Application of neutralizing antibodies against NI-35/250 myelin- associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured Purkinje cell axons

Journal of Neuroscience

Volumn 20, Issue 6, 2000, Pages 2275-2286

  Buffo, Annalisa ^a   Zagrebelsky, Marta ^a   Huber, Andrea B ^b   Skerra, Arne ^c   Schwab, Martin E ^b   Strata, Piergiorgio ^a   Rossi, Ferdinando ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b University of Zurich Brain Research Institute   (Switzerland)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Axon growth associated proteins; Axon regeneration; Cerebellum; Intrinsic determinants; Myelin associated neurite growth inhibitors; Sprouting

Indexed keywords

MYELIN ASSOCIATED GLYCOPROTEIN; NEUTRALIZING ANTIBODY; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; GRAY MATTER; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NERVE SPROUTING; NEURITE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; REGULATORY MECHANISM;

EID: 0034654086     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-06-02275.2000     Document Type: Article

References (53)

1. Bähr M. Schwab ME (1996) Antibody that neutralizes myelin-associated inhibitors of axon growth does not interfere with recognition of target-specific guidance information by retinal axons. J Neurobiol 30:281-292.
2. Bandtlow C, Zachleder T. Schwab ME (1990) Oligodendrocytcs arrest neurite growth by contact inhibition. J Neurosci 10:3837-3848.
3. Bandtlow C, Schiweck W, Tai HH, Schwab ME, Skerra A (1996) The Escherichia coli-derived Fab fragment of the IgM/kappa antibody IN-1 recognizes and neutralizes myelin-associated inhibitors of neurite growth. Eur J Biochem 241:468-475.
4. Bishop GA (1982) The pattern of distribution of the local axonal collaterals of Purkinje cells in the intermediate cortex of the anterior lobe and paramedian lobule of the cat cerebellum. J Comp Neurol 210:1-9.
5. Blank NK, Seil FJ, Herndon RM (1982) An ultrastructural study of cortical remodelling in cytosine arabinoside induced granuloprival cerebellum in tissue culture. Neuroscience 7:1509-1531.
6. Bravin M, Savio T, Strata P, Rossi F (1997) Olivocerebellar axon regeneration and target reinnervation following dissociated Schwann cell grafts in surgically injured cerebella of adult rats. Eur J Neurosci 9:2634-2649.
7. Buffo A. Holtmaat AJDG, Savio T, Verbeek S, Oberdick J, Oestreicher AB, Gispen WH, Verhaagen J, Rossi F, Strata P (1997) Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting in response to axotomy, but docs not allow axon regeneration into growth permissive transplants. J Neurosci 17:8778-8791.
8. Buffo A, Zagrebelsky M, Skerra A, Schwab ME, Strata P, Rossi F (1999) Application of JN-1 antibodies to the adult rat cerebellum induces the outgrowth of intact Purkinje cell axons. Soc Neurosci Abstr 25:1000.
9. Caroni P, Schwab ME (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes non-permissive substrate properties of CNS white matter. Neuron 1:85-96.
10. Caroni P, Schwab ME (1989) Codistribution of neurite growth inhibitors and oligodendrocytes in rat CNS: appearance follows nerve fiber growth and precedes myelination. Dev Biol 136:287-295.
11. Chan-Palay V (1971) The recurrent collaterals of Purkinje cell axons: a correlated study of the rat cerebellar cortex with electron microscopy and the Golgi method. Z Anat Entwicklungsgesch 134:200-234.
12. Chen DF, Jhaveri S, Schneider GE (1995) Intrinsic changes in developing retinal neurons result in regenerative failure of their axons. Proc Natl Acad Sci USA 92:7287-7291.
13. Chen MS, Huber AB, van der Haar ME, Frank M, Spilmann AA, Christ F, Schwab ME (1998) Neurite outgrowth inhibitory factors in CNS myelin: molecular characterization of Nogo (NI-35/250). Soc Neurosci Abstr 24:1766.
14. Colello RJ, Schwab ME (1994) A role for oligodendrocytes in the stabilization of optic axon numbers. J Neurosci 14:6446-6452.
15. Crepel F, Delhaye-Bouchaud N, Dupont JL, Sotelo C (1980) Dendritic and axonic fields of Purkinje cells in developing and X-irradiated rat cerebellum. A comparative study using intracellular staining with horseradish peroxidase. Neurosciencc 5:333-347.
16. De Camilli P, Miller PE, Levitt P. Walter U. Greengard P (1984) Anatomy of the cerebellar Purkinje cells in the rat determined by a specific immunohistochemical marker. Neuroscience 11:761-817.
17. Dusart I, Sotelo C (1994) Lack of Purkinje cell loss in adult rat cerebellum following protracted axotomy: degenerative changes and reactive attempts of the severed axons. J Comp Neurol 347:211-232.
18. Dusart I, Airaksinen MS, Sotelo C (1997) Purkinje cell survival and axonal regeneration are age dependent: an in vitro study. J Neurosci 17:3710-3726.
19. Dusart I, Morel MP, Wehrlé R, Sotelo C (1999) Late axonal sprouting of injured Purkinje cells and its temporal correlation with permissive changes in the glial scar. J Comp Neurol 408:399-418.
20. Ecclcs JC, Ito M, Szentágothái J (1967) The cerebellum as a neuronal machine. New York: Springer.
21. Frotscher M, Heimrich B, Deeller T (1997) Sprouting in the hippocampus is layer specific. Trends Neurosci 20:218-223.
22. Holm K, Isacson O (1999) Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for BCL2? Trends Neurosci 22:269-273.
23. Huber AB, Chen MS, van der Haar ME, Schwab ME (1998) Developmental expression pattern and functional analysis of Nogo (formerly NI-35/250), a major inhibitor of CNS regeneration. Soc Neurosci Abstr 24:1559.
24. Kapfhammer JP, Schwab ME (1994a) Inverse patterns of myelination and GAP-43 expression in the adult CNS: neurite growth inhibitors as regulators of neuronal plasticity? J Comp Neurol 340:194-206.
25. Kapfhammer JP, Schwab ME (1994b) Increased expression of growth-associated protein GAP-43 in myelin-free rat spinal cord. Eur J Neurosci 6:403-411.
26. Kapfhammer JP, Schwab ME, Schneider GE (1992) Antibody neutralization of neurite growth inhibitors from oligodendrocytes results in expanded pattern of postnatally sprouting retinocollicular axons. J Neurosci 12:2112-2119.
27. Marty S, Weinitz JM, Peschanski M (1994) Target dependence of adult neurons: pattern of terminal arborizations. J Neurosci 14:5257-5266.
28. McKerracher L, David S, Jackson DL, Kottis V, Dunn RJ, Braun PE (1994) Identification of myelin-associated glycoprotein as a major myclin-derived inhibitor of neurite growth. Neuron 13:805-811.
29. Mukhopadhyay G, Doherty P, Walsh FS, Crocker PR, Filbin MT (1994) A novel rule of myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13:1-20.
30. Mugnaini E (1972) The histology and cytology of the cerebellar cortex. In: The comparative anatomy and histology of the cerebellum: the human cerebellum, cerebellar connections and cerebellar cortex (Larsell O, Jansen J, eds), pp 201-265. Minneapolis: University of Minnesota.
31. Müller CM, Gardziella S, Schwab ME (1994) Role of the myelinassociated neurite growth inhibitor N135/250 in the determination of critical period plasticity in kitten visual cortex. Soc Neurosci Abstr 20:1471.
32. Palay SL, Chan-Palay V (1974) Cerebellar cortex. Cytology and organization. New York: Springer.
33. Ramón y Cajal S (1911) Histologie du système nerveux de l'homme et des vertébrés. Paris: Maloine.
34. Ramón y Cajal S (1928) Degeneration and regeneration of the nervous system. Reprint (May R, translator). Oxford: Oxford UP, 1991.
35. Rossi F, Bovsello T, Vaudano E, Strata P (1993) Regressive modifications of climbing fibres following Purkinje cell degeneration in the cerebellar cortex of the adult rat. Neuroscience 53:759-778.
36. Rossi F, Borsello T, Strata P (1994a) Embryonic Purkinje cells grafted on the surface of the adult uninjured rat cerebellum migrate in the parenchyma and induce sprouting of intact climbing fibres. Eur J Neurosci 6:121-136.
37. Rossi F, Borsello T, Strata P (1994b) Exposure to kainic acid mimics the effects of axotomy in cerebellar Purkinje cells of the adult rat. Eur J Neurosci 6:392-402.
38. Rossi F, Jankovski A, Sotelo C (1995a) Differential regenerative response of Purkinje cell and inferior olivary axons confronted with embryonic cerebellar grafts: environmental cues versus intrinsic neuronal determinants. J Comp Neurol 359:663-677.
39. Rossi F, Jankovski A, Sotelo C (1995b) Target neuron controls the integrity of afferent axon phenotype: a study on the Purkinje cell-climbing fiber system in cerebellar mutant mice. J Neurosci 15:2040-2056.
40. Schwab ME, Bartholdi D (1996) Degeneration and regeneration of axons in the lesioned spinal cord. Physiol Rev 76:319 -370.
41. Schwab ME. Schnell L (1991) Channeling of developing corticospinal tract axons by myelin-associated neurite growth inhibitors. J Neurosci 11:709-721.
42. Schwab M E, Kapfhammer JP, Bandtlow CE (1993) Inhibitors of neurite growth. Annu Rev Neurosci 16:565-595.
43. Schwegler G, Schwab ME, Kapfhammer JP (1995) Increased collateral sprouting of primary afferents in myelin-free spinal cord. J Neurosci 15:2756-2767.
44. Seil FJ (1996) Neural plasticity in cerebellar cultures. Prog Neurobiol 50:533-556.
45. Skene JHP (1989) Axonal growth-associated proteins. Annu Rev Neurosci 12:127-156.
46. Skene JHP (1992) Retrograde pathways controlling expression of major growth cone components in the adult CNS. In: The nerve growth cone (Letourneau PC, Kater SB, Macagno ER, eds), pp 463-475. New York: Raven.
47. Strata P, Zagrebelsky M, Bravin M. Rossi F (1998) Map projection rewiring in the adult cerebellum after lesion. In: Neuronal circuits and networks, Vol 167 (Nicholls J, Torre V, eds), pp 169-185. NATO/ASI series, Scries F: Computer and Systems Sciences. Berlin: Springer.
48. Thallmair M, Metz GAS, Z'Graggen WJ, Raineteau O, Kartje GL, Schwab ME (1998) Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nat Neurosci 1:124-131.
49. Vanek P. Thallmair M, Schwab ME, Kapfhammer JP (1998) Increased lesion-induced sprouting of corticospinal fibres in the myelin-free spinal cord. Eur J Neurosci 10:45-56.
50. Wizenmann A, Thies E, Klostermann S, Bonhoeffcr F, Bähr M (1993) Appearance of target-specific guidance information for regenerating axons after CNS lesions. Neuron 11:975-983.
51. Zagrebelsky M, Rossi F, Hawkes R, Strata P (1996) Topographically arranged climbing fibre sprouting in the adult rat cerebellum. Eur J Neurosci 8:1051-1054.
52. Zagrebelsky M, Buffo A, Skerra A, Schwab M E, Strata P, Rossi F (1998) Retrograde regulation of growth-associated gene expression in adult rat Purkinje cells by myelin-associated neurite growth inhibitory proteins. J Neurosci 18:7912-7929.
53. Z'Graggen WJ, Metz GAS, Kartje GL, Thallmair M, Schwab ME (1998) Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats. J Neurosci 18:4744-4757.