev. Biol. 14: 911-915.
10. Carlsson J, Acker H (1988) Relations between pH, oxygen partial pressure and growth in cultured cell spheroids. Int. J. Cancer 42: 715-720.
11. Carlsson J, Daniel-Szolgay E, Frykholm G, Glimelius B, Hedin A Larsson B (1989) Homogeneous penetration but heterogeneous binding of antibodies to carcinoembyronic antigen in colon carcinoma HT-29 spheroid. Cancer Immunol. Immunother. 30: 269-276.
12. Carlsson J, Stalnacke CG, Acker H, Haji-Karim M, Nilsson S, Larsson B (1979) The influence of oxygen on viability and proliferation in cellular spheroids. Int. J. Radiat. Oncol. Biol. Phys. 5: 2011-2020.
13. Cassieri JJ, Sotirchoss V, Sutherland RM (1988) Glucose diffusivity in multicellular tumor spheroids. Cancer Res. 48: 3905-3909.
14. Comoglio Paolo M, Trusolino L (2005) Cancer: the matrix is now in control. Nature Med. 11: 1156-1159.
15. Corbett T, Valeriote F, LoRusso P, Polin L, Panctiapor C, Pugh S, White K, Knight J, Demchik L, Jones J, Jones L, Lisocow L (1997) In vitro methods for screening and preclinical testing in: Cancer Drug Discovery and Design , B Teicher, Ed. Humana Press, Inc. Torowa, NJ. pp. 75-99.
16. Donaldson JT, Tucker JA, Keane TE, Walther PJ, Webb KS (1990) Characterization of a new model of human prostate cancer: the multicellular tumor spheroid. Int. J. Cancer 46: 238-244.
17. Durand RE (1986) Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment. J. Natl. Cancer Inst. 77: 247-252.
18. Durand RE (1989) Distribution and activity of antineoplastic drugs in a tumor model. J. Natl. Cancer Inst. 8: 146-152.
19. Durand RE, Sutherland RM (1972). Effects of intercellular contact on repair of radiation damage. Exp. Cell Res. 71: 75-80.
20. Ehrichman C, Vidgen D (1984) Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids and xenografts in immune-deprived mice. Cancer Res. 369-375.
21. Essand M, Nilsson S., Carlsson J (1993) Growth of prostatic cancer cells, DU145, as multicellular spheroids and effects of extramustine. Anticancer Res. 13: 1261-1268.
22. Freyer JP (1991) Rates of oxygen consumption for proliferating and quiescent cells isolated from multicellular tumor spheroids. Cancer Res. 51: 3831-3837.
23. Freyer JP, Schor PL (1989) Regrowth kinetics of cells from different regions of multicellular spheroids of four cell lines. J. Cell. Physiol. 138: 384-392.
24. Freyer JP, Schor PL, Jarrett KA, Neeman M, Sillerud LO (1991) Cellular energetics measured by phosphorous nuclear magnetic resonance spectroscopy are not correlated with chronic nutrient deficiency in multicellular tumor spheroids. Cancer Res. 51: 3831-3837.
25. Freyer JP, Sutherland RM (1980) Selective dissociation and characterization of cells from different regions of multicell tumor spheroids. Cancer Res. 40: 3956-3965.
26. Goodwin TJ, Jessup JM, Wolf DA (1992) Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating wall vessels. In Vitro Cell Dev. Biol. 28A: 47-60.
27. Goodwin TJ, Prewitt TL, Wolf DA, Spaulding GF (1993) Reduced shear stress: a major component in the ability of mammalian tissue to form three dimensional assemblies in simulated microgravity. J. Cell Biochem. 51: 301-311.
28. Groebe K, Mueller-Klieser WF (1991) Distribution of oxygen, nutrient and metabolic waste concentrations in multicellular spheroids and their dependence on spheroid parameters. Eur. Biophys. J. 19: 169-171.
29. Gura T (1997). Systems for identifying new drugs are often faulty. Science 278: 1041-1042.
30. Imam SA, Young L, Chaiwun B, Taylor CR (1995) Comparison of two microwave-based solutions in unmasking epitopes in formalin-fixed tissue for immunostaining. Anticancer Res. 15: 1153-1158.
31. Ingram M, Spaulding GF, Craft JJG, Ng C-P, Saroufeem R, Techy GB, Yazan O (1996). A novel hydrodynamic cell culture environment for three-dimensional tissue growth. U.S. Patent No. 5,523, 228. Assigned to HMRI.
32. Ingram M, Techy GB, Saroufeem R, Yazan O, Narayan KS, Goodwin TJ, Spaulding GF (1997) Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor. In Vitro Cell Dev. Biol. 33: 459-466.
33. Kerr DJ, Wheldon TE, Kerr AM, Kaye SB (1987) In vitro chemosensitivity testing using the multicellular tumor spheroid model. Cancer Drug Del. 4: 63-73.
34. Kobayashi H, Man S, Graham CH, Kapitain SJ, Telcher BA, Kerbel RS (1993). Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc. Natl. Acad. Sci. USA 90: 3294-3298.
35. Kruse Jr. PF, Patterson Jr. MK (1973). Tissue Culture Methods and Applications. Section 2, Preparation of Primary Cultures. Academic Press, NY, San Francisco, London. pp. 39-64.
36. Langmuir VK, McGann JK, Bachegger F, Sutherland RM (1991) The effect of antigen concentration, antibody valency and size and tumor architecture on antibody binding in multicell spheroids. Int. J. Radiat. Appl. Inst. Part B 18: 753-764.
37. LaRue KEA, Khalil M, Freyer JP (2004) Microenvironmental regulation of proliferation in multicellular spher oids is mediated through differential expression of cyclindependent kinase inhibitors. Cancer Res. 54: 1621-1631.
38. Lasfarges EY, Ozzello L (1958) Cultivation of human breast carcinomas. J. Natl. Cancer Inst. 21: 1131-1147.
39. Meltzer P, Leibovitz A (1991) Establishment of two new breast carcinomas with HER-2/neu amplification. Br. J. Cancer 63: 727-735.
40. Moscona AA (1965) Recombination of dissociated cells and the development of cell aggregates. In: Cells and Tissues in Culture , Vol.1, EN Willmer, Ed., Academic Press, London, New York. pp. 489-530.
41. Moscona AA, Trowell OA, Willmer EN (1965) Chapter 2. In: Methods in Cells and Tissues in Culture. Academic Press, London, New York. pp. 19-98.
42. Mueller-Klieser WF (1987) Multicellular spheroids. A review on cellular aggregates in cancer research. J. Cancer Res. Clin. Oncol. 113: 101-122.
43. Mueller-Klieser W (1997) Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am. J. Physiol. Cell Physiol. 273: C1109-C1123. (Pubitemid 127797683)
44. Mueller-Klieser WF, Sutherland RM (1982) Oxygen tensions in multicell spheroids of two cell lines. Br. J. Cancer 45: 256-264.
45. Navone NM, Olive M, Ozen M, Davis R, Troncoso P, Tu S-M, Johnston D, Pollack A, Pathak S, Von Eschenbach AC, Logothetis CJ (1997) Establishment of two human prostate cancer cell lines derived from a single bone metastasis. Clin. Cancer Res. 3: 2493-2500.
46. Nederman T (1984) Effects of vinblastin and 5-fluorouraceil on human glioma and thyroid cancer cell monolayers and spheroids. Cancer Res. 44: 254-258.
47. Nederman T, Carlsson J, Malmqvist M (1981) Penetration of substances into tumor tissue - a methodological study on cellular spheroids. In Vitro Cell Dev. Biol. 17: 290-298.
48. Nederman T, Carlsson J, Kuoppa K (1988) Penetration of substances into tumor tissue: model studies using saccharides thymidine and thymdine-5 ' -triphophate in cellular spheroids. Cancer Chemother. Pharmcol. (West Germany) 22: 21-25.
49. Olive PL, Durand RE (1994) Drug and radiation resistance in spheroids: cell contact and kinetics. Cancer Metas. Rev. 13: 121-138.
50. Pathak S, Nemeth MA, Multani AS (1998) Human tumor xenografts in nude mice are not always of human origin. Cancer 83: 1891-1893.
51. Pretlow TG, Yang B, Pretlow TP (1995) Organ culture of benign, ageing and hyperplastic prostate. Microsc. Res. Tech. 30: 271-281.
52. Rutgers DH, Dorien PPN, vander Linden PM (1987). Cell kinetics of hypoxic cells in a murine tumor in vivo: flow-cytometric determination of the radiation-induced blockage of cell cycle progression. Cell Tissue Kinet. 20: 37-42.
53. Saga T, Neumann RD, Heya T, Sayo J, Kinuya S, Le N, Palk CH, Weinstein JN (1995) Targeting cancer micrometastases with monoclonal antibodies: a binding site barrier. Proc. Natl. Acad. Sci. USA 92: 8999-9003.
54. Schwachofer JHM (1990) Multicellular spheroids in radiotherapy research. Anticancer Res. 10: 963-970.
55. Schweiki D, Neeman M, Itin A, Keshet E (1995) Induction of VEGF expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc. Natl. Acad. Sci. USA 92: 768-792.
56. Smalley KS, Lioni M, Herlyn M (2006) Life isn ' t flat: taking cancer biology to the next dimension. In Vitro Cell Dev. Biol. 42: 242-247.
57. Soule HD, Vazquez J, Long A, Albert S, Brennan M (1973) A human cell line from a pleural effusion derived from a breast carcinoma. J. Natl. Cancer Inst. 51: 1409-1416.
58. Stusche M, Budach V, Stuben G, Streffer C, Sack H (1995) Heterogeneity in the fractionation sensitivities of human tumor cell lines: studies in a three-dimensional model system. Int. J. Radiat. Oncol Biol. Phys. 32: 395-408.
59. Sutherland RM (1988) Cell environment interactions in tumor microregions: the multicell spheroidal model. Science 240: 177-184.
60. Sutherland RM (1995) Mapping of insular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res. 55: 6222-6226.
61. Sutherland RM, Sordat B, Bamat J, Gabbert H, Bourrat B, Mueller-Klieser W (1986) Oxygenation and differentiation in multicellular spheroids of human colon carcinoma. Cancer Res. 46: 5320-5329.
62. Taylor CR (2006) Standardization in immunohistochemistry: the role of antigen retrieval in molecular morphology. Biotech & Histochem. 81: 3-12.
63. Trempe G (1976) Human breast cancer in culture. Recent Results Cancer Res. 57: 33-41.
64. Unsworth BR, Lelkes P (1998) Growing tissues in microgravity. Nature Med. 4: 901-907.
65. Wareh N, Brody MD, Knapp MA, Mendoca HL, Lord EM, Koch CJ, Laderoute KR, Sutherland RM (1995) Mapping of vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxiaspecific marker. Cancer Res. 55: 6222-6226.
66. Walenta S, Bredel A, Karbach U, Vollrath L, Mueller-Kleiser W (1989) Interrelationship among morphology, metabolism and proliferation of tumor cells in monolayer and spheroid culture. Adv. Exp. Med. Biol. 248: 847-853.
67. Walenta S, Dotsch J, Mueller-Kleiser W (1990) ATP concentrations in multicellular tumor spheroids assessed by single photon imaging and quantitative bioluminescence. Eur. J. Cell Biol. 52: 389-393.
68. Wang S, Saboorian MA, Frenkel E, Haley BB, Siddiqui MT, Gokaslan S, Wians FH, Hynan L, Ashfaq R (2000) Laboratory assessment of the status of HER-2/ neu protein and Oncogene in breast cancer specimens: comparison of immunohistochemistry assays with fluorescence in situ hybridization assays. J. Clin. Pathol. 53: 374-381.
69. Yuhas JM, Li AP (1978) Growth fraction as the major determinant of multicellular tumor spheroid growth rates. Cancer Res. 38: 1528-1532.
70. Yunis AA (1977) Human pancreatic carcinomas in continuous culture: sensitivity to asparaginase Int. J. Cancer 19: 128-135.