Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment

European Journal of Neuroscience

Volumn 30, Issue 8, 2009, Pages 1544-1553

  Schiwy, Nora ^a   Brazda, Nicole ^a   Müller, Hans Werner ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Iron chelator; Rat; Regeneration; Scarring; Spinal cord injury

Indexed keywords

2,2' DIPYRIDINE 5,5' DICARBOXYLIC ACID; 8 BROMO CYCLIC AMP; CALCITONIN GENE RELATED PEPTIDE; IRON CHELATING AGENT; SEROTONIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN DAMAGE; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; SCAR FORMATION; SCAR SUPPRESSING TREATMENT; SPINAL CORD INJURY;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; AXONS; BIOTIN; CALCITONIN GENE-RELATED PEPTIDE; CICATRIX; DEXTRANS; DICARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; IRON CHELATING AGENTS; NERVE REGENERATION; PYRAMIDAL TRACTS; RATS; RATS, WISTAR; SEROTONIN; SPINAL CORD INJURIES; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 70350217622     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06929.x     Document Type: Article

References (37)

1. Bareyre, F.M., Kerschensteiner, M., Misgeld, T. Sanes, J.R. (2005) Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. Nat. Med., 11, 1355 1360.
2. Berry, M., Maxwell, W.L., Logan, A., Mathewson, A., McConnell, P., Ashhurst, D.E. Thomas, G.H. (1983) Deposition of scar tissue in the central nervous system. Acta Neurochir. (Wien), 32 (Suppl. 31 53.
3. Brook, G.A., Plate, D., Franzen, R., Martin, D., Moonen, G., Schoenen, J., Schmitt, A.B., Noth, J. Nacimiento, W. (1998) Spontaneous longitudinally orientated axonal regeneration is associated with the Schwann cell framework within the lesion site following spinal cord compression injury of the rat. J. Neurosci. Res., 53, 51 65.
4. Camand, E., Moral, M.-P., Faissner, A., Sotelo, C. Dusart, I. (2004) Long-term changes in the molecular composition of the glial scar and progressive increase of serotonergic fibre sprouting after hemisection of the mouse spinal cord. Eur. J. Neurosci., 20, 1161 1176.
5. de Castro, R. Jr., Tajrishi, R., Claros, J. Stallcup, W.B. (2005) Differential responses of spinal axons to transection: influence of the NG2 proteoglycan. Exp. Neurol., 192, 299 309.
6. Coumans, J.V., Lin, T.T., Dai, H.N., MacArthur, L., McAtee, M., Nash, C. Bregman, B.S. (2001) Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J. Neurosci., 21, 9334 9344.
7. Deumens, R., Koopmans, G.C. Joosten, E.A. (2005) Regeneration of descending axon tracts after spinal cord injury. Prog. Neurobiol., 77, 57 89.
8. Drew, T., Prentice, S. Schepens, B. (2004) Cortical and brainstem control of locomotion. Prog. Brain Res., 143, 251 261.
9. Duncan, M.R., Frazier, K.S., Abramson, S., Williams, S., Klapper, H., Huang, X. Grotendorst, G.R. (1999) Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J., 13, 1774 1786.
10. von Euler, M., Janson, A.M., Larsen, J.O., Seiger, A., Forno, L., Bunge, M.B. Sundstrom, E. (2002) Spontaneous axonal regeneration in rodent spinal cord after ischemic injury. J. Neuropathol. Exp. Neurol., 61, 64 75.
11. Grill, R., Murai, K., Blesch, A., Gage, F.H. Tuszynski, M.H. (1997) Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J. Neurosci., 17, 5560 5572.
12. Grotendorst, G.R. (1997) Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev., 8, 171 179.
13. Hannila, S.S. Filbin, M.T. (2008) The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp. Neurol., 209, 321 332.
14. Heise, C. Kayalioglu, G. (2009) Spinal cord transmitter substances. In Watson, C., Paxinos, G. Kayalioglu, G. (Eds The Spinal Cord - A Christopher and Dana Reeve Text and Atlas. Academic Press, London, pp. 191 208.
15. Hermanns, S., Klapka, N. Müller, H.W. (2001a) The collagenous lesion scar - an obstacle for axonal regeneration in brain and spinal cord injury. Restor. Neurol. Neurosci., 19, 139 148.
16. Hermanns, S., Reiprich, P. Müller, H.W. (2001b) A reliable method to reduce collagen scar formation in the lesioned rat spinal cord. J. Neurosci. Methods, 110, 141 146.
17. Hill, C.E., Beattie, M.S. Bresnahan, J.C. (2001) Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat. Exp. Neurol., 171, 153 169.
18. Inman, D. Steward, O. (2003) Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice. J. Comp. Neurol., 462, 431 449.
19. Joosten, E.A.J. (1997) Corticospinal tract regrowth. Prog. Neurobiol., 53, 1 25.
20. Jordan, L.M., Liu, J., Hedlund, P.B., Akay, T. Pearson, K.G. (2008) Descending command systems for the initiation of locomotion in mammals. Brain Res. Rev., 57, 183 191.
21. Kawano, H., Li, H.P., Sango, K., Kawamura, K. Raisman, G. (2005) Inhibition of collagen synthesis overrides the age-related failure of regeneration of nigrostriatal dopaminergic axons. J. Neurosci. Res., 80, 191 202.
22. Kennedy, P.R. (1990) Corticospinal, rubrospinal and rubro-olivary projections: a unifying hypothesis. Trends Neurosci., 13, 474 479.
23. Klapka, N. Müller, H.W. (2006) Collagen matrix in spinal cord injury. J. Neurotrauma, 23, 422 436.
24. Klapka, N., Hermanns, S., Straten, G., Masanneck, C., Duis, S., Hamers, F.P., Müller, D., Zuschratter, W. Müller, H.W. (2005) Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur. J. Neurosci., 22, 3047 3058.
25. Lemon, R.N. (2008) Descending pathways in motor control. Annu. Rev. Neurosci., 31, 195 218.
26. Li, Y. Raisman, G. (1995) Sprouts from cut corticospinal axons persist in the presence of astrocytic scarring in long-term lesions of the adult rat spinal cord. Exp. Neurol., 134, 102 111.
27. Lu, K.W., Chen, Z.Y., Jin, D.D., Hou, T.S., Cao, L. Fu, Q. (2002) Cationic liposome-mediated GDNF gene transfer after spinal cord injury. J. Neurotrauma, 19, 1081 1090.
28. Nakahara, Y., Gage, F.H. Tuszynski, M.H. (1996) Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant., 5, 191 204.
29. Ondarza, A.B., Ye, Z. Hulsebosch, C.E. (2003) Direct evidence of primary afferent sprouting in distant segments following spinal cord injury in the rat: colocalization of GAP-43 and CGRP. Exp. Neurol., 184, 373 380.
30. Ramon-Cueto, A., Cordero, M.I., Santos-Benito, F.F. Avila, J. (2000) Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron, 25, 425 435.
31. Rossignol, S., Dubuc, R. Gossard, J.P. (2006) Dynamic sensorimotor interactions in locomotion. Physiol. Rev., 86, 89 154.
32. Sivasankaran, R., Pei, J., Wang, K.C., Zhang, Y.P., Shields, C.B., Xu, X.-M. He, Z. (2004) PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat. Neurosci., 7, 261 268.
33. Steward, O., Zheng, B. Tessier-Lavigne, M. (2003) False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol., 459, 1 8.
34. Stichel, C.C., Hermanns, S., Luhmann, H.J., Lausberg, F., Niermann, H., D'Urso, D., Servos, G., Hartwig, H.G. Müller, H.W. (1999a) Inhibition of collagen IV deposition promotes regeneration of injured CNS axons. Eur. J. Neurosci., 11, 632 646.
35. Stichel, C.C., Niermann, H., D'Urso, D., Lausberg, F., Hermanns, S. Müller, H.W. (1999b) Basal membrane-depleted scar in lesioned CNS: characteristics and relationships with regenerating axons. Neuroscience, 93, 321 333.
36. Vavrek, R., Pearse, D.D. Fouad, K. (2007) Neuronal populations capable of regeneration following a combined treatment in rats with spinal cord transection. J. Neurotrauma, 24, 1667 1673.
37. Xiao, M., Klueber, K.M., Lu, C., Guo, Z., Marshall, C.T., Wang, H. Roisen, F.J. (2005) Human adult olfactory neural progenitors rescue axotomized rodent rubrospinal neurons and promote functional recovery. Exp. Neurol., 194, 12 30.