Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11067-11081

  Nörenberg, Wolfgang ^a   Hempel, Christoph ^a   Urban, Nicole ^a   Sobottka, Helga ^a   Illes, Peter ^a   Schaefer, Michael ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; BONE MARROW; CELL CURRENT; CLEMASTINE; COMPOUND LIBRARIES; CYTOKINES; DATA POINTS; HEK293 CELLS; HUMAN MACROPHAGES; HUMAN MONOCYTE-DERIVED MACROPHAGES; IMMUNE RESPONSE; MEDICAL CONDITIONS; NEUROPATHIC PAIN; OPEN CHANNELS; PORE FORMATION; POTENTIAL DRUG; RHEUMATOID ARTHRITIS;

ACTIVATION ANALYSIS; CELL CULTURE; CONCENTRATION (PROCESS); PHYSIOLOGICAL MODELS;

MACROPHAGES;

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CELL PROTEIN; CLEMASTINE; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; YO PRO 1 PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CELL STRAIN HEK293; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG SCREENING; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR SENSITIVITY; RECEPTOR UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTI-ALLERGIC AGENTS; BONE MARROW CELLS; CALCIUM; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CLEMASTINE; HEK293 CELLS; HUMANS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; RECEPTORS, PURINERGIC P2X7;

MURINAE;

EID: 79953169518     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.198879     Document Type: Article

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