A reliable method to reduce collagen scar formation in the lesioned rat spinal cord

Journal of Neuroscience Methods

Volumn 110, Issue 1-2, 2001, Pages 141-146

  Hermanns, Susanne ^a   Reiprich, Petra ^a   Müller, Hans Werner ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

2,2 Bipyridine; 2,2 Bipyridine 5,5 dicarboxylic acid; Axonal regeneration; Collagen scar; Connective tissue growth factor; Spinal cord injury

Indexed keywords

2,2' BIPYRIDINE; 8 BROMO CYCLIC AMP; [2,2' BIPYRIDINE] 5,5' DICARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; COLLAGEN TYPE 4; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BRAIN INJURY; CELL PROLIFERATION; CELL SECRETION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; INHIBITION KINETICS; INJECTION; MALE; MEMBRANE FORMATION; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; SCAR FORMATION; SPINAL CORD LESION;

2,2'-DIPYRIDYL; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; BASEMENT MEMBRANE; CHELATING AGENTS; CICATRIX; COLLAGEN TYPE IV; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FEMALE; GLIOSIS; INDICATORS AND REAGENTS; IRON; MALE; NERVE REGENERATION; PROCOLLAGEN-PROLINE DIOXYGENASE; RATS; RATS, WISTAR; SPINAL CORD; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 0035975663     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(01)00427-7     Document Type: Article

References (29)

1. Tenascin-R inhibits regrowth of optic fibers in vitro and persists in the optic nerve of mice after injury
2. Nervous system proteoglycans as modulators of neurite outgrowth
3. Neurite outgrowth inhibitor of gliotic brain tissue. Mode of action and cellular localization, studied with specific monoclonal antibodies
4. NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord
5. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
6. Comparing astrocytic cell lines that are inhibitory or permissive for axon growth: The major axon-inhibitory proteoglycan is NG2
7. Glial cell extracellular matrix: Boundaries for axon growth in development and regeneration
8. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor
9. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
10. Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
11. Ineffectiveness of enzyme therapy on regeneration in the transected spinal cord of the rat
12. Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2′-bipyridine and its 5,5′-dicarboxylic acid derivatives
13. Preservation and detection of lesion-induced collagenous scar in the CNS depend on the method of tissue processing
14. Evidence that an iron chelator regulates collagen synthesis by decreasing the stability of procollagen mRNA
15. Post-translational processing of procollagens
16. Lidase treatment of spinal cord transected rats
17. Role of muscle fibroblasts in the deposition of type-IV collagen in the basal lamina of myotubes
18. Enzyme therapy in organic lesions of the spinal cord
19. Robust regeneration of CNS axons through a track depleted of CNS glia
20. Brain-derived neurotrophic factor reduces necrotic zone and supports neuronal survival after spinal cord hemisection in adult rats
21. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors
22. Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord
23. Myelin-associated glycoprotein in myelin and expressed by Schwann cells inhibits axonal regeneration and branching
24. Manufacture and release characteristics of Elvax polymers containing glutamate receptor antagonists
25. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
26. Extensive and long-lasting changes of glial cells following transection of the postcommissural fornix in the adult rat
27. Basal membrane-depleted scar in lesioned CNS: Characteristics and relationships with regenerating axons
28. Inhibition of collagen IV deposition promotes regeneration of injured CNS axons
29. Elimination of basal lamina and the collagen "scar" after spinal cord injury fails to augment corticospinal tract regeneration