Multicellular resistance: A paradigm for clinical resistance?

Critical Reviews in Oncology/Hematology

Volumn 36, Issue 2-3, 2000, Pages 193-207

  Desoize, Bernard ^a   Jardillier, Jean Claude ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Anticancer drugs; Metastasis; Multicellular resistance (MCR); Multidrug resistance (MDR); Spheroid

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; AMSACRINE; ANTINEOPLASTIC AGENT; BATIMASTAT; BLEOMYCIN; CARBOPLATIN; CARMUSTINE; CHLORAMBUCIL; CHLORMETHINE; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; DAUNORUBICIN; DOXORUBICIN; ESORUBICIN; ETOPOSIDE; FLUOROURACIL; HYALURONIDASE; IRINOTECAN; LOMUSTINE; MELPHALAN; METHOTREXATE; MITOMYCIN C; TAXOL; THIOTEPA; TIRAPAZAMINE; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE; VINCRISTINE;

APOPTOSIS; CELL ADHESION; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; REVIEW; SPHEROID CELL; TUMOR SPHEROID;

ANIMAL; DRUG RESISTANCE, NEOPLASM; HUMAN; MICE; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; SPHEROIDS; SUPPORT, NON-U.S. GOV'T;

EID: 0033800091     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(00)00086-X     Document Type: Review

References (178)

1. Acquired multicellular-mediated resistance to alkylating agents in cancer
2. Multidrug resistance is not an important factor in therapeutic outcome in human malignancies
3. Effects of intercellular contact on repair of radiation damage
4. Apoptosis induced by inhibition of intercellular contact
5. Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules
6. Control of apoptosis and growth of malignant T lymphoma cells by lymph node stromal cells
7. The extracellular matrix as a cell survival factor
8. Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes
9. Anchorage dependence, integrins, and apoptosis
10. Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
11. Disruption of epithelial cell-matrix interactions induces apoptosis
12. Apoptosis in human fibrosarcoma cells is induced by a multimeric synthetic Tyr-Ile-Gly-Ser-Arg (YIGSR)-containing polypeptide from laminin
13. Extracellular matrices in multicellular spheroids of human glioma origin: increased incorporation of proteoglycans and fibronectin as compared to monolayer cultures
14. Cell adhesion and drug resistance in cancer
15. Involvement of integrins in cell survival
16. Rapid acquisition of multicellular drug resistance after a single exposure of mammary tumor cells to antitumor alkylating agents
17. Social controls on cell survival and cell death
18. Control of adhesion-dependent cell survival by focal adhesion kinase
19. Integrins and anoikis
20. Proliferation and viability in cellular spheroids of human origin
21. Growth of nodular carcinomas in rodents compared with multi-cell spheroids in tissue culture
22. A simplified method for production and growth of multicellular tumor spheroids
23. Plasmin induces the formation of multicellular spheroids of breast cancer cells
24. Inhibition of tumor cell invasion through matrigel by a peptide derived from the domain II region in urinary trypsin inhibition
25. Interaction between ionizing radiation, estrogens and antiestrogens in the modification of tumor microenvironment in estrogen dependent multicellular spheroids
26. Etoposide sensitivity and topoisomerase II activity in Chinese hamster V79 monolayers and small spheroids
27. Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: influence of growth kinetics, growth environment and DNA packaging
28. Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids
29. Effects of nIFNβ and rIFNγ on growth and morphology of two human melanoma cell lines: comparison between 2- and 3-dimensional culture
30. Growth inhibition by interferon beta and gamma of MDA 886Ln monolayer cells and multicellular tumor spheroids. A differentiation therapy model for squamous cell carcinoma
31. Effect of intercellular contact on DNA conformation, radiation-induced DNA damage, and mutation in Chinese hamster V79 cells
32. Cell fusion studies to examine the mechanism for etoposide resistance in Chinese hamster V79 spheroids
33. Oxygenation and differentiation in multicellular spheroids of human colon carcinoma
34. Differentiation patterns in two- and three-dimensional culture systems of human squamous carcinoma cell lines
35. Adhesion and invasion of three human choriocarcinoma cell lines into human endometrium in a three-dimensional organ culture system
36. Multicellular resistance: a new paradigm to explain aspects of acquired drug resistance of solid tumors
37. Impact of multicellular resistance on the survival of solid tumors, including micrometastases
38. Growth regulation of mouse mammary tumor cells in collagen gel cultures by diffusible factors produced by normal mammary gland epithelium and stromal fibroblasts
39. Integrin expression on colorectal tumor cells growing as monolayers, as multicellular tumor spheroids, or in nude mice
40. Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases [see comments]
41. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis
42. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
43. Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker
44. Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells
45. Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours
46. Anticancer drug resistance and inhibition of apoptosis
47. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
48. The α5 β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression
49. Confluence dependent resistance (CDR) to doxorubicin and E-cadherin expression in murine mammary cells
50. Circumvention of confluence-dependent resistance in a human multi-drug-resistant colon-cancer cell line
51. Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of HT29 human colon carcinoma cells
52. Kinetic resistance to anticancer agents
53. Increased activity and expression of NAD(P)H:quinone acceptor oxidoreductase in confluent cell cultures and within multicellular spheroids
54. Normal human cells at confluence get heat resistance by efficient accumulation of hsp72 in nucleus
55. HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs
56. Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by cell density
57. Mechanisms of resistance of confluent human and rat colon cancer cells to anthracyclines: alteration of drug passive diffusion
58. Penetration of substances into tumor tissue - a methodological study on cellular spheroids
59. Penetration of substances into tumour tissue. Model studies using saccharides, thymidine and thymidine-5'-triphosphate in cellular spheroids
60. Homogeneous penetration but heterogeneous binding of antibodies to carcinoembryonic antigen in human colon carcinoma HT-29 spheroids
61. Chemosensitivity testing in V79 spheroids: drug delivery and cellular microenvironment
62. Distribution and activity of antineoplastic drugs in a tumor model
63. Cytotoxicity of cisplatin and cisdiammine-1,1-cyclobutane dicarboxylate in MGH-U1 cells grown as monolayers, spheroids, and xenografts
64. Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids
65. Cytotoxic drug penetration studies in multicellular tumour spheroids
66. Adriamycin: a possible indirect radiosensitizer of hypoxic tumor cells
67. In vitro chemosensitivity testing using the multicellular tumor spheroid model
68. Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage?
69. Induction of cell death by Doxorubicin in multicellular spheroids as studied by confocal laser scanning microscopy
70. Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro
71. Use of Hoechst 33342 for cell selection from multicell systems
72. Cell and environment interactions in tumor microregions: the multicell spheroid model
73. Formation, growth and morphology of multicellular tumor spheroids from a human colon carcinoma cell line (LoVo)
74. Closing and opening of gap junction pores between two- and three dimensionally cultured tumor cells
75. Radiation response of connexin43-transfected cells in relation to the 'contact effect'
76. Massive programmed cell death in intestinal epithelial cells induced by three-dimensional growth conditions: suppression by mutant c-H-ras oncogene expression
77. A proliferation gradient in three-dimensional colonies of cultured human glioma cells
78. The fine structure of three-dimensional colonies of human glioma cells in agarose culture
79. The relationship between tumour geometry and the response of tumour cells to cytotoxic drugs - an in vitro study using EMT6 multicellular spheroids
80. Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents
81. Tumor resistance to therapy: a genetic or kinetic problem?
82. Penetration and binding of L- and D-carboranylalanine in human melanoma spheroids
83. Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH
84. Induction and reversal of cell adhesion-dependent multicellular drug resistance in solid breast tumors
85. Drug and radiation resistance in spheroids: cell contact and kinetics
86. Tumor repopulation during radiotherapy: quantitation in two xenografted human tumors
87. Multicell spheroids as a model for cell kinetic studies
88. Repair and proliferation: major determinants of the multifraction radiation response
89. Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids, and xenografts in immune-deprived mice
90. Cell kinetics and repopulation mechanisms during multifraction irradiation of spheroids
91. Detection of subpopulations resistant to DNA-damaging agents in spheroids and murine tumours
92. Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin
93. Importance of critical metabolites and cellular interactions in the biology of microregions of tumors
94. Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids
95. Oxygen tensions in multicell spheroids of two cell lines
96. Roles of thiols in cellular radiosensitivity
97. 2- and pH-gradients in multicellular spheroids and their relationship to cellular metabolism and radiation sensitivity of malignant human tumor cells
98. Influence of glucose concentration on growth and formation of necrosis in spheroids derived from a human bladder cancer cell line
99. Growth as a solid tumor, or reduced glucose concentrations in culture, reversibly induce CD44-mediated hyaluronan recognition by Chinese hamster ovary cells
100. On the relation between size of necrosis and diameter of tumor spheroids
101. Regulation of c-jun expression during hypoxic and low-glucose stress
102. Metallothionein IIA is up-regulated by hypoxia in human A431 squamous carcinoma cells
103. Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
104. Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia
105. Radioprotection by WR-2721 in vitro at low oxygen tensions: implications for its mechanisms of action
106. Cellular oxygen utilization and radiation response of V79 spheroids
107. Synergism of cisplatin and mitomycin C in sensitive and resistant cell subpopulations of a tumor model
108. Development of multicellular spheroids of HeLa cells cocultured with fibroblasts and their response to X-irradiation
109. Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance
110. Inhibition of DNA topoisomerase II by imidazoacridinones, new antineoplastic agents with strong activity against solid tumors
111. Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains
112. Cellular radiosensitivity in V79 cells is linked to alterations in chromatin structure
113. The increase in radioresistance of Chinese hamster cells cultured as spheroids is correlated to changes in nuclear morphology
114. Cell density-dependent regulation of mdr-1 gene expression in murine colon cancer cells
115. Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids
116. Daunorubicin and doxorubicin but not BCNU have deleterious effects on organotypic multicellular spheroids of gliomas
117. Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines
118. The reversal of multidrug resistance in multicellular tumor spheroids by SDZ PSC 833
119. Expression of verapamil hypersensitivity in multidrug-resistant cells grown as multicellular spheroids
120. Circumvention of P-glycoprotein-mediated drug resistance in human leukaemic cells by non-immunosuppressive cyclosporin D analogue, SDZ PSC 833
121. Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia
122. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the 'comet' assay
123. Human ovarian tumour cells can bind hyaluronic acid via membrane CD44: a possible step in peritoneal metastasis
124. Effects of hyaluronidase on doxorubicin penetration into squamous carcinoma multicellular tumor spheroids and its cell lethality
125. Establishment and characterisation of a human glioma cell line
126. Hyaluronidase significantly enhances the efficacy of regional vinblastine chemotherapy of malignant melanoma
127. Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposi's sarcoma
128. Combined application of cisplatin, vindesine, hyaluronidase and radiation for treatment of advanced squamous cell carcinoma of the head and neck
129. [Effects of adjuvant hyaluronidase in tumors refractory to chemotherapy. Review of the literature and pharmacokinetics of cisplatin after regional administration in animals and humans]
130. Expression of hyaluronidase by tumor cells induces angiogenesis in vivo
131. Hyaluronic acid facilitates glioma cell invasion in vitro
132. Increased hyaluronidase levels in breast tumor metastases
133. Hyaluronidase activity in gynaecological cancer tissues with different metastatic forms
134. Hyaluronan: fundamental principles and applications in cancer
135. The relationship between hyaluronidase activity and hyaluronic acid concentration in sera from normal controls and from patients with disseminated neoplasm
136. The role of the extracellular matrix in neoplastic glial invasion of the nervous system
137. Is there a role for 'anti-adhesives' as chemosensitizers in the treatment of solid tumours by chemotherapy?
138. Anti-CD54 (ICAM-1) has antitumor activity in SCID mice with human myeloma cells
139. Adhesion molecules as targets for cancer therapy
140. CD44: structure, function, and association with the malignant process
141. Study of the effects of dispase in the chemotherapy of multicellular tumour spheroids of small-cell lung carcinoma in man
142. Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models
143. Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat
144. Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites
145. The significance of hematogenous tumor cell clumps in the metastatic process
146. Antimetastatic effect by anti-adhesion therapy with cell-adhesive peptide of fibronectin in combination with anticancer drugs
147. Inhibitory effect of recombinant fibronectin polypeptides on the adhesion of liver-metastatic lymphoma cells to hepatic sinusoidal endothelial cells and tumor invasion
148. Antimetastatic activity of polymeric RGDT peptides conjugated with poly(ethylene glycol)
149. Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice
150. Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94)
151. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
152. Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids
153. Factors affecting growth and drug sensitivity of mouse mammary tumor lines in collagen gel cultures
154. Multicell spheroid response to drugs predicted with the comet assay
155. Response to BCNU of spheroids grown from mixtures of drug-sensitive and drug-resistant cells
156. SN-38, a metabolite of the camptothecin derivative CPT-11, potentiates the cytotoxic effect of radiation in human colon adenocarcinoma cells grown as spheroids
157. Effects of hypoxia, pH, and growth stage on cell killing in Chinese hamster V79 cells in vitro by activated cyclophosphamide
158. A comparison of adriamycin and mAMSA. II. Studies with V79 and human tumour multicellular spheroids
159. Resistance to adriamycin in multicellular spheroids
160. The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids
161. Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells
162. Activity of 4'-(9-acridinylamino)methanesulfon-m-anisidide against Chinese hamster cells in multicellular spheroids
163. Resistance of V79 multicell spheroids to mitoxantrone: drug uptake and cytotoxicity
164. Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids
165. Resistance of MGH-U1 bladder cancer spheroids to vincristine
166. A comparative study of post-irradiation growth kinetics of spheroids and monolayers
167. Negative ion irradiation of mammalian cells. 1. Survival characteristics of monolayers and spheroids of Chinese hamster lung cells
168. Increased thermoresistance developed during growth of small multicellular spheroids
169. The radiation response of a human colon adenocarcinoma grown in monolayer, as spheroids, and in nude mice
170. Repair during multifraction exposures: spheroids versus monolayers
171. The influence of cell-cell contact on radiosensitivity of human squamous carcinoma cells
172. Radiation-resistant tumor cells may be more sensitive in vitro
173. Increased dose-rate effect in V79-multicellular aggregates (spheroids). Relation to initial DNA lesions and repair
174. Flow cytometric analysis of intracellular hematoporphyrin derivative in human tumor cells and multicellular spheroids
175. Response of multicell spheroids to 1-MHz ultrasonic irradiation: cavitation-related damage
176. Proliferation of tumor spheroids after shock-wave treatment
177. Serum, trypsin, and cell shape but not cell-to-cell contact influence the X-ray sensitivity of Chinese hamster V79 cells in monolayers and in spheroids