Ephrin-A5 Exerts Positive or Inhibitory Effects on Distinct Subsets of EphA4-Positive Motor Neurons

Journal of Neuroscience

Volumn 24, Issue 5, 2004, Pages 1070-1078

  Eberhart, Johann ^a,f   Barr, Jason ^a   O'Connell, Sinead ^a   Flagg, Alleda ^a,g   Swartz, Mary E ^a,f   Cramer, Karina S ^b   Tosney, Kathryn W ^c   Pasquale, Elena B ^d   Krull, Catherine E ^a,e  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d BURNHAM INSTITUTE   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF OREGON   (United States)

^g UNIVERSITY OF CHICAGO   (United States)

Author keywords

Chick; Electroporation; Eph; Ephrin; Mesoderm; Motor axon

Indexed keywords

EPHRIN A4; EPHRIN A5;

ANIMAL TISSUE; ARTICLE; CELL SUBPOPULATION; CHICK EMBRYO; EMBRYO; MESODERM; MOTONEURON; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CELL DIFFERENTIATION; CELLS, CULTURED; CHICK EMBRYO; ELECTROPORATION; EPHRIN-A4; EPHRIN-A5; HINDLIMB; LIGANDS; MESODERM; MOTOR NEURONS; NEURAL INHIBITION; SIGNAL TRANSDUCTION;

EID: 0842282476     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4719-03.2004     Document Type: Article

References (41)

1. Brittis PA, Qiang L, Flanagan JG (2002) Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell 110:223-235.
2. Campbell DS, Holt CE (2001) Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32:1013-1026.
3. Dickson BJ (2002) Molecular mechanisms of axon guidance. Science 298:1959-1964.
4. Eberhart J, Swartz M, Koblar SA, Pasquale EB, Tanaka H, Krull CE (2000) Expression of EphA4, ephrin-A2 and ephrin-A5 during axon outgrowth to the hindlimb indicates potential roles in pathfinding. Dev Neurosci 22:237-250.
5. Eberhart J, Swartz ME, Koblar SA, Pasquale EB, Krull CE (2002) EphA4 constitutes a population-specific guidance cue for motor neurons. Dev Biol 247:89-101.
6. Ensini M, Tsuchida TN, Belting HG, Jessell TM (1988) The control of rostrocaudal pattern in the developing spinal cord: specification of motor neuron subtype identity is initiated by signals from paraxial mesoderm. Development 125:969-982.
7. Ethell IM, Irie F, Kalo MS, Couchman JR, Pasquale EB, Yamaguchi Y (2001) EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron 31:1001-1013.
8. Fukushima M, Nakamura M, Ohta K, Okamura R, Negi A, Tanaka H (1996) Regional specification of motoneurons along the anterior-posterior axis is independent of the notochord. Development 122:905-914.
9. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD (1996) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17:9-19.
10. Hamburger V, Hamilton HL (1951) A series of normal stages in the development of the chick embryo. J Morphol 88:49-92.
11. Helmbacher F, Schneider-Maunoury S, Topilko P, Tiret L, Charnay P (2000) Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development 127:3313-3324.
12. Hornberger MR, Dutting D, Ciossek T, Yamada T, Handwerker C, Lang S, Weth F, Huf J, Wessel R, Logan C, Tanaka H, Drescher U (1999) Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron 22:731-742.
13. Kania A, Jessell TM (2003) Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A: EphA interactions. Neuron 38:581-596.
14. Kania A, Johnson RL, Jessell TM (2000) Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell 102:161-173.
15. Keleman K, Rajagopalan S, Cleppien D, Teis D, Paiha K, Huber LA, Technau GM, Dickson BJ (2002) Comm sorts robo to control axon guidance at the Drosophila midline. Cell 110:415-427.
16. Kilpatrick TJ, Brown A, Lai C, Gassman M, Goulding M, Lemke G (1996) Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol Cell Neurosci 7:62-74.
17. Knoll B, Zarbalis K, Wurst W, Drescher U (2001) A role for the EphA family in the topographic targeting of vomeronasal axons. Development 128:895-906.
18. Koblar SA, Krull CE, Pasquale EB, McLennan R, Peale FD, Cerretti DP, Bothwell M (2000) Spinal motor axons and neural crest cells use different molecular guides for segmental migration through the rostral half-somite. J Neurobiol 42:437-447.
19. Krull CE (2004) A primer on using in ovo electroporation to analyze gene function. Dev Dyn, in press.
20. Kullander K, Klein R (2002) Mechanisms and functions of Eph and ephrin signaling. Nat Rev Mol Cell Biol 3:475-486.
21. Lance-Jones C, Landmesser LT (1980) Motoneuron projection patterns in the chick hind limb following early partial reversals of the spinal cord. J Physiol (Lond) 302:581-602.
22. Lance-Jones C, Landmesser LT (1981) Pathway selection by embryonic chick motoneurons in an experimentally altered environment. Proc R Soc Lond B Biol Sci 214:19-52.
23. Landmesser L (1978) The development of motor projection patterns in the chick hind limb. J Physiol (Lond) 284:391-414.
24. Lee VM, Carden MJ, Schlaepfer WW, Trojanowski JQ (1987) Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J Neurosci 7:3474-3488.
25. Mann F, Peuckert C, Dehner F, Zhou R, Bolz J (2002) Ephrins regulate the formation of terminal axonal arbors during the development of thalamocortical projections. Development 129:3945-3955.
26. McLaughlin T, Hindges R, Yates PA, O'Leary DD (2003) Bifunctional action of ephrin-B1 as a repellent and attractant to control bi-directional branch extension in dorsal-ventral retinotopic mapping. Development 130:2407-2418.
27. Ohta K, Nakamura M, Hirokawa K, Tanaka S, Iwama A, Suda T, Ando M, Tanaka H (1996) The receptor tyrosine kinase Cek8 is transiently expressed on subtypes of motoneurons in the spinal cord during development. Mech Dev 54:59-69.
28. Osumi N, Inoue T (2001) Gene transfer into cultured mammalian embryos by electroporation. Methods 24:35-42.
29. Santiago A, Erickson CA (2002) Ephrin-B ligands play a dual role in the control of neural crest cell migration. Development 129:3621-3632.
30. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME (2001) EphA receptors-regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105:233-244.
31. Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, Potter S, Westphal H, Pfaff SL (1998) LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell 95:817-828.
32. Sharma K, Leonard AE, Lettieri K, Pfaff SL (2000) Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature 406:515-519.
33. Soans C, Holash JA, Pasquale EB (1994) Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene 9:3353-3361.
34. Swartz M, Eberhart J, Mastick G, Krull CE (2001a) Sparking new frontiers: using in vivo electroporation for genetic manipulations. Dev Biol 233:13-21.
35. Swartz ME, Eberhart J, Pasquale EB, Krull CE (2001b) EphA4/ephrin-A5 interactions in muscle precursor cell migration in the avian forelimb. Development 128:4669-4680.
36. Summerbell D, Stirling RV (1981) The innervation of dorso-ventrally reversed chick wings: evidence that motor axons do not actively seek out their appropriate targets. Exp Morphol 61:233-247.
37. Tosney KW (1987) Proximal tissues and patterned neurite outgrowth at the lumbosacral level of the chick embryo: deletion of the dermomyotome. Dev Biol 122:540-548.
38. Tosney KW, Landmesser LT (1985) Growth cone morphology and trajectory in the lumbosacral region of the chick embryo. J Neurosci 5:2345-2358.
39. Tsuchida T, Ensini M, Morton SB, Baldassare M, Edlund T, Jessell TM, Pfaff SL (1994) Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79:957-970.
40. Whitelaw V, Hollyday M (1983) Neural pathway constraints in the motor innervation of the chick hindlimb following dorsoventral rotations of distal limb segments. J Neurosci 3:1226-1233.
41. Zhou X, Suh J, Cerretti DP, Zhou R, DiCicco-Bloom E (2001) Ephrins stimulate neurite outgrowth during early cortical neurogenesis. J Neurosci Res 66:1054-1063.