P2X1 and P2X2 receptors in the central nervous system as possible drug targets

CNS and Neurological Disorders - Drug Targets

Volumn 11, Issue 6, 2012, Pages 675-686

  Hausmann, Ralf ^a   Schmalzing, Günther ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Antagonist binding; CNS injury; Homology modeling; In silico docking; Neuroprotection; PPADS; Suramin

Indexed keywords

2?3? (2,4,6 TRINITROPHENYL) ADENOSINE 5? TRIPHOSPHATE; 4,4',4'',4''' [CARBONYL BIS [IMINO 5,1,3 BENZENETRIYL BIS(CARBONYLIMINO)]] TETRAKIS BENZENE 1,3 DISULFONIC ACID; 7,7' [CARBONYLBIS[IMINO 3,1 PHENYLENECARBONYLIMINO 3,1 (4 METHYLPHENYLENE) CARBONYLIMINO]] BIS [1 METHOXY NAPHTHALENE 3,6 DISULFONIC ACID]TETRASODIUM; NEUROPROTECTIVE AGENT; NF 449; NF 770; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2', 4' DISULFONIC ACID; SURAMIN; UNCLASSIFIED DRUG;

BRAIN ISCHEMIA; CELL DEATH; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROVASCULAR ACCIDENT; GLIA CELL; HUMAN; KNOCKOUT MOUSE; MOLECULAR DOCKING; NEUROPROTECTION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RECEPTOR UPREGULATION; REVIEW; SYNAPTIC TRANSMISSION; THROMBOEMBOLISM; ZEBRA FISH;

ANIMALS; CENTRAL NERVOUS SYSTEM; MICE; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P2X1; RECEPTORS, PURINERGIC P2X2; ZEBRAFISH;

EID: 84869063239     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/187152712803581128     Document Type: Review

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