The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system

Brain Research Reviews

Volumn 54, Issue 1, 2007, Pages 1-18

  Galtrey, Clare M ^a   Fawcett, James W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Axon regeneration; Central nervous system injury; Chondroitin sulfate proteoglycans; Chondroitinase; Perineuronal nets; Plasticity

Indexed keywords

AGGRECAN; BREVICAN; GLYCOSAMINOGLYCAN; N ACETYLGALACTOSAMINE 4 SULFATASE; NEUROCAN; PROTEOCHONDROITIN SULFATE; VERSICAN;

ALZHEIMER DISEASE; EPILEPSY; EYE DOMINANCE; GLIA; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LEARNING; MEMORY; NERVE CELL LESION; NERVE CELL PLASTICITY; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; STROKE;

ANIMALS; BRAIN DISEASES; CENTRAL NERVOUS SYSTEM; CICATRIX; EXTRACELLULAR MATRIX; HUMANS; MOLECULAR STRUCTURE; NERVE REGENERATION; NEURONAL PLASTICITY; NEURONS; PROTEOCHONDROITIN SULFATES;

EID: 33947645277     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2006.09.006     Document Type: Review

References (212)

1. Alberts B., Johnson A., Raff M., Roberts K., and Walter P. Cell Junctions, Cell Adhesion, and the Extracellular Matrix. Molecular Biology of the cell. Fourth ed. (2002), Garland Science, New York 1065-1125 chapter 19
2. Amet L.E., Lauri S.E., Hienola A., Croll S.D., Lu Y., Levorse J.M., Prabhakaran B., Taira T., Rauvala H., and Vogt T.F. Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol. Cell. Neurosci. 17 (2001) 1014-1024
3. Angelov D.N., Walther M., Streppel M., Guntinas-Lichius O., Neiss W.F., Probstmeier R., and Pesheva P. Tenascin-R is antiadhesive for activated microglia that induce downregulation of the protein after peripheral nerve injury: a new role in neuronal protection. J. Neurosci. 18 (1998) 6218-6229
4. Arendt T., Bruckner M.K., Gertz H.-J., and Marcova L. Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain. Neuroscience 83 (1998) 991-1002
5. Asher R.A., Scheibe R.J., Keiser H.D., and Bignami A. On the existence of a cartilage-like proteoglycan and link proteins in the central nervous system. Glia 13 (1995) 294-308
6. Asher R.A., Morgenstern D.A., Fidler P.S., Adcock K.H., Oohira A., Braistead J.E., Levine J.M., Margolis R.U., Rogers J.H., and Fawcett J.W. Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J. Neurosci. 20 (2000) 2427-2438
7. Asher R.A., Morgenstern D.A., Shearer M.C., Adcock K.H., Pesheva P., and Fawcett J.W. Versican is upregulated in CNS injury and is a product of oligodendrocyte lineage cells. J. Neurosci. 22 (2002) 2225-2236
8. Aspberg A., Miura R., Bourdoulous S., Shimonaka M., Heinegard D., Schachner M., Ruoslahti E., and Yamaguchi Y. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 10116-10121
9. Baig S., Wilcock G.K., and Love S. Loss of perineuronal net N-acetylgalactosamine in Alzheimer's disease. Acta Neuropathol. (Berl.) 110 (2005) 393-401
10. Bandtlow C.E., and Zimmermann D.R. Proteoglycans in the developing brain: new conceptual insights for old proteins. Physiol. Rev. 80 (2000) 1267-1290
11. Barritt A.W., Davies M., Marchand F., Hartley R., Grist J., Yip P., Mcmahon S.B., and Bradburry E.J. Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J. Neurosci. 26 42 (2003) 10856-10867
12. Bekku Y., Su W.D., Hirakawa S., Fassler R., Ohtsuka A., Kang J.S., Sanders J., Murakami T., Ninomiya Y., and Oohashi T. Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets. Mol. Cell. Neurosci. 24 (2003) 148-159
13. Belichenko P.V., Miklossy J., and Celio M.R. HIV-I induced destruction of neocortical extracellular matrix components in AIDS victims. Neurobiol. Dis. 4 (1997) 301-310
14. Belichenko P.V., Miklossy J., Belser B., Budka H., and Celio M.R. Early destruction of the extracellular matrix around parvalbumin-immunoreactive interneurons in Creutzfeldt-Jakob disease. Neurobiol. Dis. 6 (1999) 269-279
15. Berardi N., Pizzorusso T., and Maffei L. Critical periods during sensory development. Curr. Opin. Neurobiol. 10 (2000) 138-145
16. Berardi N., Pizzorusso T., Ratto G.M., and Maffei L. Molecular basis of plasticity in the visual cortex. Trends Neurosci. 26 (2003) 369-378
17. Berardi N., Pizzorusso T., and Maffei L. Extracellular matrix and visual cortical plasticity: freeing the synapse. Neuron 44 (2004) 905-908
18. Berghuis P., Dobszay M.B., Sousa K.M., Schulte G., Mager P.P., Hartig W., Gorcs T.J., Zilberter Y., Ernfors P., and Harkany T. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons. Eur. J. Neurosci. 20 (2004) 1290-1306
19. Bertolotto A., Manzardo E., and Guglielmone R. Immunohistochemical mapping of perineuronal nets containing chondroitin unsulfated proteoglycan in the rat central nervous system. Cell Tissue Res. 283 (1996) 283-295
20. Bidmon H.-J., Jancsik V., Schleicher A., Hagemann G., Witte O.W., Woodhams P., and Zilles K. Structural alterations and changes in cytoskeletal proteins and proteoglycans after focal cortical ischemia. Neuroscience 82 (1997) 397-420
21. Bignami A., Perides G., and Rahemtulla F. Versican, a hyaluronate-binding proteoglycan of embryonal precartilaginous mesenchyma, is mainly expressed postnatally in rat brain. J. Neurosci. Res. 34 (1993) 97-106
22. Binette F., Cravens J., Kahoussi B., Haudenschild D.R., and Goetinck P.F. Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid. J. Biol. Chem. 269 (1994) 19116-19122
23. Bodega G., Gianonatti C., Suarez I., and Fernandez B. Perineuronal glial nets in the rat spinal cord. A Golgi study. Arch. Histol. Jpn. 48 (1985) 505-510
24. Bradbury E.J., Moon L.D., Popat R.J., King V.R., Bennett G.S., Patel P.N., Fawcett J.W., and McMahon S.B. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416 (2002) 636-640
25. Brady D.R., and Mufson E.J. Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain. Neuroscience 80 (1997) 1113-1125
26. Brakebusch C., Seidenbecher C.I., Asztely F., Rauch U., Matthies H., Meyer H., Krug M., Bockers T.M., Zhou X., Kreutz M.R., Montag D., Gundelfinger E.D., and Fassler R. Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol. Cell. Biol. 22 (2002) 7417-7427
27. Brooks S.A., Dwek M.V., and Schumacher U. Functional & Molecular Glycobiology (2002), BIOS Scientific Publishers Limited, Oxford
28. Bruckner G., Seeger G., Brauer K., Hartig W., Kacza J., and Bigl V. Cortical areas are revealed by distribution patterns of proteoglycan components and parvalbumin in the Mongolian gerbil and rat. Brain Res. 658 (1994) 67-86
29. Bruckner G., Hartig W., Kacza J., Seeger J., Welt K., and Brauer K. Extracellular matrix organization in various regions of rat brain grey matter. J. Neurocytol. 25 (1996) 333-346
30. Bruckner G., Bringmann A., Hartig W., Koppe G., Delpech B., and Brauer K. Acute and long-lasting changes in extracellular-matrix chondroitin-sulphate proteoglycans induced by injection of chondroitinase ABC in the adult rat brain. Exp. Brain Res. 121 (1998) 300-310
31. Bruckner G., Hausen D., Hartig W., Drlicek M., Arendt T., and Brauer K. Cortical areas abundant in extracellular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzheimer's disease. Neuroscience 92 (1999) 791-805
32. Bruckner G., Grosche J., Schmidt S., Hartig W., Margolis R.U., Delpech B., Seidenbecher C.I., Czaniera R., and Schachner M. Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J. Comp. Neurol. 428 (2000) 616-629
33. Bruckner G., Kacza J., and Grosche J. Perineuronal nets characterized by vital labelling, confocal and electron microscopy in organotypic slice cultures of rat parietal cortex and hippocampus. J. Mol. Histol. 35 (2004) 115-122
34. Bukalo O., Schachner M., and Dityatev A. Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience 104 (2001) 359-369
35. Cafferty, W.B., Bradbury, E.J., Jones, M., Lidierth, M., McMahon, S.B. Chondroitinase ABC-mediated restitution of electrophysiological function after deafferentation. Program No. 619.3.[2004 Abstract Viewer/Itinerary Planner.]. 2004. Washington, DC: Society for Neuroscience, 2004. Online. Ref Type: Conference Proceeding.
36. Caggiano A.O., Zimber M.P., Ganguly A., Blight A.R., and Gruskin E.A. Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J. Neurotrauma 22 (2005) 226-239
37. Carmichael S.T. Plasticity of cortical projections after stroke. Neuroscientist 9 (2003) 64-75
38. Carmichael S.T., Archibeque I., Luke L., Nolan T., Momiy J., and Li S. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Exp. Neurol. 193 (2005) 291-311
39. Carulli D., Laabs T., Geller H.M., and Fawcett J.W. Chondroitin sulfate proteoglycans in neural development and regeneration. Curr. Opin. Neurobiol. 15 (2005) 252
40. Carulli D., Rhodes K.E., Brown D.J., Bonnert T.P., Pollack S.J., Oliver K., Strata P., and Fawcett J.W. Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components. J. Comp. Neurol. 494 (2006) 559-577
41. Celio M.R., and Blumcke I. Perineuronal nets-a specialized form of extracellular matrix in the adult nervous system. Brain Res. Brain Res. Rev. 19 (1994) 128-145
42. Celio M.R., and Chiquet-Ehrismann R. 'Perineuronal nets' around cortical interneurons expressing parvalbumin are rich in tenascin. Neurosci. Lett. 162 (1993) 137-140
43. Celio M.R., Spreafico R., De Biasi S., and Vitellaro-Zuccarello L. Perineuronal nets: past and present. Trends Neurosci. 21 (1998) 510-515
44. Chau C.H., Shum D.K., Li H., Pei J., Lui Y.Y., Wirthlin L., Chan Y.S., and Xu X.M. Chondroitinase ABC enhances axonal regrowth through Schwann cell-seeded guidance channels after spinal cord injury. FASEB J. 18 (2004) 194-196
45. Chen R., Cohen L.G., and Hallett M. Nervous system reorganization following injury. Neuroscience 111 (2002) 761-773
46. Clement A.M., Nadanaka S., Masayama K., Mandl C., Sugahara K., and Faissner A. The DSD-1 carbohydrate epitope depends on sulfation, correlates with chondroitin sulfate D motifs, and is sufficient to promote neurite outgrowth. J. Biol. Chem. 273 (1998) 28444-28453
47. Clement A.M., Sugahara K., and Faissner A. Chondroitin sulfate E promotes neurite outgrowth of rat embryonic day 18 hippocampal neurons. Neurosci. Lett. 269 (1999) 125-128
48. Corvetti L., and Rossi F. Degradation of chondroitin sulfate proteoglycans induces sprouting of intact Purkinje axons in the cerebellum of the adult rat. J. Neurosci. 25 (2005) 7150-7158
49. Czipri M., Otto J.M., Cs-Szabo G., Kamath R.V., Vermes C., Firneisz G., Kolman K.J., Watanabe H., Li Y., Roughley P.J., Yamada Y., Olsen B.R., and Glant T.T. Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency. J. Biol. Chem. 278 (2003) 39214-39223
50. Davies J.E., Tang X., Denning J.W., Archibald S.J., and Davies S.J.A. Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. Eur. J. Neurosci. 19 (2004) 1226-1242
51. Day J.M., Olin A.I., Murdoch A.D., Canfield A., Sasaki T., Timpl R., Hardingham T.E., and Aspberg A. Alternative splicing in the aggrecan G3 domain influences binding interactions with Tenascin-C and other extracellular matrix proteins. J. Biol. Chem. 279 (2004) 12511-12518
52. Deepa S.S., Umehara Y., Higashiyama S., Itoh N., and Sugahara K. Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues. J. Biol. Chem. 277 (2002) 43707-43716
53. Deepa S.S., Yamada S., Zako M., Goldberger O., and Sugahara K. Chondroitin sulfate chains on Syndecan-1 and Syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors: a novel function to control binding of midkine, pleiotrophin and basic fibroblast growth factor. J. Biol. Chem. 279 (2004) 37368-37376
54. Deepa S.S., Carulli D., Galtrey C., Rhodes K., Fukuda J., Mikami T., Sugahara K., and Fawcett J.W. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J. Biol. Chem. 281 (2006) 17789-17800
55. Deguchi K., Takaishi M., Hayashi T., Oohira A., Nagotani S., Li F., Jin G., Nagano I., Shoji M., Miyazaki M., Abe K., and Huh N.H. Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain. Brain Res. 1037 (2005) 194-199
56. Deller T., Haas C.A., and Frotscher M. Sprouting in the hippocampus after entorhinal cortex lesion is layer-specific but not translaminar: which molecules may be involved?. Restor. Neurol. Neurosci. 19 (2001) 159-167
57. De Wit J., De Winter F., Klooster J., and Verhaagen J. Semaphorin 3A displays a punctate distribution on the surface of neuronal cells and interacts with proteoglycans in the extracellular matrix. Mol. Cell. Neurosci. 29 (2005) 40-55
58. DeWitt D.A., and Silver J. Regenerative failure: a potential mechanism for neuritic dystrophy in Alzheimer's disease. Exp. Neurol. 142 (1996) 103-110
59. DeWitt D.A., Silver J., Canning D.R., and Perry G. Chondroitin sulfate proteoglycans are associated with the lesions of Alzheimer's disease. Exp. Neurol. 121 (1993) 149-152
60. DeWitt D.A., Richey P.L., Praprotnik D., Silver J., and Perry G. Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases. Brain Res. 656 (1994) 205-209
61. Diaz-Nido J., Wandosell F., and Avila J. Glycosaminoglycans and [beta]-amyloid, prion and tau peptides in neurodegenerative diseases. Peptides 23 (2002) 1323-1332
62. Dityatev A., and Schachner M. Extracellular matrix molecules and synaptic plasticity. Nat. Rev., Neurosci. 4 (2003) 456-468
63. Edgerton V.R., Tillakaratne N.J.K., Bigbee A.J., de Leon R.D., and Roy R.R. Plasticity of the spinal neural circuitry after injury. Annu. Rev. Neurosci. 27 (2004) 145-167
64. Emerling D.E., and Lander A.D. Inhibitors and promoters of thalamic neuron adhesion and outgrowth in embryonic neocortex: functional association with chondroitin sulfate. Neuron 17 (1996) 1089-1100
65. Engel M., Maurel P., Margolis R.U., and Margolis R.K. Chondroitin sulfate proteoglycans in the developing central nervous system. I. cellular sites of synthesis of neurocan and phosphacan. J. Comp. Neurol. 366 (1996) 34-43
66. Fawcett J.W., Rosser A.E., and Dunnett S.B. Brain Damage, Brain Repair (2002), Oxford Univ. Press, Oxford
67. Fillit H., and Leveugle B. Disorders of the extracellular matrix and the pathogenesis of senile dementia of the Alzheimer's type. Lab. Invest. 72 (1995) 249-253
68. Fouad K., Schnell L., Bunge M.B., Schwab M.E., Liebscher T., and Pearse D.D. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J. Neurosci. 25 (2005) 1169-1178
69. Fournier A.E., Takizawa B.T., and Strittmatter S.M. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J. Neurosci. 23 (2003) 1416-1423
70. Fox K., and Caterson B. Neuroscience. Freeing the brain from the perineuronal net. Science 298 (2002) 1187-1189
71. Freitag S., Schachner M., and Morellini F. Behavioral alterations in mice deficient for the extracellular matrix glycoprotein tenascin-R. Behav. Brain Res. 145 (2003) 189-207
72. Galtrey, C.M., Asher, R.A., Nothias F., Fawcett, J.W., in press. Promoting plasticity in the spinal cord with chondroitinase improves functional recovery after peripheral nerve repair. Brain.
73. Garwood J., Heck N., Reichardt F., and Faissner A. Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-{beta}, interacts with neuronal receptors and promotes neurite outgrowth. J. Biol. Chem. 278 (2003) 24164-24173
74. Gilbert R.J., McKeon R.J., Darr A., Calabro A., Hascall V.C., and Bellamkonda R.V. CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol. Cell. Neurosci. 29 (2005) 545-558
75. Goedert M., Jakes R., Spillantini M.G., Hasegawa M., Smith M.J., and Crowther R.A. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature 383 (1996) 550-553
76. Grimpe B., and Silver J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. J. Neurosci. 24 (2004) 1393-1397
77. Guntinas-Lichius O., Angelov D.N., Morellini F., Lenzen M., Skouras E., Schachner M., and Irintchev A. Opposite impacts of tenascin-C and tenascin-R deficiency in mice on the functional outcome of facial nerve repair. Eur. J. Neurosci. 22 (2005) 2171-2179
78. Gupta-Bansal R., Frederickson R.C., and Brunden K.R. Proteoglycan-mediated inhibition of A beta proteolysis. A potential cause of senile plaque accumulation. J. Biol. Chem. 270 (1995) 18666-18671
79. Habuchi O. Diversity and functions of glycosaminoglycan sulfotransferases. Biochim. Biophys. Acta (BBA)-Gen. Subj. 1474 (2000) 115-127
80. Hagihara K., Miura R., Kosaki R., Berglund E., Ranscht B., and Yamaguchi Y. Immunohistochemical evidence for the brevican-tenascin-R interaction: colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain. J. Comp. Neurol. 410 (1999) 256-264
81. Hartig W., Brauer K., and Bruckner G. Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons. NeuroReport 3 (1992) 869-872
82. Hartig W., Derouiche A., Welt K., Brauer K., Grosche J., Mader M., Reichenbach A., and Bruckner G. Cortical neurons immunoreactive for the potassium channel Kv3.1b subunit are predominantly surrounded by perineuronal nets presumed as a buffering system for cations. Brain Res. 842 (1999) 15-29
83. Hartig W., Klein C., Brauer K., Schuppel K.F., Arendt T., Bigl V., and Bruckner G. Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bison. Neurobiol. Aging 22 (2001) 25-33
84. Hartig W., Klein C., Brauer K., Schuppel K.F., Arendt T., Bigl V., and Bruckner G. Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bison. Neurobiol. Aging 22 (2001) 25-33
85. Hartmann U., and Maurer P. Proteoglycans in the nervous system-the quest for functional roles in vivo. Matrix Biol. 20 (2001) 23-35
86. Haunso A., Celio M.R., Margolis R.K., and Menoud P.A. Phosphacan immunoreactivity is associated with perineuronal nets around parvalbumin-expressing neurones. Brain Res. 834 (1999) 219-222
87. Hausen D., Bruckner G., Drlicek M., Hartig W., Brauer K., and Bigl V. Pyramidal cells ensheathed by perineuronal nets in human motor and somatosensory cortex. NeuroReport 7 (1996) 1725-1729
88. Hayashi N., Miyata S., Yamada M., Kamei K., and Oohira A. Neuronal expression of the chondroitin sulfate proteoglycans receptor-type protein-tyrosine phosphatase [beta] and phosphacan. Neuroscience 131 (2005) 331-348
89. Hayashita-Kinoh H., Kinoh H., Okada A., Komori K., Itoh Y., Chiba T., Kajita M., Yana I., and Seiki M. Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth. Cell Growth Differ. 12 (2001) 573-580
90. Heck N., Garwood J., Loeffler J.P., Larmet Y., and Faissner A. Differential upregulation of extracellular matrix molecules associated with the appearance of granule cell dispersion and mossy fiber sprouting during epileptogenesis in a murine model of temporal lobe epilepsy. Neuroscience 129 (2004) 309-324
91. Hensch T.K. Critical period regulation. Annu. Rev. Neurosci. 27 (2004) 549-579
92. Hirakawa S., Oohashi T., Su W.D., Yoshioka H., Murakami T., Arata J., and Ninomiya Y. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain. Biochem. Biophys. Res. Commun. 276 (2000) 982-989
93. Hirose J., Kawashima H., Yoshie O., Tashiro K., and Miyasaka M. Versican interacts with chemokines and modulates cellular responses. J. Biol. Chem. 276 (2001) 5228-5234
94. Hobohm C., Gunther A., Grosche J., Rossner S., Schneider D., and Bruckner G. Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal cerebral ischemia in rats. J. Neurosci. Res. 80 (2005) 539-548
95. Hockfield S., Kalb R.G., Zaremba S., and Fryer H. Expression of neural proteoglycans correlates with the acquisition of mature neuronal properties in the mammalian brain. Cold Spring Harbor Symp. Quant. Biol. 55 (1990) 505-514
96. Hocking A.M., Shinomura T., and McQuillan D.J. Leucine-rich repeat glycoproteins of the extracellular matrix. Matrix Biol. 17 (1998) 1-19
97. Houle J.D., Tom V.J., Mayes D., Wagoner G., Phillips N., and Silver J. Combining an autologous peripheral nervous system "Bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J. Neurosci. 26 (2006) 7405-7415
98. Irintchev A., Rollenhagen A., Troncoso E., Kiss J.Z., and Schachner M. Structural and functional aberrations in the cerebral cortex of tenascin-C deficient mice. Cereb. Cortex 15 (2004) 950-962
99. Jones L.L., Margolis R.U., and Tuszynski M.H. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp. Neurol. 182 (2003) 399-411
100. Kalb R.G., and Hockfield S. Molecular evidence for early activity-dependent development of hamster motor neurons. J. Neurosci. 8 (1988) 2350-2360
101. Kalb R.G., and Hockfield S. Large diameter primary afferent input is required for expression of the Cat-301 proteoglycan on the surface of motor neurons. Neuroscience 34 (1990) 391-401
102. Kantor D.B., Chivatakarn O., Peer K.L., Oster S.F., Inatani M., Hansen M.J., Flanagan J.G., Yamaguchi Y., Sretavan D.W., Giger R.J., and Kolodkin A.L. Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycans. Neuron 44 (2004) 961-975
103. Kawashima H., Atarashi K., Hirose M., Hirose J., Yamada S., Sugahara K., and Miyasaka M. Oversulfated chondroitin/dermatan sulfates containing GlcAbeta 1/IdoAalpha 1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines. J. Biol. Chem. 277 (2002) 12921-12930
104. Kitagawa H., Uyama T., and Sugahara K. Molecular cloning and expression of a human chondroitin synthase. J. Biol. Chem. 276 (2001) 38721-38726
105. Kitagawa H., Izumikawa T., Uyama T., and Sugahara K. Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. J. Biol. Chem. 278 (2003) 23666-23671
106. Knudson C.B., and Knudson W. Cartilage proteoglycans. Semin. Cell Dev. Biol. 12 (2001) 69-78
107. Knudson C.B., Nofal G.A., Pamintuan L., and Aguiar D.J. The chondrocyte pericellular matrix: a model for hyaluronan-mediated cell-matrix interactions. Biochem. Soc. Trans. 27 (1999) 142-147
108. Kobayashi K., Emson P.C., and Mountjoy C.Q. Vicia villosa lectin-positive neurones in human cerebral cortex. Loss in Alzheimer-type dementia. Brain Res. 498 (1989) 170-174
109. Komori K., Nonaka T., Okada A., Kinoh H., Hayashita-Kinoh H., Yoshida N., Yana I., and Seiki M. Absence of mechanical allodynia and A[beta]-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase. FEBS Lett. 557 (2004) 125-128
110. Koppe G., Bruckner G., Brauer K., Hartig W., and Bigl V. Developmental patterns of proteoglycan-containing extracellular matrix in perineuronal nets and neuropil of the postnatal rat brain. Cell Tissue Res. 288 (1997) 33-41
111. Koppe G., Bruckner G., Hartig W., Delpech B., and Bigl V. Characterization of proteoglycan-containing perineuronal nets by enzymatic treatments of rat brain sections. Histochem. J. 29 (1997) 11-20
112. Koprivica V., Cho K.S., Park J.B., Yiu G., Atwal J., Gore B., Kim J.A., Lin E., Tessier-Lavigne M., Chen D.F., and He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science 310 (2005) 106-110
113. Laabs T.L., Fawcett J.W., and Geller H.M. Chondroitin sulfate proteoglycan glycosaminoglycan chain synthesis: a potential molecular target. Program No. 386.4. 2005. 2005 Abstract Viewer/Itinerary Planner (2005), Society for Neuroscience, Washington, DC Online. Ref Type: Conference Proceeding
114. Lander C., Kind P., Maleski M., and Hockfield S. A family of activity-dependent neuronal cell-surface chondroitin sulfate proteoglycans in cat visual cortex. J. Neurosci. 17 (1997) 1928-1939
115. Lemons M.L., Sandy J.D., Anderson D.K., and Howland D.R. Intact aggrecan and fragments generated by both aggrecans and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury. J. Neurosci. Off. J. Soc. Neurosci. 21 (2001) 4772-4781
116. Logan A., Baird A., and Berry M. Decorin attenuates gliotic scar formation in the rat cerebral hemisphere. Exp. Neurol. 159 (1999) 504-510
117. Lundell A., Olin A.I., Morgelin M., Al Karadaghi S., Aspberg A., and Logan D.T. Structural basis for interactions between tenascins and Lectican C-Type lectin domains; evidence for a crosslinking role for tenascins. Structure (Cambridge) 12 (2004) 1495-1506
118. Malenka R.C., and Nicoll R.A. Long-term potentiation-a decade of progress?. Science 285 (1999) 1870-1874
119. Massey J.M., Hubscher C.H., Wagoner M.R., Decker J.A., Amps J., Silver J., and Onifer S.M. Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J. Neurosci. 26 (2006) 4406-4414
120. Matsui F., and Oohira A. Proteoglycans and injury of the central nervous system. Congenit. Anom. 44 (2004) 181-188
121. Matsui F., Nishizuka M., Yasuda Y., Aono S., Watanabe E., and Oohira A. Occurrence of a N-terminal proteolytic fragment of neurocan, not a C-terminal half, in a perineuronal net in the adult rat cerebrum. Brain Res. 790 (1998) 45-51
122. Matsumoto K., Shionyu M., Go M., Shimizu K., Shinomura T., Kimata K., and Watanabe H. Distinct interaction of Versican/PG-M with hyaluronan and link protein. J. Biol. Chem. 278 (2003) 41205-41212
123. Matthews R.T., Kelly G.M., Zerillo C.A., Gray G., Tiemeyer M., and Hockfield S. Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets. J. Neurosci. 22 (2002) 7536-7547
124. Maurel P., Rauch U., Flad M., Margolis R.K., and Margolis R.U. Phosphacan, a chondroitin sulfate proteoglycan of brain that interacts with neurons and neural cell-adhesion molecules, is an extracellular variant of a receptor-type protein tyrosine phosphatase. Proc. Natl. Acad. Sci. 91 (1994) 2512-2516
125. McKeon R.J., Hoke A., and Silver J. Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars. Exp. Neurol. 136 (1995) 32-43
126. McLaurin J., and Fraser P.E. Effect of amino-acid substitutions on Alzheimer's amyloid-{beta} peptide-glycosaminoglycan interactions. Eur. J. Biochem. 267 (2000) 6353-6361
127. Medina-Flores R., Wang G., Bissel S.J., Murphey-Corb M., and Wiley C.A. Destruction of extracellular matrix proteoglycans is pervasive in simian retroviral neuroinfection. Neurobiol. Dis. 16 (2004) 604-616
128. Milev P., Fischer D., Haring M., Schulthess T., Margolis R.K., Chiquet-Ehrismann R., and Margolis R.U. The fibrinogen-like globe of tenascin-C mediates its interactions with neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta. J. Biol. Chem. 272 (1997) 15501-15509
129. Milev P., Chiba A., Haring M., Rauvala H., Schachner M., Ranscht B., Margolis R.K., and Margolis R.U. High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule. J. Biol. Chem. 273 (1998) 6998-7005
130. Miyata S., Akagi A., Hayashi N., Watanabe K., and Oohira A. Activity-dependent regulation of a chondroitin sulfate proteoglycan 6B4 phosphacan/RPTPbeta in the hypothalamic supraoptic nucleus. Brain Res. 1017 (2004) 163-171
131. Miyata S., Nishimura Y., Hayashi N., and Oohira A. Construction of perineuronal net-like structure by cortical neurons in culture. Neuroscience 136 (2005) 95-104
132. Miyata S., Nakatani Y., Hayashi N., and Nakashima T. Matrix-degrading enzymes tissue plasminogen activator and matrix metalloprotease-3 in the hypothalamo-neurohypophysial system. Brain Res. 1058 (2005) 1-9
133. Moleres F.J., and Velayos J.L. Expression of PrP(C) in the rat brain and characterization of a subset of cortical neurons. Brain Res. 1056 (2005) 10-21
134. Monnier P.P., Sierra A., Schwab J.M., Henke-Fahle S., and Mueller B.K. The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol. Cell. Neurosci. 22 (2003) 319-330
135. Moon L.D.F., and Fawcett J.W. Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGF 1 and 2. Eur. J. Neurosci. 14 (2001) 1667-1677
136. Moon L.D., Asher R.A., Rhodes K.E., and Fawcett J.W. Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC. Nat. Neurosci. 4 (2001) 465-466
137. Moon L.D.F., Asher R.A., Rhodes K.E., and Fawcett J.W. Relationship between sprouting axons, proteoglycans and glial cells following unilateral nigrostriatal axotomy in the adult rat. Neuroscience 109 (2002) 101-117
138. Morawski M., Bruckner M.K., Riederer P., Bruckner G., and Arendt T. Perineuronal nets potentially protect against oxidative stress. Exp. Neurol. 188 (2004) 309-315
139. Morgenstern D.A., Asher R.A., and Fawcett J.W. Chondroitin sulphate proteoglycans in the CNS injury response. Prog. Brain Res. 137 (2002) 313-332
140. Morimoto K., Fahnestock M., and Racine R.J. Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog. Neurobiol. 73 (2004) 1-60
141. Morris N.P., and Henderson Z. Perineuronal nets ensheath fast spiking, parvalbumin-immunoreactive neurons in the medial septum/diagonal band complex. Eur. J. Neurosci. 12 (2000) 828-838
142. Muller C.M., and Griesinger C.B. Tissue plasminogen activator mediates reverse occlusion plasticity in visual cortex. Nat. Neurosci. 1 (1998) 47-53
143. Murakami T., and Ohtsuka A. Perisynaptic barrier of proteoglycans in the mature brain and spinal cord. Arch. Histol. Cytol. 66 (2003) 195-207
144. Murakami T., and Ohtsuka A. Perisynaptic barrier of proteoglycans in the mature brain and spinal cord. Arch. Histol. Cytol. 66 (2003) 195-207
145. Murakami T., Murakami T., Sato H., Mubarak W.A., Ohtsuka A., and Abe K. Perineuronal nets of proteoglycans in the adult mouse brain, with special reference to their reactions to Gomori's ammoniacal silver and Ehrlich's methylene blue. Arch. Histol. Cytol. 62 (1999) 71-81
146. Murakami T., Murakami T., Su W.D., Ohtsuka A., Abe K., and Ninomiya Y. Perineuronal nets of proteoglycans in the adult mouse brain are digested by collagenase. Arch. Histol. Cytol. 62 (1999) 199-204
147. Nagel S., Sandy J.D., Meyding-Lamade U., Schwark C., Bartsch J.W., and Wagner S. Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons. Brain Res. 1056 (2005) 43-50
148. Neame P.J., and Barry F.P. The link proteins. EXS 70 (1994) 53-72
149. Novak U., and Kaye A.H. Extracellular matrix and the brain: components and function. J. Clin. Neurosci. 7 (2000) 280-290
150. Ogawa T., Hagihara K., Suzuki M., and Yamaguchi Y. Brevican in the developing hippocampal fimbria: differential expression in myelinating oligodendrocytes and adult astrocytes suggests a dual role for brevican in central nervous system fiber tract development. J. Comp. Neurol. 432 (2001) 285-295
151. Ojima H., Sakai M., and Ohyama J. Molecular heterogeneity of Vicia villosa-recognized perineuronal nets surrounding pyramidal and nonpyramidal neurons in the guinea pig cerebral cortex. Brain Res. 786 (1998) 274-280
152. Okamoto M., Mori S., Ichimura M., and Endo H. Chondroitin sulfate proteoglycans protect cultured rat's cortical and hippocampal neurons from delayed cell death induced by excitatory amino acids. Neurosci. Lett. 172 (1994) 51-54
153. Okamoto M., Sakiyama J., Mori S., Kurazono S., Usui S., Hasegawa M., and Oohira A. Kainic acid-induced convulsions cause prolonged changes in the chondroitin sulfate proteoglycans neurocan and phosphacan in the limbic structures. Exp. Neurol. 184 (2003) 179-195
154. Olin A.I., Morgelin M., Sasaki T., Timpl R., Heinegard D., and Aspberg A. The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. J. Biol. Chem. 276 (2001) 1253-1261
155. Oohashi T., Hirakawa S., Bekku Y., Rauch U., Zimmermann D.R., Su W.D., Ohtsuka A., Murakami T., and Ninomiya Y. Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. Mol. Cell. Neurosci. 19 (2002) 43-57
156. Oohira A., Matsui F., Tokita Y., Yamauchi S., and Aono S. Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development. Arch. Biochem. Biophys. 374 (2000) 24-34
157. Oohira A., Shuo T., Tokita Y., Nakanishi K., and Aono S. Neuroglycan, C., a brain-specific part-time proteoglycan, with a particular multidomain structure. Glycoconj. J. 21 (2004) 53-57
158. Oray S., Majewska A., and Sur M. Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation. Neuron 44 (2004) 1021-1030
159. Pizzorusso T., Medini P., Berardi N., Chierzi S., Fawcett J.W., and Maffei L. Reactivation of ocular dominance plasticity in the adult visual cortex. Science 298 (2002) 1248-1251
160. Pizzorusso T., Medini P., Landi S., Baldini S., Berardi N., and Maffei L. Structural and functional recovery from early monocular deprivation in adult rats. Proc. Natl. Acad. Sci. 103 (2006) 8517-8522
161. Prabhakar V., Capila I., Bosques C.J., Pojasek K., and Sasisekharan R. Chondroitinase ABC I from Proteus vulgaris: cloning, recombinant expression and active site identification. Biochem. J. 386 (2005) 103-112
162. Properzi F., Asher R.A., and Fawcett J.W. Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury. Biochem. Soc. Trans. 31 (2003) 335-336
163. Properzi F., Carulli D., Asher R.A., Muir E., Camargo L.M., van Kuppevelt T.H., ten Dam G.B., Furukawa Y., Mikami T., Sugahara K., Toida T., Geller H.M., and Fawcett J.W. Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia. Eur. J. Neurosci. 21 (2005) 378-390
164. Prydz K., and Dalen K.T. Synthesis and sorting of proteoglycans. J. Cell Sci. 113 (2000) 193-205
165. Rauch U. Extracellular matrix components associated with remodeling processes in brain. Cell. Mol. Life Sci. 61 (2004) 2031-2045
166. Rauch U., Clement A., Retzler C., Frohlich L., Fassler R., Gohring W., and Faissner A. Mapping of a defined neurocan binding site to distinct domains of tenascin-C. J. Biol. Chem. 272 (1997) 26905-26912
167. Rauch U., Hirakawa S., Oohashi T., Kappler J., and Roos G. Cartilage link protein interacts with neurocan, which shows hyaluronan binding characteristics different from CD44 and TSG-6. Matrix Biol. 22 (2004) 629-639
168. Rauch U., Zhou X.H., and Roos G. Extracellular matrix alterations in brains lacking four of its components. Biochem. Biophys. Res. Commun. 328 (2005) 608-617
169. Rhodes K.E., and Fawcett J.W. Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?. J. Anat. 204 (2004) 33-48
170. Saghatelyan A.K., Dityatev A., Schmidt S., Schuster T., Bartsch U., and Schachner M. Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrix glycoprotein tenascin-R. Mol. Cell. Neurosci. 17 (2001) 226-240
171. Sampson V.L., Morrison J.H., and Vickers J.C. The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease. Exp. Neurol. 145 (1997) 295-302
172. Satoh J., Tabira T., Sano M., Nakayama H., and Tateishi J. Parvalbumin-immunoreactive neurons in the human central nervous system are decreased in Alzheimer's disease. Acta Neuropathol. (Berl.) 81 (1991) 388-395
173. Seidenbecher C.I., Smalla K.H., Fischer N., Gundelfinger E.D., and Kreutz M.R. Brevican isoforms associate with neural membranes. J. Neurochem. 83 (2002) 738-746
174. Seyfried N.T., McVey G.F., Almond A., Mahoney D.J., Dudhia J., and Day A.J. Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. J. Biol. Chem. 280 (2005) 5435-5448
175. Shi S., Grothe S., Zhang Y., O'Connor-McCourt M.D., Poole A.R., Roughley P.J., and Mort J.S. Link protein has greater affinity for versican than aggrecan. J. Biol. Chem. 279 (2004) 12060-12066
176. Shimazaki Y., Nagata I., Ishii M., Tanaka M., Marunouchi T., Hata T., and Maeda N. Developmental change and function of chondroitin sulfate deposited around cerebellar Purkinje cells. J. Neurosci. Res. 82 (2005) 172-183
177. Shintani T., Watanabe E., Maeda N., and Noda M. Neurons as well as astrocytes express proteoglycan-type protein tyrosine phosphatase zeta/RPTPbeta: analysis of mice in which the PTPzeta/RPTPbeta gene was replaced with the LacZ gene. Neurosci. Lett. 247 (1998) 135-138
178. Shiosaka S., and Yoshida S. Synaptic microenvironments-structural plasticity, adhesion molecules, proteases and their inhibitors. Neurosci. Res. 37 (2000) 85-89
179. Silver J., and Miller J.H. Regeneration beyond the glial scar. Nat. Rev., Neurosci. 5 (2004) 146-156
180. Sivasankaran R., Pei J., Wang K.C., Zhang Y.P., Shields C.B., Xu X.M., and He Z. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat. Neurosci. 7 (2004) 261-268
181. Smith-Thomas L.C., Stevens J., Fok-Seang J., Faissner A., Rogers J.H., and Fawcett J.W. Increased axon regeneration in astrocytes grown in the presence of proteoglycan synthesis inhibitors. J. Cell Sci. 108 (1995) 1307-1315
182. Snow D.M., Lemmon V., Carrino D.A., Caplan A.I., and Silver J. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp. Neurol. 109 (1990) 111-130
183. Snow D.M., Brown E.M., and Letourneau P.C. Growth cone behavior in the presence of soluble chondroitin sulfate proteoglycan (CSPG), compared to behavior on CSPG bound to laminin or fibronectin. Int. J. Dev. Neurosci. 14 (1996) 331-349
184. Sole S., Petegnief V., Gorina R., Chamorro A., and Planas A.M. Activation of matrix metalloproteinase-3 and agrin cleavage in cerebral ischemia/reperfusion. J Neuropathol Exp. Neurol. 63 (2004) 338-349
185. Solodkin A., Veldhuizen S.D., and Van Hoesen G.W. Contingent vulnerability of entorhinal parvalbumin-containing neurons in Alzheimer's disease. J. Neurosci. 16 (1996) 3311-3321
186. Spicer A.P., Joo A., and Bowling Jr. R.A. A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links. J. Biol. Chem. 278 (2003) 21083-21091
187. Stallcup W.B. The NG2 proteoglycan: past insights and future prospects. J. Neurocytol. 31 (2002) 423-435
188. Sugahara K., Mikami T., Uyama T., Mizuguchi S., Nomura K., and Kitagawa H. Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. Curr. Opin. Struct. Biol. 13 (2003) 612-620
189. Sur M., Frost D.O., and Hockfield S. Expression of a surface-associated antigen on Y-cells in the cat lateral geniculate nucleus is regulated by visual experience. J. Neurosci. 8 (1988) 874-882
190. Takahashi-Iwanaga H., Murakami T., and Abe K. Three-dimensional microanatomy of perineuronal proteoglycan nets enveloping motor neurons in the rat spinal cord. J. Neurocytol. 27 (1998) 817-827
191. Tanaka M., Maeda N., Noda M., and Marunouchi T. A chondroitin sulfate proteoglycan PTPzeta /RPTPbeta regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum. J. Neurosci. 23 (2003) 2804-2814
192. Tang X., Davies J.E., and Davies S.J. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. J. Neurosci. Res. 71 (2003) 427-444
193. Theodosis D.T., Piet R., Poulain D.A., and Oliet S.H. Neuronal, glial and synaptic remodeling in the adult hypothalamus: functional consequences and role of cell surface and extracellular matrix adhesion molecules. Neurochem. Int. 45 (2004) 491-501
194. Thon N., Haas C.A., Rauch U., Merten T., Fassler R., Frotscher M., and Deller T. The chondroitin sulphate proteoglycan brevican is upregulated by astrocytes after entorhinal cortex lesions in adult rats. Eur. J. Neurosci. 12 (2000) 2547-2558
195. Toole B.P. Hyaluronan: from extracellular glue to pericellular cue. Nat. Rev., Cancer 4 (2004) 528-539
196. Tropea D., Caleo M., and Maffei L. Synergistic effects of brain-derived neurotrophic factor and chondroitinase ABC on retinal fiber sprouting after denervation of the superior colliculus in adult rats. J. Neurosci. 23 (2003) 7034-7044
197. Vaillant C., Didier-Bazes M., Hutter A., Belin M.F., and Thomasset N. Spatiotemporal expression patterns of metalloproteinases and their inhibitors in the postnatal developing rat cerebellum. J. Neurosci. 19 (1999) 4994-5004
198. Vitellaro-Zuccarello L., Meroni A., Amadeo A., and De Biasi S. Chondroitin sulfate proteoglycans in the rat thalamus: expression during postnatal development and correlation with calcium-binding proteins in adults. Cell Tissue Res. 306 (2001) 15-26
199. Wall J.T., Xu J., and Wang X. Human brain plasticity: an emerging view of the multiple substrates and mechanisms that cause cortical changes and related sensory dysfunctions after injuries of sensory inputs from the body. Brain Res. Brain Res. Rev. 39 (2002) 181-215
200. Watanabe H., and Yamada Y. Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nat. Genet. 21 (1999) 225-229
201. Weber P., Bartsch U., Rasband M.N., Czaniera R., Lang Y., Bluethmann H., Margolis R.U., Levinson S.R., Shrager P., Montag D., and Schachner M. Mice deficient for tenascin-R display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. J. Neurosci. 19 (1999) 4245-4262
202. Wegner F., Hartig W., Bringmann A., Grosche J., Wohlfarth K., Zuschratter W., and Bruckner G. Diffuse perineuronal nets and modified pyramidal cells immunoreactive for glutamate and the GABA(A) receptor alpha1 subunit form a unique entity in rat cerebral cortex. Exp. Neurol. 184 (2003) 705-714
203. Wintergerst E.S., Faissner A., and Celio M.R. The proteoglycan DSD-1-PG occurs in perineuronal nets around parvalbumin-immunoreactive interneurons of the rat cerebral cortex. Int. J. Dev. Neurosci. 14 (1996) 249-255
204. Xu J., Kim G.M., Ahmed S.H., Xu J., Yan P., Xu X.M., and Hsu C.Y. Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. J. Neurosci. 21 (2001) 92-97
205. Yamaguchi Y. Lecticans: organizers of the brain extracellular matrix. Cell. Mol. Life Sci. 57 (2000) 276-289
206. Yasuhara O., Akiyama H., McGeer E.G., and McGeer P.L. Immunohistochemical localization of hyaluronic acid in rat and human brain. Brain Res. 635 (1994) 269-282
207. Yick L.W., Cheung P.T., So K.F., and Wu W. Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Exp. Neurol. 182 (2003) 160-168
208. Yick L.W., So K.F., Cheung P.T., and Wu W.T. Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury. J. Neurotrauma 21 (2004) 932-943
209. Yoshiyama Y., Asahina M., and Hattori T. Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. Acta Neuropathol. 99 (2000) 91-95
210. Yuan W., Matthews R.T., Sandy J.D., and Gottschall P.E. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Neuroscience 114 (2002) 1091-1101
211. Zaremba S., Guimaraes A., Kalb R.G., and Hockfield S. Characterization of an activity-dependent, neuronal surface proteoglycan identified with monoclonal antibody Cat-301. Neuron 2 (1989) 1207-1219
212. Zhou X.H., Brakebusch C., Matthies H., Oohashi T., Hirsch E., Moser M., Krug M., Seidenbecher C.I., Boeckers T.M., Rauch U., Buettner R., Gundelfinger E.D., and Fassler R. Neurocan is dispensable for brain development. Mol. Cell. Biol. 21 (2001) 5970-5978