Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides

Journal of Physiology

Volumn 576, Issue 1, 2006, Pages 135-149

  Fujiwara, Yuichiro ^a   Kubo, Yoshihiro ^a,b,c  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE TRIPHOSPHATE; AMINO ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; ION CHANNEL; LIPID; MEGLUMINE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PURINE P2X2 RECEPTOR; PYROXYLIN; RECOMBINANT PROTEIN; WORTMANNIN; ENHANCED GREEN FLUORESCENT PROTEIN; PURINERGIC P2X2 RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN COS7; CONTROLLED STUDY; CULTURE MEDIUM; CYTOPLASM; ELECTRICITY; ELECTRODE; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; GENE MUTATION; MEMBRANE ELECTROPHYSIOLOGY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; VOLTAGE CLAMP; XENOPUS; ANIMAL TISSUE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; VOLTAGE CLAMP TECHNIQUE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; ELECTROPHYSIOLOGY; FEMALE; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPIDS; PROTEIN BINDING; RATS; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X2; XENOPUS LAEVIS;

EID: 33748893444     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.115246     Document Type: Article

References (51)

1. Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP & Fakler B (1998). PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 282, 1141-1144.
2. Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN & Jan LY (2004). Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc Natl Acad Sci U S A 101, 4441-4446.
3. Brake AJ, Wagenbach MJ & Julius D (1994). New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371, 519-523.
4. Chaumont S, Jiang LH, Penna A, North RA & Rassendren F (2004). Identification of a trafficking motif involved in the stabilization and polarization of P2X receptors. J Biol Chem 279, 29628-29638.
5. + channel TREK-1. EMBO J 24, 44-53.
6. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A & Buell G (1996). Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16, 2495-2507.
7. Corvera S (2001). Phosphatidylinositol 3-kinase and the control of endosome dynamics: New players defined by structural motifs. Traffic 2, 859-866.
8. Czirjak G, Petheo GL, Spat A & Enyedi P (2001). Inhibition of TASK-1 potassium channel by phospholipase C. Am J Physiol Cell Physiol 281, C700-C708.
9. Ding S & Sachs F (2000). Inactivation of P2X2 purinoceptors by divalent cations. J Physiol 522, 199-214.
10. Donaldson MR, Jensen JL, Tristani-Firouzi M, Tawil R, Bendahhou S, Suarez WA, Cobo AM, Poza JJ, Behr E, Wagstaff J, Szepetowski P, Pereira S, Mozaffar T, Escolar DM, Fu YH & Ptacek LJ (2003). PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome. Neurology 60, 1811-1816.
11. Eickhorst AN, Berson A, Cockayne D, Lester HA & Khakh BS (2002). Control of P2X (2) channel permeability by the cytosolic domain. J Gen Physiol 120, 119-131.
12. Fisher JA, Girdler G & Khakh BS (2004). Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions. J Neurosci 24, 10475-10487.
13. 2+. J Gen Physiol 120, 677-693.
14. Fujiwara Y & Kubo Y (2004). Density-dependent changes of the pore properties of the P2X2 receptor channel. J Physiol 558, 31-43.
15. Hardie RC, Raghu P, Moore S, Juusola M, Baines RA & Sweeney ST (2001). Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron 30, 149-159.
16. Hilgemann DW, Feng S & Nasuhoglu C (2001). The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE 2001 (111), RE19.
17. Huang CL, Feng S & Hilgemann DW (1998). Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 391, 803-806.
18. Inoue K, Tsuda M & Koizumi S (2004). ATP- and adenosine-mediated signaling in the central nervous system: Chronic pain and microglia: involvement of the ATP receptor P2X4. J Pharmacol Sci 94, 112-114.
19. Jiang LH, Rassendren F, Mackenzie A, Zhang YH, Surprenant A & North RA (2005). N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X (7) receptors. Am J Physiol Cell Physiol 289, C1295-C1302.
20. Khakh BS, Bao XR, Labarca C & Lester HA (1999a). Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds. Nat Neurosci 2, 322-330.
21. Khakh BS & Egan TM (2005). Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics. J Biol Chem 280, 6118-6129.
22. Khakh BS & Lester HA (1999). Dynamic selectivity filters in ion channels. Neuron 23, 653-658.
23. Khakh BS, Proctor WR, Dunwiddie TV, Labarca C & Lester HA (1999b). Allosteric control of gating and kinetics at P2X (4) receptor channels. J Neurosci 19, 7289-7299.
24. Koshimizu T, Koshimizu M & Stojilkovic SS (1999). Contributions of the C-terminal domain to the control of P2X receptor desensitization. J Biol Chem 274, 37651-37657.
25. Lewis C, Neidhart S, Holy C, North RA, Buell G & Surprenant A (1995). Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377, 432-435.
26. Liou HH, Zhou SS & Huang CL (1999). Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proc Natl Acad Sci U S A 96, 5820-5825.
27. Lopes CM, Zhang H, Rohacs T, Jin T, Yang J & Logothetis DE (2002). Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron 34, 933-944.
28. Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY & Berger JM (2000). The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102, 657-670.
29. North RA (2002). Molecular physiology of P2X receptors. Physiol Rev 82, 1013-1067.
30. + channels by membrane lipids. Science 304, 265-270.
31. + channel. J Biol Chem 280, 37565-37571.
32. Prestwich GD (2004). Phosphoinositide signaling; from affinity probes to pharmaceutical targets. Chem Biol 11, 619-637.
33. Ralevic V & Burnstock G (1998). Receptors for purines and pyrimidines. Pharmacol Rev 50, 413-492.
34. Schulte U, Hahn H, Konrad M, Jeck N, Derst C, Wild K, Weidemann S, Ruppersberg JP, Fakler B & Ludwig J (1999). pH gating of ROMK (K(ir)1.1) channels: Control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome. Proc Natl Acad Sci U S A 96, 15298-15303.
35. Seguela P, Haghighi A, Soghomonian JJ & Cooper E (1996). A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J Neurosci 16, 448-455.
36. Shyng SL & Nichols CG (1998). Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 282, 1138-1141.
37. Smith FM, Humphrey PP & Murrell-Lagnado RD (1999). Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization. J Physiol 520, 91-99.
38. + channel KCa3.1. Mol Cell Biol 25, 3630-3638.
39. Suh BC & Hille B (2002). Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron 35, 507-520.
40. Surprenant A, Rassendren F, Kawashima E, North RA & Buell G (1996). The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272, 735-738.
41. Toker A (1998). The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Curr Opin Cell Biol 10, 254-261.
42. Valera S, Hussy N, Evans RJ, Adami N, North RA, Surprenant A & Buell G (1994). A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature 371, 516-519.
43. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ & Waterfield MD (2001). Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70, 535-602.
44. Virginio C, MacKenzie A, Rassendren FA, North RA & Surprenant A (1999). Pore dilation of neuronal P2X receptor channels. Nat Neurosci 2, 315-321.
45. Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC & Bourne HR (2002). A PtdInsP (3) - and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4, 509-513.
46. Werner P, Seward EP, Buell GN & North RA (1996). Domains of P2X receptors involved in desensitization. Proc Natl Acad Sci U S A 93, 15485-15490.
47. Wu L, Bauer CS, Zhen XG, Xie C & Yang J (2002). Dual regulation of voltage-gated calcium channels by PtdIns (4,5), P2. Nature 419, 947-952.
48. Zhainazarov AB, Spehr M, Wetzel CH, Hatt H & Ache BW (2004). Modulation of the olfactory CNG channel by Ptdlns (3,4,5), P3. J Membr Biol 201, 51-57.
49. Zhang H, Craciun LC, Mirshahi T, Rohacs T, Lopes CM, Jin T & Logothetis DE (2003). PIP (2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 37, 963-975.
50. Zhou Z & Hume RI (1998). Two mechanisms for inward rectification of current flow through the purinoceptor P2X2 class of ATP-gated channels. J Physiol 507, 353-364.
51. Zhou Z, Monsma LR & Hume RI (1998). Identification of a site that modifies desensitization of P2X2 receptors. Biochem Biophys Res Commun 252, 541-545.