Localization and functional expression of splice variants of the P2X2 receptor

Molecular Pharmacology

Volumn 52, Issue 2, 1997, Pages 237-248

  Simon, Joseph ^a,b   Kidd, Emma J ^b   Smith, Fiona M ^b   Chessell, Iain P ^b   Murrell Lagnado, Ruth ^b   Humphrey, Patrick P A ^b   Barnard, Eric A ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; PURINE P2X RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; RECEPTOR SUBUNIT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MAMMAL CELL; NEWBORN; NODOSE GANGLION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; RECEPTOR GENE; RECEPTOR SENSITIVITY; RNA SPLICING; SENSORY GANGLION; SYMPATHETIC GANGLION; XENOPUS LAEVIS;

EID: 0030790294     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.2.237     Document Type: Article

References (39)

1. Fredholm, B. B., M. P. Abbracchio, G. Burnstock, J. W. Daly, T. K. Harden, K. A. Jacobson, P. Leff, and M. Williams. VI. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46:143-156 (1994).
2. Zimmermann, H. Signalling via ATP in the nervous system. Trends Neurosci. 17:420-426 (1994).
3. Barnard, E. A., G. Burnstock, and T. E. Webb. G protein-coupled receptors for ATP and other nucleotides: a new receptor family. Trends Pharmacol. Sci. 15:67-71 (1994).
4. 2X receptors bring new structure to ligand-gated ion channels. Trends Neurosci. 18:224-229 (1995).
5. Barnard, E. A. The transmitter-gated channels: a range of receptor types and structures. Trends Pharmacol. Sci. 17:305-309 (1996).
6. Edwards, F. A., and A. J. Gibb. ATP: a fast neurotransmitter. FEBS Lett. 325:86-89 (1993).
7. Galligan, J. J., and P. P. Bertrand. ATP mediates fast synaptic potentials in enteric neurons. J. Neurosci. 14:7563-7571 (1994).
8. 2X receptor for extracellular ATP. Nature (Lond.) 371:516-519 (1994).
9. Brake, A. J., M. J. Wagenbach, and D. Julius. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (Lond.) 371:519-523 (1994).
10. Lewis, C., S. Neidhart, C. Holy, R. A. North, G. N. Buell, and A. Surprenant. Heteropolymerization of P2X receptor subunits can account for ATP-gated currents in sensory neurons. Nature (Lond.) 377:432-435 (1995).
11. Chen, C. C., A. N. Akopian, L. Sivilotti, D. Colquhoun, G. Burnstock, and J. N. Wood. A P2X purinoceptor expressed by a subset of sensory neurones. Nature (Lond.) 377:428-430 (1995).
12. Bo, X., Y. Zhang, M. Nassar, G. Burnstock, and R. Schoepfer. A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett. 375:129-133 (1995).
13. 2X receptor expressed in epithelia and brain. EMBO J. 15:55-62 (1996).
14. 2X ATP receptor ion channel with widespread distribution in the brain. J. Neurosci. 16:448-455 (1996).
15. Soto, F., M. Garcia-Guzman, J. M. Gomez-Hernandez, M. Hollmann, C. Karschin and W. Stuhmer. P2Xα4: an ATP-activated ionotropic receptor cloned from rat brain. Proc. Natl. Acad. Sci. USA 93:3684-3688 (1996).
16. Wang, C., N. Namba, T. Gonoi, N. Inagaki, and S. Seino. Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissue. Biochem. Biophys. Res. Commun. 220:196-202 (1996).
17. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16:2495-2507 (1996).
18. Surprenant, A., F. Rassendren, E. Kawashima, R. A. North, and G. N. Buell. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science (Washington D. C.) 272:735-738 (1996).
19. North, R. A. P2X purinoceptor plethora. Semin. Neurosci. 8:187-197 (1996).
20. 2X purinoceptor transcripts in the rat nervous system. Mol. Pharmacol. 48:569-573 (1995).
21. Vanhoutte, P. M., P. P. A. Humphrey, and M. Spedding. International Union of Pharmacology recommendations for nomenclature of new receptor subtypes. Pharmacol Rev. 48:1-2 (1996).
22. Chomczynski, P., and N. Sacchi. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform. Anal. Biochem. 162: 156-159 (1987).
23. 2X receptors) determined by immunocytochemistry. Proc. Natl. Acad. Sci. USA 93:8063-8067 (1996).
24. 2x-purinoceptors). Mol. Pharmacol. 48:178-183 (1995).
25. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. Improved patch-clamp techniques for high resolution recording from cells and cell-free membranes. Pflügers Arch. 391:85-100 (1981).
26. 2 receptor controlled by alternative splicing. FEBS Lett. 404: 294-298 (1997).
27. Smith, C. W. J., J. G. Patton, and B. Nadal-Ginard. Alternative splicing in the control of gene expression. Annu. Rev. Genet. 23:527-577 (1989).
28. A receptor genes: cloning and analysis of the chicken β4-subunit gene. J. Neurochem. 57: 352-355 (1991).
29. Ushkaryov, Y. A., and T. C. Südhof. Neurexin IIIα: extensive alternative splicing generates membrane-bound and soluble forms. Proc. Natl. Acad. Sci. USA 90:6410-6414 (1993).
30. Zukin, R. S., and M. L. V. Bennett. Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trend Neurosci. 18:306-313 (1995).
31. Housley, G. D., D. Greenwood, T. Bennett, and A. F. Ryan. Identification of a short form of the P2xR1-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea. Biochem. Biophys. Res. Commun. 212:501-508 (1995).
32. Kemp, B. E., and R. B. Pearson. Protein kinase recognition sequence motifs. Trends Biochem. Sci. 15:342-346 (1990).
33. Huganir, R. L., and P. Greengard. Regulation of neurotransmitter receptor desensitization by protein phosphorylation. Neuron 5:555-567 (1990).
34. Swope, S. L., S. J. Moss, C. D. Blackstone, and R. L. Huganir. Phosphorylation of ligand-gated ion channels: a possible mode of synaptic plasticity. FASEB J. 6:2514-2523 (1992).
35. + channel (αrENaC) mediates its localization at the apical membrane. EMBO J. 13:4440-4450 (1994).
36. Koch, C. A., D. Anderson, M. F. Moran, C. Ellis, and T. Pawson. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (Washington D. C.) 252:668-674 (1991).
37. ras through the formation of a complex of receptor, Grb2 adapter protein, and SOS nucleotide exchange factor. Cell 73:611-620 (1993).
38. Kornau, H. C., L. T. Schenker, M. B. Kennedy, and P. H. Seeburg. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science (Washington D. C.) 269:1737-1740 (1995).
39. Yamamoto-Hino, M., T. Sugiyama, K. Hikochi, M. G. Mattei, K. Hasegawa, S. Sekine, K. Sakurada, A. Miyawaki, T. Furuichi, M. Hasegawa, and K. Mikoshiba. Cloning and characterization of human type 2 and type 3 inositol 1,4,5-triphosphate receptors. Recept. Channels 2:9-22 (1994).