Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 2, 2011, Pages

  Oh, Phil Sun ^a,b   Patel, Vaishali B ^a,b   Sanders, Matthew A ^a,b   Kanwar, Shailender S ^a,b   Yu, Yingjie ^a,b   Nautiyal, Jyoti ^a,b   Patel, Bhaumik B ^a,b   Majumdar, Adhip P N ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ABCG2; Cancer stem cell; Differentiation; Drug exclusion; Transforming growth factor

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALKALINE PHOSPHATASE; BREAST CANCER RESISTANCE PROTEIN; CASPASE 3; CD133 ANTIGEN; FLUOROURACIL; HERMES ANTIGEN; HOE 33342; MESSENGER RNA; OXALIPLATIN; PROTEIN; SCHLAFEN 3; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER RESISTANCE; CANCER STEM CELL; CELL DIFFERENTIATION; COLON CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANTIGENS, CD; ANTIGENS, CD44; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; AUTOCRINE COMMUNICATION; CELL ADHESION MOLECULES, NEURONAL; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; FETAL PROTEINS; FLUOROURACIL; GLYCOPROTEINS; HCT116 CELLS; HT29 CELLS; HUMANS; ISOENZYMES; LEUCOVORIN; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; ORGANOPLATINUM COMPOUNDS; PEPTIDES; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETINAL DEHYDROGENASE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 79960992889     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00403.2010     Document Type: Article

References (45)

1. Armstrong L, Stojkovic M, Dimmick I, Ahmad S, Stojkovic P, Hole N, Lako M. Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity. Stem Cells 22: 1142-1151, 2004.
2. Bjerknes M, Cheng H, Gastrointestinal stem cells. II. Intestinal stem cells. Am J Physiol Gastrointest Liver Physiol 289: G381-G387, 2005.
3. Blanpain C, Horsley V, Fuchs E. Epithelial stem cells: turning over new leaves. Cell 128: 445-458, 2007.
4. Brady G, Boggan L, Bowie A, O'Neill LA. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J Biol Chem 280: 30723- 30734, 2005.
5. Carpentino JE, Hynes MJ, Appelman HD, Zheng T, Steindler DA, Scott EW, Huang EH. Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer. Cancer Res 69: 8208-8215, 2009.
6. Choi SR, Cho M, Kim HR, Ahn DH, Sleisenger MH, Kim YS. Biological properties and expression of mucins in 5-fluorouracil resistant HT29 human colon cancer cells. Int J Oncol 17: 141-147, 2000.
7. Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 104: 10158-10163, 2007.
8. Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, Buren G, Samuel S, Kim MP, Lim SJ, Ellis LM. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res 69: 1951-1957, 2009.
9. Dean M, Fojo T, Bates S. stem cells and drug resistance. Nat Rev Cancer 5: 275-284, 2005.
10. Demers MJ, Thibodeau S, Noel D, Fujita N, Tsuruo T, Gauthier R, Arguin M, Vachon PH. Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J Cell Biochem 107: 639-654, 2009.
11. Dick JE. Stem cell concepts renew cancer research. Blood 112: 4793- 4807, 2008.
12. Donnenberg VS, Donnenberg AD. Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis. J Clin Pharmacol 45: 872-877, 2005.
13. Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci U S A 95: 15665-15670, 1998.
14. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y, Chen Q. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 14: 6751-6760, 2008.
15. Fichera A, Little N, Jagadeeswaran S, Dougherty U, Sehdev A, Mustafi R, Cerda S, Yuan W, Khare S, Tretiakova M, Gong C, Tallerico M, Cohen G, Joseph L, Hart J, Turner JR, Bissonnette M. Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. Cancer Res 67: 827-835, 2007.
16. Geserick P, Kaiser F, Klemm U, Kaufmann SH, Zerrahn J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int Immunol 16: 1535-1548, 2004.
17. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, Jacquemier J, Viens P, Kleer CG, Liu S, Schott A, Hayes D, Birnbaum D, Wicha MS, Dontu G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1: 555-567, 2007.
18. Goodell MA, Rosenzweig M, Kim H, Marks DF, DeMaria M, Paradis G, Grupp SA, Sieff CA, Mulligan RC, Johnson RP. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 3: 1337-1345, 1997.
19. Gordon JI, Schmidt GH, Roth KA. Studies of intestinal stem cells using normal, chimeric, and transgenic mice. FASEB J 6: 3039-3050, 1992.
20. Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58, 2002.
21. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin 51: 15-36, 2001.
22. Harris MA, Yang H, Low BE, Mukherjee J, Guha A, Bronson RT, Shultz LD, Israel MA, Yun K. Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res 68: 10051- 10059, 2008.
23. Hu Y, Smyth GK. ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays. J Immunol Methods 347: 70-78, 2009.
24. Jordan CT, Guzman ML, Noble M. Cancer stem cells. N Engl J Med 355: 1253-1261, 2006.
25. Kanwar SS, Yu Y, Nautiyal J, Patel BB, Majumdar AP. The Wnt/betacatenin pathway regulates growth and maintenance of colonospheres. Mol Cancer 9: 212, 2010.
26. Kanwar SS, Yu Y, Nautiyal J, Patel BB, Padhye S, Sarkar FH, Majumdar AP. Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cells. Pharm Res 28: 827-838, 2011.
27. Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer 7: 573-584, 2007.
28. Marhaba R, Zoller M. CD44 in cancer progression: adhesion, migration and growth regulation. J Mol Histol 35: 211-231, 2004.
29. Mimeault M, Hauke R, Mehta PP, Batra SK. Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. J Cell Mol Med 11: 981-1011, 2007.
30. Neumann B, Zhao L, Murphy K, Gonda TJ. Subcellular localization of the Schlafen protein family. Biochem Biophys Res Commun 370: 62-66, 2008.
31. Patel BB, Yu Y, Du J, Rishi AK, Sarkar FH, Tarca AL, Wali A, Majumdar AP. Schlafen 3, a novel gene, regulates colonic mucosal growth during aging. Am J Physiol Gastrointest Liver Physiol 296: G955-G962, 2009.
32. Patel VB, Yu Y, Das JK, Patel BB, Majumdar AP. Schlafen-3: a novel regulator of intestinal differentiation. Biochem Biophys Res Commun 388: 752-756, 2009.
33. Preston SL, Wong WM, Chan AO, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G, Novelli M, Bodmer WF, Tomlinson IP, Wright NA. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res 63: 3819-3825, 2003.
34. Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995.
35. Scoville DH, Sato T, He XC, Li L. Current view: intestinal stem cells and signaling. Gastroenterology 134: 849-864, 2008.
36. Sporn MB, Roberts AB. Autocrine growth factors and cancer. Nature 313: 745-747, 1985.
37. Sporn MB, Todaro GJ. Autocrine secretion and malignant transformation of cells. N Engl J Med 303: 878-880, 1980.
38. Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S. CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation. Exp Mol Pathol 83: 207-215, 2007.
39. Sussman RT, Ricci MS, Hart LS, Sun SY, and El-Deiry WS. Chemotherapy- resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4. Cancer Biol Ther 6: 1490-1495, 2007.
40. Tang C, Ang BT, Pervaiz S. Cancer stem cell: target for anti-cancer therapy. FASEB J 21: 3777-3785, 2007.
41. Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, Tripodo C, Russo A, Gulotta G, Medema JP, Stassi G. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 1: 389-402, 2007.
42. Walko CM, Lindley C. Capecitabine: a review. Clin Ther 27: 23-44, 2005.
43. Xiao ZQ, Li J, Majumdar AP. Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa. Am J Physiol Gastrointest Liver Physiol 285: G396-G403, 2003.
44. Yu Y, Kanwar SS, Patel BB, Nautiyal J, Sarkar FH, Majumdar AP. Elimination of colon cancer stem-like cells by the combination of curcumin and FOLFOX. Transl Oncol 2: 321-328, 2009.
45. Yuan L, Yu Y, Sanders MA, Majumdar AP, Basson MD. Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation. Am J Physiol Gastrointest Liver Physiol 298: G994-G1003, 2010.